Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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The present work was designed to study the in vitro toxic effect of chlorpyriphos on isolated chicken hepatocytes.
Keywords: CARBON-TETRACHLORIDE, RAT HEPATOCYTES
ISI Document Delivery No.: 243CX

106. Bempah, Crentsil Kofi; Asomaning, Jacob; Ansong, Daniel Ayirebi; Boateng, Juliana; Asabere, Stephen Boahen, and Bempah, Crentsil Kofi . Contamination Levels of Selected Organochlorine and Organophosphorous Pesticides in Ghanaian Fruits and Vegetables. 2012 Aug; 24, (4): 293.


Rec #: 42629
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: A study was conducted to obtain systematic monitoring data on the contamination levels of selected organochlorine and organophosphorous pesticide residues in fruits and vegetables sold on Ghanaian markets. A total of 309 samples of fruits and vegetables were purchased from the main urban markets and supermarkets in Greater Accra through the months of July, 2009 to May, 2010. The analysis was carried out on GC-ECD employing multi residue analytical technique. The obtained results showed the predominance of methoxychlor in most of the analyzed samples. The detected concentrations of it in pineapple, lettuce, cabbage, cucumber and onion exceeded the European Commission Maximum Residue limits (EC MRLs), as did the concentrations of lindane in papaya, pineapple, cabbage and onion as well as dieldrin in papaya, banana, pineapple and cabbage. Residues of endrin in lettuce and carrot were higher than the EC MRL, as was chlorpyrifos in pineapple. Based on the observations made in these studies, it is proposed that more extensive investigations covering all foodstuffs in Ghana be carried out so as to generate data for policy making, development of consumer information laws and curtailment of the use of some of these pesticides.
Keywords: Fruits
Keywords: Ghana
Keywords: Organochlorine compounds
Keywords: Contamination
Keywords: Pesticide residues
Keywords: Consumer information
Keywords: Dieldrin
Keywords: Daucus
Keywords: Lindane
Keywords: Brassica
Keywords: Chlorpyrifos
Keywords: P 9999:GENERAL POLLUTION
Keywords: Musa
Keywords: Pesticides
Keywords: Allium cepa
Keywords: Pollution Abstracts
Date revised - 2012-11-01
Language of summary - English
Location - Ghana
Number of references - 26
Pages - 293
ProQuest ID - 1171885113
SubjectsTermNotLitGenreText - Chlorpyrifos; Fruits; Organochlorine compounds; Contamination; Pesticide residues; Consumer information; Pesticides; Dieldrin; Lindane; Musa; Allium cepa; Daucus; Brassica; Ghana
Last updated - 2012-12-03
British nursing index edition - Emirates Journal of Agricultural Sciences [Emirates J. Agric. Sci.]. Vol. 24, no. 4, 293 p. Aug 2012.
Corporate institution author - Bempah, Crentsil Kofi; Asomaning, Jacob; Ansong, Daniel Ayirebi; Boateng, Juliana; Asabere, Stephen Boahen
DOI - b5c1c96c-6a57-4952-b472mfgefd107; 16968747; 1021-1357
2004 "Mercury Pollution in Ghana: A Case Study of Environmental Impacts of Artisanal Gold Mining in Sub-Saharan Africa" British Library Inside Conferences 135-156
ABOU-ARAB, A. A. K., ABOU DONIA, M. A. 2001 "Pesticide residues in some Egyptian spices and medicinal plants as affected by processing" Food Chemistry 72 4 439-445
Albert, Lilia A. {a}, Albert, Lilia A. {a} 1996 "Persistent pesticides in Mexico" Reviews of Environmental Contamination & Toxicology 147 1-44
Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology and epidemiology in the United States, Environ. Health Perspect. 109:113-139.
Bai, Y H, Zhou, L 2006 "Organophosphorus pesticide residues in market foods in Shaanxi area, China" Food Chemistry 98 2 240-242
(19) Baird, C. In Environmental Chemistry; W.H. Freeman and Company: New York, 1999; Vol. 2, pp 557.
Bempah, Crentsil Kofi, Donkor, Augustine Kwame 2011 "Pesticide residues in fruits at the market level in Accra Metropolis, Ghana, a preliminary study" Environmental Monitoring and Assessment 175 1-4 551-561
Bempah, Crentsil Kofi, Donkor, Augustine 2011 "A preliminary assessment of consumer's exposure to organochlorine pesticides in fruits and vegetables and the potential health risk in Accra Metropolis, Ghana" Food Chemistry 128 4 1058-1065
Bhanti, Mayank, Taneia, Ajay 2007 "Contamination of vegetables of different seasons with organophosphorous pesticides and related health risk assessment in northern India" Chemosphere 69 1 63-68
Chambers, H. W., J. S. Boone, R. L. Carr, and J. E. Chambers. 2001. Chemistry of organophosphorus insecticides, pp. 913-917. In R. Krieger (ed.), Handbook of pesticide toxicology, 2nd ed. Academic Press, San Diego, CA.
Codex Alimentarius Commission. 2000. Food Standards Programme. Pesticide residues in food. Methods of analysis and sampling. Volume 2A Part 1. WHO.
European Commission, 2006. Commission amending Regulation (EC) No 396/2005 of the European Parliament and of the Council to establish Annex I listing the food and feed products to which maximum levels for pesticide residues apply. Off. J. EU.
FAO/WHO. 2004. Food and Agriculture Organization/World Health Organization, Food standards programme. Codex Alimentarius Commission. 27th Session, Geneva, Switzerland, 28 June-03 July 2004.
Fu, J., B. Mai, G. Sheng, G. Zhang, I. Wang, P. Peng, X. Xiao, R. Ran, N. Cheng, X. Peng, Z. Wang and U. W. Tang. 2003. Persistent organic pollutants in environment of the Pearl River Delta, China: an overview. Chemosphere 52:1411-1422.
GONZALEZ-RODRIGUEZ, Rosa M., RIAL-OTERO, Raquel 2008 "Occurrence of fungicide and insecticide residues in trade samples of leafy vegetables" Food Chemistry 107 3 1342-1347
Hura, C, Leanca, M 1999 "Risk assessment of pollution with pesticides in food in the Eastern Romania area (1996-1997)" Toxicology Letters 107 1-3 103-107
Jorgenson, J.L. ( 2001). Aldrin and dieldrin: A review of research on their production, environmental deposition and fate, bioaccumulation, toxicology and epidemiology in the United States. Environ. Health Perspect. 109:113-139.
LoĂŚpez-PeĂŚrez, Gonzalo C., Arias-EsteĂŚvez, Manuel 2006 "Dynamics of pesticides in potato crops" Journal of Agricultural and Food Chemistry 54 5 1797-1803
Miller, W.R., Sharpe, R.M. 1998 "Environmental oestrogens and human reproductive cancers" Endocrine-Related Cancer 5 2 69-96
Ministry of Public Health, Welfare and Sports (2007). Netherlands analytical methods of pesticide residues and foodstuffs. Netherlands.
Mukherjee, D. P., K. Bhupander, K. Sanjay, M. Meenu, R. Gaur, D. Prakash, S. K. Singh and C. S. Sharma. 2011. Occurrence and distribution of pesticide residues in selected seasonal vegetables from West Bengal. Arch. Appl. Sci. Res. 3(5):85-93.
Nakata, H., Kawazoe, M. 2002 "Organochlorine pesticides and polychlorinated biphenyl residues in foodstuffs and human tissues from China: status of contamination, historical trend, and human dietary exposure." Archives of Environmental Contamination and Toxicology 43 4 473-480
Osman, K. A., Al-Humaid, A. M. 2010 "Monitoring of pesticide residues in vegetables marketed in Al-Qassim region, Saudi Arabia" Ecotoxicology and Environmental Safety 73 6 1433-1439
Persistent organic pollutants in environment of the Pearl River Delta, China: an overview. Chemosphere 52:1411-1422.
Rejendran, B. R. and A. N. Subramanian. 1999. Chlorinated pesticide residues in surface sediments from the river Kaveri, South Indian J. Environ. Sci. Health 34: 209-288.
Saeed, T., Sawaya, W. N. 2001 "Chlorinated pesticide residues in the total diet of Kuwait." Food Control 12 2 91-98
Tchounwou, Paul B., Ashour, Bassem A. 2002 "Health risk assessment of pesticide usage in Menia El-Kamh province ofSharkia Governorate in Egypt" International Journal of Molecular Sciences 3 10 1082-1094
Yamaguchi, N., Gazzard, D. 2003 "Concentrations and hazard assessment of PCBs, organochlorine pesticides and mercury in fish species from the upper thames: River pollution and its potential effects on top predators" Chemosphere 50 3 265-273 English

