Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos

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method to predict ecological vulnerability in wildlife species by using autecological data and expert judgment; in the current study, this method is further extended to assess ecological vulnerability of food chains and terrestrial and aquatic habitats typical for The Netherlands. The method is applied to six chemicals: Cd, Cu, Zn, dichlorodiphenyltrichloroethane, chlorpyrifos, and ivermectin. The results indicate that species in different food chains differ in vulnerability, with earthworm-based food chains the most vulnerable. Within and between food chains, vulnerability varied with habitat, particularly at low trophic levels. The concept of habitat vulnerability was applied to a case study of four different habitat types in floodplains contaminated with cadmium and zinc along the river Dommel, The Netherlands. The alder floodplain forest habitat contained the most vulnerable species. The differences among habitats were significant for Cd. We further conclude that the method has good potential for application in mapping of habitat vulnerability.
Keywords: Chemicals
Keywords: Food chains
Keywords: Wildlife
Keywords: Forests
Keywords: Soil contamination
Keywords: Habitat
Keywords: flood plains
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Environmental Studies
Keywords: Chlorpyrifos
Keywords: Risk Abstracts; Environment Abstracts; Toxicology Abstracts; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality
Keywords: vulnerability
Keywords: R2 23050:Environment
Keywords: Netherlands
Date revised - 2011-05-01
Language of summary - English
Location - Netherlands
Pages - 2875-2880
ProQuest ID - 860445661
SubjectsTermNotLitGenreText - Chlorpyrifos; Chemicals; Food chains; Wildlife; Forests; vulnerability; Soil contamination; flood plains; Habitat; Netherlands
Last updated - 2011-11-09
Place of publication - Oxford
Corporate institution author - De Lange, Hendrika J; Lahr, Joost; Faber, Jack H
DOI - OB-b9fc9020-1b65-44d5-a675csamfg201; 14430060; 1552-8618 English

303. De Llasera, Martha Pgarcia; Cruz-Reyes, Leopoldo; Vera-Avila, Luz E, and De Llasera, Martha PGarcia. A Method for the Analysis of Organophosphorus Pesticide Residues in Mexican Axolotl. 2010 Jan; 45, ( 1): 25-32.

