Name of journal: World Journal of Gastroenterology esps manuscript no: 12307 Columns: Topic Highlight


CHRONIC HEPATITIS C AFTER KIDNEY TRANSPLANTATION



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CHRONIC HEPATITIS C AFTER KIDNEY TRANSPLANTATION

Although some studies have failed to find a negative impact on clinical outcomes after KT[126,127], the majority of studies so far reported indicate that HCV infection is associated with increased liver-related mortality and fibrosis progression among HCV-infected KT patients, with a significant reduction in patient and graft survival, possibly related to accelerated fibrogenesis and increased liver damage induced by the use of immunosuppressive regimens[88,91–93,123,128–133]. Recent evidence also suggests that KT recipients with chronic HCV infection have an increased risk of post-transplant de novo glomerulonephritis[89,90,134], diabetes mellitus[90,135], and azathioprine hepatotoxicity[136].

In contrast to what is observed in CKD patients under dialysis, HCV-positive KT recipients more often present with false-negative anti-HCV results, even with newer immunoassays[63,137]. In a recent study, 19 out of 417 KT recipients were HCV RNA-positive and 3 of those patients (16%) were anti-HCV-negative by using chemiluminescence immunoassays[63]. This inability to mount an antibody response against HCV is probably related to the immunosuppressive therapy. Another consequence of immunosuppression is the significant increase in HCV viral load, with no reports of intermittent viremia so far[9,138]. Interestingly, similarly to hemodialysis subjects, there is a very low prevalence of occult HCV infection in KT recipients[63].

There is still no consensus on the best immunosuppressive strategy in HCV-positive KT recipients. Antiviral activity of cyclosporine A (CsA), probably acting by antagonizing the effect of cyclophilin B on HCV replication[139], has been demonstrated both in vitro and in vivo[139–143], and it is possible that CsA may exert a beneficial effect on necroinflammatory activity in HCV-related liver disease among KT recipients[144–146].

Additional differences from hemodialysis patients are the higher prevalence of advanced liver disease in KT recipients[59,91,92], and the better accuracy of aminotransferases for the prediction of significant histological lesions[147–149]. Although liver biopsy is still recommended to evaluate the severity of hepatic lesions in patients on hemodialysis patients as well as in transplant recipients[150,151], several noninvasive methods for the assessment of liver fibrosis have been studied in HCV-positive KT patients, including simple blood tests[58], Fibrotest[85,152], and liver elastography[152,153], with fair diagnostic performances. In selected cases, these methods can be used as alternatives to liver biopsy. Screening for hepatocellular carcinoma and esophageal varices is indicated for patients with advanced fibrosis or cirrhosis.

As for antiviral therapy, there are several heterogeneous studies including small series of HCV-infected KT patients (ranging from 3 to 32 subjects), treated with standard or pegylated IFN alone or in combination with low dose ribavirin[154–170] (Table 4). Seventeen studies have been compiled in 2 meta-analyses[94,171], and the mean overall estimates for SVR with IFN monotherapy (10 studies), IFN plus ribavirin (4 studies) and PEG-IFN plus ribavirin (3 studies) were 16%, 36% and 43%, respectively.

Despite initial concerns about increased risk of graft dysfunction and loss, ranging from 0% to 40% in early studies[159–162,166], more recent series have shown lower graft rejection rates, between 0 and 5%[167–170]. Advances in immunosuppression therapy and the use of the less immunogenic PEG-IFN are possible explanations for this observation. However, dropout rates remain high (mean incidence of 28%) and do not differ greatly between early and recent studies[154–170], probably due to the worse anemia found in those receiving IFN in combination with ribavirin.

AASLD and KDIGO guidelines recommend against antiviral therapy for HCV-infected KT recipients, with the exceptions of fibrosing cholestatic hepatitis or life-threatening vasculitis[150,172]. Nevertheless, treatment with PEG-IFN and ribavirin should be considered for patients with advanced fibrosis, always taking into account time after transplantation, eGFR and renal function stability.

With the aid of EPO supplementation (doses up to 40000 IU/wk to maintain hemoglobin levels  10 g/dL), an initial ribavirin dose of 200 mg once a day is given, followed by increments of 200 mg every two weeks until the maximum dose tolerated, with target dosage of ribavirin defined according to eGFR (Table 2). After stabilization of ribavirin dosage (usually between 400 to 800 mg/d), interferon is initiated and used for 48 wk, irrespective of HCV genotype. Even in absence of comparative trials, it is suggested to use PEG-IFN (preferably PEG-IFN alfa-2a 135 g) once a week, after dialysis session, in combination with ribavirin (see Figure 3). There are no studies supporting the use of DAAs for the treatment of KT HCV-positive recipients, but it is expected that these patients will benefit from interferon-free regimens.
SIDE EFFECTS OF ANTIVIRAL THERAPY

Treatment with IFN (standard or pegylated) and ribavirin is associated with frequent and sometimes serious side effects[173,174]. Among the latter are autoimmune diseases (worsening or de novo thyroid disorders, diabetes mellitus, psoriasis, etc.), significant hemolytic anemia and severe depression. In a recent meta-analysis of eleven clinical studies published by Fabrizi et al[103], the summary estimate for dropout rate was 0.18 (95%CI: 0.08-0.35), with a large heterogeneity across studies, mainly due to anemia (24%) and infections (13%).

Except from hemolytic anemia, side effects are mainly related to IFN. The majority of the patients receiving IFN presents with a flu-like syndrome, characterized by diffuse myalgia, headache, fatigue and fever. Generally, these symptoms are self-limited and managed by common analgesics. Depression can be induced by IFN in 20% to 30% of the cases, usually after three months of treatment[175]. Being mild to moderate in intensity, IFN-induced depression can generally be handled with conservative measures, by non-psychiatrist professionals. However, if severe depression develops, HCV treatment must be stopped and the patient should be immediately referred to a psychiatrist. IFN-induced cytopenias (thrombocytopenia and leucopenia), are relatively common, typically dose-dependent and rarely associated with clinically significant complications, even in CKD patients. IFN dose reductions and the use of growth factors usually allow the continuation of therapy[173,174].

On the other hand, as previously discussed, the ribavirin-induced hemolytic anemia is very common and troublesome in CKD patients, due to its severity and potential noxious consequences in these subjects with high cardiovascular risk. Initial low doses of ribavirin, early dose reductions, and EPO supplementation are the main strategies for the management of anemia in this context. It should be mentioned that ribavirin can carry an increased risk of birth defects, and proper contraception during and up to six months after therapy must be adopted. Minor side effects like cough and skin rash also seem to be mostly associated with ribavirin[173,174].

With the first-generation HCV protease inhibitors (PIs), boceprevir and telaprevir, complex drug-to-drug interactions and tolerability issues remain a concern[176,177]. Boceprevir is associated with an increased incidence of anemia and dysgeusia and telaprevir is associated with an increased incidence of dermatological disorders, anemia, and anorectal symptoms[178-181]. An approximately 15% to 26% increase in anemia incidence in patients under triple therapy with boceprevir or telaprevir has been observed[178-181]. In these patients, anemia is considered the consequence of the combined effects of ribavirin-induced hemolysis and the bone marrow suppression of IFN and PI. In the same manner of dual therapy, ribavirin dose reductions and EPO are used for the management of anemia, although blood transfusions are also frequently required. Dysgeusia and anorectal symptoms are infrequently severe and often improve under conservative measures and dietetic modifications. A wide spectrum of dermatological disorders has been described in approximately 50% of the patients treated with first-generation PIs, particularly with telaprevir, ranging from simple pruritus with or without rash to severe skin reactions like Stevens-Johnson’s syndrome or DRESS syndrome[182]. Emollients/moisturizers and topical corticosteroids are sufficient for most cases (90% to 95%), but dermatological consultations are frequently needed for more severe cases. Treatment discontinuation is required in about 6% of patients[182].
NEW PERSPECTIVES FOR HCV THERAPY IN CKD PATIENTS

In spite of the increment in SVR rates with the use of the first-generation PIs telaprevir and boceprevir in subjects with preserved renal function, the higher incidence of significant side effects (mainly severe anemia and dermatological reactions) and the frequent drug-drug interactions have hampered their widespread use in difficult-to-treat populations, such as CKD patients. Newer DAAs, like sofosbuvir (a nucleotide NS5B polymerase inhibitor), simeprevir (a second generation PI), and daclatasvir (a NS5A replication complex inhibitor), with or without PEG-IFN and/or ribavirin, or used in different combinations with one another, produces SVR rates superior to 90%)[183-188]. Besides leading to the highest SVR rates ever seen, these emerging DDAs seems to exhibit a reduced potential for drug-drug interactions and a better safety profile, which will probably facilitate their use for the treatment of HCV infection in CKD subjects. However, the appropriate dose of sofosbuvir has not been identified for subjects with severe renal impairment (eGFR < 30 mL/min per 1.73 m2) or hemodialysis patients and dose adjustments might be necessary[189]. Likewise, although simeprevir is primarily metabolized by the liver and its renal elimination is minimal, the safety of the drug has not been evaluated in patients with CKD stages 4 and 5. Conversely, unpublished data suggested that dose reduction would not be needed for the use of daclatasvir in patients with any stage of renal impairment. Finally, a phase 3 study will evaluate the safety and efficacy of the all-oral and IFN-free combination therapy with ombitasvir (a NS5A replication complex inhibitor), paritaprevir (ABT-450, a second-generation PI) and dasabuvir (a non-nucleoside NS5B polymerase inhibitor), with or without ribavirin, for the treatment of genotype 1-infected CKD patients (ClinicalTrials.gov identifier NCT02207088)[190].


