Ikuo Tsunoda, M. D., Ph. D

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Ikuo Tsunoda, M.D., Ph.D.

角田 郁生 (つのだ いくお)
生年月日: 19649月4日生 52

本籍: 岩手県盛岡市高松4丁目4-27

住所 近畿大学医学部微生物学講座 589-8511大阪府大阪狭山市大野東377-2

電話: 072-366-0221(内線 3256

ホーム・ページ http://www.med.kindai.ac.jp/microbio/

E-mail: itsunoda@med.kindai.ac.jp, itsunoda@hotmail.com

1990年 3月 東北大学医学部卒業、医師免許取得333902号)

1994年 3 東北大学大学院博士課程修了 医学博士(医学部病態神経学講座、岩崎祐三教授)東北大学;医博第1224号)       

1994年 4月 東北大学医学部病態神経学講座 助手

1995年 1 ユタ大学医学部神経内科学講座 Postdoctoral Fellow(ポストドクトラルフェロー)

1999年 1 ユタ大学医学部神経内科学講座 Research Associate (助手)

2002年 7 ユタ大学医学部神経内科学講座 Instructor (講師)

2005年 3 ユタ大学医学部神経内科学講座 Assistant Professor (准教授)

2007年 10 ユタ大学医学部病理学講座 細胞生物学・免疫学分野Assistant Professor (准教授), ユタ大学医学部神経内科学講座 Adjunct Assistant Professor (兼任准教授)

2009年 7 ルイジアナ州立大学医学部微生物学・免疫学講座Assistant Professor (准教授)

2015年 7 ルイジアナ州立大学医学部微生物学・免疫学講座Associate Professor (准教授)

2015年 7 ルイジアナ州立大学医学部神経内科学学講座Adjunct Associate Professor (兼任准教授)

2016年 4 近畿大学医学部微生物学講座教授



1996 The Educational Commission for Foreign Medical Graduates (ECFMG) Certification (外国医学部卒業者用米国臨床研修医師許可証)(certification number 0-449-653-5)

2006 The Consortium of Multiple Sclerosis Centers (CMSC) Travel Award

2008 American Association of Immunologists (AAI) Junior Faculty Travel Grant

2015 The LSUHSC-Shreveport Chancellor’s Award: Nicholas E. Martinez, PhD (Tsunoda laboratory Graduate Student from 2009-2014). The Award is presented to the most outstanding Graduate Student of Louisiana State University Health Sciences Center (LSUHSC)-Shreveport among graduates.


1990-2011 日本神経学会

1992-2012, 2017- 日本ウイルス学会

2002-2011 International Society for NeuroVirology (国際神経ウイルス学会)

2003-present American Association of Immunologists AAI, アメリカ免疫学会)

2003-present American Society for Virology(ASV, アメリカウイルス学会)

2003-present American Society for Microbiology (アメリカ微生物学会)

2012-2013 International Society of Neuroimmunology (ISNI, 国際神経免疫学会)

2012-2013 American Academy of Neurology (AAN) (米国神経学アカデミー)

2012-2016 American Heart Association (AHA) (アメリカ心臓協会)

2013-2016 American College of Cardiology (ACC) (アメリカ心臓病学会)

2016 International Society for Neurovascular Disease (ISNVD)

2016-present 日本多発性硬化症協会 医学顧問

2016-present 日本神経免疫学会 評議員

2016-present 日本神経感染症学会

2017-present Osaka Science-based Kampo 研究会 世話人

2005-2009 Ad Hoc Merit Grant Reviewer, The Salt Lake VA Research and Development Committee

2008 Ad Hoc Reviewer for the National Multiple Sclerosis Society (全米多発性硬化症協会NMSS, Pilot Research Award), 2008

2009-present Editorial Board Member, Multiple Sclerosis International

2010-2012 Editorial Board Member, Neural Regeneration Research

2010 Reviewer, The Congressionally Directed Medical Research Programs (CDMRP), Department of Defense (アメリカ国防総省), Multiple Sclerosis Research Program (MRSP)

2010-2013 Reviewer, The Italian Multiple Sclerosis Society (イタリア多発性硬化症協会AISM-FISM)

