Medical Considerations: Uncommon adverse reactions; stimulation, drowsiness, hepatotoxicity, nausea, vomiting, abdominal pain, angioedema, rash and urticaria.
Medical Considerations: Toxicity shown with cyanosis, anemia, neutropenia, jaundice, pancytopenia, CNS stimulation, delirium; then vascular collapse, convulsions, coma and death.
Dental Drug Interactions: Barbiturates liver toxicity of high doses of acetaminophen. Therapeutic doses with alcohol may cause severe hepatic toxicity. Nephrotoxicity with long-term consumption especially if combined with NSAIDs. Buffered acetaminophen decreases tetracycline absorption.
Medical Drug Interactions: Cholestyramine reduces effect. Hepatic toxicity possible with INH and Dilantin.
Precautions: Don’t use with G-6-PD deficiency, alcoholics and liver disease.
*Dental Drug Interactions: Allergic cross reactions with other phenanthrene derivatives (morphine, codeine, levorphanol, oxycodone and oxymorphone). Increased CNS depression with alcohol, phenothiazines, sedative/hypnotics, skeletal muscle relaxants, general anesthetics and other opiods. Increased effects of anticholinergics, may cause paralytic ileus.
*Medical Drug Interactions: Use of antidepressants (MAO inhibitors or TCAs) and hydrocodone can increase effects of both antidepressant and hydrocodone.
Opium Alkaloid +
Hydrocodone and Acetaminophen (Anexia, Bancap, Co-Gesic, Lorcet, Lortab and Vicodin) (Continued)
Precautions: Don’t use if G-6-PD deficiency. Use with caution if respiratory diseases (asthma, emphysema, COPD), severe liver or renal insufficiency. Many preparations contain sulfites, watch for allergic reactions.
Hydrocodone and Aspirin (Lortab ASA)
Same action, use, considerations, drug interactions, and precautions as individual components.
Acetaminophen and *Codeine (Capital and Codeine, Phenaphen with Codeine, Tylenol with Codeine) *More nausea, vomiting and constipation than with Hydrocodone.Same action and use as Hydrocodone. Similar considerations, drug interactions and precautions as individual components. Codeine acts as hydrocodone.
Acetaminophen and *Oxycodone (Percocet, Tylox)
*Class II narcotic. Same use and action as individual components with Oxycodone acting as Hydrocodone. More side effects than with Hydrocodone. Dry mouth more common. * >10%: Fatigue, drowsiness, dizziness, nausea and vomiting. 1-10%: Anorexia, stomach cramps, xerostomia, constipation and biliary spasm.