Part I: General Information Date Prepared: March 2015 Name: Shuji Ogino Office Address



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2011 Ramzi Cotran Young Investigator Award United States and Canadian Academy of

Pathology (USCAP)

2012 Meritorious Service Award Association for Molecular Pathology


2014 The Best of AACR Journals American Association for Cancer Research (AACR)

2014 The Most Influential Scientific Minds: 2014 Thomson Reuters



Report of Funded Projects


Funding Information


Past Funded Projects




2001-2012 A Prospective Study of Diet and Cancer


NCI/NIH P01 CA55075

Co-Investigator (PI, Walter Willett)



This Program Project utilizes the Health Professionals Follow-Up Study and the Nurses' Health Study, and the hypotheses relate to dietary and hormonal influences, external carcinogens, physical activity, body mass index, tumor promoting hormonal and growth factors, and NSAID use.

2001-2006 A Prospective Study of Pancreatic Cancer Pathogenesis


NCI/NIH R01 CA86102

Co-Investigator (PI, Charles Fuchs)



The purpose of this application was to understand underlying mechanisms, interrelations among etiologic and pathogenic factors, and specificity in relation to specific tumor markers.
2007-2011 Molecular Epidemiology of Colorectal Cancer

NCI/NIH K07 CA122826

PI ($138,780; $109,837 in the 4th year; with supplement $50,800 in 2009-2011)

The specific aims are: 1) to examine the relationship between one-carbon nutrients and epigenetic changes in colorectal cancer; and 2) to examine the relation between energy balance and related molecular events in tumor as well as patient survival.
2007-2012 Prospective Studies of Diet and Cancer in Men and Women

NCI/NIH P01 CA055075

Co-Investigator [Other Significant Contributor 2008-2011] (PI, Walter Willett)

This Program Project utilizes the Health Professionals Follow-Up Study and the Nurses' Health Study, and the hypotheses relate to dietary and hormonal influences, external carcinogens (including dietary), physical activity, tumor promoting hormonal and growth factors, and NSAID use.
2007-2013 DF/HCC SPORE in Gastrointestinal Cancer

NCI/NIH P50 CA127003

Co-Investigator in Tissue and Pathology Core (PI, Charles Fuchs)

The overall aims of this SPORE project are to comprehensively understand carcinogenic mechanisms of gastrointestinal cancers and to apply novel findings to clinical practice. This SPORE represents a large multidisciplinary effort encompassing various fields such as cell biology, oncology, gastroenterology, pathology, radiology, epidemiology and biostatistics. My role is to analyze molecular and pathologic features of gastrointestinal cancer.


2008-2009 Gene Expression Profiling of Colorectal Cancer in Prospective Cohort Studies

DFCI Friends

Co-PI (PI, Charles Fuchs)

The aim is to conduct genome-wide analysis of gene expression by microarrays in nearly 1000 colorectal cancers identified in the Nurses’ Health Study and Health Professionals Follow-up Study cohorts.


2008-2013 Prospective Cohort Collaborative in Pancreatic Cancer Epidemiology and Pathogenesis NCI/NIH R01 CA124908

Co-Investigator (PI, Charles Fuchs)



This application helps understanding of underlying mechanisms, interrelations among etiologic and pathogenic factors, variation in response due to genetic susceptibility, and specificity in relation to specific tumor markers. We can specify recommendations aimed to reduce its incidence and mortality.
2010-2011 Role of Host Immune Response in Colorectal Cancer

NCI/NIH P50 CA127003 (DF/HCC SPORE in Gastrointestinal Cancer)

PI for this Developmental Project (Overall PI, Charles Fuchs) $35,000 (direct)

The aims of this GI SPORE Developmental Project are to examine the role of host immune response in colorectal cancer, to analyze expressions of immunoregulatory molecules in tumor microenvironment, and to explore genome-wide expression data for the identification of potential targets for immunotherapy.


2012-2013 Molecular Predictors of Neuroendocrine Tumor Risk and Outcome

Novartis CRAD001KUS172T

Co-PI (PI, Matthew Kulke)

Our overall aims are to identify clinical, pathological and tumor molecular characteristics of neuroendocrine tumors which can predict clinical outcome, and to identify risk factors.