CONCLUSION

HCV infection is highly prevalent among CKD subjects and, consequently, in KT recipients, exerting a significant negative impact on clinical outcomes both before and after KT. Although interferon-based antiviral therapy in CKD patients is associated with poor tolerability and suboptimal efficacy, there has been mounting evidence that many patients can benefit from treatment. In those individuals, accurate characterization of liver disease and adequate assessment of comorbidities are mandatory for optimal management and therapeutic decisions.


REFERENCES

Fabrizi F, Messa P, Basile C, Martin P. Hepatic disorders in chronic kidney disease. Nat Rev Nephrol 2010; 6: 395-403 [PMID: 20386560 DOI: 10.1038/nrneph.2010.37]

Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57: 1333-1342 [PMID: 23172780 DOI: 10.1002/hep.26141]

Moyer VA; U.S. Preventive Services Task Force. Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2013; 159: 349-357 [PMID: 23798026 DOI: 10.7326/0003-4819-159-5-201309030-00672]

Kumagai J, Komiya Y, Tanaka J, Katayama K, Tatsukawa Y, Yorioka N, Miyakawa Y, Yoshizawa H. Hepatitis C virus infection in 2,744 hemodialysis patients followed regularly at nine centers in Hiroshima during November 1999 through February 2003. J Med Virol 2005; 76: 498-502 [PMID: 15977246]

Hinrichsen H, Leimenstoll G, Stegen G, Schrader H, Fölsch UR, Schmidt WE; PHV Study Group. Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients. Gut 2002; 51: 429-433 [PMID: 12171969]

Jadoul M, Cornu C, van Ypersele de Strihou C. Incidence and risk factors for hepatitis C seroconversion in hemodialysis: a prospective study. The UCL Collaborative Group. Kidney Int 1993; 44: 1322-1326 [PMID: 7508005]

Huang CS, Ho MS, Yang CS, Lee CL, Tan CA. Hepatitis C markers in hemodialysis patients. J Clin Microbiol 1993; 31: 1764-1769 [PMID: 7688754]

Su Y, Norris JL, Zang C, Peng Z, Wang N. Incidence of hepatitis C virus infection in patients on hemodialysis: a systematic review and meta-analysis. Hemodial Int 2013; 17: 532-541 [PMID: 23072424 DOI: 10.1111/j.1542-4758.2012.00761.x]

Pereira BJ, Levey AS. Hepatitis C virus infection in dialysis and renal transplantation. Kidney Int 1997; 51: 981-999 [PMID: 9083262]

10 Rao AK, Luckman E, Wise ME, MacCannell T, Blythe D, Lin Y, Xia G, Drobeniuc J, Noble-Wang J, Arduino MJ, Thompson ND, Patel PR, Wilson LE. Outbreak of hepatitis C virus infections at an outpatient hemodialysis facility: the importance of infection control competencies. Nephrol Nurs J 2013; 40: 101-10, 164; quiz 111 [PMID: 23785746]

11 Mbaeyi C, Thompson ND. Hepatitis C virus screening and management of seroconversions in hemodialysis facilities. Semin Dial 2013; 26: 439-446 [PMID: 23859188 DOI: 10.1111/sdi.12097]

12 Arenas MD, Sánchez-Payá J, Muñoz C, Egea JJ, Martín F, Gil MT, Sarró F. [Nosocomial transmission of the hepatitis C virus in hemodialysis: monitors, personnel, or both?]. Nefrologia 2001; 21: 476-484 [PMID: 11795017]

13 Cronin RE, Reilly RF. Unfractionated heparin for hemodialysis: still the best option. Semin Dial 2010; 23: 510-515 [PMID: 21039876 DOI: 10.1111/j.1525-139X.2010.00770.x]

14 Lanini S, Abbate I, Puro V, Soscia F, Albertoni F, Battisti W, Ruta A, Capobianchi MR, Ippolito G. Molecular epidemiology of a hepatitis C virus epidemic in a haemodialysis unit: outbreak investigation and infection outcome. BMC Infect Dis 2010; 10: 257 [PMID: 20799943 DOI: 10.1186/1471-2334-10-257]

15 Izopet J, Sandres-Sauné K, Kamar N, Salama G, Dubois M, Pasquier C, Rostaing L. Incidence of HCV infection in French hemodialysis units: a prospective study. J Med Virol 2005; 77: 70-76 [PMID: 16032714]

16 Lemos LB, Perez RM, Matos CA, Silva IS, Silva AE, Ferraz ML. Clinical and laboratory characteristics of acute hepatitis C in patients with end-stage renal disease on hemodialysis. J Clin Gastroenterol 2008; 42: 208-211 [PMID: 18209594 DOI: 10.1097/MCG.0b013e31802dc57f]

17 Guh JY, Lai YH, Yang CY, Chen SC, Chuang WL, Hsu TC, Chen HC, Chang WY, Tsai JH. Impact of decreased serum transaminase levels on the evaluation of viral hepatitis in hemodialysis patients. Nephron 1995; 69: 459-465 [PMID: 7777113]

18 Yasuda K, Okuda K, Endo N, Ishiwatari Y, Ikeda R, Hayashi H, Yokozeki K, Kobayashi S, Irie Y. Hypoaminotransferasemia in patients undergoing long-term hemodialysis: clinical and biochemical appraisal. Gastroenterology 1995; 109: 1295-1300 [PMID: 7557098]

19 Okuda K, Hayashi H, Yokozeki K, Kobayashi S, Kashima T, Irie Y. Acute hepatitis C among renal failure patients on chronic haemodialysis. J Gastroenterol Hepatol 1998; 13: 62-67 [PMID: 9737574]

20 Furusyo N, Hayashi J, Kakuda K, Ariyama I, Kanamoto-Tanaka Y, Shimizu C, Etoh Y, Shigematsu M, Kashiwagi S. Acute hepatitis C among Japanese hemodialysis patients: a prospective 9-year study. Am J Gastroenterol 2001; 96: 1592-1600 [PMID: 11374705]

21 Espinosa M, Martin-Malo A, Alvarez de Lara MA, Gonzalez R, Rodriguez M, Aljama P. Natural history of acute HCV infection in hemodialysis patients. Clin Nephrol 2002; 58: 143-150 [PMID: 12227687]

22 Uyttendaele S, Claeys H, Mertens W, Verhaert H, Vermylen C. Evaluation of third-generation screening and confirmatory assays for HCV antibodies. Vox Sang 1994; 66: 122-129 [PMID: 7514324]

23 Carithers RL, Marquardt A, Gretch DR. Diagnostic testing for hepatitis C. Semin Liver Dis 2000; 20: 159-171 [PMID: 10946421]

24 Moreira R, Pinho JR, Fares J, Oba IT, Cardoso MR, Saraceni CP, Granato C. Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies. Can J Microbiol 2003; 49: 503-507 [PMID: 14608385]

25 Maheshwari A, Thuluvath PJ. Management of acute hepatitis C. Clin Liver Dis 2010; 14: 169-76; x [PMID: 20123448 DOI: 10.1016/j.cld.2009.11.007]

26 Süleymanlar I, Sezer T, Işitan F, Yakupoglu G, Süleymanlar G. Efficacy of interferon alpha in acute hepatitis C in patients on chronic hemodialysis. Nephron 1998; 79: 353-354 [PMID: 9678442]

