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16th May – 18th May 2018

International Hepatitis Symposium Heidelberg

Ralf Bartenschlager’s 60th Birthday Symposium (16th)


International Symposium of the TRR179 (17th to 18th)

Conference Venue: DKFZ Heidelberg

Confirmed Speakers:

Andrea Ablasser, Lausanne

Andreas Bergthaler, Vienna

Eva Billerbeck, New York

Maura Dandri, Hamburg

Carlo Ferrari, Parma

Markus Heim, Basel

Matteo Iannacone, Milan

Stanley M. Lemon, Chapel Hill

Wenhui Li, Peking

Mala Maini, London

Darius Moradpour, Lausanne

Christine Neuveut, Paris

Thomas Pietschmann, Hannover

Barbara Rehermann, Bethesda

Charles M. Rice, New York

Naglaa Shoukry, Montreal

John E. Wherry, Philadelphia

Adam Zlotnick, Bloomington

Please register at until 15th April 18

Ralf Bartenschlager’s 60th Birthday Symposium
Symposium Chair:

PD Dr. Volker Lohmann

Department of Infectious Diseases, Molecular Virology,

Heidelberg University Hospital;

International Symposium of the TRR179

Symposium Chairs:

Prof. Dr. Ralf Bartenschlager

Department of Infectious Diseases, Molecular Virology,

Heidelberg University Hospital;

Research Division ‘Virus-associated Carcinogenesis’,

German Cancer Research Center Heidelberg;

German Centre for Infection Research (DZIF e.V.)

Prof. Dr. Robert Thimme

Department of Internal Medicine II,

University Hospital Freiburg
Prof. Dr. Ulrike Protzer

Institute of Virology,

TU München/ Helmholtz Zentrum München;

German Centre for Infection Research (DZIF e.V.)

Organizing Committee:

PD Dr. Volker Lohmann

Dr. Sandra Bühler

Dr. Catherine Moreau

Steffi Schimang

Organizing Committee:

Prof. Dr. Ralf Bartenschlager

Prof. Dr. Robert Thimme

Prof. Dr. Ulrike Protzer

Dr. Sandra Bühler

Dr. Catherine Moreau

Steffi Schimang

Conference Language:

The conference language will be English.

Registration: Admission free! Please register until 15th April 2018


Dr. Sandra Bühler or Steffi Schimang, Department of Infectious Diseases, Molecular Virology, Im Neuenheimer Feld 344, 69120 Heidelberg

Tel.: +49 6221 56 7895 or 7598
AGENDA Ralf Bartenschlager’s 60th Birthday Symposium

Wednesday, 16th May 2018

10:00 Welcome addresses

11:00 Darius Moradpour, Lausanne, Switzerland

11:45 – 13:00 LUNCH

Foyer DKFZ Communication Center

13:00 Michael Nassal, Freiburg, Germany

13:20 Ursula Klingmüller, Heidelberg, Germany

13:40 tba

14:00 Rene Devos, St. Albans, United Kingdom

14:20 Matthias Reddehase, Mainz, Germany

14:40 Thomas Pietschmann, Hannover, Germany

15:00 David Paul, Cambridge, United Kingdom

15:30 – 16:00 COFFEE BREAK

Foyer DKFZ Communication Center

16:00 Laurent Chatel-Chaix, Montreal, Canada

16:20 Marco Binder, Heidelberg, Germany

16:40 Stefan Seitz, Heidelberg, Germany

17:00 Mathias Heikenwälder, München and Heidelberg, Germany

17:20 Stephan Urban, Heidelberg, Germany

17:40 Charles Rice, New York, USA

18:15- 20:30 TRR179 Welcome Reception

Foyer DKFZ Communication Center


AGENDA International Symposium of the TRR179

Thursday, 17th May 2018

09:00 Welcome address

Ralf Bartenschlager

Inflammation and Microbiome

Chairman: Hartmut Hengel

09:20 Role of microbiota in host fitness

Barbara Rehermann, Bethesda, USA

09:45 Hepatic metabolism directs antiviral immunity in persistent infection

Andreas Bergthaler, Vienna, Austria

10:10 Lymphotoxin β receptor signalling-dependent control of virus clearance in chronic hepatitis B virus and hepatitis C virus infections

