Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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noted for in vivo exposures in developing rats. Surprisingly, the effects of diazinon, dieldrin and Ni(2+) showed basic similarities despite the fact that all three come from different classes of toxicants. Our findings provide some of the first evidence for a specific mechanistic cascade contributing to the cholinesterase-independent developmental neurotoxicant actions of chlorpyrifos and its differences from diazinon, while at the same time identifying mechanistic convergence between otherwise unrelated toxicants that provides predictions about common neurodevelopmental outcomes. These results further show how combined use of cell cultures and microarray technology can guide future in vivo work on diverse developmental neurotoxicants.
Keywords: 2921-88-2
Keywords: Animals
Keywords: Analysis of Variance
Keywords: Transcription, Genetic -- drug effects
Keywords: Neurons -- drug effects
Keywords: Protein Kinase C -- genetics
Keywords: Nickel
Keywords: Cations, Divalent -- toxicity
Keywords: 60-57-1
Keywords: Rats
Keywords: Dieldrin -- toxicity
Keywords: Microarray Analysis
Keywords: Cations, Divalent
Keywords: 333-41-5
Keywords: 7440-02-0
Keywords: Protein Kinase C
Keywords: Neurons -- metabolism
Keywords: Diazinon -- toxicity
Keywords: Dieldrin
Keywords: EC 2.7.11.13
Keywords: Neurogenesis -- drug effects
Keywords: Neurotoxins -- toxicity
Keywords: Protein Kinase C -- metabolism
Keywords: Chlorpyrifos
Keywords: Neurogenesis -- physiology
Keywords: 0
Keywords: Chlorpyrifos -- toxicity
Keywords: Neurons -- cytology
Keywords: Nickel -- toxicity
Keywords: Neurotoxins
Keywords: Diazinon
Keywords: PC12 Cells
Date completed - 2009-06-24
Date created - 2009-04-20
Date revised - 2012-12-20
Language of summary - English
Pages - 23-32
ProQuest ID - 67140744
SuppNotes - Cites: Brain Res Bull. 2008 Jul 1;76(4):424-38[18502319]; Cites: Brain Res Bull. 2008 Mar 28;75(5):640-7[18355640]; Cites: Toxicol Appl Pharmacol. 2008 Dec 1;233(2):211-9[18835401]; Cites: Environ Health Perspect. 1989 Mar;80:127-42[2647474]; Cites: Environ Health Perspect. 1994 Jun;102 Suppl 2:117-20[7925181]; Cites: Toxicol Lett. 1994 Jan;70(1):71-6[8310459]; Cites: Toxicology. 1995 Dec 15;104(1-3):129-40[8560491]; Cites: Toxicology. 1996 Aug 1;112(1):57-68[8792849]; Cites: Toxicol Appl Pharmacol. 1997 Jul;145(1):158-74[9221834]; Cites: Neurotoxicology. 1997;18(3):719-26[9339819]; Cites: Brain Res. 1997 Sep 26;769(2):211-8[9374188]; Cites: Toxicol Appl Pharmacol. 1998 Jul;151(1):182-91[9705902]; Cites: Brain Res Dev Brain Res. 1998 Jul 1;109(1):33-49[9706389]; Cites: Toxicol Lett. 1998 Sep 15;98(3):139-46[9788582]; Cites: Environ Health Perspect. 1999 Feb;107 Suppl 1:71-80[10229709]; Cites: Environ Health Perspect. 1999 Jun;107 Suppl 3:431-7[10346991]; Cites: Toxicol Appl Pharmacol. 1999 Nov 1;160(3):217-30[10544056]; Cites: Brain Res. 2000 Feb 28;857(1-2):87-98[10700556]; Cites: Neurotoxicology. 2000 Feb-Apr;21(1-2):15-36[10794382]; Cites: Brain Res Dev Brain Res. 2000 Jun 30;121(2):189-95[10876031]; Cites: Brain Res Dev Brain Res. 2000 Dec 29;125(1-2):9-19[11154756]; Cites: Neurosci Lett. 2001 Mar 30;301(2):135-8[11248441]; Cites: Brain Res. 2001 Jun 1;902(2):229-43[11384617]; Cites: Cancer Lett. 2001 Aug 28;169(2):107-14[11431098]; Cites: Brain Res Dev Brain Res. 2001 Sep 23;130(1):83-9[11557096]; Cites: Environ Health Perspect. 2001 Sep;109(9):909-13[11673119]; Cites: J Biochem Mol Toxicol. 2001;15(5):263-9[11835623]; Cites: Ann N Y Acad Sci. 2002 Jun;965:473-8[12105122]; Cites: Neurotoxicology. 2002 Sep;23(3):329-39[12389578]; Cites: J Pharmacol Exp Ther. 2003 Jul;306(1):1-7[12682213]; Cites: Cell Tissue Res. 2003 Aug;313(2):139-57[12845521]; Cites: Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):183-90[14741763]; Cites: Environ Health Perspect. 2004 Feb;112(2):148-55[14754568]; Cites: Environ Health Perspect. 2004 Mar;112(3):295-301[14998743]; Cites: Pediatrics. 2004 Apr;113(4 Suppl):1030-6[15060196]; Cites: Toxicol Appl Pharmacol. 2004 Jul 15;198(2):132-51[15236950]; Cites: Chem Res Toxicol. 2004 Aug;17(8):983-98[15310231]; Cites: J Neurosci Res. 2004 Nov 15;78(4):499-507[15470723]; Cites: Neuropsychopharmacology. 2005 Jan;30(1):156-65[15496940]; Cites: Ann N Y Acad Sci. 2004 Oct;1025:595-601[15542768]; Cites: Prog Histochem Cytochem. 2004;39(3):131-82[15580762]; Cites: Toxicol Appl Pharmacol. 2005 Mar 1;203(2):154-66[15710176]; Cites: Environ Health Perspect. 2005 May;113(5):527-31[15866758]; Cites: Toxicol Appl Pharmacol. 2005 Aug 1;206(1):17-26[15963341]; Cites: Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):115-9[16024092]; Cites: Curr Neurovasc Res. 2005 Oct;2(4):331-40[16181124]; Cites: Environ Health Perspect. 2006 Jan;114(1):10-7[16393651]; Cites: Crit Rev Toxicol. 2005 Oct-Nov;35(8-9):703-11[16417037]; Cites: Environ Health Perspect. 2006 May;114(5):667-72[16675418]; Cites: Environ Health Perspect. 2006 May;114(5):746-51[16675431]; Cites: Environ Health Perspect. 2006 Jul;114(7):A412-8[16835042]; Cites: Lancet. 2006 Dec 16;368(9553):2167-78[17174709]; Cites: Environ Health Perspect. 2007 Jan;115(1):65-70[17366821]; Cites: Environ Health Perspect. 2007 Jan;115(1):93-101[17366826]; Cites: Brain Res Bull. 2007 May 30;72(4-6):232-74[17452286]; Cites: Environ Health Perspect. 2007 Jun;115(6):909-16[17589599]; Cites: Environ Health Perspect. 2007 Sep;115(9):1306-13[17805420]; Cites: Neurotoxicol Teratol. 2008 Jan-Feb;30(1):38-45[18096363]; Cites: Brain Res Bull. 2008 Jan 31;75(1):166-72[18158111]; Cites: Environ Health Perspect. 2008 Mar;116(3):340-8[18335101]; Cites: Brain Res Bull. 2009 Mar 16;78(4-5):211-25[18812211]
Last updated - 2013-01-19
British nursing index edition - Brain research, March 31, 2009, 1263:23-32
Corporate institution author - Slotkin, Theodore A; Seidler, Frederic J
DOI - MEDL-19368821; 19368821; NIHMS96229; PMC2670938; 1872-6240 eng