27 Gürsoy M, Gür G, Arslan H, Ozdemir N, Boyacioglu S. Interferon therapy in haemodialysis patients with acute hepatitis C virus infection and factors that predict response to treatment. J Viral Hepat 2001; 8: 70-77 [PMID: 11155154]

28 Urbánek P, Tesar V, Procházková-Francisci E, Lachmanová J, Marecek Z, Svobodník A. Treatment of early diagnosed HCV infection in hemodialyzed patients with interferon-alpha. Treatment of hepatitis C. Blood Purif 2004; 22: 344-350 [PMID: 15258445]

29 Al-Harbi AS, Malik GH, Subaity Y, Mansy H, Abutaleb N. Treatment of acute hepatitis C virus infection with alpha interferon in patients on hemodialysis. Saudi J Kidney Dis Transpl 2005; 16: 293-297 [PMID: 17642795]

30 Rocha CM, Perez RM, Narciso JL, Ferreira AP, Lemos LB, Medina-Pestana JO, Silva AE, Ferraz ML. Interferon-alpha therapy within the first year after acute hepatitis C infection in hemodialysis patients: efficacy and tolerance. Eur J Gastroenterol Hepatol 2007; 19: 119-123 [PMID: 17272996]

31 Ferreira Ade S, Perez Rde M, Ferraz ML, Lewis-Ximenez LL, Pereira JL, de Almeida PR, de Mattos AA; Acute Hepatitis C Study Group of The Brazilian Society of Hepatology. Acute hepatitis C in Brazil: results of a national survey. J Med Virol 2011; 83: 1738-1743 [PMID: 21837789 DOI: 10.1002/jmv.22175]

32 Engel M, Malta FM, Gomes MM, Mello IM, Pinho JR, Ono-Nita SK, Carrilho FJ. Acute hepatitis C virus infection assessment among chronic hemodialysis patients in the Southwest Parana State, Brazil. BMC Public Health 2007; 7: 50 [PMID: 17408470]

33 Liu CH, Liang CC, Liu CJ, Lin JW, Chen SI, Hung PH, Tsai HB, Lai MY, Chen PJ, Chen DS, Kao JH. Pegylated interferon alfa-2a monotherapy for hemodialysis patients with acute hepatitis C. Clin Infect Dis 2010; 51: 541-549 [PMID: 20645865 DOI: 10.1086/655682]

34 Fabrizi F, Dixit V, Messa P, Martin P. Interferon therapy of acute hepatitis C in dialysis patients: meta-analysis. J Viral Hepat 2012; 19: 784-791 [PMID: 23043385 DOI: 10.1111/j.1365-2893.2012.01607.x]

35 Santantonio T, Fasano M, Sagnelli E, Tundo P, Babudieri S, Fabris P, Toti M, Di Perri G, Marino N, Pizzigallo E, Angarano G; Acute Hepatitis C Study Group. Acute hepatitis C: a 24-week course of pegylated interferon α-2b versus a 12-week course of pegylated interferon α-2b alone or with ribavirin. Hepatology 2014; 59: 2101-2109 [PMID: 24442928 DOI: 10.1002/hep.26991]

36 Althaf MM, Abdelsalam MS, Rashwan M, Nadri Q. Acute hepatitis C infection in a renal transplant recipient: primacy of the liver or kidney? BMJ Case Rep 2014; 2014: [PMID: 24907214 DOI: 10.1136/bcr-2014-203643]

37 Rogachev B, Vorobiov M, Shnaider A, Hausmann M, Zlotnik M, Basok A. Acute viral hepatitis (C - genotype 6a and B) acquired during kidney transplantation by two patients and review of the literature. Clin Nephrol 2009; 72: 482-487 [PMID: 19954726]

38 Siddiqui AR, Abbas Z, Luck NH, Hassan SM, Aziz T, Mubarak M, Naqvi SA, Rizvi SA. Experience of fibrosing cholestatic hepatitis with hepatitis C virus in kidney transplant recipients. Transplant Proc 2012; 44: 721-724 [PMID: 22483477 DOI: 10.1016/j.transproceed.2011.12.019]

39 Delladetsima I, Psichogiou M, Sypsa V, Psimenou E, Kostakis A, Hatzakis A, Boletis JN. The course of hepatitis C virus infection in pretransplantation anti-hepatitis C virus-negative renal transplant recipients: a retrospective follow-up study. Am J Kidney Dis 2006; 47: 309-316 [PMID: 16431260]

40 Fabrizi F, Marcelli D, Bacchini G, Guarnori I, Erba G, Locatelli F. Antibodies to hepatitis C virus (HCV) in chronic renal failure (CRF) patients on conservative therapy: prevalence, risk factors and relationship to liver disease. Nephrol Dial Transplant 1994; 9: 780-784 [PMID: 7526275]

41 Ilçöl B, Ozener C, Avşar M, Ilçol Y, Lawrence R, Ozer A, Cirakoğlu B, Akoğlu E. Hepatitis C infection in patients with chronic renal failure receiving conservative therapy. Nephrol Dial Transplant 1997; 12: 626 [PMID: 9075165]

42 López-Alcorocho JM, Barril G, Ortiz-Movilla N, Traver JA, Bartolomé J, Sanz P, Selgas R, Carreño V. Prevalence of hepatitis B, hepatitis C, GB virus C/hepatitis G and TT viruses in predialysis and hemodialysis patients. J Med Virol 2001; 63: 103-107 [PMID: 11170045]

43 Lemos LB, Perez RM, Lemos MM, Lanzoni VP, Draibe SA, Silva IS, Silva AE, Ferraz ML. Hepatitis C in chronic kidney disease: predialysis patients present more severe histological liver injury than hemodialysis patients? Am J Nephrol 2007; 27: 191-196 [PMID: 17356254]

44 Lemos LB, Perez RM, Lemos MM, Draibe SA, Silva IS, Silva AE, Ferraz ML. Hepatitis C among predialysis patients: prevalence and characteristics in a large cohort of patients. Nephron Clin Pract 2008; 108: c135-c140 [PMID: 18230916 DOI: 10.1159/000114452]

45 Halfon P, Khiri H, Feryn JM, Sayada C, Chanas M, Ouzan D. Prospective virological follow-up of hepatitis C infection in a haemodialysis unit. J Viral Hepat 1998; 5: 115-121 [PMID: 9572036]

46 Fabrizi F, Martin P, Dixit V, Brezina M, Cole MJ, Vinson S, Mousa M, Gitnick G. Biological dynamics of viral load in hemodialysis patients with hepatitis C virus. Am J Kidney Dis 2000; 35: 122-129 [PMID: 10620553]

47 Furusyo N, Hayashi J, Ariyama I, Sawayama Y, Etoh Y, Shigematsu M, Kashiwagi S. Maintenance hemodialysis decreases serum hepatitis C virus (HCV) RNA levels in hemodialysis patients with chronic HCV infection. Am J Gastroenterol 2000; 95: 490-496 [PMID: 10685756]

48 Willson RA. Nephrotoxicity of interferon alfa-ribavirin therapy for chronic hepatitis C. J Clin Gastroenterol 2002; 35: 89-92 [PMID: 12080234]

49 Gluhovschi C, Gadalean F, Kaycsa A, Curescu M, Sporea I, Gluhovschi G, Petrica L, Velciov S, Bozdog G, Bob F, Vernic C, Cioca D. Does the antiviral therapy of patients with chronic hepatitis exert nephrotoxic effects? Immunopharmacol Immunotoxicol 2011; 33: 744-750 [PMID: 21320001 DOI: 10.3109/08923973.2010.551129]

50 Bruchfeld A, Lindahl K, Schvarcz R, Ståhle L. Dosage of ribavirin in patients with hepatitis C should be based on renal function: a population pharmacokinetic analysis. Ther Drug Monit 2002; 24: 701-708 [PMID: 12451285]

51 Laskin OL, Longstreth JA, Hart CC, Scavuzzo D, Kalman CM, Connor JD, Roberts RB. Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome. Clin Pharmacol Ther 1987; 41: 546-555 [PMID: 3568539]

52 Homma M, Matsuzaki Y, Inoue Y, Shibata M, Mitamura K, Tanaka N, Kohda Y. Marked elevation of erythrocyte ribavirin levels in interferon and ribavirin-induced anemia. Clin Gastroenterol Hepatol 2004; 2: 337-339 [PMID: 15067629]

53 De Franceschi L, Fattovich G, Turrini F, Ayi K, Brugnara C, Manzato F, Noventa F, Stanzial AM, Solero P, Corrocher R. Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage. Hepatology 2000; 31: 997-1004 [PMID: 10733558]

