Jennifer Ai-wen Chan, M. D. Assistant Professor



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Jennifer Ai-wen Chan, M.D.

Assistant Professor

Departments of Pathology & Laboratory Medicine, Oncology, and Clinical Neurosciences

Health Research Innovation Centre, HRIC room 2A-08

3330 Hospital Drive NW

Calgary, Alberta T2N 4N1

E-mail: jawchan@ucalgary.ca

Phone: 403-210-6380


SELECTED PUBLICATIONS


  1. Li S, Mattar P, Dixit R, Lawn SO, Wilkinson G, Eisenstat D, Kurrasch DM, Chan JA*, Schuurmans C*. RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis. (*co-corresponding authors) J Neurosci. 2014 Feb 5;34(6):2169-90. PMID: 24501358

  2. Shih D, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang KX, Dubuc A, Garzia L, Peacock J, Mack S, Wu X, Rolider A, Morrissy S, Cavalli F, Jones DTW, Zitterbart K, Faria C, Schüller U, Kren L, Kumabe T, Tominaga T, Ra Y-S, Garami M, Hauser P, Chan JA, Robinson S, Bognar L, Klekner A, Saad AG, Liau L, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels E, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart C, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack I, Weiss WA, Lee J-Y, Cho B-K, Kim S-K, Wang K-C, Leonard J, Rubin J, de Torres C, Lavarino C, Mora J, Cho Y-J, Tabori U, Olson J, Gajjar A, Packer RJ, Rutkowski S, Pomeroy S, French P, Kloosterhof NK, Kros J, Van Meir E, Clifford SC, Bourdeaut F, Delattre O, Doz F, Hawkins C, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka J, Pfister SM, and Taylor MD. Cytogenetic Prognostication within Medulloblastoma Subgroups. J Clin Oncol. 2014 Feb 18. [Epub ahead of print]

  3. Dixit R, Wilkinson G, Cancino G, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson E, Kaplan D, Zimmer C, Schuurmans C. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014 Jan 8;34(2):539-53. PMID: 24403153

  4. Chesnelong C, Chaumeil M, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG. LDHA silencing in IDH mutant gliomas. Neuro Oncol. 2013 Dec 22 [Epub ahead of print] PMID: 24366912.

  5. Kleinman CL, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Quang DA, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso AM, Spence T, Schwartzentruber J, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes JL, Staffa A, Montpetit A, Berube P, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel PM, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor MD, Sladek R, Pastinen T, Chan JA, Huang A, Majewski J, Jabado N. Fusion of TTYH1 with the C19C microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumour ETMR. Nat Genet. 2014 Jan;46(1):39-44. PMID: 24316981.

  6. Spence T†, Perotti C†, Sin-Chan P, Picard D, Wu W, Singh A, Anderson C, Blough MD, Cairncross JG, Lafay-Cousin L, Strother D, Hawkins C, Narendran A, Huang A*, Chan JA*. A novel C19MC-amplified cell line links Lin28/let-7 to mTOR signaling in Embryonal Tumor with Multilayered Rosettes. (*co-corresponding authors) Neuro Oncol, 2014 Jan;16(1):62-71. PMID: 24311633

  7. Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N, Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B, Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF, Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR, Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ, Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska WA, Kim SK, Rutka JT, Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD. TERT promoter mutations are highly recrrent in SHH subgroup medulloblastoma. Acta Neuropathol. 2013 Dec;126(6):917-29. PMID: 24174164.

  8. Lafay-Cousin L, Hader W, Wei X, Nordal R, Strother D, Hawkins C, Chan JA. Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors. Brain Pathol 2013 Aug 30 (Epub ahead of print).

  9. Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA. Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem 2013 Sep 6;288(36):26275-88. PMID: 23867465

  10. Margolin DH, Lousi M, Chan Y-M, Lim ET, Schmahmann JD, Hadjiyassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O’Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. New Engl J Med 2013 May 23;368(21):1992-2003. PMID: 23656588

  11. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence M, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Hummelen PV, MacConaill L, Pouissant-Young T, Cho Y-J, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer R, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MQ, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent, oncogenic MYBL1-truncating rearrangements. Proc Natl Acad Sci 2013 May 14;110(20):8188-93. PMID: 23633565

  12. Northcott PA, Shih DJH, Peacock J, Garzia L, Morrissy S, Stütz AM, Zichner T, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli F, Wang X, Remke M, Wu X, Chiu RYB, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AGJ, Thiessen N, Varhol RJ, Birol VI, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DTW, Witt H, Fernandez A, Kenney AM, Wechsler-Reya R, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre OO, SteReynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Wolfram W, Scheurlen W, Eberhart CG, Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie YC, Rocco CD, Massimi L, Michiels EMC, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Gupta N, Weiss WA, BognaÅr L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau L, Van Meir EG, Fouladi M, Cinalli G, Garami M, Hauser P, Saad A, Iolascon A, Zollo M, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Faria CC, Chan JA, Levy ML, Sorensen PHB, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJM, Korbel JO, Pfister SM, Marra MA, Taylor MD. Subgroup specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 2;488(7409):49-56. PMID: 22832581