107. Ben Abdallah, F.; Gargouri, B.; Bejaoui, H.; Lassoued, S., and Ammar-Keskes, L. Dimethoate-Induced Oxidative Stress in Human Erythrocytes and the Protective Effect of Vitamins C and E In Vitro. 2011; 26, (3): 287-291.


Rec #: 56519
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Organophosphorus insecticides may induce oxidative stress leading to the generation of free radicals and alteration in the antioxidant system. The aim of this study was to examine the potency of Dimethoate (Dim) to induce oxidative stress response in human erythrocyte in vitro and the role of Vitamins C (Vit C) and E (Vit E) in alleviating the cytotoxic effects. Erythrocytes were divided into three groups. The first group, erythrocytes were incubated for 4 h at 37 degrees C with different concentrations (0, 20, 40, 60, 80, and 100 mM) of Dim. The second and third groups were preincubated with Vit C or Vit E, respectively, for 30 min and followed by Dim incubation for 4 h at 37 degrees C. Following in vitro exposure, Dim caused a significant increase in malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) in erythrocytes at different concentrations. Vit E or Vit C pretreated erythrocytes showed a significant protection against the cytotoxic effects inducted by Dim on the studied parameters. In conclusion, antioxidant Vit E and C could protect against Dim-induced oxidative stress by decreasing lipid peroxidation and hyperactivity of SOD and CAT in human erythrocytes. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol 26: 287-291, 2011.
Keywords: human erythrocytes, dimethoate, in vitro, antioxidants enzymes, lipid
ISI Document Delivery No.: 762OO

108. Ben Cheikh, R.; Berticat, C.; Berthomieu, A.; Pasteur, N.; Ben Cheikh, H., and Weill, M. Characterization of a Novel High-Activity Esterase in Tunisian Populations of the Mosquito Culex pipiens. 2008; 101, (2): 484-491.


Rec #: 52299
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: In the mosquito Culex pipiens (L.) (Diptera: Culicidae) esterases contribute to insecticide resistance by their increased activity. These esterases display a heterogeneous geographical distribution, particularly in Tunisia, where they are very diverse. In this study, we extended the characterization of a highly active esterase first detected in 1996: B12. Esterase B12 displayed the fastest electrophoretic mobility of all the previously described highly active esterases. We showed that it was encoded by the EsterB12 allele at the Ester locus, and we isolated a strain, TunB12, homozygous for this allele. TunB12 displayed a low (approximately two- to three-fold) but significant resistance to the organophosphates temephos and chlorpyrifos, and to the pyrethroid permethrin. Only temephos resistance was synergized by S,S,S-tributyl-phosphorotrithioate. Real-time quantitative polymerase chain reaction revealed that the EsterB12 allele was not amplified in TunB12 strain, indicating that B12 high activity could be due to a gene up-regulation mechanism. EsterB12 allele frequencies also were estimated in 20 Tunisian populations collected in 2005. Analyses revealed a large distribution of this allele all over the country. Finally, sequences of EsterB12 were acquired and genetic distance trees were constructed with the resistance Ester alleles already published, providing indications about allele's origins. The diverse array of highly active esterases in C. pipiens from Tunisia and the possible scenario of the origin of their coding alleles are discussed in the context of their possible evolution.
Keywords: esterase B12
Includes references 1022619809

109. Benedetto, A.; Abete, M. C.; Prearo, M.; Fioravanti, F., and Squadrone, S. Chlorpyrifos effects on rainbow trout (Oncorhynchus Mykiss): analysis of gene expression profiles. 2010; 150, (Supplement): 125-126.