54 Stehman-Breen CO, Emerson S, Gretch D, Johnson RJ. Risk of death among chronic dialysis patients infected with hepatitis C virus. Am J Kidney Dis 1998; 32: 629-634 [PMID: 9774125]

55 Fabrizi F, Takkouche B, Lunghi G, Dixit V, Messa P, Martin P. The impact of hepatitis C virus infection on survival in dialysis patients: meta-analysis of observational studies. J Viral Hepat 2007; 14: 697-703 [PMID: 17875004]

56 Scott DR, Wong JK, Spicer TS, Dent H, Mensah FK, McDonald S, Levy MT. Adverse impact of hepatitis C virus infection on renal replacement therapy and renal transplant patients in Australia and New Zealand. Transplantation 2010; 90: 1165-1171 [PMID: 20861806 DOI: 10.1097/TP.0b013e3181f92548]

57 Fabrizi F, Dixit V, Messa P. Impact of hepatitis C on survival in dialysis patients: a link with cardiovascular mortality? J Viral Hepat 2012; 19: 601-607 [PMID: 22863263 DOI: 10.1111/j.1365-2893.2012.01633.x]

58 Schiavon LL, Schiavon JL, Filho RJ, Sampaio JP, Lanzoni VP, Silva AE, Ferraz ML. Simple blood tests as noninvasive markers of liver fibrosis in hemodialysis patients with chronic hepatitis C virus infection. Hepatology 2007; 46: 307-314 [PMID: 17634962]

59 Vallet-Pichard A, Pol S. Hepatitis C virus infection in hemodialysis patients. Clin Res Hepatol Gastroenterol 2013; 37: 340-346 [PMID: 23933193 DOI: 10.1016/j.clinre.2013.03.005]

60 Okuda K, Yokosuka O. Natural history of chronic hepatitis C in patients on hemodialysis: case control study with 4-23 years of follow-up. World J Gastroenterol 2004; 10: 2209-2212 [PMID: 15259067]

61 Fabrizi F, Lunghi G, Finazzi S, Colucci P, Pagano A, Ponticelli C, Locatelli F. Decreased serum aminotransferase activity in patients with chronic renal failure: impact on the detection of viral hepatitis. Am J Kidney Dis 2001; 38: 1009-1015 [PMID: 11684554]

62 Sauné K, Kamar N, Miédougé M, Weclawiak H, Dubois M, Izopet J, Rostaing L. Decreased prevalence and incidence of HCV markers in haemodialysis units: a multicentric French survey. Nephrol Dial Transplant 2011; 26: 2309-2316 [PMID: 21097646 DOI: 10.1093/ndt/gfq696]

63 Baid-Agrawal S, Schindler R, Reinke P, Staedtler A, Rimpler S, Malik B, Frei U, Berg T. Prevalence of occult hepatitis C infection in chronic hemodialysis and kidney transplant patients. J Hepatol 2014; 60: 928-933 [PMID: 24447875 DOI: 10.1016/j.jhep.2014.01.012]

64 Ishida H, Tanabe K, Tokumoto T, Shimizu T, Shimmura H, Yoshioka T, Toma H. Hepatitis C virus decreases in patients with maintenance hemofiltration therapy. Artif Organs 2004; 28: 316-318 [PMID: 15046633]

65 Dussol B, de Lamballerie X, Brunet P, Roubicek C, Chicheportiche C, Cantaloube JF, Biagini P, de Micco P, Berland Y. Is hepatitis C virus-RNA detection by nested polymerase chain reaction clinically relevant in hemodialysis patients? Clin Nephrol 1996; 45: 257-260 [PMID: 8861802]

66 Galán F, Pérez-Gracia MT, Lozano A, Benavides B, Fernandez-Ruíz E, Rodríguez-Iglesias MA. A 3-year follow-up of HCV-RNA viraemia in haemodialysis patients. Nephrol Dial Transplant 1998; 13: 1211-1214 [PMID: 9623556]

67 Fabrizi F, Bunnapradist S, Lunghi G, Martin P. Kinetics of hepatitis C virus load during hemodialysis: novel perspectives. J Nephrol 2003; 16: 467-475 [PMID: 14696748]

68 Dzekova-Vidimliski P, Asani A, Selim G, Gelev S, Polenakovic M, Sikole A. Patterns of viraemia in haemodialysis patients with hepatitis C. Prilozi 2008; 29: 201-211 [PMID: 19259047]

69 Satsangi J, Jewell DP, Welsh K, Bunce M, Bell JI. Effect of heparin on polymerase chain reaction. Lancet 1994; 343: 1509-1510 [PMID: 7911214]

70 Okuda K, Hayashi H, Yokozeki K, Irie Y. Destruction of hepatitis C virus particles by haemodialysis. Lancet 1996; 347: 909-910 [PMID: 8622434]

71 Rampino T, Libetta C, Mazzone A, Gregorini M, Soccio G, Ranghino A, Maggio M, Guallini P, Girola S, Dal Canton A. Hepatocyte growth factor protects the liver against hepatitis C virus in patients on regular hemodialysis. J Chemother 1998; 10: 164-166 [PMID: 9603647]

72 Badalamenti S, Catania A, Lunghi G, Covini G, Bredi E, Brancaccio D, Salvadori M, Como G, Ponticelli C, Graziani G. Changes in viremia and circulating interferon-alpha during hemodialysis in hepatitis C virus-positive patients: only coincidental phenomena? Am J Kidney Dis 2003; 42: 143-150 [PMID: 12830466]

73 Fabrizi F, Messa P, Martin P. Impact of hemodialysis therapy on hepatitis C virus infection: a deeper insight. Int J Artif Organs 2009; 32: 1-11 [PMID: 19241358]

74 Khan N, Aswad S, Shidban H, Aghajani M, Mendez R, Mendez R, Comanor L. Improved detection of HCV Infection in hemodialysis patients using a new HCV RNA qualitative assay: experience of a transplant center. J Clin Virol 2004; 30: 175-182 [PMID: 15125874]

75 Rao V, Fabrizi F, Pennell P, Schiff E, de Medina M, Lane JR, Martin P, Ivor L. Improved detection of hepatitis C virus infection by transcription-mediated amplification technology in dialysis population. Ren Fail 2010; 32: 721-726 [PMID: 20540641 DOI: 10.3109/0886022X.2010.486499]

76 Bastos DO, Perez RM, Silva IS, Lemos LB, Simonetti JP, Medina-Pestana JO, Silva AE, Ferraz ML. Transcription-mediated amplification (TMA) for the assessment of viremia in hemodialysis patients with hepatitis C. J Med Virol 2012; 84: 596-600 [PMID: 22337298 DOI: 10.1002/jmv.23216]

77 Chevaliez S, Rodriguez C, Pawlotsky JM. New virologic tools for management of chronic hepatitis B and C. Gastroenterology 2012; 142: 1303-1313.e1 [PMID: 22537437 DOI: 10.1053/j.gastro.2012.02.027]

78 Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med 2001; 344: 495-500 [PMID: 11172192]

79 Sabovic M, Salobir B, Preloznik Zupan I, Bratina P, Bojec V, Buturovic Ponikvar J. The influence of the haemodialysis procedure on platelets, coagulation and fibrinolysis. Pathophysiol Haemost Thromb 2005; 34: 274-278 [PMID: 16772739]

80 Cotler SJ, Diaz G, Gundlapalli S, Jakate S, Chawla A, Mital D, Jensik S, Jensen DM. Characteristics of hepatitis C in renal transplant candidates. J Clin Gastroenterol 2002; 35: 191-195 [PMID: 12172367]

81 Ahmad A, Hasan F, Abdeen S, Sheikh M, Kodaj J, Nampoory MR, Johny KV, Asker H, Siddique I, Thalib L, Al-Nakib B. Transjugular liver biopsy in patients with end-stage renal disease. J Vasc Interv Radiol 2004; 15: 257-260 [PMID: 15028810]

82 Ozdoğan M, Ozgür O, Boyacioğlu S, Coşkun M, Kart H, Ozdal S, Telatar H. Percutaneous liver biopsy complications in patients with chronic renal failure. Nephron 1996; 74: 442-443 [PMID: 8893179]

83 Terjung B, Lemnitzer I, Dumoulin FL, Effenberger W, Brackmann HH, Sauerbruch T, Spengler U. Bleeding complications after percutaneous liver biopsy. An analysis of risk factors. Digestion 2003; 67: 138-145 [PMID: 12853725]

