Type of SOP: Process Hazardous Chemical Hazardous Class
Purpose Vanadium Pentoxide (V2O5) is a highly acute toxin, suspect carcinogen, teratogen and a suspect reproductive toxin. It is a poisonous brown/yellow solid which, because of its high oxidation state, is both an amphoteric oxide and an oxidizing agent. Additional safety protocols must be in place to work Vanadium Pentoxide. This SOP helps to safely store, handle and dispose of Vanadium Pentoxide in the lab.
Use: V2O5 catalyzes several useful aerobic oxidation reactions, the largest scale of which underpins the production of sulfuric acid from sulfur dioxide.
Physical & Chemical Properties/Definition of Chemical Group Vanadium Pentoxide - CAS-No. 1314-62-1
P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call POISON CENTER or doctor/ physician.
HMIS Classification Health hazard: 3
Chronic Health Hazard: *
Physical hazards: 0
NFPA Rating Health hazard: 3
Reactivity Hazard: 0
Potential Health Effects Acute toxicity
Oral LD50: LD50 Oral - rat - 10 mg/kg
OSHA PEL: C 0.5 mg V2O5/m3 (resp)
IARC: 2B - Group 2B: Possibly carcinogenic to humans
Possible risk of congenital malformation in the fetus
Suspected human reproductive toxicant)
Symptoms of Exposure: Irritation eyes, skin, throat; green tongue, metallic taste, eczema; cough; wheezing, bronchitis, dyspnea (breathing difficulty)
Inhalation May be fatal if inhaled. Causes respiratory tract irritation
Skin May be fatal if absorbed through skin. Causes skin irritation.
Eyes Causes eye irritation.
Ingestion May be fatal if swallowed.
Personal Protective Equipment (PPE) Respiratory protection
General guidelines: Respirators should be used only under any the following circumstances:
As a last line of defense (i.e., after engineering and administrative controls have been exhausted).
When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will be exceeded.
Regulations require the use of a respirator.
An employer requires the use of a respirator.
There is potential for harmful exposure due to an atmospheric contaminant (in the absence of PEL)
As PPE in the event of a chemical spill clean-up process
Lab personnel intending to use/wear a respirator mask must be training and fit-tested by EH&S. This is a regulatory requirement. (http://map.ais.ucla.edu/go/1004655)
*Handle with extended cuff, double layer, Neoprene/Nitrile disposable gloves.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with Vanadium Pentoxide.
Wash and dry hands.
Skin and body protection
Lab coat (full sleeves)
Full length pants
Close toed shoes
Avoid contact with skin, eyes and clothing.
Wash hands before breaks and immediately after handling Vanadium Pentoxide.
All operations involving Vanadium Pentoxide must be carried out in a certified chemical fume hood (certified once every year by EH&S).
Chemical fume hoods used as containment areas for Vanadium Pentoxide – in general Particularly Hazardous Substances (Select Carcinogens, Regulated Carcinogens, Reproductive Toxins and Acute Toxins) must have a face velocity of 100 linear feet/minute averaged over the face of the fume hood.
Laboratory rooms must be at negative pressure with respect to the corridors and external environment. To achieve this, the laboratory/room door must be kept closed at all times.
Hazardous decomposition products formed under fire conditions. - Vanadium/vanadium oxides
Chemical Spill Dial 911 and x59797 General Guidelines – Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. Eliminate sources of ignition if the chemical is flammable. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Dial 911 (or 310-825-1491 from cell phone) and EH&S at x59797 immediately for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S at x59797 immediately. Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor and EH&S at x59797 immediately.
Medical Emergency Dial 911 or x52111
Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911 (or 310-825-1491 from cell phone) or contact the Ronald Reagan UCLA Medical Center (emergency room) directly at x52111 (located at 757 Westwood Plaza, enter from Gayley Avenue). Note: All serious injuries must be reported to EH&S at x59797 within 8 hours. Non-Life Threatening Emergency– Go to the Occupational Health Facility (OHF), x56771, CHS room 67-120 (This is on the 6th floor, 7thcorridor, room 120. Enter through the School of Dentistry on Tiverton Drive and proceed to the “O” elevator to the 6th floor.)Hours: M - F, 7:30 a.m. to 4:30 p.m. At all other times report to Ronald Regan UCLA Medical Center (emergency room) at x52111. Note: All serious injuries must be reported to EH&S at x59797 within 8 hours. Needle stick/punctureexposure (as applicable to chemical handling procedure)– Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 231 from a campus phone, enter 93333 when prompted and then enter your extension. Hours: M – F, 8:00 a.m. to 4:00 p.m. At all other times report to Ronald Regan UCLA Medical Center (emergency room) at x52111. Note: All needle stick/puncture exposures must be reported to EH&S at x59797 within 8 hours. Decontamination/Waste Disposal Procedure NOTE: Vanadium Pentoxide is listed as Extremely Hazardous (EH) Substance by the State. Even the containers (irrespective of the size) which once held Vanadium Pentoxide must be disposed of as hazardous waste with an on-line hazardous waste tag affixed on the container. (http://map.ais.ucla.edu/go/1002774)
All dry hazardous waste (such as Vanadium Pentoxide contaminated gloves and lab coats, pipettes, vials etc.), must be double bagged (use transparent bags only) and affixed with an on-line waste tag. Note: Black, Red, Orange or Yellow bags are prohibited by EH&S Hazardous Materials Division, for hazardous waste disposal.
On the on-line waste tag for the dry waste generated from Vanadium Pentoxide;
In the contents section, mention as Dry Waste 99%
Vanadium Pentoxide 1%
General hazardous waste disposal guidelines:
Affix an on-line hazardous waste tag on all waste containers using the Online Tag Program http://otp.ucop.edu/ as soon as the first drop of waste is added to the container
(State the location of MSDS) Hardcopy and electronic copy must be available for Vanadium Pentoxide.
Online MSDS can be accessed at http://msds.ehs.ucla.edu.
(Add specific description of procedure) Any deviation from this SOP requires approval from PI. Documentation of Training (signature of all users is required)
Prior to conducting any work with Vanadium Pentoxide, designated personnel must provide training to his/her laboratory personnel specific to the hazards involved in working with this substance, work area decontamination, and emergency procedures.
The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the Vanadium Pentoxide MSDS provided by the manufacturer.
The Principal Investigator must ensure that his/her laboratory personnel have attended appropriate laboratory safety training or refresher training within the last two years.
I have read and understand the content of this SOP: Name Signature Date