Rec #: 2500
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY
Abstract: Biomarkers/ Real Time RT-PCR/ +ö+öCT method

110. Berger-Preiss, Edith; Koch, Wolfgang; Gerling, Susanne; Kock, Heiko; Appel, Klaus E, and Berger-Preiss, Edith. Use of Biocidal Products (Insect Sprays and Electro-Vaporizer) in Indoor Areas - Exposure Scenarios and Exposure Modeling. 2009 Sep; 212, (5): 505-518.


Rec #: 44649
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Five commercially available insect sprays were applied in a model room. Spraying was performed in accordance with the manufacturers' instructions and in an overdosed manner in order to simulate worst-case conditions or an unforeseeable misuse. In addition, we examined electro-vaporizers. The Respicon[TM] aerosol monitoring system was applied to determine inhalation exposure. During normal spraying (10 seconds) and during the following 2-3 minutes, exposure concentrations ranged from 70 to 590 kg/m super(3) for the pyrethroids tetramethrin, d-phenothrin, cyfluthrin, bioallethrin, and the pyrethrins. Calculated inhalable doses were 2-16 kg. A concentration of approximately 850 kg chlorpyrifos/m super(3) (inhalable dose: approximately 20 kg) was determined when the "Contra insect fly spray" was applied. Highest exposure concentrations (1100-2100 kg/m super(3)) were measured for piperonyl butoxide (PBO), corresponding to an inhalation intake of 30-60 kg. When simulating worst-case conditions, exposure concentrations of 200-3400 kg/m super(3) and inhalable doses of 10-210 kg were determined for the various active substances. Highest concentrations (4800-8000 kg/m super(3)) were measured for PBO (inhalable: 290-480 kg). By applying the electro-vaporizer "Nexa Lotte" plug-in mosquito killer concentrations for d-allethrin were in the range of 5-12 kg/m super(3) and 0.5-2 kg/m super(3) for PBO while with the "Paral" plug-in mosquito killer concentrations of 0.4-5 kg/m super(3) for pyrethrins and 1-7 kg/m super(3) for PBO were measured. Potential dermal exposures were determined using exposure pads. Between 80 and 1000 kg active substance (tetramethrin, phenothrin, cyfluthrin, bioallethrin, pyrethrins, chlorpyrifos) were deposited on the clothing of the total body surface area of the spray user. Highest levels (up to 3000 kg) were determined for PBO. Worst-case uses of the sprays led to 5-9 times higher concentrations. Also a 2-hour stay nearby an operating electro-vaporizer led to a contamination of the clothing (total amounts on the whole body were 450 kg d-allethrin and 50 kg PBO for "Nexa Lotte" plug-in mosquito killer and 80 kg pyrethrins and 190 kg PBO for "Paral" plug-in mosquito killer). Human biomonitoring data revealed urine concentrations of the metabolite (E)-trans-chrysanthemum dicarboxylic acid ((E)-trans-CDCA) between 1.7 kg/l and 7.1 kg/l after 5 minutes of exposure to the different sprays. Also the use of electro-vaporizers led to (E)-trans-CDCA concentrations in the urine in the range of 1.0 kg/l to 6.2 kg/l (1-3 hours exposure period). The exposure data presented can be used for performing human risk assessment when these biocidal products were applied indoors. The airborne concentrations of the non-volatile active chemical compounds could be predicted from first principles using a deterministic exposure model (SprayExpo).
Keywords: Inhalation
Keywords: Risk assessment
Keywords: Z 05300:General
Keywords: Contamination
Keywords: Piperonyl butoxide
Keywords: Metabolites
Keywords: Spraying
Keywords: insects
Keywords: tetramethrin
Keywords: Models
Keywords: H 5000:Pesticides
Keywords: biomonitoring
Keywords: R2 23060:Medical and environmental health
Keywords: Entomology Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Environment Abstracts
Keywords: Pyrethroids
Keywords: X 24330:Agrochemicals
Keywords: pyrethrins
Keywords: Bioindicators
Keywords: Aerosols
Keywords: Data processing
Keywords: Skin
Keywords: Surface area
Keywords: Sprays
Keywords: Clothing
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Urine
Keywords: Pesticides
Keywords: Indoor environments
Keywords: surface area
Date revised - 2009-09-01
Language of summary - English
Pages - 505-518
ProQuest ID - 20787918
SubjectsTermNotLitGenreText - Inhalation; Risk assessment; Aerosols; Skin; Data processing; Contamination; Surface area; Piperonyl butoxide; Metabolites; Spraying; tetramethrin; Clothing; Models; Chlorpyrifos; Urine; biomonitoring; Pyrethroids; pyrethrins; Bioindicators; Sprays; insects; Pesticides; Indoor environments; surface area
Last updated - 2012-03-29
British nursing index edition - International Journal of Hygiene and Environmental Health [Int. J. Hyg. Environ. Health]. Vol. 212, no. 5, pp. 505-518. Sep 2009.
Corporate institution author - Berger-Preiss, Edith; Koch, Wolfgang; Gerling, Susanne; Kock, Heiko; Appel, Klaus E
DOI - MD-0010348004; 10830022; 1438-4639 English

111. Berhanu, Tarekegn; Megersa, Negussie; Solomon, Theodros; Jonsson, Jan Ake, and Berhanu, Tarekegn. A Novel Equilibrium Extraction Technique Employing Hollow Fibre Liquid Phase Microextraction for Trace Enrichment of Freely Dissolved Organophosphorus Pesticides in Environmental Waters. 2008 Nov; 88, (13): 933-945.