  13. Picard D, Miller S, Hawkins CE, Bouffet E, Rogers HA, Chan TSY, Kim SK, Ra YS, Fangusaro J, Korshunov A, Toledano H, Nakamura H, Hayden JT, Chan JA, Lafay-Cousin L, Hu PX, Fan X, Muraszko KM, Pomeroy SL, Lau CC, Ng HK, Jones C, Huang A. Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Lancet Oncol 2012; 13(8):838-48. PMID: 22691720

  14. Blough MD, Al-Najjar M, Chesnelong C, Binding CE, Rogers AD, H. Luchman HA, Kelly JJ, Fliegel L, Morozova O, Yip S, Marra M, Weiss S, Chan JA*, Cairncross JG*. DNA Hypermethylation and 1p Loss Silence NHE-1 in Oligodendroglioma. Ann Neurol 2012 Jun;71(6):845-9. (*co-corresponding author). PMID: 22718548

  15. Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Kurrasch DM, Ma Y, Chan JA, Wallace V, Dilworth J, Brand M, Schuurmans C. GSK3b temporally regulates Neurogenin 2 proneural activity in the neocortex. J Neurosci. 2012 Jun 6;32(23):7791-805. PMID: 22674256

  16. Perizzolo M, Winkfein B, Hui S, Krilicki W, Chan JA, Demetrick DJ. IDH mutation detection in formalin-fixed paraffin-embedded gliomas using multiplex PCR and single-base extension. Brain Pathol 2012 Sep;22(5):619-24 PMID: 22360629

  17. Luchman HA, Stechishin OD, Dang NH, Blough MD, Chesnelong C, Kelly JJ, Nguyen SA, Chan JA, Weljie, AM, Cairncross JG, Weiss W. An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro Oncol. 2012 Feb;14(2):184-91. PMID: 22166263

  18. Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J, Birol I, Chesnelong C, Chiu R, Chuah E, Corbett R, Docking R, Firme M, Hirst M, Jackman S, Karsan A, Li H, Louis DN, Maslova S, Moore R, Moradian A, Mungall K, Perizzolo M, Qian J, Roldan G, Smith EE, Tamura-Wells J, Thiessen N, Varhol R, Weiss S, Wu W, Young S, Zhao Y, Mungall A, Morin GB, Chan JA, Cairncross JG*, Marra MA*. Concurrent CIC mutations, IDH mutations and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol. 2012 Jan; 226(1):7-16. PMID: 22072542

  19. Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen F, Sahin M, Kwiatkowski DJ. Regulable neural progenitor-specific TSC1 loss yields giant cells with multi-organelle dysfunction in a mouse brain model of tuberous sclerosis complex. Proc Natl Acad Sci USA 2011 Nov 8; 108(45):E1070-9. PMID: 22025691

  20. Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles C, Santagata S, Chan JA, Kieran MW, Ligon KL. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov; 13(6):669-77. PMID: 21884820

  21. Roldan G, Chan J, Eliasziw M, Cairncross JG, Forsyth PA. Leptomeningeal disease in oligodendroglial tumors: a population-based study. J Neuro-Oncol, 2011; 104(3): 811-5. PMID: 21373968

  22. Lun XQ, Chan J, Zhou H, Sun B, Kelly JP, Stechishin O, Bell JC, Parato K, Hu K, Vaillant D, Wang J, Liu TC, Breitbach C, Kirn D, Senger DL, Forsyth PA. Efficacy and safety/toxicity of recombinant vaccinia virus JX-594 in two immunocompetent animal models of glioma. Molec Ther, 2010; 18(11): 1927-36. PMID: 20808290

  23. Pomerantz MM, Shrestha Y, Flavin RJ, Regan MM, Penney KL, Mucci LA, Stampfer MJ, Hunter DJ, Chanock SJ, Schafer EJ, Chan JA, Tabernero J, Baselga J, Richardson AL, Loda M, Oh WK, Kantoff PW, Hahn WC, Freedman ML. Analysis of the 10a11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis. PLoS Genet. 2010 Nov 11; 6(11):e1001204. PMID: 21085629

  24. Qin W*, Chan J*, Vinters H, Mathern G, Franz D, Taillon B, Bouffard P, Kwiatkowski D. Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2, and KRAS demonstrates that small second hit mutations in these genes are rare events. Brain Pathol. 2010 Nov;20(6):1096-105. (*equal contribution) PMID: 20633017

