Neurobiology of Disease 4340/6340



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Neurobiology of Disease 4340/6340

Spring 2014 MWF 11:00-11:50, Jones 204

James Cronin, PhD, cronin@tulane.edu, 1003 Stern

Office Hours: MWF, 9-11, or by appointment (let me know if you are coming)


This class surveys several of the significant diseases and/or conditions addressed by Neuroscience. For each disease, a general outline of the clinical presentation will be given, followed by a review of recent research papers in the field. Emphasis is placed on original publications elucidating either mechanisms of the disease or potential interventions.

Readings for the class will be taken from book chapters, review papers, and original research papers. I will either provide copies of articles/chapters in class, or will post the readings as PDF files on Black Board. Lectures will be in the form of PowerPoint presentations, which will also be posted on Black Board. Graduate students will conduct assigned presentations during the course of the semester relating to and reinforcing the class material. The schedule and readings may be modified as the semester progresses depending on student interest, as I discover additional material, and as new material is published. Additional information on the diseases discussed in this class can be found at: www.ninds.nih.gov/disorders/disorder_index.htm, as well as at the websites of the various support societies for each disease


Exams are multiple choice, “fill-in-the-blanks”, and short answer. Make-up exams are only given for valid significant reasons (e.g. Medical/Dental/Graduate School interview). Arrangements must be made prior to the exam. In the event of illness, documentation is required for a make-up exam. Missed exams are counted as 0 points. Over the course of the semester there will be short “class participation” quizzes covering the reading material for that class, or other recent classes. These will not be difficult but rather will assess if the material was read and the level of understanding obtained from the readings. For undergraduate grades, quizzes are 10%, exams count for 90% of the final grade. Graduate students’ grades are calculated as based on 10% quiz scores, 10% presentations, and 80% exams. Material presented during graduate student presentations can be included on tests- so pay attention. There are no extra-credit projects; please do not ask.

Tests scores are posted on BlackBoard, and test are typically reviewed the next class. Do not send me (or other faculty) emails asking if I will look up your grade on a test, or ask what score you need to make on a test to get a desired final grade, or ask if you can take a test at a different time because you have other tests scheduled around the same time.

For testing and presentation purposes, the class material is divided into “Blocks”

Block Lectures

I 1-10

II 11-18


III 19-26

IV 27-36


Learning Objectives:

  • Understanding of fundamentals of neuronal and membrane physiology, and how these relate to pathology.

  • Familiarization with contemporary thought in the Neuroscience community regarding the underlying basis for the diseases and conditions discussed in the class.

  • Familiarization with contemporary therapeutic treatments and interventions for the diseases discussed in the class, as well as the limitations and expected outcomes of those treatments.

  • Familiarization with common research techniques and technologies used in Neuroscience.


Service Learning Component

An optional service-learning component is available with this course. Students wishing to participate in the Service Learning component must register for service learning separately from the lecture course. Participating students will choose one of the participating community partners to complete their service requirements. The specific regular duties will vary depending on the community partner, with whom the students will spend either 20 hour or 40 hours over the course of the semester. The 20 hour option is for 0 credit hours, the 40 hour option is for one credit hour. All students will



  • Keep a daily journal of their experiences with the community partner in which they will record their activities while on-site. Copies of journals are provided to the instructor on Friday of every week as ‘progress reports’. Students are therefore required to keep their journals up-to-date. Entries should be written on the day of the service

  • Each participating student will give two 10 minute presentations on their Service Learning experiences. Emphasis is placed on any correlates that can be drawn to the material discussed in class. These presentations are made to the other students participating in Service Learning and are to be scheduled outside of class-time. The first presentations will occur around mid-semester, while the second presentations are at the end of the semester. Students are also asked to reflect on ‘non-class room lessons learned’.







date

lecture

reading

1

1/13/2014

1. Introduction, Neuroscience Review/Membrane Physiology I

 

2

1/15/2014

2. Neuroscience Review/Membrane Physiology II

 

3

1/17/2014

no class- Jury Duty

 

4

1/20/2014

no class- MLK day

 

5

1/22/2014

3. Neuroscience Review/Synaptic Physiology I

 

6

1/24/2014

4. Neuroscience Review/Synaptic Physiology II/Myasthenia Gravis

Myasthenia and related disorders of the neuromuscular junction. J Neurol Neurosurg Psychiatry 2010;81:850-857.

7

1/27/2014

5. Neuromuscular Diseases; Parkinson’s I

Neuroscience, Chapter 17, Modulation of Movement by the Basal Ganglia. Parkinson’s Disease: Genetics and Pathogenesis. Ann. Rev. Path. Mech. Dis. Supplemental Reading: Cell Transportation…Mount Sinai J Med 78:126-158, 2011.2011(6):193-222

8

1/29/2014

6. Neuromuscular Diseases; Parkinson’s II

Cell transplantation and gene therapy in Parkinson’s Disease. 2011 Mount Sinai Journal of medicine 78:126-158.

9

1/31/2014

7. Neuromuscular Diseases II; Huntington’s/ Multiple Sclerosis

Huntington's Disease: a Clinical Review. Orphanet Journal of Rare Diseases 2010 5:40. Multiple Sclerosis, Journal of Clinical Investigation, 2012

10

2/3/2014

8. ALS

Amyotrophic Lateral Sclerosis. The Lancet Vol 377, March 12, 2011. 942-954

11

2/5/2014

9 Student presentation: RNAi therapeutics for CNS Disorders.

Brain Research 1338(2010) 112-121

12

2/7/2014

10 Student presentation: Stem Cells in Human Neurodegenerative Disorders.

Stem Cells in Human Neurodegenerative Disorders. Journal of Clinical Investigation 120(1) Jan 2010.