2010 Reviewer, The Italian Ministry of Health (イタリア保健省Research Funding Call grant 2009)

2011-2015 Editorial Board Member, The World Journal of Virology

2012-2015 Editorial Board Member, Virology Discovery

2013 Reviewer, アメリカ合衆国退役軍人省The Department of Veterans Affairs Neurobiology-B (NURB) Scientific Review Group

2014-present Editorial Board Member, BMC Neurology
2014 Reviewer, Multiple Sclerosis Society, UK (イギリス多発性硬化症協会Project Grant)

2015-present Reviewer, Swiss Multiple Sclerosis Society (スイス多発性硬化症協会Research Grant)

2015-present Ad Hoc Reviewer, アメリカ国立衛生研究所(NIH), Centers of Biomedical Research Excellence (COBRE), Pacific Center for Emerging Infectious Diseases Research, COBRE Small Grants Program P30GM114737. University of Hawaii

2016-present Editorial Board Member, Clinical & Experimental Neuroimmunology (CENI)

2016 Reviewer, フロリダ州保健省Florida Department of Health, Zika Research Grant Initiative


Acta Neurobiologiae Experimentalis, Acta Neuropathologica, Acta Neuropathologica Communications, Advances in Virology, Advances in Virus Research

American Journal of Physiology – Heart and Circulatory Physiology

Antiviral Research. Autoimmunity, Bioscience Reports, BioTechniques, BMC Neurology, BMC Neuroscience

Brain, Behavior, and Immunity, Brain Research, Brain Sciences

Clinical and Experimental Neuroimmunology, Clinical Investigation

European Journal of Pharmacology, Expert Review of Neurotherapeutics

Hepatic Medicine: Evidence and Research, Human Immunology

Immunological Investigations, International Journal of Molecular Sciences, Journal of Cellular and Molecular Medicine

Journal of Neuroimmune Pharmacology, Journal of Neuroimmunology

Journal of Neuroinflammation, Journal of Neuropathology & Experimental Neurology

Journal of NeuroVirology, Journal of Virology, Journal of Visualized Experiments (JoVE)

Nanomedicine: Nanotechnology, Biology and Medicine, Neuroscience

Neuroscience Journal, Neuroscience Research, Neurotherapeutics, Oxidative Medicine and Cellular Longevity, Pathophysiology, PLoS One, PLoS Pathogen, Progress in Neurobiology, Scientific Reports, Vaccine, Viral Immunology, Virology, Virology Journal, World Journal of Neurology


National Multiple Sclerosis Society (NMSS) Pilot Research Award PP0994, 2004-2005, Lesion development from inside (axon) to outside (myelin): Inside-Out models. $44,000. 代表
The Funding Incentive Seed Grant, University of Utah, 2006-2008, Does Axonal Injury Recruit Inflammatory Cells to the Site of Axonal Degeneration, Targeting Demyelinating Lesions? Inside-Out Model for Multiple Sclerosis. $24,000. 代表
National Multiple Sclerosis Society (NMSS) Pilot Research Award PP1499, 2008-2009, Treatment of Animal Models for MS with Resveratrol, a Natural Compound in Red Wine. $44,000. 代表
National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS), R21NS059724, 2008-2011
Axonal Degeneration can Trigger Demyelinating Disease.  

$341,840. 代表

Louisiana State University Health Sciences Center (LSIHSC), Research Council Seed Package, 2009 – 2012

$150,000. 代表
アメリカ国立衛生研究所 (NIH)/National Center for Research Resources (NCRR) (5P20RR018724-10) and National Institute of General Medical Sciences (NINGS) (8P20GM103433-10), 2010-2014
Th Cells in Theiler’s Virus Persistence and Pathology. $
370,000. プロジェクト・リーダー
TEVA Neuroscience Investigator-Initiated Studies Program, 2012-2014

Neuroprotective Role of Glatiramer Acetate in a Viral Model for Multiple Sclerosis. $125,000. 代表
Malcolm Feist Cardiovascular Research Fellowship, 2011-2014

Systems Biology Approach for Molecular Mechanisms in Viral Myocarditis. $225,000. (Funds support salary and supplies for Dr. Seiichi Omura in Tsunoda laboratory, Tsunoda I, Sponsor/mentor)

