Korean Division of the International Association for Dental Research (KADR) 1. Abstract a. Only poster presentation is available in the meeting, except invited speakers for the special lectures and symposium
b. Please download the abstract form from the KADR homepage (www.iadr.or.kr). Also, please find the abstract form below
b. Only email submission is available. Please submit the abstract at email@example.com (recipient: Secretary of Academic Affairs, Jin Chung (School of Dentistry, Pusan National University)
c. Deadline: Oct 23rd 2015 (Fri)
d: All poster presenters will be required to pre-register for the meeting. There will be NO on-site registration available for the poster presenters. 2. Registration a. Pre-registration: Early – before Oct 16, Regular – before Oct 30, Late/On-site- on Nov 14.
b. Local wire-transfer is available for registration of residents of Korea.
Bank account No: Shinhan bank 110-405-635032 YU FRANK HONG
After wire-transfer, please email following information (Name, Affiliation, Amount and Date Transferred) to firstname.lastname@example.org (prof. Frank Yu, Treasurer, Seoul National University)
c. If you are Pre-registering from outside Korea, please contact Pr. Frank Yu by email (email@example.com).
Early (before Oct 16)
Regular (before Oct 30)
3. Poster Presentation The dimensions of the poster should not exceed 120 cm wide x 200 cm high. Allocate the top of the poster for the title and authors as stated on the submitted abstract. Only tacks and Velcro-tape are permitted for the mounting of poster.
of the International Association for
Dental Research (KADR)
November 14, 2015
Seoul National University School of Dentistry (Main Auditorium), Seoul, Korea
4Department of Dentistry, College of Medicine, The Catholic University of Korea, Seoul, Korea Objectives: Gingival epithelial barriers provide the first line of defense against plaque-associated bacteria, the primary cause of periodontitis. However, the role of physical barriers in the pathogenesis of periodontitis has not been studied. The aim of this study was to investigate the role of physical barrier in the pathogenesis of periodontitis.
Methods: To investigate the role of physical barriers in the pathogenesis of periodontitis, dextran sulfate sodium (DSS), a tight junction (TJ)-disrupting chemical, was applied onto the gingival mucosa of mice in the absence or presence of Porphyromonas gingivalis and alveolar bone loss was measured. The levels of the TJ protein ZO-1, the number of T cells, and the presence of bacteria with in gingival tissue were examined by immunohistochemistry and in situ hybridization, respectively. In addition, oral bacterial communities were analyzed by pyrosequencing.
Results: Both DSS and P. gingivalis induced alveolar bone loss accompanied by the reduced ZO-1 expression in the junctional epithelia. The reduction in ZO-1 expression was associated with increased bacterial invasion and T-cell infiltration into gingival tissue, providing a link to alveolar bone loss. Interestingly, DSS and P. gingivalis induced similar dysbiosis of oral microbiota. The association between compromised physical barriers and periodontitis was further supported by the reduced ZO-1 expression in the periodontal lesions of patients with chronic periodontitis.
Conclusions: These findings suggest that a barrier-disrupting periodontal pathogen or chemical induces periodontitis by facilitating bacterial invasion into tissues. Therefore, physical barriers may be a promising future target for the prevention and treatment of periodontitis.
Acknowledgements: This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2011-0024650). Awards ♣ Only current members (2015 or 2016) are qualified to apply for the awards. ■ Hatton Award Competition (5 awardees)
- Pre-qualified to attend 2016 JADR annual meeting (Mandatory).
● Outstanding presentation awards (2 awardees)
4th, 5th: 200,000 won ■ Competition for Dental School Students
● Johnson & Johnson KADR Award 2awardees (basic science 1, clinical science 1)
- Only for undergraduate students who currently attend dental schools,
- US $600 provided from Johnson and Johnson Co.
- Pre-qualified to attend 2016 IADR Joseph Lister Award competition during IADR SEA Division annual meeting (Mandatory). ■ Poster Award
● ~ two awardees from each presentation theme, 100,000 won scholarship from KADR * With any questions you may have, please contact, prof. Jin Chung (Secretary of Academic Affairs, School of Dentistry, Pusan National University, Tel; 051-510-8245, email; firstname.lastname@example.org). Or visit KADR homepage at http://iadr.or.kr