Rec #: 45469
Keywords: CHEM METHODS
Notes: Chemical of Concern: CPY
Abstract: Abstract: A new design of equilibrium hollow fibre liquid phase microextraction (HF-LPME) was developed for the determination of three freely dissolved organophosphorus pesticides (OPPs), i.e. diazinon (O,O-diethyl-O-2-isopropyl-4-methyl-6-pyrimidyl thiophosphate), chlorpyrifos (O,O-diethyl-O-[3,5,6-trichloro-2-pyridyl] phosphorothioate), and fenthion (O,O-dimethyl-O-4-methylthio-m-tolyl phosphorothioate) as model compounds. In this new design a 1.2-1.4 cm length of a hollow fibre (HF), inserted to the end of 20 cm copper wire and impregnated with organic solvent, was used to extract the freely dissolved concentration of OPPs in various water samples. The limits of detection (LOD) in reagent water using gas chromatography-mass spectrometry in the selected ion monitoring (SIM) mode was in the range of 15-80 ng L-1. The relative standard deviations of the analysis (inter- and intra-day) were 8.7-30%. The method was applied to the extraction of spiked lake and ground water samples. The ground water sample was spiked at 0.1 and 0.2 mg L-1 concentrations of the analytes under study and the average extraction efficiency at the two concentrations was below 1% showing the non-depletive nature of the extraction, meaning that the freely dissolved concentrations are measured as opposed to total concentrations. Good linearity was obtained for all of the analytes in both reagent water and lake water samples with correlation coefficients, R2, ranging from 0.991 to 0.996, in the concentration ranges of 25-400 ng L-1. The method was found to be very simple and inexpensive, with the possibility of running hundreds of samples in parallel with very minimal expenses for the determination of freely dissolved OPPs.
Keywords: Molecular structure
Keywords: Reagents
Keywords: Water sampling
Keywords: ENA 09:Land Use & Planning
Keywords: Water Analysis
Keywords: Water Sampling
Keywords: Groundwater Mining
Keywords: SW 3030:Effects of pollution
Keywords: Copper
Keywords: Q5 01502:Methods and instruments
Keywords: Mass spectroscopy
Keywords: Models
Keywords: Lakes
Keywords: Efficiency
Keywords: Toxicology Abstracts; Pollution Abstracts; Environment Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality
Keywords: Organophosphorus Pesticides
Keywords: Gas chromatography
Keywords: Organic Solvents
Keywords: Ground water
Keywords: X 24330:Agrochemicals
Keywords: Pesticides (organophosphorus)
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Running
Keywords: Solvents
Keywords: Fenthion
Keywords: Water pollution
Keywords: Spectrometry
Keywords: Methodology
Keywords: Chlorpyrifos
Keywords: phosphorothioate
Keywords: Standard deviation
Keywords: Thiophosphate
Keywords: Analytical techniques
Keywords: Pesticides
Keywords: Monitoring
Keywords: Groundwater
Keywords: Diazinon
Date revised - 2009-08-01
Language of summary - English
Pages - 933-945
ProQuest ID - 20770024
SubjectsTermNotLitGenreText - Molecular structure; Analytical techniques; Pesticides; Water pollution; Methodology; Pesticides (organophosphorus); Running; Solvents; Copper; Fenthion; Mass spectroscopy; Models; Chlorpyrifos; phosphorothioate; Lakes; Standard deviation; Gas chromatography; Thiophosphate; Ground water; Diazinon; Efficiency; Water sampling; Groundwater; Spectrometry; Reagents; Organophosphorus Pesticides; Water Analysis; Water Sampling; Groundwater Mining; Organic Solvents; Monitoring
Last updated - 2011-12-14
British nursing index edition - International Journal of Environmental and Analytical Chemistry [Int. J. Environ. Anal. Chem.]. Vol. 88, no. 13, pp. 933-945. Nov 2008.
Corporate institution author - Berhanu, Tarekegn; Megersa, Negussie; Solomon, Theodros; Jonsson, Jan Ake
DOI - MD-0010233463; 10310883; CS0949021; 0306-7319 English

112. Berman, Tamar; Hochner-Celnikier, Drorit; Barr, Dana Boyd; Needham, Larry L; Amitai, Yona; Wormser, Uri; Richter, Elihu, and Berman, Tamar. Pesticide Exposure Among Pregnant Women in Jerusalem, Israel: Results of a Pilot Study. 2011 Jan; 37, (1): 198-203.