1271. Slotkin, Theodore a; Seidler, Frederic J, and Slotkin, Theodore A. Diverse Neurotoxicants Converge on Gene Expression for Neuropeptides and Their Receptors in an in Vitro Model of Neurodifferentiation: Effects of Chlorpyrifos, Diazinon, Dieldrin and Divalent Nickel in Pc12 Cells. 2010 Sep 24; 1353, 36-52.


Rec #: 40329
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: Unrelated developmental neurotoxicants can produce similar neurobehavioral outcomes. We examined whether disparate agents affect neuromodulators that control numerous neurotransmitters and circuits, employing PC12 cells to explore the targeting of neuroactive peptides by organophosphates (chlorpyrifos, diazinon), an organochlorine (dieldrin) and a metal (Ni2+); we utilized microarrays to profile gene expression for the peptides and their receptors. Chlorpyrifos evoked robust upregulation of cholecystokinin, corticotropin releasing hormone, galanin, neuropeptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the commencement of neurodifferentiation, since the effects were much less notable in undifferentiated PC12 cells. Diazinon targeted a similar but smaller repertoire of neuropeptide genes and the magnitude of the effects was also generally less. Surprisingly, dieldrin shared many of the same neuropeptide targets as the organophosphates and concordance analysis showed significant overlap among all three pesticides. However, dieldrin had more notable effects on neuropeptide receptors, and overlap between diazinon and dieldrin for the receptors led to a stronger resemblance of these two agents than of chlorpyrifos and dieldrin. Ni2+ was unique, evoking upregulation of only one of the peptides affected by the other agents, while causing downregulation of several others. Nevertheless, there was still significant concordance between Ni2+ and either diazinon or dieldrin, reflecting similarities toward the receptors. Our results show that neuropeptides are likely to be a prominent target for the developmental neurotoxicity of organophosphates and other neurotoxicants, and further, that the convergence of disparate agents on the same genes and pathways may contribute to similar neurobehavioral outcomes.
Keywords: Organochlorine compounds
Keywords: Toxicants
Keywords: Neuropeptide receptors
Keywords: Heavy metals
Keywords: Neuropeptide Y
Keywords: Nickel
Keywords: Toxicology Abstracts; CSA Neurosciences Abstracts
Keywords: DNA microarrays
Keywords: Hormones
Keywords: Gene expression
Keywords: Neuromodulation
Keywords: Pheochromocytoma cells
Keywords: Convergence
Keywords: Neurotransmitters
Keywords: X 24330:Agrochemicals
Keywords: Pesticides (organophosphorus)
Keywords: Neurotensin
Keywords: Cholecystokinin
Keywords: N3 11028:Neuropharmacology & toxicology
Keywords: Dieldrin
Keywords: Developmental stages
Keywords: Circuits
Keywords: organophosphates
Keywords: Chlorpyrifos
Keywords: Galanin
Keywords: Neurotoxicity
Keywords: Tachykinin
Keywords: Critical period
Keywords: Preproenkephalin
Keywords: Diazinon
Date revised - 2011-05-01
Language of summary - English
Pages - 36-52
ProQuest ID - 867733631
SubjectsTermNotLitGenreText - Organochlorine compounds; Toxicants; Neuropeptide receptors; Heavy metals; Neuropeptide Y; Nickel; DNA microarrays; Hormones; Gene expression; Neuromodulation; Pheochromocytoma cells; Convergence; Neurotransmitters; Pesticides (organophosphorus); Neurotensin; Cholecystokinin; Dieldrin; Developmental stages; Circuits; organophosphates; Galanin; Chlorpyrifos; Neurotoxicity; Tachykinin; Critical period; Preproenkephalin; Diazinon
Last updated - 2012-03-29
British nursing index edition - Brain Research [Brain Res.]. Vol. 1353, pp. 36-52. 24 Sep 2010.
Corporate institution author - Slotkin, Theodore A; Seidler, Frederic J
DOI - a1c186ea-a326-4ab5-bd58csaobj202; 13667789; 0006-8993 English

1272. ---. Oxidative Stress From Diverse Developmental Neurotoxicants: Antioxidants Protect Against Lipid Peroxidation Without Preventing Cell Loss. 2010 Mar; 32, (2): 124-131.