84 Pawa S, Ehrinpreis M, Mutchnick M, Janisse J, Dhar R, Siddiqui FA. Percutaneous liver biopsy is safe in chronic hepatitis C patients with end-stage renal disease. Clin Gastroenterol Hepatol 2007; 5: 1316-1320 [PMID: 17904916]

85 Varaut A, Fontaine H, Serpaggi J, Verkarre V, Vallet-Pichard A, Nalpas B, Imbertbismuth F, Lebray P, Pol S. Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus. Transplantation 2005; 80: 1550-1555 [PMID: 16371924]

86 Liu CH, Liang CC, Liu CJ, Hsu SJ, Lin JW, Chen SI, Hung PH, Tsai HB, Lai MY, Chen PJ, Chen JH, Chen DS, Kao JH. The ratio of aminotransferase to platelets is a useful index for predicting hepatic fibrosis in hemodialysis patients with chronic hepatitis C. Kidney Int 2010; 78: 103-109 [PMID: 20357753 DOI: 10.1038/ki.2010.74]

87 Liu CH, Liang CC, Huang KW, Liu CJ, Chen SI, Lin JW, Hung PH, Tsai HB, Lai MY, Chen PJ, Chen JH, Chen DS, Kao JH. Transient elastography to assess hepatic fibrosis in hemodialysis chronic hepatitis C patients. Clin J Am Soc Nephrol 2011; 6: 1057-1065 [PMID: 21393486 DOI: 10.2215/CJN.04320510]

88 Singh N, Neidlinger N, Djamali A, Leverson G, Voss B, Sollinger HW, Pirsch JD. The impact of hepatitis C virus donor and recipient status on long-term kidney transplant outcomes: University of Wisconsin experience. Clin Transplant 2012; 26: 684-693 [PMID: 22283142 DOI: 10.1111/j.1399-0012.2011.01583.x]

89 Cruzado JM, Casanovas-Taltavull T, Torras J, Baliellas C, Gil-Vernet S, Grinyó JM. Pretransplant interferon prevents hepatitis C virus-associated glomerulonephritis in renal allografts by HCV-RNA clearance. Am J Transplant 2003; 3: 357-360 [PMID: 12614294]

90 Guitard J, Rostaing L, Kamar N. New-onset diabetes and nephropathy after renal transplantation. Contrib Nephrol 2011; 170: 247-255 [PMID: 21659777 DOI: 10.1159/000325778]

91 Zylberberg H, Nalpas B, Carnot F, Skhiri H, Fontaine H, Legendre C, Kreis H, Bréchot C, Pol S. Severe evolution of chronic hepatitis C in renal transplantation: a case control study. Nephrol Dial Transplant 2002; 17: 129-133 [PMID: 11773476]

92 de Oliveira Uehara SN, Emori CT, da Silva Fucuta Pereira P, Perez RM, Pestana JO, Lanzoni VP, e Silva IS, Silva AE, Ferraz ML. Histological evolution of hepatitis C virus infection after renal transplantation. Clin Transplant 2012; 26: 842-848 [PMID: 22594774 DOI: 10.1111/j.1399-0012.2012.01635.x]

93 Fabrizi F, Martin P, Dixit V, Bunnapradist S, Dulai G. Hepatitis C virus antibody status and survival after renal transplantation: meta-analysis of observational studies. Am J Transplant 2005; 5: 1452-1461 [PMID: 15888054]

94 Fabrizi F, Lunghi G, Dixit V, Martin P. Meta-analysis: anti-viral therapy of hepatitis C virus-related liver disease in renal transplant patients. Aliment Pharmacol Ther 2006; 24: 1413-1422 [PMID: 17081162]

95 Russo MW, Goldsweig CD, Jacobson IM, Brown RS. Interferon monotherapy for dialysis patients with chronic hepatitis C: an analysis of the literature on efficacy and safety. Am J Gastroenterol 2003; 98: 1610-1615 [PMID: 12873587]

96 Fabrizi F, Dulai G, Dixit V, Bunnapradist S, Martin P. Meta-analysis: interferon for the treatment of chronic hepatitis C in dialysis patients. Aliment Pharmacol Ther 2003; 18: 1071-1081 [PMID: 14653826]

97 Gordon CE, Uhlig K, Lau J, Schmid CH, Levey AS, Wong JB. Interferon treatment in hemodialysis patients with chronic hepatitis C virus infection: a systematic review of the literature and meta-analysis of treatment efficacy and harms. Am J Kidney Dis 2008; 51: 263-277 [PMID: 18215704 DOI: 10.1053/j.ajkd.2007.11.003]

98 Gordon CE, Uhlig K, Lau J, Schmid CH, Levey AS, Wong JB. Interferon for hepatitis C virus in hemodialysis--an individual patient meta-analysis of factors associated with sustained virological response. Clin J Am Soc Nephrol 2009; 4: 1449-1458 [PMID: 19643927 DOI: 10.2215/CJN.01850309]

99 Fabrizi F, Ganeshan SV, Lunghi G, Messa P, Martin P. Antiviral therapy of hepatitis C in chronic kidney diseases: meta-analysis of controlled clinical trials. J Viral Hepat 2008; 15: 600-606 [PMID: 18444984 DOI: 10.1111/j.1365-2893.2008.00990.x]

100 Alavian SM, Tabatabaei SV. Meta-analysis of factors associated with sustained viral response in patients on hemodialysis treated with standard or pegylated interferon for hepatitis C infection. Iran J Kidney Dis 2010; 4: 181-194 [PMID: 20622305]

101 Fabrizi F, Dixit V, Messa P, Martin P. Pegylated interferon monotherapy of chronic hepatitis C in dialysis patients: Meta-analysis of clinical trials. J Med Virol 2010; 82: 768-775 [PMID: 20336712 DOI: 10.1002/jmv.21542]

102 Fabrizi F, Dixit V, Martin P, Messa P. Combined antiviral therapy of hepatitis C virus in dialysis patients: meta-analysis of clinical trials. J Viral Hepat 2011; 18: e263-e269 [PMID: 21108701 DOI: 10.1111/j.1365-2893.2010.01405.x]

103 Fabrizi F, Dixit V, Messa P, Martin P. Antiviral therapy (pegylated interferon and ribavirin) of hepatitis C in dialysis patients: meta-analysis of clinical studies. J Viral Hepat 2014; 21: 681-689 [PMID: 25040244 DOI: 10.1111/jvh.12276]

104 Liu CH, Liang CC, Lin JW, Chen SI, Tsai HB, Chang CS, Hung PH, Kao JH, Liu CJ, Lai MY, Chen JH, Chen PJ, Kao JH, Chen DS. Pegylated interferon alpha-2a versus standard interferon alpha-2a for treatment-naive dialysis patients with chronic hepatitis C: a randomised study. Gut 2008; 57: 525-530 [PMID: 17881538]

105 Bruchfeld A, Ståhle L, Andersson J, Schvarcz R. Interferon and ribavirin therapy in dialysis patients with chronic hepatitis C. Nephrol Dial Transplant 2001; 16: 1729 [PMID: 11477195]

106 Mousa DH, Abdalla AH, Al-Shoail G, Al-Sulaiman MH, Al-Hawas FA, Al-Khader AA. Alpha-interferon with ribavirin in the treatment of hemodialysis patients with hepatitis C. Transplant Proc 2004; 36: 1831-1834 [PMID: 15350490]

107 Bruchfeld A, Lindahl K, Reichard O, Carlsson T, Schvarcz R. Pegylated interferon and ribavirin treatment for hepatitis C in haemodialysis patients. J Viral Hepat 2006; 13: 316-321 [PMID: 16637862]

108 Rendina M, Schena A, Castellaneta NM, Losito F, Amoruso AC, Stallone G, Schena FP, Di Leo A, Francavilla A. The treatment of chronic hepatitis C with peginterferon alfa-2a (40 kDa) plus ribavirin in haemodialysed patients awaiting renal transplant. J Hepatol 2007; 46: 768-774 [PMID: 17383045]

109 van Leusen R, Adang RP, de Vries RA, Cnossen TT, Konings CJ, Schalm SW, Tan AC. Pegylated interferon alfa-2a (40 kD) and ribavirin in haemodialysis patients with chronic hepatitis C. Nephrol Dial Transplant 2008; 23: 721-725 [PMID: 18042614]

110 Carriero D, Fabrizi F, Uriel AJ, Park J, Martin P, Dieterich DT. Treatment of dialysis patients with chronic hepatitis C using pegylated interferon and low-dose ribavirin. Int J Artif Organs 2008; 31: 295-302 [PMID: 18432584]