Malcolm Feist Cardiovascular Research Fellowship, 2011-2014

Regulatory Role of Natural Killer T cells in Cardiovirus-induced Myocarditis. $225,000. (Funds support salary and supplies for Dr. Fumitaka Sato in Tsunoda laboratory, Tsunoda I, Sponsor/mentor)

Louisiana State University Health Sciences Center (LSUHSC), Research Development funds, 2013 – 2014. $100,000. 代表
アメリカ国立衛生研究所 (NIH)/National Institute of General Medical Sciences (NIGMS) Centers of Biomedical Research Excellence (COBRE) III Pilot Grant (P30-GM110703), 2014-2016
Role of Th17/Treg Immunoregulatory Axis in a Viral Model for Multiple Sclerosis. $100,000.
Louisiana State University Health Sciences Center (LSUHSC), Neurology Research Grant, 2015-2017. $75,000. (Tsunoda I is PI).
日本学術振興会 科学研究費助成事業 研究種目 研究活動スタート円 研究課題/領域番号 16H07356 多発性硬化症のウイルスモデルのTh17/Treg細胞の役割は病期によって異なるか 2016-08-26 – 2018-03-31 2,730千円 (直接経費 : 2,100千円、間接経費 : 630千円) 2016年度 : 1,430千円 (直接経費 : 1,100千円、間接経費 : 330千円)
I. 著書


  1. 角田郁生. (2017). MSの動物モデルについて教えてください 吉良潤一編集 <シリーズ>神経内科 Clinical Questions Pearls「中枢性脱髄疾患」中外医学社 東京 日本

  2. 角田郁生. (2017). 中枢神経系の免疫疾患 宮澤正顕編集 カラーイラストで学ぶ 集中講義 免疫学 メジカルビュー社 東京 日本

  3. 角田郁生. (2017). 末梢神経系の免疫疾患 宮澤正顕編集 カラーイラストで学ぶ 集中講義 免疫学 メジカルビュー社 東京 日本


  1. Tsunoda I and Fujinami RS. (1999). Theiler’s murine encephalomyelitis virus (TMEV). In: Persistent Viral Infections. Ahmed R and Chen ISY (Eds.), John Wiley & Sons, Ltd., Chichester, West Sussex, England, pp. 517-536.

  2. Tsunoda I and Fujinami RS. (2005). TMEV and neuroantigens: Myelin genes and proteins, molecular mimicry, epitope spreading and autoantibody-mediated remyelination. In: Experimental Models of Multiple Sclerosis. Lavi E and Constantinescu CS (Eds.), Springer, New York NY. pp. 593-616.

  3. Tsunoda I, Kobayashi-Warren, M, Libbey JE, and Fujinami RS. (2009). Central nervous system degeneration caused by autoimmune cytotoxic CD8+ T cell clones and hybridomas. Binder MD, Hirokawa N, Windhorst U (Eds), Encyclopedia of Neuroscience, Springer-Verlag GmbH Berlin Heidelberg. pp. 619-625.

  4. Sato F, Omura S, Martinez NE and Tsunoda I. (2011). Animal models for multiple sclerosis. In: Neuroinflammation. Minagar A (Ed), Elsevier, Burlington, MA. pp. 55-79.

  5. Sato F, Omura S, Jaffe SL, and Tsunoda I. (2016). Role of CD4+ T lymphocytes in pathophysiology of  multiple sclerosis. In: Multiple Sclerosis: A Mechanistic View. Minagar A (Ed), Elsevier Inc., London, UK. pp. 41-69.

  6. Sato F, Omura S, Martinez NE and Tsunoda I. (2017). Animal models for multiple sclerosis. In: Neuroinflammation (2nd edition). Minagar A (Ed), Elsevier, Burlington, MA. in press.

II. 総説


  1. 角田郁生. (2016). 多発性硬化症と心筋炎のウイルスモデル. 近畿大医誌 (Med J. Kindai Univ413-4):7A-9A

  2. 角田郁生、尾村誠一、佐藤文孝、崎山奈美江、朴雅美 藤田貢. (2017).  ウイルス感染によって誘導される“軸索型”多発性硬化症動物モデル:インサイド-アウト・モデル. Neuroinfection 神経感染症 22128-35.