Rec #: 44189
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: Oxidative stress has been hypothesized to provide a mechanism by which apparently unrelated chemicals can nevertheless produce similar developmental neurotoxic outcomes. We used differentiating PC12 cells to compare the effects of agents from four different classes and then to evaluate antioxidant amelioration: fipronil, perfluorooctanesulfonamide (PFOSA), dieldrin and chlorpyrifos. The rank order for lipid peroxidation corresponded to the ability to evoke cell loss: fipronil>PFOSA>dieldrin>chlorpyrifos. The same sequence was found for an index of cell enlargement (protein/DNA ratio) but the effects on neurite outgrowth (membrane/total protein) diverged, with fipronil producing a decrease and PFOSA an increase. Cotreatment with antioxidants reduced (ascorbate) or eliminated (Vitamin E) lipid peroxidation caused by each of the agents but failed to protect against cell loss, with the sole exception of chlorpyrifos, for which we earlier showed partial protection by Vitamin E; addition of higher NGF concentrations protected neither against oxidative stress nor cell loss. Despite the failure to prevent cell loss, ascorbate protected the cells from the effects of PFOSA on neuritic outgrowth; NGF, and to a lesser extent, ascorbate, offset the effects of fipronil on both cell enlargement and neuritogenesis. At the same time, the ameliorant treatments also worsened some of the other toxicant effects. Our results point out the problems in concluding that, just because a neurotoxicant produces oxidative stress, antioxidant therapy will be effective in preventing damage. Instead, additional mechanisms for each agent may provide alternative routes to neurotoxicity, or may be additive or synergistic with oxidative stress.
Keywords: Nerve growth factor
Keywords: Antioxidants
Keywords: Toxicants
Keywords: Nucleotide sequence
Keywords: Lipids
Keywords: Membrane proteins
Keywords: Toxicology Abstracts; Environment Abstracts; CSA Neurosciences Abstracts
Keywords: Pheochromocytoma cells
Keywords: Oxidative stress
Keywords: Axonogenesis
Keywords: X 24330:Agrochemicals
Keywords: Dieldrin
Keywords: N3 11028:Neuropharmacology & toxicology
Keywords: peroxidation
Keywords: oxidative stress
Keywords: Lipid peroxidation
Keywords: Ascorbic acid
Keywords: Chlorpyrifos
Keywords: Vitamin E
Keywords: fipronil
Keywords: Pesticides
Keywords: Neurotoxicity
Keywords: DNA
Keywords: Proteins
Keywords: ENA 07:General
Date revised - 2010-06-01
Language of summary - English
Pages - 124-131
ProQuest ID - 746074162
SubjectsTermNotLitGenreText - Nerve growth factor; Antioxidants; Toxicants; Nucleotide sequence; Dieldrin; Membrane proteins; Lipid peroxidation; Ascorbic acid; Chlorpyrifos; Vitamin E; Pheochromocytoma cells; Oxidative stress; fipronil; Neurotoxicity; DNA; Axonogenesis; Lipids; Pesticides; Proteins; peroxidation; oxidative stress
Last updated - 2012-11-20
British nursing index edition - Neurotoxicology and Teratology [Neurotoxicol. Teratol.]. Vol. 32, no. 2, pp. 124-131. Mar 2010.
Corporate institution author - Slotkin, Theodore A; Seidler, Frederic J
DOI - 17a878d7-e4b6-4305-84c6csaobj201; 13022734; 0892-0362 English

1273. Smagin, V. N.; Lukashev, E. A.; Sheftel, V. O.; Kvitka, L. A., and Khiryaev, V. M. Technological Studies of Water Treatment from Pesticides by Common Plants ED-500 and KPV-1000. SOIL; 1992; 14, (10): 769-777(RUS) (ENG ABS).


Rec #: 1360
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

1274. Smith, E. H. and Logan, D. T. Invertebrate Behavior as an Indicator of Contaminated Water and Sediments. 1993: 48-61.


Rec #: 1370
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (CPY), NO REVIEW (CPY)
Notes: Chemical of Concern: CPY

1275. Smith, J. N.; Timchalk, C.; Bartels, M. J., and Poet, T. S. In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma. 2011; 39, (8): 1353-1362.


Rec #: 69469
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Age-dependent chlorpyrifos (CPF) metabolism was quantified by in vitro product formation in human hepatic microsomes (ages 13 days to 75 years) and plasma (ages 3 days to 43 years) with gas chromatography-mass spectrometry. Hepatic CPF cytochrome P450 desulfuration [CPF to chlorpyrifos-oxon (CPF-oxon)] and dearylation (CPF to 3,5,6-trichloro-2-pyridinol) V(max) values were 0.35 +/- 0.21 and 0.73 +/- 0.38 nmol . min(-1) . mg microsomal protein (-1) (mean +/- S. D.), respectively. The mean (+/- S.D.) hepatic CPF-oxon hydrolysis (chlorpyrifos-oxonase [CPFOase]) V(max) was 78 +/- 44 nmol . min(-1) . mg microsomal protein (-1). None of these hepatic measures demonstrated age-dependent relationships on a per microsomal protein basis using linear regression models. Ratios of CPF bioactivation to detoxification (CPF desulfuration to dearylation) V(max) values were consistent across ages. CPFOase in plasma demonstrated age-dependent increases on a volume of plasma basis, as did total plasma protein levels. Mean (+/- S.D.) CPF-oxon hydrolysis V(max) values for children <6 months of age and adults (>= 16 years) were 1900 +/- 660 and 6800 +/- 1600 nmol . min(-1) . ml(-1), respectively, and at environmental exposure levels, this high-capacity enzyme is likely to be sufficient even in infants. Plasma samples were phenotyped for paraoxonase status, and frequencies were 0.5, 0.4, and 0.1 for QQ, QR, and RR phenotypes, respectively. These results will be integrated into a physiologically based pharmacokinetic and pharmacodynamic model for CPF and, once integrated, will be useful for assessing biological response to CPF exposures across life stages.
Keywords: HUMAN LIVER-MICROSOMES, ORGANOPHOSPHATE PESTICIDES, PARAOXONASE
ISI Document Delivery No.: 793JJ

1276. Smith, K. E.; Putnam, R. A.; Phaneuf, C.; Lanza, G. R.; Dhankher, O. P., and Clark, J. M. Selection of Plants for Optimization of Vegetative Filter Strips Treating Runoff from Turfgrass. American Society of Agronomy, 677 South Segoe Rd Madison WI 53711 USA//: SOIL; 2008; 37, (5): 1855-1861.