111 Hakim W, Sheikh S, Inayat I, Caldwell C, Smith D, Lorber M, Friedman A, Jain D, Bia M, Formica R, Mehal W. HCV response in patients with end stage renal disease treated with combination pegylated interferon alpha-2a and ribavirin. J Clin Gastroenterol 2009; 43: 477-481 [PMID: 19142165 DOI: 10.1097/MCG.0b013e318180803a]

112 Liu CH, Liang CC, Liu CJ, Tsai HB, Hung PH, Hsu SJ, Chen SI, Lin JW, Lai MY, Chen JH, Chen PJ, Chen DS, Kao JH. Pegylated interferon alpha-2a plus low-dose ribavirin for the retreatment of dialysis chronic hepatitis C patients who relapsed from prior interferon monotherapy. Gut 2009; 58: 314-316 [PMID: 19136527 DOI: 10.1136/gut.2008.165076]

113 Alsaran K, Sabry A, Shaheen N. Pegylated interferon alpha-2a for treatment of chronic HCV infection in hemodialysis patients: a single Saudi center experience. Int Urol Nephrol 2011; 43: 865-873 [PMID: 20490669 DOI: 10.1007/s11255-010-9756-1]

114 Liu CH, Huang CF, Liu CJ, Dai CY, Liang CC, Huang JF, Hung PH, Tsai HB, Tsai MK, Chen SI, Lin JW, Yang SS, Su TH, Yang HC, Chen PJ, Chen DS, Chuang WL, Yu ML, Kao JH. Pegylated interferon-α2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 1 receiving hemodialysis: a randomized trial. Ann Intern Med 2013; 159: 729-738 [PMID: 24297189 DOI: 10.7326/0003-4819-159-11-201312030-00005]

115 Liu CH, Liu CJ, Huang CF, Lin JW, Dai CY, Liang CC, Huang JF, Hung PH, Tsai HB, Tsai MK, Lee CY, Chen SI, Yang SS, Su TH, Yang HC, Chen PJ, Chen DS, Chuang WL, Yu ML, Kao JH. Peginterferon alfa-2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 2 receiving haemodialysis: a randomised trial. Gut 2014; Epub ahead of print [PMID: 24747867 DOI: 10.1136/gutjnl-2014-307080]

116 Fucuta Pereira Pda S, Uehara SN, de Mello Perez R, Feldner AC, de Melo IC, de Souza e Silva IS, Silva AE, Ferraz ML. Is early virological response as predictive of the hepatitis C treatment response in dialysis patients as in non-uremic patients? Int J Infect Dis 2013; 17: e50-e53 [PMID: 23041364 DOI: 10.1016/j.ijid.2012.09.001]

117 Dumortier J, Guillaud O, Gagnieu MC, Janbon B, Juillard L, Morelon E, Leroy V. Anti-viral triple therapy with telaprevir in haemodialysed HCV patients: is it feasible? J Clin Virol 2013; 56: 146-149 [PMID: 23149155 DOI: 10.1016/j.jcv.2012.10.009]

118 Knapstein J, Galle PR, Zimmermann T. Antiviral triple therapy with boceprevir in a chronic hepatitis C haemodialysis patient awaiting kidney re-transplantation. Dig Liver Dis 2014; 46: 88-89 [PMID: 24054768 DOI: 10.1016/j.dld.2013.08.133]

119 Slim J, Scangarello N, Samaha P, Dazley J. A case of sustained virologic response of HCV with telaprevir-based therapy in a patient with HIV and end stage kidney disease. Int J STD AIDS 2014; 25: 830-832 [PMID: 24557545]

120 Wiegand J, Maasoumy B, Buggisch P, Buslau A, Schiefke I, Berg T, Wedemeyer H, Sarrazin C, Hinrichsen H. Letter: Telaprevir triple therapy in chronic hepatitis C genotype 1 patients receiving haemodialysis. Aliment Pharmacol Ther 2014; 39: 1342-1344 [PMID: 24803258 DOI: 10.1111/apt.12748]

121 Treitel M, Marbury T, Preston RA, Triantafyllou I, Feely W, O'Mara E, Kasserra C, Gupta S, Hughes EA. Single-dose pharmacokinetics of boceprevir in subjects with impaired hepatic or renal function. Clin Pharmacokinet 2012; 51: 619-628 [PMID: 22799589 DOI: 10.2165/11633440-000000000-00000]

122 de Kanter CT, den Hollander JG, Verweij-van Wissen CP, Burger DM. Telaprevir pharmacokinetics in a hepatitis C virus infected patient on haemodialysis. J Clin Virol 2014; 60: 431-432 [PMID: 24929751 DOI: 10.1016/j.jcv.2014.05.008]

123 Mathurin P, Mouquet C, Poynard T, Sylla C, Benalia H, Fretz C, Thibault V, Cadranel JF, Bernard B, Opolon P, Coriat P, Bitker MO. Impact of hepatitis B and C virus on kidney transplantation outcome. Hepatology 1999; 29: 257-263 [PMID: 9862875]

124 Paramesh AS, Davis JY, Mallikarjun C, Zhang R, Cannon R, Shores N, Killackey MT, McGee J, Saggi BH, Slakey DP, Balart L, Buell JF. Kidney transplantation alone in ESRD patients with hepatitis C cirrhosis. Transplantation 2012; 94: 250-254 [PMID: 22790385 DOI: 10.1097/TP.0b013e318255f890]

125 Campos S, Parsikia A, Zaki RF, Ortiz JA. Kidney transplantation alone in ESRD patients with hepatitis C cirrhosis. Transplantation 2012; 94: e65-e66 [PMID: 23222741 DOI: 10.1097/TP.0b013e318274abc1]

126 Alric L, Di-Martino V, Selves J, Cacoub P, Charlotte F, Reynaud D, Piette JC, Péron JM, Vinel JP, Durand D, Izopet J, Poynard T, Duffaut M, Rostaing L. Long-term impact of renal transplantation on liver fibrosis during hepatitis C virus infection. Gastroenterology 2002; 123: 1494-1499 [PMID: 12404224]

127 Kamar N, Rostaing L, Selves J, Sandres-Saune K, Alric L, Durand D, Izopet J. Natural history of hepatitis C virus-related liver fibrosis after renal transplantation. Am J Transplant 2005; 5: 1704-1712 [PMID: 15943629]

128 Legendre C, Garrigue V, Le Bihan C, Mamzer-Bruneel MF, Chaix ML, Landais P, Kreis H, Pol S. Harmful long-term impact of hepatitis C virus infection in kidney transplant recipients. Transplantation 1998; 65: 667-670 [PMID: 9521201]

129 Breitenfeldt MK, Rasenack J, Berthold H, Olschewski M, Schroff J, Strey C, Grotz WH. Impact of hepatitis B and C on graft loss and mortality of patients after kidney transplantation. Clin Transplant 2002; 16: 130-136 [PMID: 11966783]

130 Ridruejo E, Díaz C, Michel MD, Soler Pujol G, Martínez A, Marciano S, Mandó OG, Vilches A. Short and long term outcome of kidney transplanted patients with chronic viral hepatitis B and C. Ann Hepatol 2010; 9: 271-277 [PMID: 20720267]

131 Rostami Z, Nourbala MH, Alavian SM, Bieraghdar F, Jahani Y, Einollahi B. The impact of Hepatitis C virus infection on kidney transplantation outcomes: A systematic review of 18 observational studies: The impact of HCV on renal transplantation. Hepat Mon 2011; 11: 247-254 [PMID: 22087151]

132 Fabrizi F, Martin P, Dixit V, Messa P. Meta-analysis of observational studies: hepatitis C and survival after renal transplant. J Viral Hepat 2014; 21: 314-324 [PMID: 24716634 DOI: 10.1111/jvh.12148]

133 Periera BJ, Wright TL, Schmid CH, Levey AS. The impact of pretransplantation hepatitis C infection on the outcome of renal transplantation. Transplantation 1995; 60: 799-805 [PMID: 7482738]

134 Ozdemir BH, Ozdemir FN, Sezer S, Colak T, Haberal M. De novo glomerulonephritis in renal allografts with hepatitis C virus infection. Transplant Proc 2006; 38: 492-495 [PMID: 16549157]

135 Fabrizi F, Messa P, Martin P, Takkouche B. Hepatitis C virus infection and post-transplant diabetes mellitus among renal transplant patients: a meta-analysis. Int J Artif Organs 2008; 31: 675-682 [PMID: 18825640]