1. Tsunoda I and Fujinami RS. (1996). Two models for multiple sclerosis: Experimental allergic encephalomyelitis and Theiler’s murine encephalomyelitis virus. J. Neuropathol. Exp. Neurol. 55 (6): 673-686.

2. Tsunoda I and Fujinami RS. (2002). Inside-Out versus Outside-In models for virus induced demyelination: Axonal damage triggering demyelination. Springer Semin. Immunopathol. 24 (2): 105-125.

3. McCoy L, Tsunoda I and Fujinami RS. (2006). Multiple sclerosis and virus induced immune responses: Autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity, 39 (1): 9-19.

4. Libbey JE, Tsunoda I and Fujinami RS. (2006). Autologous hematopoietic stem cell transplantation: A cure for multiple sclerosis? Future Neurol. 1 (4): 403-408.

5. Tsunoda I. Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. (2008). Future Virol. 3 (6): 579-593.

6. Penberthy WT and Tsunoda I. The importance of NAD in multiple sclerosis. (2009). Curr. Pharm. Des, 15 (1): 64-99.

7. Tsunoda I and Fujinami RS. (2009). Neuropathogenesis of Theiler’s Murine Encephalomyelitis Virus Infection, a viral model for multiple sclerosis. J. Neuroimmune Pharmacol, 5 (3): 355-369.

8. Libbey JE, Tsunoda I and Fujinami RS. (2010). Studies in the modulation of experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol, 5 (2): 168-175.

9. Sato F, Tanaka H, Hasanovic F and Tsunoda I. (2011). Theiler’s murine virus infection: Pathophysiology of demyelination and neurodegeneration. Pathophysiology 18 (1): 31-41.

10. Sato F, Martinez NE, Omura S and Tsunoda I. (2011). Heterogeneity versus homogeneity of multiple sclerosis. Expert Rev Clin Immunol, 7 (2):165-167.

11. Martinez NE, Sato F, Omura S, Chervenak RP and Tsunoda I. (2012). Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis. Future Virol, 7 (6): 593-608.

12. Martinez NE, Sato F, Omura S, Minagar A, Alexander JS and Tsunoda I. (2013). Immunopathological patterns from EAE and Theiler’s virus infection: Is multiple sclerosis a homogenous 1-stage or heterogeneous 2-stage disease? Pathophysiology 20 (1): 71-84. PMCID: PMC3430756

13. Sato F, Martinez NE, Stewart EC, Omura S, Alexander JS, and Tsunoda I. (2015). “Microglial nodule” and “newly forming lesion” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model. BMC Neurol., 15:219

14. Yun J.W. Xiao A, Tsunoda I, Minagar A, and Alexander JS. (2016). From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases. Pathophysiology 23 (4): 265-274.

15. Tsunoda I, Sato F, Omura S, Fujita M, Sakiyama N, and Park A-M. (2016). Three immune-mediated disease models induced by Theiler’s virus: Multiple sclerosis, seizures, and myocarditis. Clin Exp Neuroimmunol, 7 (4): 330-345.

16. Tsunoda I, Omura S, Sato F, Kusunoki S, Fujita M, Park A-M, Hasanovic F, Yanagihara R, and Nagata S. (2016). Neuropathogenesis of Zika virus infection: Potential roles of antibody-mediated pathology. Acta Med Kindai Univ, 41 (2): 37-52.

17. Tsunoda I. (2017). Lymphatic system and gut microbiota affect immunopathology of neuroinflammatory diseases, including multiple sclerosis, neuromyelitis optica, and Alzheimer’s disease. Clin Exp Neuroimmunol, 8(3): 177-179.

18. Park A-M, Omura S, Fujita M, Sato F, and Tsunoda I. (2017). Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer’s disease: 10 pitfalls of microbiome studies. Clin Exp Neuroimmunol, 8(3): 215-232.

19. Fujita M, Omura S, Sato F, Park AM, and Tsunoda I. (2017). Influx and efflux of immune cells in the central nervous system. Anat Physiol 7 (4): 274.

III. 原著


  1. 角田郁生、粟野裕行、斉藤佐、塚本哲朗、山本悌司. (1991). 胃切除後亜急性連合性脊髄変性症の1例. 消化器科15 (5): 490-494.

  2. 角田郁生. (2011). 望小達大 ルイジアナ州シュリーブポートより-Louisiana State University Health Sciences Center. 実験医学 29 (9): 1460-1462.


