Surgery: Advantages: quick & effective; largest no of cures; confirmation of excision Disadvantages



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BB20023/BB20110: DNA and disease

Cancer therapy I: Conventional therapies

Surgery:

Advantages: quick & effective; largest no of cures; confirmation of excision

Disadvantages: no guarantee of complete removal; critical normal tissues invasion & most important ineffective for metastasis.

Radiotherapy


Primary curative modality in ~ 30% of patients

technological innovations has led to improved & expanded applications including radium, high vacuum tubes, linear accelerators, transistors, imaging techniques



Advantages: quicker recovery by healthy tissues, preservation of anatomical structures surrounding tumour maintaining function eg uterine cervix, prostate

Disadvantages: failure of complete remission, metastasis (whole body radiation). Radiation dose required depends on tumour type & number of tumour clonogens, does not avoid adverse effects in normal tissue.

Conformal radiotherapy


Uses advances in imaging, computers & treatment planning. CAT, MRI

e.g. liver tumours -25Gy usually deleterious but 60Gy can be done with conformal radiotherapy

time, dose & fractionation: Small dose fractions produces relatively less damage to late responding than early responding tissues.


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