  25. Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res. 2010 Aug 15;16(16):4155-64. PMID: 20682713

  26. Kelly JP, Blough MD, Stechisin ODM, Chan JA, Beauchamp D, Perizzolo M, Demetrick DJ, Steele L, Auer RN, Hader WJ, Westgate M, Parney IF, Jenkins R, Cairncross JG, Weiss W. Oligodendroglioma cell lines containing t(1:19)(q10;p10). Neuro Oncol. 2010 Jul;12(7):745-55. PMID: 20388696

  27. MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18;4(11):e7887. PMID: 19924296

  28. Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, Watanabe G, Gabriel S, Friedman SL, Kumada H, Llovet JM, Golub TR. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 2009 Sep 15; 69(18): 7385-92. PMID: 19723656

  29. Pomerantz MM, Ahmadiyeh N, Jia L, Herman P, Verzi MP, Doddapaneni H, Beckwith CA, Chan JA, Hills A, Davis M, Yao K, Kehoe SM, Lenz HJ, Haiman CA, Yan C, Henderson BE, Frenkel B, Barretina J, Bass A, Tabernero J, Baselga J, Regan MM, Manak JR, Shivdasani R, Coetzee GA, Freedman ML. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet 2009 Aug;41(8):882-4. (IF: 35.53) PMID: 19561607

  30. Pomerantz MM, Beckwith CA, Regan MM, Wyman SK, Petrovics G, Chen Y, Hawksworth DJ, Schumacher FR, Mucci L, Penney KL, Stampfer MJ, Chan JA, Ardlie KG, Fritz BR, Parkin RK, Lin DW, Dyke M, Herman P, Lee S, Oh WK, Kantoff PW, Tewari M, McLeod DG, Srivastava S, Freedman ML. Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression. Cancer Res. 2009 Jul 1;69(13):5568-74. PMID: 19549893

  31. Chan JA*, Balasubramanian S*, Witt RM*, Nazemi KJ, Choi Y, Olson CA, Thompson M, Segal RA. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci, 2009 Apr;12 (4):409-17. (*equal contribution) PMID: 19287388

  32. Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang D, Camargo A, Gupta S, Moore J, Wrobel MJ, Lerner J, Reich M, Chan JA, Glickman JN, Ikeda K, Hashimoto M, Watanabe G, Roayaie S, Schwartz M, Thung S, Salvesen HB, Kumada H, Llovet JM, Golub TR. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 2008 Nov 6; 359(19): 1995-2004. PMID: 18923165

  33. Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25; 455(7212): 547-51. PMID: 18794900

  34. de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, DePinho RA, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 2008 Feb 15; 22: 449-62. PMID: 18258752

  35. Claus EB, Park PJ, Carroll R, Chan J, Black PM. Specific genes expressed in association with progesterone receptors in meningioma. Cancer Res. 2008 Jan 1; 68(1): 314-22. PMID: 18172325

  36. Cargioli TG, Ugur HC, Ramakrishna N, Chan JA, Carroll RS. Establishment of an in vivo Meningioma Model with hTERT. Neurosurg 2007 Apr; 60(4): 750-9. PMID: 17415213

  37. Redjal N, Chan JA, Segal RA, Kung AL. CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas. Clin Cancer Res, 2006 Nov 15; 12(22): 6765-71. PMID: 17121897

  38. Choi Y, Borghesani PR, Chan JA, Segal RA. Migration away from a mitogenic niche promotes cell cycle exit. J Neurosci, 2005 Nov 9; 25(45): 10437-45. PMID: 16280582

  39. Chan JA*, Krichevsky AM*, Kosik KS. Micro-RNA 21 is an anti-apoptotic factor in glioblastoma cells. Cancer Res, 2005 Jul 15; 65(14): 6029-33. (*equal contribution) PMID: 16024602

  40. Meikle L, McMullen JR, Sherwood MC, Lader AS, Walker V, Chan JA, Kwiatkowski DJ. A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes. Hum Mol Gen, 2005 Feb 1; 14: 429-35.: 15601645

  41. Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ. Pathogenesis of Tuberous Sclerosis Subependymal Giant Cell Astrocytomas: Biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropath Exp Neurol, 2004 Dec; 63(12): 1236-42. PMID: 15624760

  42. Lu T, Pan Y, Kao S-Y, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the aging human brain. Nature, 2004 Jun 24; 429(6994): 883-91. PMID: 15190254

  43. Rubin JB, Kung AL, Klein RS, Chan JA, Sun YP, Schmidt K, Kieran MW, Luster AD, Segal RA. A small molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci USA 2003; 100: 13513-8. PMID: 14595012

  44. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM. Oligodendrocyte lineage genes (OLIG) as markers for human glial brain tumors. Proc Natl Acad Sci USA 2001; 98:10851-6. PMID: 11526205






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