Rec #: 44349
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: A method based on matrix solid-phase dispersion (MSPD) was developed for quantitative extraction of three organophosphorus pesticides (OPPs) from the Mexican axolotl, Ambystoma mexicanum. The determination was carried out using high- performance liquid chromatography (HPLC) with diode array spectrophotometric UV detection (DAD). The MSPD extraction with octadecylsilyl (C18) sorbent combined with a silica gel clean-up and acetonitrile elution was optimised for chlorpyrifos, fenthion and methyl parathion. The method was validated, yielding recovery values higher than 90%. The precision, expressed as the relative standard deviation (RSD), was less than or equal to 6% in muscle samples at spiking levels of 10 and 5 ppm. Linearity was studied from 15 to 60 ppm for chlorpyrifos and fenthion, and from 7.5 to 30 ppm for methyl parathion. The limits of detection (LODs) were found to be less than or equal to 0.5 ppm.This method was applied to the analysis of samples from a chlorpyrifos-exposed axolotl, demonstrating its use as an analytical tool for toxicological studies.
Keywords: High-performance liquid chromatography
Keywords: Molecular structure
Keywords: Pesticide residues
Keywords: Chromatographic techniques
Keywords: silica gel
Keywords: Q5 01502:Methods and instruments
Keywords: Sorbents
Keywords: Agricultural Chemicals
Keywords: Organophosphorus Pesticides
Keywords: Pollutants
Keywords: Standard Deviation
Keywords: Ultraviolet radiation
Keywords: Muscle
Keywords: Liquid Chromatography
Keywords: Spectrophotometry
Keywords: Methyl parathion
Keywords: Toxicology Abstracts; Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts; Pollution Abstracts
Keywords: Pesticides (organophosphorus)
Keywords: octadecylsilyl
Keywords: SW 3050:Ultimate disposal of wastes
Keywords: Pollution detection
Keywords: Agricultural wastes
Keywords: Wastes
Keywords: Muscles
Keywords: X 24320:Food Additives & Contaminants
Keywords: AQ 00008:Effects of Pollution
Keywords: Pest control
Keywords: Food contamination
Keywords: Fenthion
Keywords: Ambystoma
Keywords: Firing pattern
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Standard deviation
Keywords: Silica
Keywords: Liquid chromatography
Keywords: Pesticides
Keywords: Acetonitrile
Keywords: Ambystoma mexicanum
Keywords: Toxicity testing
Keywords: Pollution control
Keywords: Parathion
Keywords: Dispersion
Date revised - 2011-02-01
Language of summary - English
Number of references - 32
Pages - 25-32
ProQuest ID - 853470130
SubjectsTermNotLitGenreText - Molecular structure; Pollution detection; Chromatographic techniques; Ultraviolet radiation; Pesticides; Wastes; Pest control; Dispersion; Pollution control; High-performance liquid chromatography; Pesticides (organophosphorus); octadecylsilyl; Agricultural wastes; silica gel; Muscles; Fenthion; Food contamination; Firing pattern; Chlorpyrifos; Standard deviation; Liquid chromatography; Spectrophotometry; Methyl parathion; Acetonitrile; Toxicity testing; Sorbents; Pesticide residues; Parathion; Silica; Agricultural Chemicals; Organophosphorus Pesticides; Standard Deviation; Pollutants; Muscle; Liquid Chromatography; Ambystoma mexicanum; Ambystoma
Last updated - 2012-12-14
British nursing index edition - Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes [J. Environ. Sci. Health, Pt. B: Pestic., Food Contam., Agric. Wastes]. Vol. 45, no. 1, pp. 25-32. Jan 2010.
Corporate institution author - De Llasera, Martha PGarcia; Cruz-Reyes, Leopoldo; Vera-Avila, Luz E
DOI - fb1e84ba-e31e-4ea5-b73cmfgefd107; 13810497; CS1247478; 0360-1234; 1532-4109

304. de Oliveira, T. A.; dos Santos, J. B.; Camelo, G. N.; Botelho, R. G., and de Lazari, T. M. EFFECT OF SEQUENTIAL NICOSULFURON AND CHLORPYRIFOS APPLICATION ON SEED BANK AND SOIL MICROBIAL CHARACTERISTICS. 2009; 33, (3): 563-570.

Rec #: 58919
Notes: Chemical of Concern: CPY
Abstract: Abstract: In the period of competition of weeds and the incidence of fall armyworm in the corn crop there is a need for herbicide and insecticide such as nicosulfuron and chlorpyrifos application within short time intervals. The aim of this study was to evaluate the effect of sequential applications of nicosulfuron and chlorpyrifos on the emergence of seedlings of the seed bank in the soil, the basal CO(2) emission rate, and the microbial biomass carbon (MBC) of soil. Sequential applications of nicosulfuron (doses from 0 to 64 g ha(-1)) with or without chlorpyrifos (0 and 240 g ha(-1)) were performed. At 20, 40 and 60 days after application (DAA) of the products, the species of all seedlings that emerged from the seed bank were identified, and the frequency, density and abundance estimated, as well as the importance value IV. Sixty DAA the CO(2) emission rate and CBM were were also determined, and based on the relationship between the accumulated CO(2) and total soil MBC the metabolic coefficient (qCO(2)) was estimated. The application of nicosulfuron rates of over 20 g ha(-1) severely affected the seedling dry weight and number of species. In the presence of the herbicide, the species with highest IV were Boehavia diffusa and Commelina bengalensis. There was a decrease in the basal soil respiration rate with increasing nicosulfuron doses, in the presence as well as in the absence of the insecticide chlorpyrifos. There was a linear decrease in MBC in all cases regardless of the chlorpyrifos application, although the reduction was 4.5 times greater in soil that received the combined application of the insecticide and nicosulfuron. The qCO(2) confirmed the negative effect of the application of insecticide and herbicide. It was concluded that the application of chlorpyrifos + nicosulfuron causes a negative impact on the seeds in the soil and the soil microbial activity.
Keywords: pesticides, microbial biomass carbon, environmental impact, synergism
ISI Document Delivery No.: 481LL POR,

305. de Pinho, G. P.; Neves, A. A.; de Queiroz, Melr, and Silverio, F. O. Optimization of the liquid-liquid extraction method and low temperature purification (LLE-LTP) for pesticide residue analysis in honey samples by gas chromatography. 2010; 21, (10): 1307-1311.