136 Pol S, Cavalcanti R, Carnot F, Legendre C, Driss F, Chaix ML, Thervet E, Chkoff N, Brechot C, Berthelot P, Kreis H. Azathioprine hepatitis in kidney transplant recipients. A predisposing role of chronic viral hepatitis. Transplantation 1996; 61: 1774-1776 [PMID: 8685959]

137 Preiksaitis JK, Cockfield SM, Fenton JM, Burton NI, Chui LW. Serologic responses to hepatitis C virus in solid organ transplant recipients. Transplantation 1997; 64: 1775-1780 [PMID: 9422419]

138 Roth D, Zucker K, Cirocco R, Burke G, Ciancio G, Esquenazi V, Swanson SJ, Miller J. A prospective study of hepatitis C virus infection in renal allograft recipients. Transplantation 1996; 61: 886-889 [PMID: 8623154]

139 Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M. Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. Gastroenterology 2005; 129: 1031-1041 [PMID: 16143140]

140 Fernandes F, Poole DS, Hoover S, Middleton R, Andrei AC, Gerstner J, Striker R. Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B. Hepatology 2007; 46: 1026-1033 [PMID: 17600342]

141 Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003; 38: 1282-1288 [PMID: 14578868]

142 Villamil F, Levy G, Grazi GL, Mies S, Samuel D, Sanjuan F, Rossi M, Lake J, Munn S, Mühlbacher F, Leonardi L, Cillo U. Long-term outcomes in liver transplant patients with hepatic C infection receiving tacrolimus or cyclosporine. Transplant Proc 2006; 38: 2964-2967 [PMID: 17112875]

143 Rayhill SC, Barbeito R, Katz D, Voigt M, Labrecque D, Kirby P, Miller R, Stolpen A, Wu Y, Schmidt W. A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C. Transplant Proc 2006; 38: 3625-3628 [PMID: 17175350]

144 Kamar N, Selves J, Sandres-Saune K, Durand D, Izopet J, Rostaing L. Does cyclosporine have a beneficial effect on the course of chronic hepatitis C infection after renal transplantation? Transplant Proc 2006; 38: 1329-1332 [PMID: 16797294]

145 Schiavon LL, Carvalho-Filho RJ, Narciso-Schiavon JL, Barbosa DV, Lanzoni VP, Ferraz ML, Silva AE. Impact of cyclosporine-based immunosuppressive therapy on liver histology of hepatitis C virus-infected renal transplant patients. Hepatology 2008; 48: 348-349 [PMID: 18521870 DOI: 10.1002/hep.22331]

146 Manuel O, Baid-Agrawal S, Moradpour D, Pascual M. Immunosuppression in hepatitis C virus-infected patients after kidney transplantation. Contrib Nephrol 2012; 176: 97-107 [PMID: 22310785 DOI: 10.1159/000332387]

147 Fabrizi F, Martin P, Ponticelli C. Hepatitis C virus infection and renal transplantation. Am J Kidney Dis 2001; 38: 919-934 [PMID: 11684543]

148 Giordano HM, França AV, Meirelles L, Escanhoela CA, Nishimura NF, Santos RL, Quadros KR, Mazzali M, Alves-Filho G, Soares EC. Chronic liver disease in kidney recipients with hepatitis C virus infection. Clin Transplant 2003; 17: 195-199 [PMID: 12780667]

149 Perez RM, Ferreira AS, Medina-Pestana JO, Lanzoni VP, Silva AE, Ferraz ML. Is alanine aminotransferase a good marker of histologic hepatic damage in renal transplant patients with hepatitis C virus infection? Clin Transplant 2005; 19: 622-625 [PMID: 16146553]

150 Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int Suppl 2008; (109): S1-99 [PMID: 18382440 DOI: 10.1038/ki.2008.81]

151 Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 2009; 9 Suppl 3: S1-155 [PMID: 19845597 DOI: 10.1111/j.1600-6143.2009.02834.x]

152 Alric L, Kamar N, Bonnet D, Danjoux M, Abravanel F, Lauwers-Cances V, Rostaing L. Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis. Transpl Int 2009; 22: 568-573 [PMID: 19196449 DOI: 10.1111/j.1432-2277.2009.00834.x]

153 Muñoz R, Ramírez E, Fernandez I, Martin A, Romero M, Romero E, Dominguez-Gil B, Hernandez A, Morales E, Andres A, Castellano G, Morales JM. Correlation between fibroscan, liver biopsy, and clinical liver function in patients with hepatitis C virus infection after renal transplantation. Transplant Proc 2009; 41: 2425-2426 [PMID: 19715940 DOI: 10.1016/j.transproceed.2009.06.103]

154 Harihara Y, Kurooka Y, Yanagisawa T, Kuzuhara K, Otsubo O, Kumada H. Interferon therapy in renal allograft recipients with chronic hepatitis C. Transplant Proc 1994; 26: 2075 [PMID: 8066675]

155 Therret E, Pol S, Legendre C, Gagnadoux MF, Cavalcanti R, Kreis H. Low-dose recombinant leukocyte interferon-alpha treatment of hepatitis C viral infection in renal transplant recipients. A pilot study. Transplantation 1994; 58: 625-628 [PMID: 7916505]

156 Magnone M, Holley JL, Shapiro R, Scantlebury V, McCauley J, Jordan M, Vivas C, Starzl T, Johnson JP. Interferon-alpha-induced acute renal allograft rejection. Transplantation 1995; 59: 1068-1070 [PMID: 7709447]

157 Rostaing L, Izopet J, Baron E, Duffaut M, Puel J, Durand D. Treatment of chronic hepatitis C with recombinant interferon alpha in kidney transplant recipients. Transplantation 1995; 59: 1426-1431 [PMID: 7770930]

158 Ozgür O, Boyacioğlu S, Telatar H, Haberal M. Recombinant alpha-interferon in renal allograft recipients with chronic hepatitis C. Nephrol Dial Transplant 1995; 10: 2104-2106 [PMID: 8643176]

159 Yasumura T, Nakajima H, Hamashima T, Nakai I, Yoshimura N, Ohmori Y, Oka T. Long-term outcome of recombinant INF-alpha treatment of chronic hepatitis C in kidney transplant recipients. Transplant Proc 1997; 29: 784-786 [PMID: 9123525]

160 Durlik M, Gaciong Z, Rowińska D, Rancewicz Z, Lewandowska D, Kozłowska B, Wyzgał J, Soluch L, Walewska-Zielecka B, Rowiński W, Lao M. Long-term results of treatment of chronic hepatitis B, C and D with interferon-alpha in renal allograft recipients. Transpl Int 1998; 11 Suppl 1: S135-S139 [PMID: 9664963]

161 Hanafusa T, Ichikawa Y, Kishikawa H, Kyo M, Fukunishi T, Kokado Y, Okuyama A, Shinji Y, Nagano S. Retrospective study on the impact of hepatitis C virus infection on kidney transplant patients over 20 years. Transplantation 1998; 66: 471-476 [PMID: 9734490]

162 Tokumoto T, Tanabe K, Ishikawa N, Simizu T, Oshima T, Noguchi S, Gouya N, Nakazawa H, Hashimoto E, Fuchinoue S, Hayashi N, Toma H. Effect of interferon-alfa treatment in renal transplant recipients with chronic hepatitis C. Transplant Proc 1998; 30: 3270-3272 [PMID: 9838445]

163 Baid S, Tolkoff-Rubin N, Saidman S, Chung R, Williams WW, Auchincloss H, Colvin RB, Delmonico FL, Cosimi AB, Pascual M. Acute humoral rejection in hepatitis C-infected renal transplant recipients receiving antiviral therapy. Am J Transplant 2003; 3: 74-78 [PMID: 12492714]

164 Tang S, Cheng IK, Leung VK, Kuok UI, Tang AW, Wing Ho Y, Neng Lai K, Mao Chan T. Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin. J Hepatol 2003; 39: 875-878 [PMID: 14568274]

165 Shu KH, Lan JL, Wu MJ, Cheng CH, Chen CH, Lee WC, Chang HR, Lian JD. Ultralow-dose alpha-interferon plus ribavirin for the treatment of active hepatitis C in renal transplant recipients. Transplantation 2004; 77: 1894-1896 [PMID: 15223909]

166 Izopet J, Rostaing L, Ton-That H, Dubois M, Cazabat M, Charlet JP, Sayada C, Duffaut M, Durand D, Puel J. Kinetics of HCV viremia in kidney transplant recipients during and after alpha-interferon therapy. Am J Nephrol 1997; 17: 417-420 [PMID: 9382158]