Rec #: 43609
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pesticides have been shown to disrupt neurodevelopment in laboratory animals and in human populations. To date, there have been no studies on exposure to pesticides in pregnant women in Israel, despite reports of widespread exposure in other populations of pregnant women and the importance of evaluating exposure in this susceptible sub-population. We measured urinary concentrations of organophosphorus (OP) insecticide metabolites and plasma concentrations of OP and other pesticides in 20 pregnant women, recruited in Jerusalem, Israel in 2006, and collected questionnaire data on demographic factors and consumer habits from these women. We compared geometric mean concentrations in subgroups using the Mann-Whitney U-test for independent samples. We compared creatinine-adjusted OP pesticide metabolite concentrations, as well as plasma pesticide concentrations, with other populations of pregnant women. Creatinine-adjusted total dimethyl (DM) metabolite concentrations were between 4 and 6 times higher in this population compared to other populations of pregnant women in the United States while total diethyl (DE) metabolite concentrations were lower. Dimethylphosphate (DMP) was detected in 74% of the urine samples whereas dimethylthiophosphate (DMTP) was detected in 90% of the urine samples. The carbamate bendiocarb was detected in 89% of the plasma samples, while the OP insecticide chlorpyrifos was detected in 42% of the samples. Mean plasma concentrations of bendiocarb and chlorpyrifos in our sample were 4.4 and 3.9 times higher, respectively, than that of an urban minority cohort from New York City. Twelve women (63%) reported using some form of household pest control during their pregnancy and five (26%) reported using household pest control during the past month. Women with a graduate degree had significantly higher geometric mean concentrations of total urinary DM metabolite concentrations compared to other women (P=0.006). Finally, one woman in the study had exceptionally high concentrations of DMP, DMTP, DMDTP compared to the other women in the study, despite reporting no current occupational exposure to OP pesticides and no other significant exposure sources. Pregnant women in the Jerusalem area are exposed to OP pesticides and to the carbamate pesticide bendiocarb. It is unclear why total DM metabolites concentrations were much higher in this population compared to other populations of pregnant women in the United States and Netherlands. Finally, the finding of very high DM metabolite concentrations in one woman who reported being moved from her regular laboratory work to administrative work upon becoming pregnant, raises questions about the adequacy of measures to protect pregnant women from pesticide exposures during pregnancy.
Keywords: Laboratory animals
Keywords: Metabolites
Keywords: Israel
Keywords: P 6000:TOXICOLOGY AND HEALTH
Keywords: Demography
Keywords: households
Keywords: USA, New York, New York City
Keywords: Insecticides
Keywords: Israel, Jerusalem
Keywords: H 5000:Pesticides
Keywords: Consumers
Keywords: Netherlands
Keywords: X 24330:Agrochemicals
Keywords: Occupational exposure
Keywords: Inventories
Keywords: Data processing
Keywords: Health & Safety Science Abstracts; Toxicology Abstracts; Pollution Abstracts; Environment Abstracts
Keywords: Pest control
Keywords: Pesticides (carbamates)
Keywords: Pregnancy
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Urine
Keywords: Pesticides
Keywords: human populations
Date revised - 2011-02-01
Language of summary - English
Location - USA, New York, New York City; Israel, Jerusalem; Israel; Netherlands
Pages - 198-203
ProQuest ID - 853475176
SubjectsTermNotLitGenreText - Inventories; Data processing; Laboratory animals; Metabolites; Pest control; Pesticides (carbamates); Pregnancy; Chlorpyrifos; Demography; Insecticides; Urine; Pesticides; Consumers; Occupational exposure; households; human populations; USA, New York, New York City; Israel, Jerusalem; Israel; Netherlands
Last updated - 2012-03-29
British nursing index edition - Environment International [Environ. Int.]. Vol. 37, no. 1, pp. 198-203. Jan 2011.
Corporate institution author - Berman, Tamar; Hochner-Celnikier, Drorit; Barr, Dana Boyd; Needham, Larry L; Amitai, Yona; Wormser, Uri; Richter, Elihu
DOI - d2f02393-8422-44b8-ad56csaobj202; 14041260; 0160-4120 English

113. Bermudez-Saldana, J. M.; Escuber-Gilabert, L.; Medina-Hernandez, M. J.; Villaneuva-Camanas, R. M., and Sagrado, S. Chromatographic Evaluation of the Toxicity in Fish of Pesticides. 2005; 814, 115-125.


Rec #: 50
Keywords: MODELING,REFS CHECKED
Call Number: NO MODELING (24D,24DXY,ADC,BMY,CBF,CBL,CMPH,CPY,CPYM,DCB,DCF,DCNA,DMT,DU,DZ,ES2,FNPP,LNR,MCPB,MCPP1,MDT,MLN,MLNR,MLT,MOM,MP,OML,PCBZ,PIRM,PMT,PPX,PRO,PSM,SZ,TBZ,TCF), NO REFS CHECKED (24D,24DXY,ADC,BMY,CBF,CBL,CMPH,CPY,CPYM,DCB,DCF,DCNA,DMT,DU,DZ,ES2,FNPP,LNR,MCPB,MCPP1,MDT,MLN,MLNR,MLT,MOM,MP,OML,PCBZ,PIRM,PMT,PPX,PRO,PSM,SZ,TBZ,TCF)
Notes: Chemical of Concern: 24D,24DXY,ADC,AMTR,BMY,CBF,CBL,CMPH,CPY,CPYM,CZE,DCB,DCF,DCNA,DMT,DU,DZ,ES2,FMU,FNPP,FNTH,LNR,MCPA,MCPB,MCPP1,MDT,MLN,MLNR,MLT,MOM,MP,OML,PCBZ,PEB,PHSL,PIM,PIRM,PMT,PPX,PRO,PSM,SZ,TBZ,TCF,TCM

114. Beutler, B. A. Tlrs and Innate Immunity.


Rec #: 50939
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: One of the most fundamental questions in immunology pertains to the recognition of non-self, which for the most part means microbes. How do we initially realize that we have been inoculated with microbes, and how is the immune response ignited? Genetic studies have made important inroads into this question during the past decade, and we now know that in mammals, a relatively small number of receptors operate to detect signature molecules that herald infection. One or more of these signature molecules are displayed by almost all microbes. These receptors and the signals they initiate have been studied in depth by random germline mutagenesis and positional cloning (forward genetics). Herein is a concise description of what has been learned about the Toll-like receptors, which play an essential part in the perception of microbes and shape the complex host responses that occur during infection.
MESH HEADINGS: Animals
MESH HEADINGS: Bacteria/*immunology
MESH HEADINGS: Bacterial Infections/*immunology
MESH HEADINGS: Humans
MESH HEADINGS: Immune Tolerance/*immunology
MESH HEADINGS: Toll-Like Receptors/*immunology eng

115. Bhagobaty, R. K. Comments on the manuscript "Fungal degradation of chlorpyrifos by Acremonium sp.strain (GFRC-1) isolated from a laboratory-enriched red agricultural soil". 2011; 47, (2): 235-235.


