Table of Contents Chapter 1: Introduction



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Chapter 10 - Record Keeping, Review and Update of Laboratory Safety Plan
DSO’s – note and delete: This section requires little tailoring. Please identify individuals, the department, or college as appropriate in the underlined portions of this section.
10.1 Record Keeping

A. Exposure evaluation

Any records of exposure evaluation carried out by individual departments (including continuous monitoring systems) will be kept within the department and also sent to DEHS. Results of exposure evaluations carried out by DEHS will be kept by DEHS and sent to the affected department. Raw data will be kept for one year and summary data for the term of employment plus 30 years.


B. Medical consultation and examination

Results of medical consultations and examinations will be kept by the University’s Occupational Health provider for a length of time specified by the appropriate medical records standard. This time will be at least the term of employment plus 30 years as required by OSHA.


C. Training

Web-based training and many in-person training sessions for employees are tracked electronically in the university’s learning management system. Paper records are still acceptable, and must include the name and title of the trainer, the trainee(s), the date, and the content of the training. Training records must be kept in an individual's department or college for five years. Training records for laboratory volunteers must also be maintained for at least five years. Hard copy and/or electronic forms must be available in the event of an audit by the University Audit Department or state or county regulators. A lab-specific training document is available in Appendix K.


D. Fume hood monitoring

Data on annual fume hood monitoring will be kept in the Department of Environmental Health and Safety. Fume hood monitoring data are considered maintenance records and as such the raw data will be kept for one year and summary data for 5 years.


E. Eyewash Records

Eyewash user logs should be kept on file for 1 year, because they are considered maintenance records.


F. Laboratory audits and reports

Departmental Safety Officers must coordinate and/or conduct formal audits of laboratories in their sphere of responsibility, annually or bi-annually depending on level of risk. Risk levels are made in collaboration with your DEHS Research Safety Professional. A checklist is available in Appendix J. Checklists and reports should be kept for at least 5 years.




  1. Accident investigation reports

Departmental Safety Officers work with PIs and researchers to complete the Accident Investigation Form in Appendix C. Reports should be kept for at least 5 years.
10.2 Review and Update of Laboratory Safety Plan

On an annual basis, this Laboratory Safety Plan will be reviewed and evaluated for effectiveness by DEHS and updated as necessary. Any changes in the Laboratory Safety Plan will be transmitted to college and Departmental Safety Officers, who are responsible for carrying out a similar review and modification of their plans, and may submit a revised copy to DEHS.


Table 1 - Poisonous Gases
The gases on this list are either on the Department of Transportation's Category 1 list, or the Linde Specialty Gases Company's Group 6 – Very Poisonous list. These chemicals are highly toxic gases at ambient temperature and pressure. They have an extremely high potential for causing significant harm if not adequately controlled.


Arsine

Boron trichloride

Chlorine pentafluoride

Chlorine trifluoride

Cyanogen

Cyanogen chloride

Diborane

Dinitrogen tetroxide

Fluorine

Germane

Hydrogen selenide

Nitric oxide

Nitrogen dioxide

Nitrogen trioxide

Nitrosyl chloride

Oxygen difluoride

Phosgene

Phosphine

Phosphorus pentafluoride

Selenium hexafluoride

Stibine

Sulfur tetrafluoride

Tellurium Hexafluoride

Tetraethyldithiopyrophosphate

Tetraethylpyrophosphate









Guidance: Departments may choose to add other chemicals to the above list. For example, sulfur-containing compounds such as mercaptans can cause significant odor problems when used in the laboratory. Pre-approval of the conditions under which they can be used may prevent odor complaints.
Table 2 - Shock Sensitive Chemicals
The classes of chemicals listed below may explode when subjected to shock or friction. Therefore users must have appropriate laboratory equipment, information, knowledge and training to use these compounds safely.


  • Acetylenic compounds, especially polyacetylenes, haloacetylenes, and heavy metal salts of acetylenes (copper, silver, and mercury salts are particularly sensitive)

  • Acyl nitrates

  • Alkyl nitrates, particularly polyol nitrates such as nitrocellulose and nitroglycerine

  • Alkyl and acyl nitrites

  • Amminemetal oxosalts: metal compounds with coordinated ammonia, hydrazine, or similar nitrogenous donors and ionic perchlorate, nitrate, permanganate, or other oxidizing group

  • Azides, including metal, nonmetal, and organic azides

  • Chlorite salts of metals, such as AgClO2 and Hg(ClO2)2

  • Diazo compounds such as CH2N2

  • Diazonium salts, when dry

  • Fulminates such as mercury fulminate (Hg(CNO)2)

  • Hydrogen peroxide (which becomes increasingly treacherous as the concentration rises above 30%, forming explosive mixtures with organic materials and decomposing violently in the presence of traces of transition metals

  • N-Nitro compounds such as N-nitromethylamine, nitrourea, nitroguanidine, and nitric amide

  • Oxo salts of nitrogenous bases: perchlorates, dichromates, nitrates, iodates, chlorites, chlorates, and permanganates of ammonia, amines, hydroxylamine, guanidine, etc.