2012-2013 Prospective Studies of Diet and Cancer in Men and Women

NCI/NIH 5U19 CA055075

Co-Investigator (PI, Walter Willett)

The purpose of this subcontract to the U19 project is to address hypotheses related to colorectal neoplasias in the Health Professionals Follow-Up Study and the Nurses' Health Study. Hypotheses relate to dietary, lifestyle and hormonal influences on colorectal neoplasias.
2013-2014 Role of Gut Microbiota in Colorectal Cancer Development and Progression

DFCI Friends

PI ($23,104)

The aim is to conduct a pilot study of microbial profiling by microbiome sequencing on paraffin-embedded cancer tissue, for possible application to over 1000 colorectal cancers identified in the Nurses’ Health Study and Health Professionals Follow-up Study.


Current Funded Projects
2001-2020 Dietary and Hormonal Determinations of Cancer in Women

NCI/NIH P01 CA087969

Co-Investigator [Other Significant Contributor 2008-2011] (PI, Graham Colditz 2001-2006, Susan Hankinson 2006-2015, Meir Stampfer 2015-2020)

The objective of this Program Project, utilizing the Nurses’ Health Study cohort of 121,700 women followed since 1976, is to identify dietary and hormonal determinants of breast, gastrointestinal, and ovarian cancer risk in women, with the ultimate aim to find means for prevention and improved survival.
2007-2020 Dietary and Lifestyle Determinants of Colon Cancer Recurrence and Survival NCI/NIH R01 CA118553

Co-Investigator (PI, Charles Fuchs)

We propose to utilize a NCI-sponsored adjuvant chemotherapy trial in stage III colon cancer (CALGB 89803) which provides: 1) longitudinal prospective assessments of diet, medication, and lifestyle; 2) paraffin-embedded tumor specimens; and 3) comprehensive data on recurrence, mortality, and chemotherapy toxicity.
2009-2014 Inflammation and Colorectal Neoplasia (NCE)

NCI/NIH R01 CA137178

Co-Investigator [Other Significant Contributor 2009-2011] (PI, Andrew Chan)

The primary aim of this proposal is to understand the role of inflammation in colorectal carcinogenic process. Especially, the roles of PTGS2 (cyclooxygenase-2), and downstream inflammatory mediators will be examined in the Nurses’ Health Study and the Health Professionals Follow-Up Study.


2010-2015 Epigenetic Events and Colorectal Cancer Epidemiology NCI/NIH R01 CA151993

PI ($1,821,170)

We propose to examine epigenetic changes in cancer cells in relation to one-carbon nutrients and constitutive loss of imprinting, to shed lights on epigenetic events during carcinogenic process. In addition, we will utilize genome-wide mRNA expression data to explore for genes potentially important in altered one-carbon metabolism and DNA methylation reactions.
2010-2015 The Influence of Diet and Lifestyle on Patients with Advanced Colorectal Cancer

NCI/NIH R01 CA149222

Co-Investigator [Other Significant Contributor 2010-2011] (PI, Jeffrey Meyerhardt)

The aim of this proposal is to examine the role of dietary and lifestyle factors on outcome of patients with metastatic colorectal cancer who enrolled in clinical trials. My role is to analyze molecular and pathologic features of metastatic colorectal cancer.


2011-2015 Molecular and Genetic Analysis of Neuroendocrine Tumor Risk and Survival NCI/NIH R01 CA151532

Co-Investigator (PI, Matthew Kulke)

The aim of this proposal is to examine etiologies and behavior of neuroendocrine tumors (carcinoids and pancreatic endocrine tumors). My role is to analyze molecular and pathologic features of tumors.
2012-2017 Cancer Epidemiology Cohort in Male Health Professionals

NCI/NIH UM1 CA167552

DFCI Subcontract PI ($755,966) (PI, Walter Willett)

This grant supports the Health Professionals Follow-Up Study. My roles are to manage pathology laboratory and to provide expertise in tumor tissue analysis and molecular pathological epidemiology (MPE).
2013-2018 Impact of Celecoxib and Inflammation on Survival in Stage Ill Colon Cancer NCI/NIH R01 CA168141 Co-Investigator (PI, Charles Fuchs)

We aim to utilize resource of Alliance trial (CALGB 80702), including a) assessments of diet, medication usage, and lifestyle; b) tumor specimens; c) blood and germline DNA; and d) extensive data on cancer recurrence and mortality. My role is to assess tumor molecular changes and their interactive effects on outcome.