Rec #: 2220
Keywords: FATE
Call Number: NO FATE (CPY,CTN,PCZ,PDM,PPCP,PPCP2011)
Notes: Chemical of Concern: CPY,CTN,PCZ,PDM,PPCP,PPCP2011

1277. Sobus, J. R.; Tan, Y. M.; Pleil, J. D., and Sheldon, L. S. A biomonitoring framework to support exposure and risk assessments. 2011; 409, (22): 4875-4884.


Rec #: 69519
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Background: Biomonitoring is used in exposure and risk assessments to reduce uncertainties along the source-to-outcome continuum. Specifically, biomarkers can help identify exposure sources, routes, and distributions, and reflect kinetic and dynamic processes following exposure events. A variety of computational models now utilize biomarkers to better understand exposures at the population, individual, and sub-individual (target) levels. However, guidance is needed to clarify biomonitoring use given available measurements and models. Objective: This article presents a biomonitoring research framework designed to improve biomarker use and interpretation in support of exposure and risk assessments. Discussion: The biomonitoring research framework is based on a modified source-to-outcome continuum. Five tiers of biomonitoring analyses are included in the framework, beginning with simple cross-sectional and longitudinal analyses, and ending with complex analyses using various empirical and mechanistic models. Measurements and model requirements of each tier are given, as well as considerations to enhance analyses. Simple theoretical examples are also given to demonstrate applications of the framework for observational exposure studies. Conclusion: This biomonitoring framework can be used as a guide for interpreting existing biomarker data, designing new studies to answer specific exposure- and risk-based questions, and integrating knowledge across scientific disciplines to better address human health risks. Published by Elsevier B.V.
Keywords: Biomonitoring, Biomarkers, Exposure science, Exposure assessment, Risk
ISI Document Delivery No.: 838QI

1278. Sogorb, M. A.; Gonzalez-Gonzalez, I.; Pamies, D., and Vilanova, E. An alternative in vitro method for detecting neuropathic compounds based on acetylcholinesterase inhibition and on inhibition and aging of neuropathy target esterase (NTE). 2010; 24, (3): 942-952.


Rec #: 69549
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Organophosphorus-induced delayed polyneuropathy (OPIDP) is a syndrome induced by certain organophosphorus compounds (OPs) through a mechanism based on the inhibition and further modification (aging) of neuropathy target esterase (NTE). OECD guidelines for testing the capability of OPs to trigger OPIDP include two in vivo tests with hens. Activities of acetylcholinesterase and NTE found in SH-SY5Y human neuroblastoma cells were inhibited by 10 different OPs with kinetics similar to those found with chicken brain enzymes (model system for in vivo and in vitro-ex vivo assays). NTE in SH-SY5Y cells inhibited by these OPs aged and reactivated similarly to that described for hen brain NTE ex vivo. In short, we have developed an alternative methodology for predicting the capability of OPs to induce OPIDP based on the inhibition kinetics of acetylcholinesterase and NTE and on the capability of OPs to age the inhibited NTE from SH-SY5Y cell line. The results obtained always agreed with the previously reported ex vivo results with hen brain. The developed methodology correctly predicted the neuropathic potential of the tested OPs in eight cases. The in vivo-in vitro discrepancies with two of the tested compounds can be explained on the basis of differences between in vivo and in vitro biotransformation. (C) 2010 Elsevier Ltd. All rights reserved.
Keywords: NTE, Inhibition and aging, Neuroblastoma, Alternative method,
ISI Document Delivery No.: 583IT

1279. Sogorb, Ma; Garcia-Arguelles, S; Carrera, V; Quesada, E; Vilanova, E, and Sogorb, MA. Human Serum Albumin Hydrolyzes the Organophosphorus Insecticides Paraoxon, Diazoxon, Chlorpyrifos-Oxon and O-Hexyl O-2,5-Dichlorophenyl Phosphoramidate. 2008 Oct 24; 180, 1-S29.


Rec #: 41899
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Keywords: Insecticides
Keywords: Pharmacy And Pharmacology
Keywords: human serum albumin
Keywords: Paraoxon
Keywords: X 24330:Agrochemicals
Keywords: Toxicology Abstracts
Date revised - 2008-10-01
Language of summary - English
Pages - S29
ProQuest ID - 290180370
SubjectsTermNotLitGenreText - Paraoxon; human serum albumin; Insecticides
Last updated - 2011-11-04
Corporate institution author - Sogorb, MA; Garcia-Arguelles, S; Carrera, V; Quesada, E; Vilanova, E
DOI - OB-MD-0008398319; 8417679; 0378-4274 English

1280. Sogorb, Miguel A.; Estevan, Carmen; Romero, Andrea C.; Pamies, David, and Vilanova, Eugenio. Chlorpyrifos and metabolites alter differentiation at non-cytotoxic concentrations. 2012 Jun 17-; 211, Supplement, (0 ): S106.


Rec #: 2390
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY

1281. Sogorb, Miguel A.; Garc+¡a-Arg++elles, Sara; Carrera, Victoria; Quesada, Encarnaci+ n, and Vilanova, Eugenio. Human serum albumin hydrolyzes the organophosphorus insecticides paraoxon, diazoxon, chlorpyrifos-oxon and O-hexyl O-2,5-dichlorophenyl phosphoramidate: Abstracts of the 45th Congress of the European Societies of Toxicology. 2008 Oct 5-; 180, Supplement, (0): S29.


