Supplemental data Table e Number of included mr measurements per quantitative method



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Table e-1. Number of included MR measurements per quantitative method





Patients (N=28)

Controls (N=61)

Mean age (±sd)5

(patients/controls)

Age range5

(patients/controls)

DTI

25

44

12.5(10.7)/7.8(9.2)

0.5-47/0.5-44

Not performed

0

11







Discarded1

3

6







Included with fewer volumes2

1

7







MTI

28

53

11.4 (9.9)/6.9(8.6)

0.5-47/0.3-44

Not performed

0

5







Discarded3

0

3







Not in splenium4

4

0







T2

28

54

11.4(9.9)/7.0(8.5)

0.5-47/0.3-44

Not performed

0

7







Not in splenium4

8

0







CSI

27

61

10.7(10.2)/7.9(9.4)

0.5-47/0.3-44

Not performed

1

0







DTI, diffusion tensor imaging; MTI, magnetisation transfer imaging; CSI, chemical shift imaging


1 because of serious movement artefacts beyond repair

2 included after removal of 1-5 (mean 2.7) diffusion-weighted volumes affected by motion artefacts

3 because of serious movement artifacts

4 because the splenium was very thin, hampering positioning of a ROI

5 in years


MR parametermeasure

WM area

a

b

tau

FA

Splenium

0.792

-0.688

0.573




Corticospinal tracts

0.399

-0.125

4.604




Parietal WM

0.306

-0.105

2.272

MD

Splenium

83.7

293.7

0.355




Corticospinal tracts

76.4

28.4

1.893




Parietal WM

87.8

27.9

1.935

AD

Splenium

182.7

372.3

0.293




Corticospinal tracts

111.4

36.3

0.906




Parietal WM

116.4

24.4

1.914

RD

Splenium

34.3

290.9

0.368




Corticospinal tracts

58.4

27.7

2.736




Parietal WM

73.5

29.6

1.944

T2

Splenium

91.0

375.2

0.312




Corticospinal tracts

103.9

94.6

0.351




Parietal WM

100.7

111.1

0.551

MTR

Splenium

0.356

-0.514

0.349




Corticospinal tracts

0.349

-0.109

0.844




Parietal WM

0.337

-0.162

0.920

Cr

Parietal WM

3.883

1.420

0.887

NAA

Parietal WM

8.065

-1.986

10.390

Cho

Parietal WM

1.397

0.395

3.290

Ins

Parietal WM

3.264

5.487

0.212

NAA/Cr

Parietal WM

1.960

-0.719

3.088
Table e-2. Coefficients of the mono-exponential function fitted per MR measure and WM area

MR, magnetic resonance; WM, white matter; FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity; MTR, magnetic transfer ratio; Cr, creatine; NAA, N-acetyl aspartate; Cho, choline; Ins, myo-inositol. Coefficients a and b are given in 10-5 mm2/s for MD, AD and RD, in ms for T2, and in mM for metabolite concentrations. Coefficient tau is given in years.



Figure e-1

Quantitative MR measures versus age per white matter area. MD, AD and RD are given in 10-5mm2/s, in ms for T2 in ms and metabolite concentrations in mM.


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