Use: Simple, complex (petit mal) absence, mixed seizures, complex partial seizures, migraine prophylaxis, tonic-clonic (grand mal) seizures and infantile spasms. Depakote for manic episodes in bipolar disorder.
Dental Considerations: Local anesthesia with vasoconstrictor ok. Gingival enlargements, headache, erythema multiforme, blood dyscrasias with prolonged bleeding and delayed healing.
Dental Drug Interactions: Increases toxicity of barbiturates, alcohol and CNS depressants potentiates depressant effects of valproic acid. Increases bleeding with aspirin, NSAIDs and coumadin.
Action: Inhibits nerve impulses by limiting influx of sodium ions across cell membrane in motor cortex. Also has anticholinergic, antineuralgic, antidiuretic, muscle relaxant and antiarrhythmic properties.