2013-2018 DF/HCC SPORE in Gastrointestinal Cancer

NCI/NIH P50 CA127003

Co-Director of Tissue and Pathology Core (PI, Charles Fuchs)

The overall aims of this SPORE project are to comprehensively understand carcinogenic mechanisms of gastrointestinal cancers and to translate novel findings into clinical practice. This SPORE represents a large multidisciplinary effort encompassing various fields such as cell biology, oncology, pathology, radiology, epidemiology and biostatistics.


2014-2015 Analysis of Host Immunity and Tumor Molecular Characteristics in Colorectal Cancer

NCI/NIH P50 CA127003 (DF/HCC SPORE in Gastrointestinal Cancer)

PI for this Developmental Project (Overall PI, Charles Fuchs) $50,000

The aims of this GI SPORE Developmental Project are to analyze expression of immunoregulatory molecules in the tumor microenvironment; to explore whole exome sequencing and gene expression profiling data for the identification of potential targets for immunotherapy; and to examine the role of host immunity in colorectal cancer survival.


2014-2015 Analysis of Microbiome in Colorectal Cancer

DFCI Friends

PI ($18,000)

The aims are to conduct a pilot study of microbiome analysis on paraffin-embedded colorectal cancer tissue by 16S rRNA sequencing and PathSeq analysis using whole exome sequencing (WES) data, and to apply a validated method to over 1500 colorectal cancers identified in the Nurses’ Health Study and Health Professionals Follow-up Study.


2014-2019 Molecular Pathological Epidemiology of Colorectal Cancer

NCI/NIH U01 CA137088

Co-Investigator (PI, Ulrike Peters)

This competitive renewal application is based on a multi-institutional large-scale consortium, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). In the renewal application, molecular pathological epidemiology (MPE) has become a central theme, to address etiologic heterogeneity of colorectal carcinomas. I will play a major role as a molecular pathological epidemiologist in this proposal.



Report of Local Teaching and Training

Teaching of Students in Courses
Teaching prior to start of current Harvard appointment
1997-1999 Pathology Laboratory Course Case Western Reserve University

Second year medical students 3-hour session/day for 14 days/year


1997-1998 Pathologic Basis of Diseases Case Western Reserve University

Second year medical students 3-hour session/day for 5 days/year




    1. Renal Pathology Case Western Reserve University

Second year medical students 3-hour session/day for 3 days/year
1997-1998 Infectious Diseases Case Western Reserve University

Second year medical students 3-hour session/day for 5 days/year


1998-1999 Pulmonary Pathology Case Western Reserve University

Second year medical students 3-hour session/day for 3 days/year


Teaching during current Harvard appointment
2003-2004 HST030 Human Pathology Laboratory Harvard Medical School

Second year medical students 2-hour session/day for 7 days/year


2011 HST030 Human Pathology Laboratory Harvard Medical School

Second year medical students 1-hour session/day for 15 days/year


2011 Nutritional Epidemiology of Cancer Harvard School of Public Health

Doctoral and Master students (ID510) 2-hour lecture


2012 HST030 Human Pathology Laboratory Harvard Medical School

Second year medical students 1-hour session/day for 5 days/year


2013 Nutritional Epidemiology of Cancer Harvard School of Public Health

Doctoral and Master students (ID510) 2-hour lecture


Formal Teaching of Residents, Clinical Fellows and Research Fellows
Teaching during current Harvard appointment
2002-2003 Genetic Risk Analysis Brigham and Women's Hospital

Molecular Genetic Pathology Fellows 2-hour session/year


2003-2010 Genetic Risk Assessment Workshop Brigham and Women's Hospital

Genetics and Pathology Residents/Fellows 2-hour session/day for 2 days/year


2003-2011 Advanced Genetic Risk Assessment Brigham and Women's Hospital

Genetics and Pathology Residents/Fellows 1-hour lecture/year


2010- Molecular Diagnostics Lecture Series Brigham and Women's Hospital

Pathology Residents/Fellows 1-hour lecture/year



Clinical Supervisory and Training Responsibilities
Teaching prior to start of current Harvard appointment
1996-1997 Supervision of junior residents / 200 hours/year

