2008-per date Post.Doc in toxicology. Norwegian Veterinary Institute, Oslo. Project: Toxicological characterization of selected secondary fungal metabolites in Norwegian grain. Included 4 months in Dr. James Peska`s lab at Michigan State University, USA (2009) and 1 week in Dr. Dominique Lagadic-Gossman`s lab in Rennes, France (2011).
2008, 2009: (7 months total) Guest researcher at Nordic Institute of Dental Materials (NIOM), Haslum, Norway. Project: Biological effects of leachables from polymer based restorative materials.
2005-2008. Post.Doc in cell biology. University Hospital, Oslo, Norway. Project: Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases.
2000-2005: Dr.Scient in toxicology. Norwegian Institute of Public Health, Oslo, Norway. Thesis: Mechanisms involved in PAH-/CP-PAH-induced apoptosis.
1998-2000: Cand.Scient in biotechnology; NTNU, Trondheim, Norway. Thesis:Phospholipase A2s role and regulation in IL-1-/TNF- induced activation of transcription factor NF-B
1995-1998 Cand.Mag in biotechnology; University in Trondheim (AVH)/Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Co-supervisor for an apprentice (2001-2003), joint responsibility for work tasks to an engineer (2001-2003), joint responsibility for organising of semester tasks for students from UiO (2001-2004), joint supervisor for two master students in toxicology from UiO 2009-2011 and 2011-2013. Secretary of the local division of Norwegian Biochemical Society (NBS), Biochemical interest group BIG, (2002-2003). Board member in Norwegian flow cytometri association 2009- per date. Attendance of several national and international meetings with poster presentation (Society of Toxicology, Nashville, USA, 2002; Apoptosis, Luxembourg, 2003; NBS winter meeting, Norway 1999 and 2003; NordTox, Norway 2001, Gordon conference, mycotoxins and phycotoxins 2009 NH, USA). Attendance at FEBS-EMBO advanced lecture course in Molecular Mechanisms in Signal Transduction, Greece, 18-29 2003 and Gordon conference Satelite workshop; Early warning and integrated management of natural toxin events, ME, USA 2009.
Ansteinson V1; Solhaug A1; Samuelsen J.T; Holme JA; Dahl J.E. DNA damage, cell-cycle arrest and apoptosis induced in BEAS-2B cells by 2-hydroxyethyl methacrylate (HEMA). Mutat Res. 2011. In press.1Both authors contributed equally to this work
Landvik, N. E.; Arlt, V. M.; Nagy, E.; Solhaug, A.; Tekpli, X.; Schmeiser, H. H.; Refsnes, M.; Phillips, D. H.; Lagadic-Gossmann, D.; Holme, J. A. 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells. Mutat. Res. 2010, 684 (1-2), 11-23.
Rakkestad, K. E.; Skaar, I.; Ansteinsson, V. E.; Solhaug, A.; Holme, J. A.; Pestka, J. J.; Samuelsen, J. T.; Dahlman, H. J.; Hongslo, J. K.; Becher, R. DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. Toxicol. Sci. 2010, 115 (1), 140-155.
Asare, N.; Tekpli, X.; Rissel, M.; Solhaug, A.; Landvik, N.; Lecureur, V.; Podechard, N.; Brunborg, G.; Lag, M.; Lagadic-Gossmann, D.; Holme, J. A. Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells. Mutagenesis 2009, 24 (6), 481-493.
Olsen PA.1, Solhaug A1., Booth JA., Gelazauskaite M., Krauss S. Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases. DNA repair. Dec 2008. 1Both authors contributed equally to this work
Laurence Huc, Xavier Tekpli, Jørn A. Holme, Mary Rissel, Anita Solhaug, Claire Gardyn, Gwénaelle Le Moigne, Morgane Gorria, Marie-Terese Dimanche-Boitrel and Dominique Lagadic-Grossman. c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in B[a]P-induced apoptosis. Cancer Research. 2007 Feb 15; 67 (4) :1696-705.
Jørn A. Holme, Morgane Gorria, Volker M. Arlt, Steinar Øvrebø, Anita Solhaug, Xavier Tekpli, Nina E. Landvik, Laurence Huc, Olivier Fardel, Dominique Lagadic-Gossmann. Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells. Chem Biol Interact. 2007 Jan 17
Nina E. Landvik, Morgane Gorria, Volker M. Arlt, Nana Asare, Anita Solhaug, Dominique Lagadic-Gossmann, Jørn A. Holme. Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: Possible implications for their mutagenic and carcinogenic effects. Toxicology. 2007 Mar 7;231(2-3):159-74.
Laurence Huc, Mary Rissel, Anita Solhaug, Xavier Tekpli, Morgane Gorria, Alicia Torriglia, Jørn A. Holme, Marie-Terese Dimanche-Boitrel and Dominique Lagadic-Grossman. Multiple Apoptotic Pathways Induced by p53-Dependent Acidification in Benzo[a]pyrene-Exposed Hepatic F258 Cells. Journal of cellular physiology. 2006. 208:527–537.
Solhaug A, Øvrebø S, Steen Mollerup, Låg M, Schwarze PE, Nesnow S and Holme JA. Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites. Chem Biol Interact. 2005 Jan 15;151(2):101-19.
Solhaug A, Refsnes M and Holme JA. The role of cell signalling involved in induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells. J Cell Biochem. 2004 Dec 15;93(6):1143-54.
Solhaug A, Refsnes M, Låg M, Schwarze PE, Husøy T and Holme JA. Polycyclic aromatic hydrocarbons induce both apoptotic as well as anti-apoptotic signals in Hepa1c1c7 cells. Carcinogenesis. 2004 May;25(5):809-19
Anthonsen MW, Andersen S, Solhaug A, Johansen B. Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta. J Biol Chem. 2001 Sep 21;276(38):35344-51.
Anthonsen MW, Solhaug A, Johansen B. Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1beta-induced NF-kappa B activation. J Biol Chem. 2001 Aug 10;276(32):30527-36.