167 Sharma RK, Bansal SB, Gupta A, Gulati S, Kumar A, Prasad N. Chronic hepatitis C virus infection in renal transplant: treatment and outcome. Clin Transplant 2006; 20: 677-683 [PMID: 17100715]

168 Pageaux GP, Hilleret MN, Garrigues V, Bismuth M, Audin-Mamlouk H, Zarski JP, Mourad G. Pegylated interferon-alpha-based treatment for chronic hepatitis C in renal transplant recipients: an open pilot study. Transpl Int 2009; 22: 562-567 [PMID: 19175562 DOI: 10.1111/j.1432-2277.2008.00831.x]

169 Aljumah AA, Saeed MA, Al Flaiw AI, Al Traif IH, Al Alwan AM, Al Qurashi SH, Al Ghamdi GA, Al Hejaili FF, Al Balwi MA, Al Sayyari AA. Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients. World J Gastroenterol 2012; 18: 55-63 [PMID: 22228971 DOI: 10.3748/wjg.v18.i1.55]

170 Sanai FM, Mousa D, Al-Mdani A, Al-Shoail G, Al-Ashgar H, Al Meshari K, Al-Qahtani A, Saadeh M, Bzeizi KI, Aleid H. Safety and efficacy of peginterferon-α2a plus ribavirin treatment in renal transplant recipients with chronic hepatitis C. J Hepatol 2013; 58: 1096-1103 [PMID: 23428875 DOI: 10.1016/j.jhep.2013.02.004]

171 Wei F, Liu J, Liu F, Hu H, Ren H, Hu P. Interferon-based anti-viral therapy for hepatitis C virus infection after renal transplantation: an updated meta-analysis. PLoS One 2014; 9: e90611 [PMID: 24699257 DOI: 10.1371/journal.pone.0090611]

172 Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009; 49: 1335-1374 [PMID: 19330875 DOI: 10.1002/hep.22759]

173 Carvalho-Filho RJ, Dalgard O. Individualized treatment of chronic hepatitis C with pegylated interferon and ribavirin. Pharmgenomics Pers Med 2010; 3: 1-13 [PMID: 23226039]

174 Sulkowski MS, Cooper C, Hunyady B, Jia J, Ogurtsov P, Peck-Radosavljevic M, Shiffman ML, Yurdaydin C, Dalgard O. Management of adverse effects of Peg-IFN and ribavirin therapy for hepatitis C. Nat Rev Gastroenterol Hepatol 2011; 8: 212-223 [PMID: 21386812 DOI: 10.1038/nrgastro.2011.21]

175 Dieperink E, Willenbring M, Ho SB. Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: A review. Am J Psychiatry 2000; 157: 867-876 [PMID: 10831463]

176 Kiser JJ, Burton JR, Everson GT. Drug-drug interactions during antiviral therapy for chronic hepatitis C. Nat Rev Gastroenterol Hepatol 2013; 10: 596-606 [PMID: 23817323 DOI: 10.1038/nrgastro.2013.106]

177 Chopra A, Klein PL, Drinnan T, Lee SS. How to optimize HCV therapy in genotype 1 patients: management of side-effects. Liver Int 2013; 33 Suppl 1: 30-34 [PMID: 23286843 DOI: 10.1111/liv.12080]

178 Poordad F, McCone J, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP; SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1195-1206 [PMID: 21449783 DOI: 10.1056/NEJMoa1010494]

179 Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, Burroughs M, Brass CA, Albrecht JK, Esteban R; HCV RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1207-1217 [PMID: 21449784 DOI: 10.1056/NEJMoa1009482]

180 Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Ferenci P, Flisiak R, George J, Rizzetto M, Shouval D, Sola R, Terg RA, Yoshida EM, Adda N, Bengtsson L, Sankoh AJ, Kieffer TL, George S, Kauffman RS, Zeuzem S; ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011; 364: 2405-2416 [PMID: 21696307 DOI: 10.1056/NEJMoa1012912]

181 Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, Focaccia R, Younossi Z, Foster GR, Horban A, Ferenci P, Nevens F, Müllhaupt B, Pockros P, Terg R, Shouval D, van Hoek B, Weiland O, Van Heeswijk R, De Meyer S, Luo D, Boogaerts G, Polo R, Picchio G, Beumont M; REALIZE Study Team. Telaprevir for retreatment of HCV infection. N Engl J Med 2011; 364: 2417-2428 [PMID: 21696308 DOI: 10.1056/NEJMoa1013086]

182 Cacoub P, Bourlière M, Lübbe J, Dupin N, Buggisch P, Dusheiko G, Hézode C, Picard O, Pujol R, Segaert S, Thio B, Roujeau JC. Dermatological side effects of hepatitis C and its treatment: patient management in the era of direct-acting antivirals. J Hepatol 2012; 56: 455-463 [PMID: 21884670 DOI: 10.1016/j.jhep.2011.08.006]

183 Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M, Hassanein T, Gordon SC, Schultz M, Davis MN, Kayali Z, Reddy KR, Jacobson IM, Kowdley KV, Nyberg L, Subramanian GM, Hyland RH, Arterburn S, Jiang D, McNally J, Brainard D, Symonds WT, McHutchison JG, Sheikh AM, Younossi Z, Gane EJ. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013; 368: 1878-1887 [PMID: 23607594 DOI: 10.1056/NEJMoa1214853]

184 Jacobson IM, Dore GJ, Foster GR, Fried MW, Radu M, Rafalsky VV, Moroz L, Craxi A, Peeters M, Lenz O, Ouwerkerk-Mahadevan S, De La Rosa G, Kalmeijer R, Scott J, Sinha R, Beumont-Mauviel M. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet 2014; 384: 403-413 [PMID: 24907225 DOI: 10.1016/S0140-6736(14)60494-3]

185 Manns M, Marcellin P, Poordad F, de Araujo ES, Buti M, Horsmans Y, Janczewska E, Villamil F, Scott J, Peeters M, Lenz O, Ouwerkerk-Mahadevan S, De La Rosa G, Kalmeijer R, Sinha R, Beumont-Mauviel M. Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2014; 384: 414-426 [PMID: 24907224 DOI: 10.1016/S0140-6736(14)60538-9]

186 Forns X, Lawitz E, Zeuzem S, Gane E, Bronowicki JP, Andreone P, Horban A, Brown A, Peeters M, Lenz O, Ouwerkerk-Mahadevan S, Scott J, De La Rosa G, Kalmeijer R, Sinha R, Beumont-Mauviel M. Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial. Gastroenterology 2014; 146: 1669-79.e3 [PMID: 24602923 DOI: 10.1053/j.gastro.2014.02.051]

187 Sulkowski MS, Gardiner DF, Rodriguez-Torres M, Reddy KR, Hassanein T, Jacobson I, Lawitz E, Lok AS, Hinestrosa F, Thuluvath PJ, Schwartz H, Nelson DR, Everson GT, Eley T, Wind-Rotolo M, Huang SP, Gao M, Hernandez D, McPhee F, Sherman D, Hindes R, Symonds W, Pasquinelli C, Grasela DM; AI444040 Study Group. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med 2014; 370: 211-221 [PMID: 24428467 DOI: 10.1056/NEJMoa1306218]

188 Lawitz E, Sulkowski MS, Ghalib R, Rodriguez-Torres M, Younossi ZM, Corregidor A, DeJesus E, Pearlman B, Rabinovitz M, Gitlin N, Lim JK, Pockros PJ, Scott JD, Fevery B, Lambrecht T, Ouwerkerk-Mahadevan S, Callewaert K, Symonds WT, Picchio G, Lindsay KL, Beumont M, Jacobson IM. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet 2014; Epub ahead of print [PMID: 25078309 DOI: 10.1016/S0140-6736(14)61036-9]

189 Cornpropst MT, Denning JM, Clemons D, Marbury TC, Alcorn H, Smith WB, Sale M, Fang L, Berrey MM, Symonds WT. The effect of renal impairment and end stage renal disease on the single-dose pharmacokinetics of PSI-7977. J Hepatol 2012; 56 (Suppl.2): S443



190 AbbVie. Ombitasvir/ABT-450/Ritonavir and Dasabuvir With or Without Ribavirin in Treatment-Naïve HCV Genotype 1-Infected Adults With Chronic Kidney Disease. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2014 Aug 20]. Available from: URL of the record NLM Identifier: NCT02207088


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