Rec #: 56609
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: ISI Document Delivery No.: 709TL

116. Bhat, a R; Wani, Ma; Kirmani, a R, and Bhat, A R. Brain Cancer and Pesticide Relationship in Orchard Farmers of Kashmir. 2010 Dec; 14, (3): 78-86.


Rec #: 47599
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Background: The increasing trend in the incidence of primary malignant brain tumors in orchard farmers and their families in Kashmir. Aim: To determine the relationship between the patients of primary malignant brain tumors and their occupation. Materials and Methods: Retrospectively, case files along with death certificates of 432 patients of primary malignant brain tumors and 457 controls (non-tumor neurologic diseases), admitted for treatment simultaneously over a period of 4 years from January 2005 to December 2008, to the Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Kashmir, were studied. Follow-up and family interaction was established. Results: Analysis revealed that 90.04% (389 out of 432) patients were orchard farm workers, orchard residents and orchard playing children exposed to the high levels of multiple types of neurotoxic and carcinogenic (chlorpyriphos, dimethoate, mancozeb and captan) chemicals for more than 10 years [relative risk (RR) = 10.6; odds ratio (OR) = > 10; 95% confidence interval (CI) = > 25-40], The 9.96% (43 out of 432) patients were not exposed to pesticides. On the other hand, only 19 patients out of 457 controls had recorded history of pesticide exposure and 438 were unrelated to pesticides. Out of 389 patients, 71.7% (279 out of 389) were males and 28.3% (110 out of 389), including six members of three families, were females (one male child). Conclusion: All orchard-related 389 patients had high-grade tumors as compared to the non-pesticide tumors. Mortality in pesticide-exposed tumors was 12%. The higher or upper-normal levels of serum cholinesterase (AChE) were observed in 54.7% (213 out of 389) patients and decreased levels were found in only 45.3% (176 out of 389) orchard-related patients (RR = 19.4; OR = > 5; 95% CI = > 1-10). Although serum AChE levels were a routine investigation in malignant brain tumors, this was not a routine in other neurological conditions (hospitalized controls). The familial gliomas have shown an emerging trend in the orchard residents of valley of Kashmir.
Keywords: Risk assessment
Keywords: Pakistan, Kashmir
Keywords: Neurological diseases
Keywords: Farms
Keywords: Mancozeb
Keywords: tumors
Keywords: Cholinesterase
Keywords: Orchards
Keywords: Neurosurgery
Keywords: orchards
Keywords: farms
Keywords: Glioma
Keywords: N3 11027:Neurology & neuropathology
Keywords: brain tumors
Keywords: Captan
Keywords: Mortality
Keywords: valleys
Keywords: H 1000:Occupational Safety and Health
Keywords: Children
Keywords: Cancer
Keywords: Brain tumors
Keywords: Fungicides
Keywords: Neurotoxicity
Keywords: Pesticides
Keywords: Dimethoate
Keywords: CSA Neurosciences Abstracts; Health & Safety Science Abstracts
Date revised - 2011-12-01
Language of summary - English
Location - Pakistan, Kashmir
Pages - 78-86
ProQuest ID - 911163952
SubjectsTermNotLitGenreText - Risk assessment; Mortality; Neurological diseases; Farms; Mancozeb; Children; Cholinesterase; Orchards; Neurosurgery; Cancer; Brain tumors; Pesticides; Neurotoxicity; Glioma; Dimethoate; Captan; orchards; valleys; farms; Fungicides; tumors; brain tumors; Pakistan, Kashmir
Last updated - 2012-04-23
British nursing index edition - Indian Journal of Occupational & Environmental Medicine [Indian J. Occup. Environ. Med.]. Vol. 14, no. 3, pp. 78-86. Sep-Dec 2010.
Corporate institution author - Bhat, A R; Wani, MA; Kirmani, A R
DOI - MD-0017879059; 16084101; 0973-2284 English

117. Bhatia, S.; Tykodi, S. S., and Thompson, J. A. Treatment of Metastatic Melanoma: an Overview.


Rec #: 50859
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: The 10-year survival rate for patients with metastatic melanoma is less than 10%. Although surgery and radiation therapy have a role in the treatment of metastatic disease, systemic therapy is the mainstay of treatment for most patients. Single-agent chemotherapy is well tolerated but is associated with response rates of only 5% to 20%. Combination chemotherapy and biochemotherapy may improve objective response rates but do not extend survival and are associated with greater toxicity. Immunotherapeutic approaches such as high-dose interleukin-2 are associated with durable responses in a small percentage of patients. In this article, we review the treatments for metastatic melanoma including promising investigational approaches.
MESH HEADINGS: Adoptive Transfer
MESH HEADINGS: Antibodies, Monoclonal/therapeutic use
MESH HEADINGS: Antigens, CD/immunology
MESH HEADINGS: Antineoplastic Agents/therapeutic use
MESH HEADINGS: Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MESH HEADINGS: Cancer Vaccines
MESH HEADINGS: Humans
MESH HEADINGS: Immunotherapy
MESH HEADINGS: Interferon-alpha/therapeutic use
MESH HEADINGS: Interleukin-2/therapeutic use
MESH HEADINGS: Melanoma/mortality/pathology/*therapy
MESH HEADINGS: Prognosis
MESH HEADINGS: Recombinant Proteins
MESH HEADINGS: Skin Neoplasms/mortality/pathology/*therapy eng

118. Bhattacharjee, Shubhra; Fakhruddin, Anm; Chowdhury, Maz; Rahman, Ma; Alam, M K, and Bhattacharjee, Shubhra. Monitoring of Selected Pesticides Residue Levels in Water Samples of Paddy Fields and Removal of Cypermethrin and Chlorpyrifos Residues From Water Using Rice Bran. 2012 Aug; 89, (2): 348-353.