Rec #: 2510
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY

1282. Sogorb, Miguel a and Vilanova, Eugenio. Serum Albumins and Detoxication of Anti-Cholinesterase Agents. 2010 Sep 6; 187, (1-3): 325-329.


Rec #: 47719
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Serum albumin displays an esterase activity that is capable of hydrolysing the anti-cholinesterase compounds carbaryl, paraoxon, chlorpyrifos-oxon, diazoxon and O-hexyl, O-2,5-dichlorphenyl phosphoramidate. The detoxication of all these anti-cholinesterase compounds takes place at significant rates with substrate concentrations in the same order of magnitude as expected during in vivo exposures, even when these substrate concentrations are between 15 and 1300 times lower than the recorded K(m) constants. Our data suggest that the efficacy of this detoxication system is based on the high concentration of albumin in plasma (and in the rest of the body), and not on the catalytic efficacy itself, which is low for albumin. We conclude the need for a structure-activity relationship study into the albumin-associated esterase activities because this protein is universally present in vertebrates and could compensate for reduced levels of other esterases, i.e., lipoprotein paraoxonase, in some species. It is also remarkable that the biotransformation of xenobiotics can be reliably studied in vitro, although conditions as similar as possible to in vivo situations are necessary. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Keywords: Serum Albumin -- metabolism
Keywords: Animals
Keywords: Cholinesterases
Keywords: Humans
Keywords: Hydrolysis
Keywords: Organophosphorus Compounds -- pharmacokinetics
Keywords: Cholinesterases -- metabolism
Keywords: Cholinesterase Inhibitors
Keywords: Organophosphorus Compounds
Keywords: Cattle
Keywords: Cholinesterase Inhibitors -- toxicity
Keywords: 0
Keywords: Kinetics
Keywords: Organophosphorus Compounds -- toxicity
Keywords: Cholinesterase Inhibitors -- pharmacokinetics
Keywords: EC 3.1.1.8
Keywords: Metabolic Detoxication, Drug
Keywords: Serum Albumin, Bovine
Keywords: Serum Albumin, Bovine -- metabolism
Keywords: Serum Albumin
Date completed - 2010-09-01
Date created - 2010-07-30
Date revised - 2012-12-20
Language of summary - English
Pages - 325-329
ProQuest ID - 749028815
Last updated - 2013-01-19
British nursing index edition - Chemico-biological interactions, September 6, 2010, 187(1-3):325-329
Corporate institution author - Sogorb, Miguel A; Vilanova, Eugenio
DOI - MEDL-20211614; 20211614; 1872-7786 eng

1283. Soler, Carla; Girotti, Stefano; Ghini, Severino; Fini, Fabiana; Montoya, Angel; Manclus, Juan J; Manes, Jordi, and Soler, Carla. Analysis of Chlorpyrifos in Water, Fruit Juice, and Honeybee Extract by Chemiluminescent Elisa. 2008 Jan; 41, (14): 2539-2553.


Rec #: 42309
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: The suitability of competitive enzyme-linked immunosorbent assays (ELISAs) with chemiluminescent detection-based immobilized antigen (indirect assay) for rapid and accurate determination of chlorpyrifos in various food matrices was tested. The limit of detection (LOD) values were 1-1.75 ng mL-1, the standard curve midpoint (IC50) was 3.5 ng mL-1, and the assay duration was 1.5 h. Assay application to the analysis of honeybee extract resulted in chlorpyrifos recoveries varying between 62 and 83% in 5-15 ng mL-1 herbicide concentration range.
Keywords: Testing Procedures
Keywords: Enzyme-linked immunosorbent assay
Keywords: Z 05300:General
Keywords: Food
Keywords: SW 3030:Effects of pollution
Keywords: Apis mellifera
Keywords: Herbicides
Keywords: Chlorpyrifos
Keywords: Fruit juices
Keywords: Foods
Keywords: Pesticides
Keywords: Assay
Keywords: Entomology Abstracts; Water Resources Abstracts
Keywords: Standards
Date revised - 2010-08-01
Language of summary - English
Pages - 2539-2553
ProQuest ID - 753692151
SubjectsTermNotLitGenreText - Chlorpyrifos; Fruit juices; Enzyme-linked immunosorbent assay; Food; Herbicides; Testing Procedures; Foods; Pesticides; Assay; Standards; Apis mellifera
Last updated - 2012-03-29
British nursing index edition - Analytical Letters [Anal. Lett.]. Vol. 41, no. 14, pp. 2539-2553. Jan 2008.
Corporate institution author - Soler, Carla; Girotti, Stefano; Ghini, Severino; Fini, Fabiana; Montoya, Angel; Manclus, Juan J; Manes, Jordi
DOI - 032ad848-7157-4ad8-8df5csamfg201; 13325540; 0003-2719; 1532-236X English

1284. Solokov, I. Fipronil Versus Chlorpyrifos: Which is Softer on Non-Target Organisms in Siberia? I. Sokolov, All-Russian Institute for Plant Protection, igor@os2897.spb.edu//: 2000: 18-19(ABS).


Rec #: 2370
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY,FPN

1285. Solomon, K. R.; Anadon, A.; Brain, R. A.; Cerdeira, A. L.; Crossan, A. N.; Marshall, J.; Sanin, L. H., and Smith, L. Comparative Hazard Assessment of the Substances Used for Production and Control of Coca and Poppy in Colombia. Centre for Toxicology,University of Guelph,Guelph,ON,Can////: SOIL; 2007: 87-99.