Allegheny General Hospital


1997-1999 Supervision of junior residents / 200 hours/year

Case Western Reserve University


1999-2000 Supervision of pathology residents and medical 800 hours/year

students in Molecular Pathology Laboratory /

University of Pennsylvania
2000-2001 Supervision of fellows, residents and medical 100 hours/year

students in Molecular Pathology Laboratory /

University of Pennsylvania


Teaching during current Harvard appointment


    1. Supervision of residents in general surgical 450 hours/year

pathology / Brigham and Women’s Hospital
2004- Supervision of residents and fellows in molecular 300 hours/year

diagnostics / Brigham and Women’s Hospital

Laboratory and Other Research Supervisory and Training Responsibilities
2002- Supervision of research fellows / Daily mentorship for 11 years

Dana-Farber Cancer Institute

Formally Supervised Trainees (publication data are based on up to the 157th original article)
2001-2002 Ruliang Xu, MD, PhD / Associate Professor of Pathology, New York University

He published one paper as the first author under my supervision.


2002-2003 Chong Xu, MD / Former Instructor in Obstetrics and Gynecology, Harvard Medical School
2005-2006 Taiki Yamaji, MD, MPH / Staff Scientist, National Cancer Center, Japan
2003-2007 Takako Kawasaki, MD, PhD / Physician, Singapore

She published 5 original papers as the first author and 2 other original papers as a co-first author under my supervision.
2006-2008 Mutsuko Ohnishi, MD / Postdoctoral Fellow, Harvard School of Dental Medicine

She received a fellowship grant (2007-2008) from Japanese Society for Multidisciplinary

Treatment of Cancer, and published 2 original papers as a co-first author under my

supervision.
2006-2008 Aditi Hazra, PhD, MPH / Assistant Professor of Medicine, Harvard Medical School

She received 2008 American Association of Cancer Research Scholar-in-Training Award under my supervision.


2007-2010 Katsuhiko Nosho, MD, PhD / Assistant Professor of Medicine, Sapporo Medical University

He received a fellowship grant (2008-2010) from Japan Society for Promotion of Science, and published 8 original papers as the first author and 17 other original papers as a co-first author under my supervision.


2008-2009 Shoko Kure, MD / Resident in Pathology, Japan Medical University

She published 1 original paper as the first author, and 3 other original papers as a co-first author under my supervision.


2008-2009 Natsumi Irahara, PhD / Senior Medical Science Liaison Specialist, MSD (Merck)

She published 2 original paper as the first author, and 4 other original papers as a co-first author under my supervision.


2008-2010 Yoshifumi Baba, MD, PhD / Assistant Professor of Surgery, Kumamoto University

He received a fellowship grant (2009-2010) from Uehara Memorial Foundation, and published 8 original papers as the first author and 10 other original papers as a co-first author under my supervision.


2008-2011 Kaori Shima, DDS, PhD / Assistant Professor, Kagoshima University

She published 3 original papers as the first author and 12 other original papers as a co-first author under my supervision.


2009-2010 Noriko (Yamaguchi) Tanaka, PhD / Chief, Division of Biostatistics, National Center for Global Health and Medicine, Japan

She published 1 original paper as the first author and 3 other original papers as a co-first author under my supervision.


2009-2013 Kimmie Ng, MD, MPH / Assistant Professor of Medicine, Dana-Farber Cancer Institute

I serve as a consultant and advisor for her K07 entitled "Role of Vitamin D, Inflammation, and Energy Balance in Colorectal Cancer Survival" (K07 CA148894. 7/19/11-6/30/16).


2010-2013 Levi Waldron, PhD / Assistant Professor, University of Massachusetts

He published one original paper as the first author under my supervision.


2010-2011 Jing Xie, MD, MS / Doctoral Student, Harvard School of Public Health
2010 Maiko Suzuki, DDS, PhD / Research Fellow, Forsyth Institute
2010-2014 Mai Yamauchi, PhD / Assistant Professor, University of Tokyo

She published 2 original paper as the first author, and 4 other original papers as a co-first author under my supervision.


2010-2012 Teppei Morikawa, MD, PhD / Assistant Professor of Pathology, University of Tokyo

He received a fellowship grant (2010-2011) from Japan Society for Promotion of Science, and published 7 original papers as the first author (including one in JAMA 2011) and 9 other original papers as a co-first author, under my supervision.