Rec #: 38609
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Consumption of pesticides associated foods increased in recent decades in Bangladesh. Most of the pesticides come from paddy, as rice is the main food items here and about 70 % pesticides are used only on paddy fields. Water samples of paddy fields and Kaliganga River of Manikganj district were analyzed to provide base line data on cypermethrin, chlorpyrifos and diazinon residue by using high performance liquid chromatography. Levels of Cypermethrin, chlorpyrifos and diazinon detected in the paddy field water samples were (0.605 plus or minus 0.011 mu g/L), (0.06 plus or minus 0.001 mu g/L) and (0.039 plus or minus 0.002 mu g/L), respectively. 0.11 plus or minus 0.003 mu g/L of cypermethrin and 0.012 plus or minus 0.0006 mu g/L of chlorpyrifos were also identified in the water samples of Kaligonga River. Diazinon residue was not detected in the river water samples. The detected concentrations of pesticide residues in the river water were below the accepted maximum residue limit (MRL) value of drinking water (0.1 mu g/l) adopted by the FAO/WHO Codex Alimentarius Commission. Cypermethrin and chlorpyrifos were chosen for decontamination through rice bran, as it was found in river water. Two gm rice bran could easily decontaminated 95.6 % and 96.4 % of cypermethrin and chlorpyrifos. The result of this study showed that pesticide residue was detected in water samples were below the MRLs value, which can easily be decontaminated through absorption of rice bran.
Keywords: High-performance liquid chromatography
Keywords: Pollution monitoring
Keywords: Q5 01520:Environmental quality
Keywords: Water sampling
Keywords: Pesticide residues
Keywords: Food
Keywords: Decontamination
Keywords: Freshwater
Keywords: Environmental Studies
Keywords: Drinking Water
Keywords: Rice fields
Keywords: Codex standards
Keywords: Absorption
Keywords: X 24330:Agrochemicals
Keywords: Bangladesh
Keywords: Toxicology
Keywords: Rivers
Keywords: HPLC
Keywords: Data processing
Keywords: Cypermethrin
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Oryza sativa
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Toxicology Abstracts
Keywords: River water
Keywords: Food absorption
Keywords: Pesticides
Keywords: Drinking water
Keywords: Diazinon
Date revised - 2012-11-01
Language of summary - English
Location - Bangladesh
Pages - 348-353
ProQuest ID - 1223128332
SubjectsTermNotLitGenreText - HPLC; Pollution monitoring; Drinking Water; Food absorption; River water; Rice fields; Codex standards; Pesticides; Toxicology; High-performance liquid chromatography; Rivers; Chlorpyrifos; Data processing; Cypermethrin; Pesticide residues; Food; Decontamination; Drinking water; Diazinon; Water sampling; Absorption; Oryza sativa; Bangladesh; Freshwater
Last updated - 2012-12-06
Corporate institution author - Bhattacharjee, Shubhra; Fakhruddin, ANM; Chowdhury, MAZ; Rahman, MA; Alam, M K
DOI - OB-b26b1572-b056-42b2-a5d3mfgefd101; 16922162; CS1252210; 0007-4861; 1432-0800 English

119. Bian, W. J.; Xu, Y.; Li, S. N., and Zhu, G. N. Desulfuration of Chlorpyrifos, Parathion, and Malathion by Hepatic Cytochrome P450 in Four Species of Fish. The Institution of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou 310029, China,//: 2011; 30, (7): 1282-1288(CHI) (ENG ABS).


Rec #: 2510
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (CPY,MLN)
Notes: Chemical of Concern: CPY,EPRN,MLN,PRN

120. Bidwell, Joseph R; Becker, Carol; Hensley, Steve; Stark, Richard; Meyer, Michael T, and Bidwell, Joseph R. Occurrence of Organic Wastewater and Other Contaminants in Cave Streams in Northeastern Oklahoma and Northwestern Arkansas. 2010 Feb; 58, (2): 286-298.