Rec #: 310
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (24D,24DXY,CBD,CBL,CPY,CYP,DZ,ES,GYP,LCYT,MOM,MTM,PDM,PFF,PQT), NO REVIEW (24D,24DXY,CBD,CBL,CPY,CYP,DZ,ES,GYP,LCYT,MOM,MTM,PDM,PFF,PQT)
Notes: Chemical of Concern: 24D,24DXY,CBD,CBL,CPY,CYP,DZ,EPRN,ES,GYP,LCYT,MOM,MTM,PDM,PFF,PQT,PRN

1286. Somerset, V; Baker, P; Iwuoha, E, and Somerset, V. Mercaptobenzothiazole-on-Gold Organic Phase Biosensor Systems: 1. Enhanced Organosphosphate Pesticide Determination. 2009 Feb; 44, (2): 164-178.


Rec #: 45069
Keywords: CHEM METHODS
Notes: Chemical of Concern: CPY
Abstract: Abstract: This paper reports the construction of the gold/mercaptobenzothiazole/polyaniline/acetylcholinesterase/polyvi nylacetat e (Au/ MBT/PANI/AChE/PVAc) thick-film biosensor for the determination of certain organophosphate pesticide solutions in selected aqueous organic solvent solutions. The Au/MBT/PANI/AChE/PVAc electrocatalytic biosensor device was constructed by encapsulating acetylcholinesterase (AChE) enzyme in the PANI polymer composite, followed by the coating of poly(vinyl acetate) (PVAc) on top to secure the biosensor film from disintegration in the organic solvents evaluated. The electroactive substrate called acetylthiocholine (ATCh) was employed to provide the movement of electrons in the amperometric biosensor. The voltammetric results have shown that the current shifts more anodically as the Au/MBT/PANI/AChE/PVAc biosensor responded to successive acetylthiocholine (ATCh) substrate addition under anaerobic conditions in 0.1 M phosphate buffer, KCl (pH 7.2) solution and aqueous organic solvent solutions. For the Au/MBT/PANI/AChE/PVAc biosensor, various performance and stability parameters were evaluated. These factors include the optimal enzyme loading, effect of pH, long-term stability of the biosensor, temperature stability of the biosensor, the effect of polar organic solvents, and the effect of non-polar organic solvents on the amperometric behavior of the biosensor. The biosensor was then applied to detect a series of 5 organophosphorous pesticides in aqueous organic solvents and the pesticides studied were parathion-methyl, malathion and chlorpyrifos. The results obtained have shown that the detection limit values for the individual pesticides were 1.332 nM (parathion-methyl), 0.189 nM (malathion), 0.018 nM (chlorpyrifos).
Keywords: Biotechnology and Bioengineering Abstracts; Pollution Abstracts
Keywords: Acetylcholinesterase
Keywords: Organophosphates
Keywords: Malathion
Keywords: Biosensors
Keywords: W 30955:Biosensors
Keywords: Gold
Keywords: pH effects
Keywords: pH
Keywords: Temperature effects
Keywords: Pesticides (organophosphorus)
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Agricultural wastes
Keywords: Solvents
Keywords: Temperature
Keywords: Enzymes
Keywords: potassium chloride
Keywords: Anaerobic conditions
Keywords: Food contamination
Keywords: Acetic acid
Keywords: Chlorpyrifos
Keywords: Phosphates
Keywords: Phosphate
Keywords: Pesticides
Keywords: Construction industry wastes
Keywords: Polymers
Keywords: Coatings
Date revised - 2009-03-01
Language of summary - English
Pages - 164-178
ProQuest ID - 20421149
SubjectsTermNotLitGenreText - Temperature effects; Pesticides (organophosphorus); Acetylcholinesterase; Agricultural wastes; Solvents; Enzymes; potassium chloride; Food contamination; Anaerobic conditions; Acetic acid; Malathion; Biosensors; Chlorpyrifos; Phosphate; Gold; pH effects; Coatings; Organophosphates; Temperature; Phosphates; Pesticides; Construction industry wastes; Polymers; pH
Last updated - 2011-12-14
British nursing index edition - Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes [J. Environ. Sci. Health, Pt. B: Pestic., Food Contam., Agric. Wastes]. Vol. 44, no. 2, pp. 164-178. Feb 2009.
Corporate institution author - Somerset, V; Baker, P; Iwuoha, E
DOI - MD-0009453425; 9094845; 0360-1234 English

1287. Songsasen, N. and Wildt, D. E. Oocyte Biology and Challenges in Developing in Vitro Maturation Systems in the Domestic Dog.


Rec #: 51589
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
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ABSTRACT: The oocyte of the domestic dog is unique from that of other mammalian species studied to date. Ovulation occurs either once or twice per year, with the oocyte released at the germinal vesicle stage, and then completing nuclear and cytoplasmic maturation within the oviduct under the influence of rising circulating progesterone. In vivo meiotic maturation of the bitch oocyte is completed within 48-72 h after ovulation, which is longer than 12-36 h required for oocytes from most other mammalian species. Due to these inherently novel traits, in vitro culture systems developed for maturing oocytes of other species have been found inadequate for maturation of dog oocytes. On average, only 15-20% of ovarian oocytes achieve the metaphase II stage after 48-72 h of in vitro culture. Thus far, no offspring have been produced in the dog (or other canids) by transferring embryos derived from in vitro matured oocytes. This review addresses current knowledge about dog reproductive physiology, specifically those factors influencing in vitro developmental competence of the oocyte. This summary lays a foundation for identifying the next steps to understanding the mechanisms regulating meiotic maturation and developmental competence of the dog oocyte.
MESH HEADINGS: Animals
MESH HEADINGS: Cell Culture Techniques
MESH HEADINGS: Cell Nucleus/physiology
MESH HEADINGS: Culture Media
MESH HEADINGS: Cytoplasm/physiology
MESH HEADINGS: Dogs
MESH HEADINGS: Female
MESH HEADINGS: Fertilization in Vitro
MESH HEADINGS: Hormones/pharmacology
MESH HEADINGS: Mammals
MESH HEADINGS: Oocytes/drug effects/*physiology
MESH HEADINGS: Ovulation
MESH HEADINGS: Proteins/physiology
MESH HEADINGS: Zona Pellucida/physiology eng

1288. Sonnenschein, C. and Soto, A. M. An Updated Review of Environmental Estrogen and Androgen Mimics and Antagonists. 1998; 65, (1-6): 143-150.


