Supplementary material: Linking Signaling Pathways to Transcriptional Programs in Breast Cancer



Download 0.63 Mb.
Page3/5
Date conversion08.07.2018
Size0.63 Mb.
1   2   3   4   5

Figure S5. Unsupervised hierarchical clustering of tumors of Basal-like, HER2, LumA and LumB subtypes by their measured RPPA expression profiles. The clustering was performed using all features, but for readability only the features with largest standard deviations across samples are shown in the heatmap. The bottom panel shows clinical features: coral (positive), blue (negative), white (NA).



Figure S6. Correlation of inferred GATA3 transcriptional activity with its inferred and measured protein activity. Correlation of inferred TF activity with protein expression variation (left) and inferred protein activity (right) for the TF GATA3. (Basal-like (red), HER2 (pink), Luminal A (dark blue), Luminal B (light blue)).




Figure S7. Correlation of inferred FOXO3 transcriptional activity with its inferred and measured protein activity. Correlation of inferred TF activity with protein expression variation (left) and inferred protein activity (right) for the TF FOXO3. (Basal-like (red), HER2 (pink), Luminal A (dark blue), Luminal B (light blue)).

Figure S8. Clustering of breast cancer cell lines by inferred protein activities. Unsupervised hierarchical clustering of breast cancer cell lines by their inferred protein activity, using the TCGA affinity regression model, correctly distinguishes between Basal-like and Luminal cell lines.


1   2   3   4   5


The database is protected by copyright ©dentisty.org 2016
send message

    Main page