13

2/10/2014

Test I

 

14

2/12/2014

11. Alzheimer’s I

Alzheimer’s Mechanisms, Cell, March 2012. New Concepts in Neurobiology…Radiology, May 2012. Synapses and Alzheimer’s. Cold Spring Harbor, May 2012. Pathways Towards Alzheimer’s. Nature 2004

15

2/14/2014

12. Alzheimer’s II

 

16

2/17/2014

13. The Aging Brain

The Aging Cortical Synapse, Nature Reviews Neuroscience, April 2012

17

2/19/2014

14. Student presentation: Preventing Dementia.

Preventing Dementia. Current Opinion in Psychiatry 2013

18

2/21/2014

15. Stroke/Rehab

Plasticity during stroke recovery: from synapses to behavior. Nature Review Neuroscience Vol 10, December 2009.See also: Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacology and Therapeutics 132(2011)57-71 Neuroscience 2006 (7)628-638

19

2/24/2014

16. Spinal Cord Injuries

Glial inhibition of CNS Axon Regeneration, Nature Reviews Neuroscience 2006 (7)617-627. Therapeutic interventions after spinal cord injury, Nature Reviews. See also: Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacology and Therapeutics 132(2011)57-71. Neuroscience 2006 (7)628-638

20

2/26/2014

17. Epilepsy

Primary and secondary mechanisms of epileptogenesis…Current Review in Basic Science. Vol10, no5, 2010. See also: The neurobiology of Antiepileptic drugs. Nature Review neuroscience, Vol 5, July 2004.

21

2/28/2014

18. Student presentation: Neuroscience of Pain

Central Mechanisms of Pain, nature Medicine 2010. When is a doctor a drug pusher? NYT 6/2007

22

3/3 to 3/7

Mardi Gras/Spring Break

 

23

3/10/2014

Test II

 

24

3/12/2014

19. Autism I

Autism Spectrum Disorders: Clinical Features and Diagnosis. Pediatr Clin N Am 59 (2012) 19–25. Neurobiological Basis of Autism. Pediatr Clin N Am 59 (2012) 45–61

25

3/14/2014

20. Autism II

 

26

3/17/2014

21. Autism III

An Epidemic of Fear, Wired, 2009. Prenatal and Infant Exposure to Thimersol… Pediatrics 2010; 126:4. 656-664. Population-based study of measles, mumps, and rubella vaccination and autism. New England journal of Medicine Vol347, No19, 2002.

27

3/19/2014

22. Developmental and Neural Tube Disorders

Neural tube defects: recent advances, unsolved questions,
and controversies. The Lancet 2013

28

3/21/2014

23. Schizophrenia

Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia. Curr Opion in Neurobio 2013

29

3/24/2014

24. Vision/Hearing

 

30

3/26/2014

25. Student Presentation: ADHD

ADHD Models. Trends in Cognitive Sciences 2012

31

3/28/2014

26. Diabetic Neuropathy

Diabetic Neuropathy. Nature Reviews Endocrinology 2013

32

3/31/2014

Test III

 

33

4/2/2014

27. Depression

Brain reward circuitry in mood disorders. Nature Reviews Neuroscience 2013

34

4/4/2014

28. Addiction

Systems level neuroplasticity in drug addiction. Cold Spring Habor Perspectives in Medicine 2013

35

4/7/2014

29. PTSD

Biological studies of post-traumatic stress disorder. Nature Reviews Neuroscience, November 2012

36

4/9/2014

30. Migraine

Neurobiology of Migraine. Nature Reviews Neuroscience, 2003 (4)386-398.
Emerging migraine treatments and drug targets. Trends in Pharmacological Sciences. 2011

37

4/11/2014

31. Dyslexia

Overcoming Dyslexia, S Shaywitz. Chapters 3-7. Dyslexia, Science 325(280):2009

38

4/14/2014

32. Neurobiology of Eating and Obesity

Anti-obesity drugs and neural circuits of feeding. Trends in Pharmacological Sciences Vol29,No4 (2008)208-217. Obesity in Neurobiology. Progress in Neurobiology 84(2008) 85-103. Beating Obesity. The Atlantic, May 2010. The Economist, December 2012 Series on Obesity

39

4/16/2014

33. Computer/Brain Interface

Neural interfaces for the brain and spinal cord…Nature Reviews Neurology 2012. Bionic Brains and Beyond, Wall Street Journal 2012
Targeted muscle innervations for real-time myoelectric control of multifunctional artificial arms. Journal of the American Medical Association, Feb 11 (301)6, 619-628.

40

3/18 to 3/21

no class- Easter break

 

41

4/23/2014

34. Brain Death

Death, Unconsciousness and the Brain. (2005) 6:899-909. Chronic Consciousness Disorders, Ann.Rev.Med. 2009

42

4/25/2014

35. Neuroscience of Gender

Why sex matters for neuroscience. Nat. Rev. Neurosci. 2006 Jun;7(6):477-84. Neurodevelopment of Human Sexual Orientation. Neuroscience & Biobehavioral Reviews 2005(29):1057-1066. Sexual Differentiation of the brain & behavior. Best Practices & Research, Clinical Endocrinology & Metabolism. 2007(21); 431-444. Psychosocial and psychosexual aspects of disorders of sex development. Best Practice & Research Clinical Endocrinology & Metabolism 24 (2010) 325–334. Sex differences in molecular neuroscience: from fruit flies to humans.
Nature Reviews Neuroscience 2010 (11)9-17.

43

4/28/2014

36. Student Presentation: Cognitive Enhancement

Cognitive Enhancement. Trends in Cognitive Sciences, 2011. Brain Gain, New Yorker 4/2009

Final Wednesday May 7






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