Rec #: 1680
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (24D,24DXY,ACR,ATZ,CBF,CBL,CPY,CTN,DCF,DCPA,DZ,ES,ES1,ES2,HXZ,MEM,MLN,MTL,MTPN,Maneb,PPZ,RTN,SZ,TFN,THM,Ziram), NO REVIEW (24D,24DXY,ACR,ATZ,CBF,CBL,CPY,CTN,DCF,DCPA,DZ,ES,ES1,ES2,HXZ,MEM,MLN,MTL,MTPN,Maneb,PPZ,RTN,SZ,TFN,THM,Ziram)
Notes: Chemical of Concern: 24D,24DXY,ACR,ATZ,BDC,CBF,CBL,CHD,CPY,CTN,CZE,DCF,DCPA,DDT,DLD,DZ,ES,ES1,ES2,HCCH,HPT,HXZ,MEM,MLN,MRX,MTL,MTPN,MXC,Maneb,PCB,PCL,PPCP,PPZ,PYN,RTN,SZ,TFN,THM,TXP,Zineb,Ziram

1289. Sormunen, Arto J; Tuikka, Anita I; Akkanen, Jarkko; Leppă¤Nen, Matti T; Kukkonen, Jussi V, and K. Predicting the Bioavailability of Sediment-Associated Spiked Compounds by Using the Polyoxymethylene Passive Sampling and Tenaxâ® Extraction Methods in Sediments From Three River Basins in Europe. 2010 Jul; 59, (1): 80-90.


Rec #: 43989
Keywords: SEDIMENT CONC
Notes: Chemical of Concern: CPY
Abstract: Abstract: This study presents the bioavailability of four spiked compounds to Lumbriculus variegatus, in sediment samples from three river basins in Europe: the Elbe, the Llobregat, and the Scheldt. Twenty sediment samples differing in physical and chemical properties were spiked with chlorpyrifos, pyrene, tetrachloribiphenyl, and tetrabromo diphenyl ether. The main focus of this study was to compare the suitability of two chemical approaches--the rapidly desorbing fraction method based on the Tenax® extraction and the freely dissolved chemical concentration method based on polyoxymethylene passive sampling--for predicting the bioavailability of sediment-associated hydrophobic compounds. It appears that accessible concentration estimated by Tenax extraction does not result in equal freely dissolved concentrations based on polyoxymethylene passive sampling results. The present data show that freely dissolved concentration in pore water mainly determines the uptake by organisms and, therefore, the polyoxymethylene passive sampling method was a successful approach to estimating the bioavailability of sediment-associated lipophilic contaminants (log octanol-water partitioning coefficient >6). The sediment characteristics or river basin differences had only a minor effect on the bioavailability estimates. Overall, passive samplers have not been tested to a sufficient extent in various chemicals or exposure matrixes. For this reason, bioassays are still needed in the risk assessment process in order to verify results based on passive sampling methods. [PUBLICATION ABSTRACT]
Keywords: Geologic Sediments -- chemistry
Keywords: Animals
Keywords: Oligochaeta -- metabolism
Keywords: Polybrominated Biphenyls -- metabolism
Keywords: Polybrominated Biphenyls
Keywords: Polybrominated Biphenyls -- chemistry
Keywords: Resins, Synthetic
Keywords: Polymers -- chemistry
Keywords: Europe
Keywords: Pyrenes
Keywords: Soil Pollutants -- chemistry
Keywords: Environmental Studies
Keywords: 1540:Pollution control
Keywords: Soil Pollutants
Keywords: pyrene
Keywords: Water Pollutants, Chemical
Keywords: Rivers -- chemistry
Keywords: Pyrenes -- chemistry
Keywords: Water Pollutants, Chemical -- chemistry
Keywords: 9175:Western Europe
Keywords: Chlorpyrifos -- chemistry
Keywords: Resins, Synthetic -- chemistry
Keywords: Soil Pollutants -- metabolism
Keywords: Pyrenes -- metabolism
Keywords: 9130:Experimental/theoretical
Keywords: Chlorpyrifos
Keywords: delrin
Keywords: tenax
Keywords: Polymers
Keywords: Environmental Monitoring -- methods
Keywords: Water Pollutants, Chemical -- metabolism
Keywords: Chlorpyrifos -- metabolism
Copyright - Springer Science+Business Media, LLC 2010
Language of summary - English
Location - Europe
Pages - 80-90
ProQuest ID - 607992948
Document feature - References; Tables; Equations
SubjectsTermNotLitGenreText - Europe
Last updated - 2012-03-05
Place of publication - Heidelberg
Corporate institution author - Sormunen, Arto J; Tuikka, Anita I; Akkanen, Jarkko; Leppänen, Matti T; Kukkonen, Jussi V; K
DOI - 2078932961; 53307071; 108161; AECT; 20058002; SPVLAECT2445919453 English

1290. Sosa Gomes, D. R.; Manzur, J., and Nasca, A. Influence of Some Pesticides on Three Varieties of Hirsutella thompsonii Fisher (Hyphomycetes: Moniliales). 1987; 16, (2): 399-408(POR).


Rec #: 1380
Keywords: NOT PURSUING,NON-ENGLISH
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

1291. Soummer, A.; Megarbane, B.; Boroli, F.; Arbelot, C.; Saleh, M.; Moesch, C.; Fournier, E., and Rouby, J. J. Severe and prolonged neurologic toxicity following subcutaneous chlorpyrifos self-administration: A case report. 2011; 49, (2): 124-127.


