Patient: [patient first name] [patient last name] Insurance Company



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[DATE]
Patient: [PATIENT_FIRST_NAME] [PATIENT_LAST_NAME]
Insurance Company: [INSURANCE_COMPANY_NAME]

Subscriber Name: [POLICY_HOLDER_NAME]

Policy #: [POLICY_NUMBER]
Dear Claims Specialist,
I am writing this letter on behalf of my patient [PATIENT_FIRST_NAME] [PATIENT_LAST_NAME] to request coverage for genetic testing for Hypertrophic Cardiomyopathy offered through GeneDx, a high complexity CLIA certified laboratory located in Gaithersburg, Maryland.
Information on patient’s Condition:

[PATIENT_FIRST_NAME] is a [PATIENT_AGE] year-old [PATIENT_GENDER] suspected to have hypertrophic cardiomyopathy (HCM). [HIS_HER] family history is [NOT] notable for sudden cardiac death. [PATIENT_FIRST_NAME]’s clinical symptoms and results of the routine diagnostic tests suggest a diagnosis of HCM. However, the only way to confirm this diagnosis is to perform genetic testing on this patient. Results from this genetic test will have a direct impact on this patient’s treatment and management. HCM is well known to occur as part of systemic conditions, which can be the underlying cause of HCM even if this cardiac feature presents in apparent isolation. This HCM genetic testing panel includes genes associated with Fabry disease, Transthyretin Amyloidosis, Danon disease, and Limb Girdle Muscular Dystrophy. It is extremely important to know if this patient’s HCM was caused by a mutation in any of the genes associated with these other systemic conditions, as these conditions are treated and managed very differently. A positive genetic test result would provide a definitive cause for this patient’s hypertrophic cardiomyopathy and would ensure this patient is being treated appropriately.


The recommendations for hypertrophic cardiomyopathy can be reviewed in the 2006 ACC/AHA/ESC Practice Guidelines Executive Summary for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death as co- published in September of 2006 in Circulation, the Journal of the American College of Cardiology and the European Heart Journal.
Family History:

Hypertrophic cardiomyopathy is most commonly inherited in an autosomal dominant manner. Therefore, genetic testing results not only have implications for the patient, but also [HIS_HER] relatives. If a genetic mutation is identified in [PATIENT_FIRST_NAME] we will be able to assess the risk for [HIS_HER] family members who may also have the same condition and thus be able to provide them with the appropriate medical management and counseling.


Knowledge of this patient's genetic information is important for me to more accurately assess [HIS_HER] risk for sudden cardiac death and will guide my recommendations for [HIS_HER] care. I am specifying GeneDx because this laboratory has highly sensitive and cost-effective test for hypertrophic cardiomyopathy.
Thank you for your review and consideration. I hope you will support this request for genetic testing coverage for [PATIENT_FIRST_NAME] [PATIENT_LAST_NAME]. If you have questions, or if I can be of further assistance, please do not hesitate to call me at [PHYSICIAN_PHONE_NUMBER].
Sincerely,
[PHYSICIAN_FIRST_NAME] [PHYSICIAN_LAST_NAME], MD
cc: [PATIENT_FIRST_NAME] [PATIENT_LAST_NAME]


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