Rec #: 58929
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: This work optimized a simple and practical method for identification and quantification of the pesticides chlorpyrifos, lambda-cyhalothrin, cypermethrin and deltamethrin in honey samples. The method was based on liquid-liquid extraction and low temperature purification using acetonitrile: ethyl acetate (6.5 mL:1.5 mL) as the solvent for extraction. A final clean up step with 2 g florisil was performed before analysis by gas chromatography using electron-capture-detector. The technique was proven satisfactory with efficiency exceeding 85% and linear chromatographic response for the tested pesticides, ranging from 0.033 to 1.7 mu g g(-1) with correlation coefficients above 0.99. Detection and quantification limits were lower than 0.016 and 0.032 mu g g(-1) respectively. The proposed method was applied to 11 honey samples. Chlorpyrifos and lambda-cyhalothrin residues were found in two samples at concentrations below maximum residue limit (MRL) established for food products. The presence of these compounds was confirmed by mass spectrometry in SIM mode (GC-MS-SIM). (C) 2010 Published by Elsevier Ltd.
Keywords: Extraction method, Honey, Pesticide, Gas chromatography
ISI Document Delivery No.: 621WW

306. ---. Pesticide determination in tomatoes by solid-liquid extraction with purification at low temperature and gas chromatography. 2010; 121, (1): 251-256.

Rec #: 58939
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: In this work, a simple and low cost method, based on solid-liquid extraction with low temperature purification (SLE-LTP), was optimized and validated for the determination of chlorpyrifos,;,lambda-cyhalothrin, cypermethrin and deltamethrin in tomato samples. The analyses were performed by the GC-ECD and confirmed by the GC-MS. The method requires 4 g of tomato and an extraction mixture (8.0 mL acetonitrile, 0.5 mL water and 1.5 mL ethyl acetate), which was established by mixture experimental design. After optimization, pesticide recovery rates ranged from 79% to 97%, with a standard deviation of less than 5%. The SLE-LTP analytical characteristics were compared very favorably to the matrix solid phase dispersion technique, which used ethyl acetate and Florisil for extraction. (C) 2009 Elsevier Ltd. All rights reserved.
Keywords: Pesticide, Tomato, Food analysis, Extraction methods, Gas chromatography
ISI Document Delivery No.: 566HH

307. Dean, C.; Liu, H.; Staudt, T.; Stahlberg, M. A.; Vingill, S.; BĀCkers, J.; Kamin, D.; Engelhardt, J.; Jackson, M. B.; Hell, S. W., and Chapman, E. R. Distinct Subsets of Syt-Iv/Bdnf Vesicles Are Sorted to Axons Versus Dendrites and Recruited to Synapses by Activity.

