Curriculum vitae the Johns Hopkins University School of Medicine

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The Johns Hopkins University School of Medicine
Charles G. Eberhart MD PhD Oct 19, 2016
Current Appointments

2006-present Chief of Ophthalmic Pathology

2009-present Director of Neuropathology

2011-present Professor, Departments of Pathology, Ophthalmology and Oncology

Personal Data

Charles G. Eberhart M.D., Ph.D.

Department of Pathology-Ross Building 558

720 Rutland Ave

Baltimore, MD, 21205

Phone: 410-502-5185

FAX: 410-955-9777/410-614-3457


Education and Training

1983-1988 BA University of Texas at Austin, Major: Biochemistry

1988-1989 Research Fellow Max Planck Institute for Biochemistry, Munich, Germany.

Laboratory of Dr. Dieter Oesterheldt

1989-1997 MD-PhD University of Texas Southwestern Medical School, Dallas, Texas.

Dissertation research in laboratory of Dr. Steven Wasserman

1997-1999 Resident Anatomic Pathology, Johns Hopkins Hospital, Baltimore, MD

1999-2001 Fellow Neuropathology, Johns Hopkins Hospital, Baltimore, MD.

Professional Experience
2001-2002 Instructor, Department of Pathology, Johns Hopkins University School of Medicine

2003-2006 Assistant Professor, Department of Pathology, Johns Hopkins University School of Medicine

2004-2006 Assistant Professor, Department of Oncology, Johns Hopkins University School of Medicine

2006-2011 Associate Professor, Departments of Pathology, Ophthalmology and Oncology, Johns Hopkins

University School of Medicine

2011-present Professor, Departments of Pathology, Ophthalmology and Oncology, Johns Hopkins

University School of Medicine

2006-present Chief of Ophthalmic Pathology Division, Johns Hopkins University School of Medicine

2009-present Director of Neuropathology Division, Johns Hopkins University School of Medicine

2014-present Volunteer Clinical Professor, Department of Ophthalmology, University of Maryland

2015-present Member, Wilmer Center for Nanomedicine, Johns Hopkins University School of Medicine


Original Research (Mentee names underlined)
1. Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, DiNardo S, Wasserman SA. Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 1993;135(2):489-505.
2. Eberhart CG, Wasserman SA. The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis. Development 1995;121(10):3477-3486.
3. Eberhart CG, Maines JZ, Wasserman SA. Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia. Nature 1996;381:783-785.
4. Eberhart CG, Tihan T, Burger PC. Nuclear localization and mutation of beta-catenin in medulloblastomas. J Neuropathol Exp Neurol 2000;59(4):333-337.
5. Eberhart CG, Brat DJ, Cohen KJ, Burger PC. Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 2000;3(4):346-352.

6. Eberhart CG, Kaufman WE, Tihan T, Burger PC. Apoptosis, neuronal maturation and neurotrophin signaling within medulloblastoma nodules. J Neuropath Exp Neurol 2001; 60(5):462-469.

7. Clatterbuck RE, Eberhart CG, Crain BJ, Rigamonti D. Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations. J Neurol Neurosurg Psychiatry 2001; 71(2):188-192.

8. Eberhart CG and Argani P. Wnt signaling in human development: beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal and cartilage. Pediatr Dev Pathol 2001;4(4):351-357.
9. Eberhart CG, Morrison A, Gyure KA, Frazier J, Smialek JE, Troncoso JC. Decreasing incidence of sudden death due to undiagnosed primary central nervous system tumors. Arch Pathol Lab Med 2001;125(8):1024-1030.
10. Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 2001;29(4):404-411.
11. Brat DJ, Scheithauer BW, Eberhart CG, Burger PC. Extraventricular neurocytomas: pathologic features and clinical outcome. Am J Surg Pathol 2001;25(10):1252-1260.
12. Eberhart CG, Kratz JE, Schuster A, Goldthwaite P, Cohen KJ, Perlman EJ, Burger PC. Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol 2002;12(1):36-44.

13. Eberhart CG, Kepner JL, Goldthwaite PT, Kun LE, Duffner PK, Friedman HS, Strother DR, Burger PC. Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002;94(2):552-560.

14. Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297(5586):1559-1561.

15. Caparrelli DJ, Cattaneo SM 2nd, Bethea BT, Shake JG, Eberhart C, Blue ME, Marbán E, Johnston MV, Baumgartner WA, Gott VL. Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. Ann Thorac Surg 2002;74(3):838-844.
16. Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 2002;110(6):751-762.
17. Kratz JE, Stearns D, Huso DL, Slunt HH, Price DL, Borchelt DR, Eberhart CG. Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation. BMC Cancer 2002;2(2):33.
18. Gabikian P, Clatterbuck RE, Eberhart CG, Tyler BM, Tierney TS, Tamargo RJ. Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and efficacy studies in rabbits and rats. Stroke 2002;33(11):2681-2686.
19. Eberhart CG, Cohen KJ, Tihan T, Goldthwaite PT, Burger PC. Medulloblastomas with systemic metastases: evaluation of tumor histopathology and clinical behavior in 23 patients. J Pediatr Hematol Oncol 2003;25(3):198-203.
20. Fan X, Wang Y, Kratz J, Brat DJ, Robitaille Y, Moghrabi A, Perlman EJ, Dang CV, Burger PC, Eberhart CG. hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. Am J Pathol 2003;162(6):1763-1769.
21. Boon K, Edwards JB, Siu I-M, Olschner D, Eberhart CG, Marra MA, Strausberg RL, Riggins GJ. Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene 2003;22(48):7687-7694.
22. Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne R, Rehg JE, Eberhart CG, Sherr CJ, Roussel MF. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res 2003;63(17):5420-5427.

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