  • Perchlorate salts (which can form when perchloric acid mists dry in fume hoods or associated duct work. Most metal, nonmetal, and amine perchlorates can be detonated and may undergo violent reaction in contact with combustible materials)

  • Peroxides (solid) that crystallize from or are left from evaporation of peroxidizable solvents (see the following Section 3)

  • Peroxides, transition-metal salts

  • Picrates, especially salts of transition and heavy metals, such as Ni, Pb, Hg, Cu, and Zn

  • Polynitroalkyl compounds such as tetranitromethane and dinitroacetonitrile

  • Polynitroaromatic compounds especially polynitrohydrocarbons, phenols, and amines (e.g., dinitrotoluene, trinitrotoluene, and picric acid)

Note: Perchloric acid must be used only in specially-designed perchloric acid fume hoods that have built-in wash down systems to remove shock-sensitive deposits. Before purchasing this acid, laboratory supervisors must arrange for use of an approved perchloric acid hood.


Table 3 - Pyrophoric Chemicals
The classes of chemicals listed below will readily oxidize and ignite spontaneously in air. Therefore, users must demonstrate to the department that they have the appropriate laboratory equipment, information, knowledge and training to use these compounds safely. Please see the Pyrophoric Chemicals Fact Sheet for further information.


  • Grignard reagents, RMgX

  • Metal carbonyls such as Ni(CO)4, Fe(CO)5, Co2(CO)8

  • Alkali metals such as Na, K

  • Metal powders, such as Al, Co, Fe, Mg, Mn, Pd, Pt, Ti, Sn, Zn, Zr

  • Metal hydrides such as NaH, LiAlH4

  • Nonmetal hydrides, such as B2H6 and other boranes, PH3, AsH3

  • Nonmetal alkyls, such as R3B, R3P, R3As

  • Phosphorus (white)


Table 4 - Peroxide-Forming Chemicals
The chemicals listed below can form explosive peroxide crystals on exposure to air, and therefore require special handling procedures after the container is opened. Some of the chemicals form peroxides that are violently explosive in concentrated solution or as solids, and therefore should never be evaporated to dryness. Others are polymerizable unsaturated compounds and can initiate a runaway, explosive polymerization reaction. All peroxidizable compounds should be stored away from heat and light. They should be protected from physical damage and ignition sources. A warning label should be affixed to all peroxidizable materials to indicate the date of receipt and the date the container was first opened. Due to these special handling requirements, users must have the appropriate laboratory equipment, information, knowledge and training to use these compounds safely.
A. Severe Peroxide Hazard with Exposure to Air (discard within 3 months from opening)

  • diisopropyl ether (isopropyl ether)

  • divinylacetylene (DVA)

  • vinylidene chloride (1,1-dichloroethylene)

  • potassium metal

  • sodium amide (sodamide)

  • potassium amide


B. Peroxide Hazard on Concentration

Do not distill or evaporate without first testing for the presence of peroxides (discard or test for peroxides after 6 months):



  • acetaldehyde diethyl acetal (acetal)

  • cumene (isopropylbenzene)

  • cyclohexene

  • cyclopentene

  • decalin (decahydronaphthalene)

  • diacetylene (butadiene)

  • dicyclopentadiene

  • diethyl ether (ether)

  • diethylene glycol dimethyl ether (diglyme)

  • dioxane

  • ethylene glycol dimethyl ether (glyme)

  • ethylene glycol ether acetates

  • ethylene glycol monoethers (cellosolves)

  • furan

  • methylacetylene

  • methylcyclopentane

  • methyl isobutyl ketone

  • tetrahydrofuran (THF)

  • tetralin (tetrahydronaphthalene)

  • vinyl ethers


C. Hazard of Rapid Polymerization Initiated by Internally-Formed Peroxides

Liquids (discard or test for peroxides after 6 months):



  • Chloroprene (2-chloro-1, 3-butadiene)

  • vinyl acetate

  • styrene

  • vinylpyridine

Gases (discard after 12 months):



  • butadiene

  • vinylacetylene (MVA)

  • tetrafluoroethylene (TFE)

  • vinyl chloride

Table 5 - Carcinogens, Reproductive Toxins or Highly Toxic Chemicals
The chemicals listed below are extremely hazardous. Workers must have knowledge of the dangers of these chemicals prior to use, and documentation of training in safe working procedures.
Biologically active compounds:

  • protease inhibitors (e.g. PMSF, Aprotin, Pepstatin A, Leopeptin);

  • protein synthesis inhibitors (e.g. cycloheximide, Puromycin);

  • transcriptional inhibitors (e.g. a-amanitin and actinomycin D);

  • DNA synthesis inhibitors (e.g. hydroxyurea, nucleotide analogs (i.e.

  • dideoxy nucleotides), actinomycin D, acidicolin);

  • phosphatase inhibitors (e.g. okadaic acid);

  • respiratory chain inhibitors (e.g. sodium azide);

  • kinase inhibitors (e.g. NaF);

  • mitogenic inhibitors (e.g. colcemid); and

  • mitogenic compounds (e.g. concanavalin A).


Castor bean (Ricinus communis) lectin: Ricin A, Ricin B, RCA toxins
Diisopropyl fluorophosphate: highly toxic cholinesterase inhibitor; the antidote, atropine sulfate and 2-PAM (2-pyridinealdoxime methiodide) must be readily available
Jaquirity bean lectin (Abrus precatorius)
N-methyl-N'-nitro-N-nitrosoguanidine: carcinogen (this chemical forms explosive compounds upon degradation)
Phalloidin from Amanita Phalloides: used for staining actin filaments
Retinoids: potential human teratogens
Streptozotocin: potential human carcinogen (See SOP Template example)
Urethane (ethyl carbamate): an anesthetic agent, potent carcinogen and strong teratogen, volatile at room temperature

*See the DEHS Web site at http://www.dehs.umn.edu/ressafety_rsp.htm for appendices.






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