Rec #: 49929
Notes: Chemical of Concern: CPY
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ABSTRACT: BDNF plays a critical role in the regulation of synaptic strength and is essential for long-term potentiation, a phenomenon that underlies learning and memory. However, whether BDNF acts in a diffuse manner or is targeted to specific neuronal subcompartments or synaptic sites to affect circuit function remains unknown. Here, using photoactivation of BDNF or syt-IV (a regulator of exocytosis present on BDNF-containing vesicles) in transfected rat hippocampal neurons, we discovered that distinct subsets of BDNF vesicles are targeted to axons versus dendrites and are not shared between these compartments. Moreover, syt-IV- and BDNF-harboring vesicles are recruited to both presynaptic and postsynaptic sites in response to increased neuronal activity. Finally, using syt-IV knockout mouse neurons, we found that syt-IV is necessary for both presynaptic and postsynaptic scaling of synaptic strength in response to changes in network activity. These findings demonstrate that BDNF-containing vesicles can be targeted to specific sites in neurons and suggest that syt-IV-regulated BDNF secretion is subject to spatial control to regulate synaptic function in a site-specific manner.
MESH HEADINGS: Activated-Leukocyte Cell Adhesion Molecule/metabolism
MESH HEADINGS: Animals, Newborn
MESH HEADINGS: Axons/*metabolism
MESH HEADINGS: Brain-Derived Neurotrophic Factor/genetics/metabolism
MESH HEADINGS: Cells, Cultured
MESH HEADINGS: Coculture Techniques
MESH HEADINGS: Dendrites/*metabolism
MESH HEADINGS: Embryo, Mammalian
MESH HEADINGS: Excitatory Amino Acid Agents/pharmacology
MESH HEADINGS: Excitatory Postsynaptic Potentials/drug effects/genetics
MESH HEADINGS: Forskolin/pharmacology
MESH HEADINGS: Glycine/pharmacology
MESH HEADINGS: Hippocampus/cytology
MESH HEADINGS: Intracellular Signaling Peptides and Proteins/metabolism
MESH HEADINGS: Luminescent Proteins/genetics/metabolism
MESH HEADINGS: Membrane Proteins/metabolism
MESH HEADINGS: Mice, Knockout
MESH HEADINGS: Microtubule-Associated Proteins/metabolism
MESH HEADINGS: Neurons/*cytology/metabolism
MESH HEADINGS: Patch-Clamp Techniques
MESH HEADINGS: Receptors, AMPA/metabolism
MESH HEADINGS: Sodium Channel Blockers/pharmacology
MESH HEADINGS: Synapses/physiology
MESH HEADINGS: Synaptic Vesicles/*classification/*metabolism
MESH HEADINGS: Synaptophysin/metabolism
MESH HEADINGS: Synaptotagmins/deficiency/*metabolism
MESH HEADINGS: Tetrodotoxin/pharmacology
MESH HEADINGS: Transfection
MESH HEADINGS: Vesicular Glutamate Transport Protein 1/metabolism
MESH HEADINGS: Vesicular Inhibitory Amino Acid Transport Proteins/metabolism eng

308. Deb, I.; Poddar, R., and Paul, S. Oxidative Stress-Induced Oligomerization Inhibits the Activity of the Non-Receptor Tyrosine Phosphatase Step61.

Rec #: 50289
Notes: Chemical of Concern: CPY
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ABSTRACT: The neuron-specific tyrosine phosphatase STriatal Enriched Phosphatase (STEP) is emerging as an important mediator of glutamatergic transmission in the brain. STEP is also thought to be involved in the etiology of neurodegenerative disorders that are linked to oxidative stress such as Alzheimer's disease and cerebral ischemia. However, the mechanism by which oxidative stress can modulate STEP activity is still unclear. In this study, we have investigated whether dimerization may play a role in regulating the activity of STEP. Our findings show that STEP(61), the membrane associated isoform, can undergo homodimerization under basal conditions in neurons. Dimerization of STEP(61) involves intermolecular disulfide bond formation between two cysteine residues (Cys 65 and Cys 76 respectively) present in the hydrophobic region at the N-terminus specific to STEP(61). Oxidative stress induced by hydrogen peroxide leads to a significant increase in the formation of dimers and higher-order oligomers of STEP(61). Using two substrates, para-nitrophenylphosphate and extracellular-regulated kinase MAPK we further demonstrate that oligomerization leads to a significant reduction in its enzymatic activity.
MESH HEADINGS: Brain/cytology/metabolism
MESH HEADINGS: Cells, Cultured
MESH HEADINGS: Cercopithecus aethiops
MESH HEADINGS: Cysteine/metabolism
MESH HEADINGS: *Dimerization
MESH HEADINGS: Dose-Response Relationship, Drug
MESH HEADINGS: Embryo, Mammalian
MESH HEADINGS: Gene Expression Regulation, Enzymologic/drug effects/genetics/physiology
MESH HEADINGS: Hydrogen Peroxide/pharmacology
MESH HEADINGS: Immunoprecipitation/methods
MESH HEADINGS: Mitogen-Activated Protein Kinase Kinases/metabolism
MESH HEADINGS: Neurons/drug effects/metabolism
MESH HEADINGS: Nitrophenols/metabolism
MESH HEADINGS: Organophosphorus Compounds/metabolism
MESH HEADINGS: Oxidative Stress/drug effects/*physiology
MESH HEADINGS: Phosphorylation/drug effects
MESH HEADINGS: Protein Tyrosine Phosphatases, Non-Receptor/*chemistry/genetics/*metabolism
MESH HEADINGS: Rats, Sprague-Dawley
MESH HEADINGS: Transfection/methods eng

