Supplement Search strategy used in the databases



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Supplement 1.

Search strategy used in the databases

(((((("Dental Caries"[Mesh]) OR caries[Title/Abstract])) AND (((((prevent*[Title/Abstract]) OR control*[Title/Abstract]) OR treat*[Title/Abstract]) OR progress*[Title/Abstract]) OR avoid[Title/Abstract]))) AND (((((fluoride*) AND (((((((((*wash[Title/Abstract]) OR *rinse[Title/Abstract]) OR gel[Title/Abstract]) OR foam[Title/Abstract]) OR *paste[Title/Abstract]))))) OR ((((((toothpaste[Title/Abstract]) OR supplements[Title/Abstract]) OR gums[Title/Abstract]) OR drops[Title/Abstract]) OR *rinse[Title/Abstract]) OR varnishes[Title/Abstract])) OR topical[Title/Abstract])))) OR "Fluorides, Topical"[Mesh])) Filters: Publication date from 2003/01/01

(((((("Dental Caries"[Mesh]) OR caries[Title/Abstract])) AND (((((prevent*[Title/Abstract]) OR control*[Title/Abstract]) OR treat*[Title/Abstract]) OR progress*[Title/Abstract]) OR avoid[Title/Abstract]))) AND (((((fluoride*) AND (((((((((*wash[Title/Abstract]) OR *rinse[Title/Abstract]) OR gel[Title/Abstract]) OR foam[Title/Abstract]) OR *paste[Title/Abstract]))))) OR ((((((toothpaste[Title/Abstract]) OR supplements[Title/Abstract]) OR gums[Title/Abstract]) OR drops[Title/Abstract]) OR *rinse[Title/Abstract]) OR varnishes[Title/Abstract])) OR topical[Title/Abstract])))) OR "Fluorides, Topical"[Mesh])) AND (((((clinical[Title/Abstract] AND trial[Title/Abstract]) OR clinical trials[MeSH Terms] OR clinical trial[Publication Type] OR random*[Title/Abstract] OR random allocation[MeSH Terms] OR therapeutic use[MeSH Subheading]))) Filters: Publication date from 2003/01/01



Supplement 2.

Table 5. Excluded papers

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First author, year Topic Main reason for exclusion

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Altenburger, 2007 Fluoride mouth rinse In situ study

Altenburger, 2008 Fluoride gel In situ study

Bonow, 2013 APF gel Small sample size

Calvo, 2012 APF gel In situ study

Delbem, 2010 Fluoride gel and foam In situ study

Divaris, 2012 School-based FMR Retrospective quasi-experimental, no controls

Duarte, 2008 Fluoride mouth rinse No controls

Krithikadatta, 2013 Fluoride mouth rinse Small sample size

Laheij, 2010 Fluoride mouth rinse In situ study

Martinez, 2012 Fluoride gel Small sample size, no controls

Nakamura, 2009 Fluoride moth rinse FMR combined with fissure sealants

Paraskevas, 2004 Fluoride mouth rinse No controls

Songsiripradubboon, 2014 Fluoride mouth rinse In situ study

Vale, 2011 APF gel In situ study

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Supplement 3

Reference list – Excluded papers

Altenburger MJ, Schirrmeister JF, Wrbas KT, Hellwig E. Remineralization of artificial interproximal carious lesions using a fluoride mouthrinse. Am J Dent 2007;20:385-389.

Altenburger MJ, Schirrmeister JF, Wrbas KT, Klasser M, Hellwig E. Fluoride uptake and remineralisation of enamel lesions after weekly application of differently concentrated fluoride gels. Caries Res 2008;42:312-318.

Bonow ML, Azevedo MS, Goettems ML, Rodrigues CR. Efficacy of 1.23% APF gel applications on incipient carious lesions: a double-blind randomized clinical trial. Braz Oral Res 2013;27:279-285.

Calvo AF, Tabchoury CP, Del Bel Cury AA, Tenuta LM, da Silva WJ, Cury JA. Effect of acidulated phosphate fluoride gel application time on enamel demineralization of deciduous and permanent teeth. Caries Res 2012;46:31-37.

Delbem AC, Danelon M, Sassaki KT, Vieira AE, Takeshita EM, Brighenti FL, Rodrigues E. Effect of rinsing with water immediately after neutral gel and foam fluoride topical application on enamel remineralization: An in situ study. Arch Oral Biol 2010;55:913-918.

Divaris K, Rozier RG, King RS. Effectiveness of a school-based fluoride mouthrinse program. J Dent Res 2012;91:282-287.

Duarte AR, Peres MA, Vieira RS, Ramos-Jorge ML, Modesto A. Effectiveness of two mouth rinses solutions in arresting caries lesions: a short-term clinical trial. Oral Health Prev Dent 2008;6:231-238.

Krithikadatta J, Fredrick C, Abarajithan M, Kandaswamy D. Remineralisation of occlusal white spot lesion with a combination of 10% CPP-ACP and 0.2% sodium fluoride evaluated using Diagnodent: a pilot study. Oral Health Prev Dent 2013;11:191-196.

Laheij AM, van Strijp AJ, van Loveren C. In situ remineralisation of enamel and dentin after the use of an amine fluoride mouthrinse in addition to twice daily brushings with amine fluoride toothpaste. Caries Res 2010;44:260-266.

Martínez MC, Tolcachir B, Lescano de Ferrer A, Bojanich MA, Barembaum SR, Calamari SE, Azcurra AI. Comparative study of preventive protocols in children at high cariogenic risk. Acta Odontol Latinoam 2012;25:218-222.

Nakamura A, Sakuma S, Yoshihara A, Deguchi T, Yagi M, Miyazaki H. Long-term follow-up of the effects of a school-based caries preventive programme involving fluoride mouth rinse and targeted fissure sealant: evaluation at 20 years old. Int Dent J 2009;59:215-221.

Paraskevas S, Danser MM, Timmerman MF, van der Velden U, van der Weijden GA. Amine fluoride/stannous fluoride and incidence of root caries in periodontal maintenance patients. A 2 year evaluation. J Clin Periodontol 2004;31:965-371.

Songsiripradubboon S, Hamba H, Trairatvorakul C, Tagami J. Sodium fluoride mouthrinse used twice daily increased incipient caries lesion remineralization in an in situ model. J Dent 2014;42:271-278.



Vale GC, Tabchoury CP, Del Bel Cury AA, Tenuta LM, ten Cate JM, Cury JA. APF and dentifrice effect on root dentin demineralization and biofilm. J Dent Res 2011;90:77-81.


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