Safety Plan for the Use and Storage of High Risk Hazardous Chemicals Instruction Guide background



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Safety Plan for the Use and Storage of High Risk Hazardous Chemicals

Instruction Guide


BACKGROUND

High Risk Hazardous Chemicals (HRHC) are those that require stringent controls for their containment because they are extremely hazardous to laboratory personnel or could cause toxic effects or disease if released to the environment. Due to a combination of hazardous properties, these chemicals must be considered an extreme health hazard when used under any conditions. In general, one accident with one of these chemicals is likely to result in death, cancer or serious illness to one or more people. Very few chemicals are currently classified as High Risk Hazardous Chemicals by the UTMB Chemical Safety Committee (CSC). They are as follows:




Abrin 100mg*

p-Toluidine, 3-chloro-, hydrochloride

Aconitine (amorphous/crystalline)

Ricin 100mg*

Aflatoxins

Sarin

Amanitin

Saxitoxin 100mg*

Batrachotoxin

Shiga-like ribosome inactivating proteins*

Bis (chloromethyl) ether, syn. Dichloromethyl ether

Shigatoxin

Botulinum neurotoxin 0.5mg*

Soman*

Chloromethyl ether, methyl

Staphylococcal enterotoxins 5mg*

Clostridium perfringens epsilon toxin

Tabun

Conotoxins 100mg*

Taipoxin

Ciguatoxin

Tetrachlorodibenzodioxin

Diacetoxyscirpenol 1000mg*

Tetanus toxin

Diisopropyl fluorophosphate

Tetrodotoxin 100mg*

Diphtheria toxin

Textilotoxin

Etoposide

Triethylenethiophosophoramide

Maitotoxin

T-2 Toxin 1000mg*

Microcystin

VX

Mustard Gas

4- [bis(2-chloroethyl)amino]L-phenylalanine

*Select Agent – NOTE: In addition to the High Risk Hazardous Chemical Safety Plan (HRHCSP), these agents also require approval by the CDC Select Agent Program.


Other chemicals may be considered HRHCs by the Chemical Safety Committee (CSC) if they meet certain criteria (refer to Chapter 8, Chemical Safety in the UTMB Safety Manual).
SAFETY PLAN SUBMISSION

A HRHCSP must be submitted to the CSC for review and approval prior to ALL use of the UTMB HRHC(s).


Following are detailed instructions for completing each section of the safety plan document. Environmental Health and Safety (EHS) will assist you in completing this HRHCSP (Call x21781).


CHANGES TO APPROVED SAFETY PLANS AND ANNUAL UPDATE

Approved HRHCSPs must be amended prior to any changes in quantities or procedures outlined in the original approved plan. An annual update is required. If no changes are made, documentation to this effect must be submitted and added to the plan.


TRAINING OF LAB PERSONNEL

The completed, approved HRHCSP is to be used as a training aid for laboratory personnel using the HRHC.


The following instructions should be used as a guide to complete this form. Proper development of this High Risk Hazardous Chemical Safety Plan will ensure prompt review and evaluation by the Chemical Safety Committee. Failure to provide requested information may result in a delay in approval of the High Risk Hazardous Chemical Safety Plan. Please contact EHS at extension 21781 with questions and for support in the development of this High Risk Hazardous Chemical Safety Plan.


SAFETY PLAN COVER PAGE

Fill in the blanks on the cover page of the safety plan document. Check “Update” if you are updating any information (e.g., quantities used) in an approved safety plan. Check “Renewal” if you are submitting an approved safety plan for the required renewal review every five years.


Section I. PROJECT DESCRIPTION
1. List the High Risk Hazardous Chemical to be addressed in this High Risk Hazardous Chemical Safety Plan.
2. Provide a brief description of the project or use of the chemical, include purpose, objectives and methodology. The box will expand as you type.
3-6. Self explanatory
7. Provide examples specific to your experiment.
8. Self explanatory
9. List all personnel working with the agent; include their personal experience with the agent and techniques used with the agent. In the table below list anyone with access to the agent.

Section II. SOP

This section is designed to assist you in building your SOP for handling the agent.


1. Include PPE used, containment, safe and secure storage, equipment used, record keeping and anything else that would be useful in determining staff safety while handling this agent.
2. Include all methods for disposal and step by step details.
3. Include emergency procedures in the event of a storm, an extended power interruption, or an employee exposure.
4. Include containment, the method of transportation and the route to be used.
Section III. CHEMICAL SPECIFIC INFORMATION
1. Check all that apply. This information can be found on the chemical material safety data sheet.
2. Provide information on how often the chemical will be used (daily, weekly).
3. Provide information on the quantity of the agent to be used at any one time (mg, ml, etc).
4. Include the highest concentration used at any time over the course of the experiment.


    1. Self explanatory


Section IV. SHIPPING/RECEIVING OF HIGH RISK HAZARDOUS CHEMICALS
1 - 2. Self explanatory
Section V. SAFETY TRAINING
The Texas Hazard Communication Act requires that all employees be given training about the specific chemical hazards they work with. The Principal Investigator is responsible for the content and effectiveness of this training. Employees should illustrate ongoing competence in the areas of training. Failure to show a familiarity with this material should result in prompt "refresher" training in the deficient areas.

The High Risk Hazardous Chemical Safety Plan (HRHCSP) will serve as a safety training outline and a ready written reference for actions to be taken in the event of an accident or release involving this agent. A copy of this HRHCSP shall be given to and discussed with each employee involved in the study.


1-2. List HCA Trainer. Train all personnel working with the HRHC on the HRHCSP as well as the HRHC Material Safety Data Sheet (MSDS). This training must occur prior to any work with the HRHC. At a minimum, any time changes are made to the HRHCSP or new information becomes available on the HRHC, personnel must be retrained. Attach documentation of chemical specific training (annual online lab safety certificates for all staff listed on the protocol and HCA or PI documents).
3. Attach a copy of the MSDS

4-9. Self explanatory. If a respirator is used, it will require a consultation from EHS to ensure personnel have met respirator use requirements.




Section VI. EMERGENCY FIRST AID PREPAREDNESS

1-2. Self explanatory


3. Provide specific conditions under which an exposure could occur and what procedures/safety precautions are in place to avoid these exposures.
4. Provide specific step by step employee exposures. Include who needs to be contacted/ reported to, what needs to be conveyed by whom, where the employee needs to report, etc.
Section VII. EXPERIMENTAL ANIMAL USE
If animals are used, attach a description which includes IACUC #, the labels placed on cages indicating hazards, hazards associated with animal waste, bedding, and carcasses and proper precautions taken during handling. Use EHS provided Appendix I.
NOTE: Investigators are reminded that when planning experiments with animals which includes hazardous agents, please contact ARC staff at extension 21275 two weeks prior to use of the agents to coordinate animal housing and husbandry concerns.
Section VIII. EMERGENCY AND DISASTER PREPAREDNESS
1-2. Self explanatory.
3. Provide as much information as is available.
4. The P.I. can contact EHS at ext. 21781 to arrange for short term storage.


Last edited 1/7/2013




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