Rec #: 48089
Keywords: EFFLUENT
Notes: Chemical of Concern: CPY
Abstract: Abstract: The prevalence of organic wastewater compounds in surface waters of the United States has been reported in a number of recent studies. In karstic areas, surface contaminants might be transported to groundwater and, ultimately, cave ecosystems, where they might impact resident biota. In this study, polar organic chemical integrative samplers (POCISs) and semipermeable membrane devices (SPMDs) were deployed in six caves and two surface-water sites located within the Ozark Plateau of northeastern Oklahoma and northwestern Arkansas in order to detect potential chemical contaminants in these systems. All caves sampled were known to contain populations of the threatened Ozark cavefish (Amblyopsis rosae). The surface-water site in Oklahoma was downstream from the outfall of a municipal wastewater treatment plant and a previous study indicated a hydrologic link between this stream and one of the caves. A total of 83 chemicals were detected in the POCIS and SPMD extracts from the surface-water and cave sites. Of these, 55 chemicals were detected in the caves. Regardless of the sampler used, more compounds were detected in the Oklahoma surface-water site than in the Arkansas site or the caves. The organic wastewater chemicals with the greatest mass measured in the sampler extracts included sterols (cholesterol and beta -sitosterol), plasticizers [diethylhexylphthalate and tris(2-butoxyethyl) phosphate], the herbicide bromacil, and the fragrance indole. Sampler extracts from most of the cave sites did not contain many wastewater contaminants, although extracts from samplers in the Oklahoma surface-water site and the cave hydrologically linked to it had similar levels of diethylhexyphthalate and common detections of carbamazapine, sulfamethoxazole, benzophenone, N-diethyl-3-methylbenzamide (DEET), and octophenol monoethoxylate. Further evaluation of this system is warranted due to potential ongoing transport of wastewater-associated chemicals into the cave. Halogenated organics found in caves and surface-water sites included brominated flame retardants, organochlorine pesticides (chlordane and nonachlor), and polychlorinated biphenyls. The placement of samplers in the caves (near the cave mouth compared to farther in the system) might have influenced the number of halogenated organics detected due to possible aerial transport of residues. Guano from cave-dwelling bats also might have been a source of some of these chlorinated organics. Seven-day survival and growth bioassays with fathead minnows (Pimephales promelas) exposed to samples of cave water indicated initial toxicity in water from two of the caves, but these effects were transient, with no toxicity observed in follow-up tests.
Keywords: Guano
Keywords: Ecosystems
Keywords: Environmental Engineering Abstracts; Environment Abstracts; Water Resources Abstracts; Pollution Abstracts; Aqualine Abstracts; Toxicology Abstracts
Keywords: SW 3030:Effects of pollution
Keywords: Biota
Keywords: Insecticides
Keywords: Sterols
Keywords: PCB
Keywords: Sulfamethoxazole
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Cholesterol
Keywords: cholesterol
Keywords: Outfalls
Keywords: polychlorinated biphenyls
Keywords: Bioassays
Keywords: DEET
Keywords: Water Pollution Effects
Keywords: USA, Arkansas
Keywords: Organic Compounds
Keywords: Contaminants
Keywords: Groundwater
Keywords: Wastewater
Keywords: Surface water
Keywords: caves
Keywords: Plasticizers
Keywords: USA, Arkansas, Ozark Plateau
Keywords: Survival
Keywords: Fire retardant chemicals
Keywords: Wastewater treatment
Keywords: Streams
Keywords: Environmental Studies
Keywords: USA, Oklahoma
Keywords: Amblyopsis rosae
Keywords: Pollutants
Keywords: Ground water
Keywords: bromacil
Keywords: Municipal wastes
Keywords: Chemical pollution
Keywords: Mouth
Keywords: X 24330:Agrochemicals
Keywords: PCB compounds
Keywords: Benzophenone
Keywords: Chlordane
Keywords: AQ 00008:Effects of Pollution
Keywords: Pesticides (organochlorine)
Keywords: Herbicides
Keywords: Toxicity
Keywords: Samplers
Keywords: Pimephales promelas
Keywords: Phosphates
Keywords: Phosphate
Keywords: Indole
Keywords: indoles
Keywords: Caves
Keywords: Fire retardants
Keywords: Waste water
Keywords: Fragrances
Date revised - 2010-02-01
Language of summary - English
Location - USA, Oklahoma; USA, Arkansas, Ozark Plateau; USA, Arkansas
Pages - 286-298
ProQuest ID - 809709874
SubjectsTermNotLitGenreText - Guano; Surface water; Plasticizers; Survival; Fire retardant chemicals; Streams; Wastewater treatment; Sterols; bromacil; Ground water; Mouth; PCB; Benzophenone; Sulfamethoxazole; Chlordane; Pesticides (organochlorine); Herbicides; Toxicity; Cholesterol; Samplers; polychlorinated biphenyls; DEET; Phosphate; Indole; Caves; Waste water; Contaminants; Fragrances; Ecosystems; caves; cholesterol; Outfalls; Biota; Insecticides; Phosphates; Bioassays; indoles; Municipal wastes; Fire retardants; Chemical pollution; Groundwater; PCB compounds; Pollutants; Water Pollution Effects; Organic Compounds; Wastewater; Pimephales promelas; Amblyopsis rosae; USA, Oklahoma; USA, Arkansas, Ozark Plateau; USA, Arkansas
Last updated - 2011-11-03
Corporate institution author - Bidwell, Joseph R; Becker, Carol; Hensley, Steve; Stark, Richard; Meyer, Michael T
DOI - OB-c31f69b7-9bf6-4f15-a22fmfgefd108; 12588281; 0090-4341; 1432-0703 English

121. Biello, D. Bad for Bugs and Brains? A Common Pesticide May Interfere With a Child's Brain Development.


Rec #: 74109
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: MESH HEADINGS: Brain/*growth &
MESH HEADINGS: development
MESH HEADINGS: Child
MESH HEADINGS: Chlorpyrifos/*adverse effects
MESH HEADINGS: Female
MESH HEADINGS: Humans
MESH HEADINGS: Insecticides/*adverse effects
MESH HEADINGS: Male
MESH HEADINGS: Pregnancy
MESH HEADINGS: Prenatal Exposure Delayed Effects eng

122. Bintintan, I. and Meyers, G. A New Type of Signal Peptidase Cleavage Site Identified in an Rna Virus Polyprotein.


Rec #: 50639
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Pestiviruses, a group of enveloped positive strand RNA viruses belonging to the family Flaviviridae, express their genes via a polyprotein that is subsequently processed by proteases. The structural protein region contains typical signal peptidase cleavage sites. Only the site at the C terminus of the glycoprotein E(rns) is different because it does not contain a hydrophobic transmembrane region but an amphipathic helix functioning as the E(rns) membrane anchor. Despite the absence of a hydrophobic region, the site between the C terminus of E(rns) and E1, the protein located downstream in the polyprotein, is cleaved by signal peptidase, as demonstrated by mutagenesis and inhibitor studies. Thus, E(rns)E1 is processed at a novel type of signal peptidase cleavage site showing a different membrane topology. Prevention of glycosylation or introduction of mutations into the C-terminal region of E(rns) severely impairs processing, presumably by preventing proper membrane interaction or disturbing a conformation critical for the protein to be accepted as a substrate by signal peptidase.
MESH HEADINGS: Amino Acid Sequence
MESH HEADINGS: Animals
MESH HEADINGS: Cell Line
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