309. DeJoux, C. Ecotoxicological Consequences of the Antivectorial Battle in Tropical Countries: The Situation in African Lotic Ecosystems (Consequences Ecotoxicologiques de la Lutte Antivectorielle en pays Tropicaux: La Situation des Milieux Lotiques Africains). 1990; 97-98, 799-813(FRE) (ENG ABS).

Rec #: 590
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

310. Del Pilar Crespo, M.; Avery, T. D.; Hanssen, E.; Fox, E.; Robinson, T. V.; Valente, P.; Taylor, D. K., and Tilley, L. Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology.

Rec #: 51389
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Artermisinin and its derivatives are now the mainstays of antimalarial treatment; however, their mechanism of action is only poorly understood. We report on the synthesis of a novel series of epoxy-endoperoxides that can be prepared in high yields from simple starting materials. Endoperoxides that are disubstituted with alkyl or benzyl side chains show efficient inhibition of the growth of both chloroquine-sensitive and -resistant strains of Plasmodium falciparum. A trans-epoxide with respect to the peroxide linkage increases the activity compared to that of its cis-epoxy counterpart or the parent endoperoxide. The novel endoperoxides do not show a strong interaction with artemisinin. We have compared the mechanism of action of the novel endoperoxides with that of artemisinin. Electron microscopy reveals that the novel endoperoxides cause the early accumulation of endocytic vesicles, while artemisinin causes the disruption of the digestive vacuole membrane. At longer incubation times artemisinin causes extensive loss of organellar structures, while the novel endoperoxides cause myelin body formation as well as the accumulation of endocytic vesicles. An early event following endoperoxide treatment is the redistribution of the pH-sensitive probe LysoSensor Blue from the digestive vacuole to punctate structures. By contrast, neither artemisinin nor the novel endoperoxides caused alterations in the morphology of the endoplasmic reticulum nor showed antagonistic antimalarial activity when they were used with thapsigargin. Analysis of rhodamine 123 uptake by P. falciparum suggests that disruption of the mitochondrial membrane potential occurs as a downstream effect rather than as an initiator of parasite killing. The data suggest that the digestive vacuole is an important initial site of endoperoxide antimalarial activity.
MESH HEADINGS: Antimalarials/chemistry/*pharmacology
MESH HEADINGS: Artemisinins/*pharmacology
MESH HEADINGS: Drug Interactions
MESH HEADINGS: Endoplasmic Reticulum/drug effects/ultrastructure
MESH HEADINGS: Inhibitory Concentration 50
MESH HEADINGS: Mitochondria/drug effects/ultrastructure
MESH HEADINGS: Parasitic Sensitivity Tests
MESH HEADINGS: Peroxides/chemical synthesis/chemistry/*pharmacology
MESH HEADINGS: Plasmodium falciparum/*drug effects/growth &
MESH HEADINGS: development/ultrastructure
MESH HEADINGS: Vacuoles/*drug effects/*ultrastructure eng

311. Delgado-Moreno, L.; Lin, K.; Veiga-Nascimento, R., and Gan, J. Occurrence and Toxicity of Three Classes of Insecticides in Water and Sediment in Two Southern California Coastal Watersheds. 2011; 59, (17): 9448-9456.

Rec #: 2150
Keywords: MIXTURE

312. DeLorenzo, M. E. and Fulton, M. H. Comparative risk assessment of permethrin, chlorothalonil, and diuron to coastal aquatic species. 2012; 64, (7): 1291-1299.

Rec #: 59029
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: Abstract: The precise application of risk assessment can lead to different conclusions about risk depending on how species are grouped in the assessment. We compared the use of different risk assessment methods for three different classes of pesticide, the herbicide
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