Rec #: 69659
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Introduction. Organophosphate poisoning by oral or inhalation routes is characterized by a typical time-course of clinical features. Case presentation. We report a case of subcutaneous chlorpyrifos self-injection leading to a delayed cholinergic phase, prolonged coma, and severe permanent neurologic injury with electrophysiological patterns suggestive of overlapping intermediate syndrome and distal peripheral neuropathy. Time-course and severity of clinical features were not altered by either atropine or pralidoxime administration. Due to prolonged and severe alteration in consciousness, we used brain multimodal nuclear magnetic imaging and auditory cognitive event-related potentials to assess the patient's potential for awakening. Electrophysiological testing used to monitor muscle weakness showed the coexistence of 20 Hz-decremental responses in proximal muscles and severe denervation in distal muscles. Red blood cell acetylcholinesterase activity progressively normalized on day 60, while plasma butyrylcholinesterase activity remained low until day 100. Chlorpyrifos was detectable in serum until day 30 and urine metabolites for up to three months, supporting the hypothesis of a continuous chlorpyrifos release despite repeated surgical debridement. We suggest that adipose and muscle tissues acted as a chlorpyrifos reservoir. At one-year follow-up, the patient exhibited significant neuromuscular sequelae. Conclusion. Subcutaneous chlorpyrifos self-injection may result in severe toxicity with prolonged neurologic injury, atypical overlapping electrophysiological patterns, and a poor final outcome.
Keywords: Organophosphate, Oxime, Poisoning, Functional brain MRI, Neuropathy,
ISI Document Delivery No.: 729RF

1292. South, D. B. and Zwolinski, J. B. Chemicals Used in Southern Forest Nurseries. SOIL; 1996; 20, (3): 127-135.


Rec #: 320
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (ACP,ACR,ATZ,BMY,BRA3,CLP,CPY,CTN,Captan,DCF,DMT,DZ,EFV,EP,EPTC,FNV,FSF,GYP,LCF,LQN,MLN,MLX,MTL,MZB,OXF,PMT,PSM,SFR,SMM,SXD,TDF,TFN,THM,Zn,Zn element), NO REVIEW (ACP,ACR,ATZ,BMY,BRA3,CLP,CPY,CTN,Captan,DCF,DMT,DZ,EFV,EP,EPTC,FNV,FSF,GYP,LCF,LQN,MLN,MLX,MTL,MZB,OXF,PMT,PSM,SFR,SMM,SXD,TDF,TFN,THM,Zn,Zn element)
Notes: Chemical of Concern: ACP,ACR,ATZ,BMY,BORON,BRA3,CLP,CPY,CTN,Captan,DCF,DMT,DZ,EFV,EP,EPTC,FBM,FNV,FSF,GYP,HMN,LCF,LQN,MLN,MLX,MTL,MZB,NPP,ODZ,OXF,PMT,PSM,SFR,SMM,SXD,TDF,TFN,THM,TPM,Zn

1293. Sowik-Borowiec, Magdalena; Szpyrka, Ewa; Walorczyk, Stanisaw, and Sowik-Borowiec, Magdalena. Analysis of Pesticide Residues in Fresh Peppermint, Mentha Piperita L., Using the Quick Easy Cheap Effective Rugged and Safe Method (Quechers) Followed by Gas Chromatography With Electron Capture and Nitrogen Phosphorus Detection. 2012 Sep; 89, (3): 633-637.


Rec #: 46509
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: A new analytical method for the determination of 14 pesticide residues in fresh peppermint was developed based on the QuEChERS sample preparation technique followed by gas chromatography coupled to electron capture and nitrogen phosphorus detectors (GC/ECD/NPD). The validation study clearly demonstrated suitability of the method for its intended application. The overall recoveries of the pesticides from peppermint, at the three spiking levels of 0.01, 0.1 and 1.0 mg kg super(-1), were 100 % plus or minus 10 % with relative standard deviations of 6 % plus or minus 5 % on average. The limit of quantification was 0.01 mg kg super(-1) for all the pesticides. The expanded uncertainties were in the range between 7 % and 30 % (14 % on average), which was distinctively less than a maximum default value of plus or minus 50 %. Compared with our previous method, that entailed dichloromethane/acetone extraction and florisil column cleanup with collection of four fractions, the new method was more straightforward, less time and labour intensive as well as more sensitive, selective and accurate, simultaneously.
Keywords: Pesticide residues
Keywords: Phosphorus
Keywords: Environment Abstracts; Pollution Abstracts; Toxicology Abstracts
Keywords: P 6000:TOXICOLOGY AND HEALTH
Keywords: Firing pattern
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Environmental Studies
Keywords: Standard deviation
Keywords: Dichloromethane
Keywords: Gas chromatography
Keywords: Economics
Keywords: Pesticides
Keywords: Acetone
Keywords: X 24330:Agrochemicals
Keywords: Mentha piperita
Keywords: Nitrogen
Date revised - 2012-11-01
Language of summary - English
Pages - 633-637
ProQuest ID - 1222928861
SubjectsTermNotLitGenreText - Dichloromethane; Standard deviation; Gas chromatography; Pesticide residues; Pesticides; Phosphorus; Acetone; Firing pattern; Nitrogen; Economics; Mentha piperita
Last updated - 2012-12-06
Corporate institution author - Sowik-Borowiec, Magdalena; Szpyrka, Ewa; Walorczyk, Stanisaw
DOI - OB-ce8d5a2f-08ea-400c-be3emfgefd101; 17134800; 0007-4861; 1432-0800 English

1294. Spearow, Jimmy L; Kota, Rama S; Ostrach, David J, and Spearow, Jimmy L. Environmental Contaminant Effects on Juvenile Striped Bass in the San Francisco Estuary, California, Usa. 2011 Feb 1; 30, (2): 393-402.


Rec #: 47449
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: The decline of pelagic organisms in the San Francisco Estuary (SFE) (California, USA) is attributed to several factors, including water diversions, invasive species, and exposure to environmental toxicants. The present study evaluated the effects of environmental contaminants on liver vitellogenin, metallothionein, 7-ethoxyresorufin-O-deethylase (EROD), and benzyloxyresorufin O-deethylase (BROD) activity in juvenile striped bass (Morone saxitilis) in the SFE.
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