2010-2013 Aya Kuchiba, PhD / Biostatistician, National Cancer Center, Tokyo

She published 1 original paper as the first author, and 11 other original papers as a co-first author under my supervision.


2010-2013 Yu Imamura, MD, PhD / Staff Surgeon, Kyushu University

He published 1 original paper as the first author, and 4 other original papers as a co-first author under my supervision.


2010-2013 Xiaoyun Liao, MD, PhD / Senior Research Scientist, Dana-Farber Cancer Institute

She published 2 original papers as the first author (including one in NEJM 2012), and published 3 other original papers as a co-first author under my supervision.


2011- Zhirong Qian, MD, PhD / Instructor in Medicine, Dana-Farber Cancer Institute

He published 1 original paper as the first author, and 1 other original paper as a co-first author under my supervision.


2011- Reiko Nishihara, PhD / Instructor in Medicine, Dana-Farber Cancer Institute and

Harvard School of Public Health

She has been PI of K07 CA190673 (2014-2019) under my mentorship.

She published 3 original papers as the first author (including one in NEJM 2013, and another in JAMA 2013), and 3 other original papers as a co-first author under my supervision.


2011- Akihiro Nishi, MD, DrPH / Research Fellow, Yale University and Harvard School of Public Health

Under my supervision, he received a fellowship grant from Japan Society for Promotion of Science (2013-2015).


2011-2012 Paul Lochhead, MBBCh, MRCP / Clinical Lecturer, University of Aberdeen

Under my supervision, he received Frank Knox Memorial Fellowship Grant (2011-2012), and published 2 original papers as the first author, and 9 other original papers as a co-first author.


2011-2012 Ruifang Sun, MB / Research Scholar, Xi’an Jiaotong University

Under my supervision, she received a scholarship grant from Chinese Scholarship Council and National Scholarship for Building High Level University.


2012- Nadine J McCleary, MD / Instructor in Medicine, Dana-Farber Cancer Institute
2012-2013 Seungyoun Jung, ScD / Research Fellow, Brigham and Women’s Hospital
2012-2015 Kentaro Inamura, MD, PhD / Research Fellow, Dana-Farber Cancer Institute

Under my supervision, he received fellowship grants from Japan Society for Promotion of Science, and Takashi Tsuruo Memorial Fund.


2012-2013 Chen (Cindy) Wu, MD, PhD / Research Fellow, Harvard School of Public Health
2013-2014 Sung Kwan Shin, MD, PhD / Research Fellow, Dana-Farber Cancer Institute
2013- Kathryn Fitzgerald, MS / Doctoral Student, Harvard School of Public Health
2013-2015 Sun A Kim, MD, PhD / Research Fellow, Dana-Farber Cancer Institute

Under my supervision, she received Early Exchange Postdoctoral Fellowship Grant from Asan Medical Center, Korea


2013- Kosuke Mima, MD, PhD / Research Fellow, Dana-Farber Cancer Institute

Under my supervision, he received a fellowship grant from Uehara Memorial Foundation (2013-2015).


2013-2015 Yasutaka Sukawa, MD, PhD / Research Fellow, Dana-Farber Cancer Institute

Under my supervision, he received Sapporo Hibarigaoka Hospital Postdoctoral Fellowship Grant for Research Abroad.


2013- Ting-Ting Li, MD / Research Fellow, Dana-Farber Cancer Institute
2013- Xuehong Zhang, MD, ScD / Instructor in Medicine, Brigham and Women's Hospital

Under my supervision, he received NIH/NCI R03 award.


2013- Mingyang Song, MD, MS / Doctoral Student, Harvard School of Public Health
2014-2015 Atsuhiro Masuda, MD, PhD / Research Fellow, Dana-Farber Cancer Institute
2014- Juhong Yang, PhD / Research Fellow, Dana-Farber Cancer Institute
2014- Ruoxu Dou, MD, PhD / Research Fellow, Dana-Farber Cancer Institute
2014- Jonathan A. Nowak, MD, PhD / GI Pathology and Molecular Genetic Pathology Fellow, Brigham and Women's Hospital

Under my supervision, he received Stanley Robbins Research Award in 2015.


2015- Lauren L. Ritterhouse, MD, PhD / Pathology Resident, Brigham and Women's Hospital
2015- Yin Cao, ScD / Research Fellow, Harvard T.H. Chan School of Public Health

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