Mathias Heikenwälder TRR179

10:25– 10:50 COFFEE BREAK

Foyer DKFZ Communication Center

Innate Immune Response

Chairman: Andreas Pichlmair

10:50 Intracellular DNA sensing strategies

Andrea Ablasser, Lausanne, Switzerland

11:15 Dissecting NK cell-mediated immune responses against hepatitis B virus and hepatitis C virus infection

Adelheid Cerwenka TRR179

11:30 Mechanisms of interferon induction by hepatitis D virus and impact of chronic innate immune activation on antiviral immunity

Veit Hornung/Percy Knolle TRR179

11:45 Strategies to harness an effective antiviral response targeting hepatitis B virus

Ursula Klingmüller/Jens Timmer TRR179

12:00 Global effects on host cell signalling by continuous stimulation of innate antiviral responses in persistent viral infections

Marco Binder/Andreas Pichlmair TRR179

12:15 Role of innate immune response in HCV infection

Markus Heim, Basel, Switzerland

12:45 – 13:45 LUNCH

Foyer DKFZ Communication Center

In Vivo Imaging and Mouse Models

Chairman: Percy Knolle

13:45 Pathogenetic mechanisms underlying liver immunopathology during viral hepatitis

Matteo Iannacone, Milan, Italy

14:10 Molecular mechanisms of HBV and HDV persistence

Maura Dandri, Hamburg, Germany

14:35 Dynamics of antiviral T cell immunity against viral infection of the liver

Dirk Wohlleber/Vasilis Ntziachristos TRR179

14:50 Mouse models of acute and chronis hepacivirus infection

Eva Billerbeck, New York, USA

Cell biology of hepatitis virus replication

Chairman: Dirk Grimm

15:15 Unravelling the role of DNA repair in the formation of the hepatitis B virus cccDNA persistence reservoir

Sabrina Schreiner/Michael Nassal TRR179

15:30 Contribution of innate immune response to persistence versus clearance of hepatitis C virus and hepatitis A virus infections

Volker Lohmann TRR179

15:45 tba

Alessia Ruggieri TRR179

16:00 Means of modification and degradation of hepatitis B virus cccDNA

Ulrike Protzer/ Dirk Grimm TRR179

16:15 – 16:45 COFFEE BREAK

Foyer DKFZ Communication Center

Chairman: Michael Nassal

16:45 Highjacking of cell regulation by HBV : a 3D nuclear perspective

Christine Neuveut, Paris, France

17:10 Assembly and Misassembly of HBV capsids

Adam Zlotnick, Bloomington, USA

17:35 Determinants of success and failure to control hepatitis C virus infection by the interferon system

Ralf Bartenschlager TRR179

17:50 Hepatitis B virus X-protein-mediated transcriptional regulation and stability of cccDNA

Stephan Urban TRR179

18:05 HBV entry

Wenhui Li, Peking, China

18:30 Cellular egress and entry of quasi-enveloped hepatitis A virus

Stanley M. Lemon, Chapel Hill, USA


Castle Schriesheim – Bus transfer

Friday, 18th May 2018

Adaptive Immune Response

Chairman: Robert Thimme

09:15 T cell exhaustion in chronic HBV infection or T cell exhaustion in chronic HBV infection and potential correction strategies

Carlo Ferrari, Parma

09:40 Protective immunity against HCV, insights from reinfection studies

Naglaa Shoukry, Montreal, Canada; Cooperation CanHepc

10:05 Characterization of follicular T helper cell responses in viral hepatitis

Tobias Böttler TRR179

10:20 Heterogeneity of HBV- and HCV-specific CD8+ T cells in chronic infection

Maike Hofmann/Robert Thimme TRR179

10:35 Role of myeloid cells in the liver for antiviral immunity

Percy Knolle TRR179

10:50 Viral escape from dominant virus-specific CD8+ T cell responses in hepatitis B virus (HBV) mono-infection and HBV/hepatitis D virus co-infection and strategies to restore antiviral CD8+ T cell response

Christoph Neumann-Häfelin TRR179

10:50 – 11:20 COFFEE BREAK

Foyer DKFZ Communication Center

11:20 Immune correlates of viral persistence and liver damage

Mala Maini, London

11:45 T-cell exhaustion

John E. Wherry, Philadelphia

12:10 Farewell

Ralf Bartenschlager, Robert Thimme and Ulrike Protzer


Foyer DKFZ Communication Center

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