To explain the arrangement of hepatocytes and sinusoidal space of liver.
To give the different arrangement of hepatic lobules.
To give the normal histology of gall bladder.
It is the largest gland of body.
Covered by connective tissue capsule.
Parenchyma consists of hepatocytes.
Histologically liver consists of innumerable pyramidal lobule
Lobules consists of hepatocytes.
They are located in flat irregular plates that are arranged radially like the spokes of a wheel around a branch of the hepatic vein, called the central vein or central venule since it really has the structure of a venule.
Between these plates of hepatocytes are blood spaces known as liver sinusoids.
Section of Liver (in two dimension)
Hepatocytes are arranged in rows that radiate out from the central vein.
These rows are one cell wide and are surrounded by sinusoidal capillaries or sinusoids.
This arrangement ensures that each hepatocyte is in very close contact with blood flowing through the sinusoids, i.e. bathed in blood.
They are large cells.
Nucleus is large and rounded with prominent nucleolus
25% cells are binucleated.
Cytoplasm is strongly eosinophilic.
There is fine basophilic granularity due to the presence of free ribosomes.
Lipofuscin granules are also present in cytoplasm and increase with age.
The sinusoidal lining cells are endothelial cells, kupffer cells and cells of The endothelial cells lining sinusoids are fenestrated and in most species lack a basal lamina
A narrow space is present between the surface of the hepatocyte and the surface of the endothelial cell.