Table e-1: Rating templates of key cerebrovascular lesions



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NEUROLOGY 2011/389189 – Deramecourt et al.

Supplemental material

Table e-1: Rating templates of key cerebrovascular lesions (written definitions)


Arteriolosclerosis

0

Normal aspect

1

Mild thickening of the vessel media

2

Partial loss of smooth muscle cells in the media, deposits of fibrohyaline material, endothelial proliferation

3

Complete loss of smooth muscle cells in the media with concentric deposits of fibrohyaline material (lipohyalinosis) and lumen stenosis, or fibrinoid necrosis, or micro atheroma, or microaneurysm

Cortical amyloid angiopathy

0

Absent

1

Isolated pericapillar amyloid deposits

2

Focal arteriolar amyloid deposits (<50% of arteriolar sections)

3

Extensive arteriolar amyloid deposits (≥50% of arteriolar sections)

Perivascular hemosiderin leakage

0

Absent

1

< 3 hemosiderin granule deposits in the perivascular space

2

3 to 5 hemosiderin granule deposits in the perivascular space

3

>5 hemosiderin granule deposits in the perivascular space

Perivascular space dilatation

0

Absent

1

The perivascular space is < the artery diameter in all sections

2

The perivascular space is ≥ the artery diameter in a minority of sections

3

The perivascular space is ≥ the artery diameter in the majority of sections

Myelin loss (LFB staining)

0

Dense and homogeneous myelin staining

1

Mild diffuse or focal myelin pallor

2

Severe focal/diffuse myelin pallor with vacuolization of the white matter or tigroid aspect

3

Total focal/diffuse destruction of the myelin, or white matter infarcts



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