  1. Iwasaki Y, Sako K, Tsunoda I and Ohara Y. (1993). Phenotypes of mononuclear cell infiltrates in human CNS. Acta Neuropathol. (Berl) 85 (6): 653-657.

  2. Tsunoda I, Awano H, Kayama H, Tsukamoto T, Ueno S, Fujiwara T, Watanabe M and Yamamoto T. (1994). Idiopathic AA amyloidosis manifested by autonomic neuropathy, vestibulocochleopathy, and lattice corneal dystrophy. J. Neurol. Neurosurg. Psychiatry 57 (5): 635-637.

  3. Saito T, Hida C, Tsunoda I, Tsukamoto T and Yamamoto T. (1994). Melkerson-Rosenthal syndrome: distal facial nerve branch palsies, masseter myopathy and corticosteroid treatment. Fukushima J. Med. Sci. 40 (1): 39-44.

  4. Tsunoda I, Kanno H, Watanabe M, Shimoji S, Hirayama K, Sumita H and Yamamoto T. (1994). Acute simultaneous bilateral vestibulocochlear impairment in neuro-Behcet's disease: A case report. Auris Nasus Larynx 21 (4): 243-247.

  5. Tsunoda I, Endo K, Hirayama K, Saito N, Hida C, Tsukamoto T and Yamamoto T. (1995). The POEMS syndrome with intracranial hypertension. Fukushima J. Med. Sci. 41 (1): 61-69.

  6. Tsunoda I, Iwasaki Y, Sako K, Terunuma H and Ohara Y. (1996). A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses (TMEV). Acta Neuropathol. (Berl) 91 (6): 595-602.

  7. Tsunoda I, Kurtz CIB and Fujinami RS. (1997). Apoptosis in acute and chronic central nervous system disease induced by Theiler’s murine encephalomyelitis virus. Virology 228 (2): 388-393.

  8. Tsunoda I, McCright IJ, Kuang L-Q, Zurbriggen A and Fujinami RS. (1997). Hydrocephalus in mice infected with Theiler’s murine encephalomyelitis virus variant. J. Neuropathol. Exp. Neurol. 56 (12): 1302-1313.

  9. Rose J, Hill K, Wada Y, Kurtz C, Tsunoda I, Fujinami RS and Cross A. (1998). Nitric oxide synthase inhibitor, aminoguanidine, alters inflammation and demyelination produced by Theiler’s virus infection. J. Neuroimmunol. 81 (1-2): 82-89.

  10. Tsunoda I, Kuang L-Q, Tolley ND, Whitton JL and Fujinami RS. (1998). Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA. J. Neuropathol. Exp. Neurol. 57 (8): 758-767.

  11. Wada Y, McCright IJ, Whitby FG, Tsunoda I and Fujinami RS. (1998). Replacement of loop II of VP1 of the DA strain with loop II of the GDVII strain of Theiler’s murine encephalomyelitis virus alters neurovirulence, viral persistence and demyelination. J. Virol. 72 (9): 7557-7562.

  12. Tolley ND, Tsunoda I and Fujinami RS. (1999). DNA vaccination of SJL/J mice against Theiler’s murine encephalomyelitis virus leads to alternations in CNS disease. J. Virol. 73 (2): 993-1000.

  13. Tsunoda I, Sette A, Fujinami RS, Oseroff C, Ruppert J, Dahlberg C, Southwood, S, Arrhenius T, Kuang L-Q, Kubo RT, Chesnut RW and Ishioka G. (1999). Lipopeptide particles as the immunologically active component of CTL inducing vaccines. Vaccine 17 (7-8): 675-685.

  14. McCright IJ, Tsunoda I, Whitby FG and Fujinami RS. (1999). Theiler’s viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. J. Virol. 73 (4): 2814-2824.

  15. Tsunoda I, Tolley ND, Theil DJ, Whitton JL, Kobayashi H and Fujinami RS. (1999). Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA. Brain Pathol. 9 (3): 481-493.

  16. Theil DJ, Tsunoda I, Libbey JE, Derfuss TJ and Fujinami RS. (2000). Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler’s virus infections. J. Neuroimmunol. 104 (1): 22-30.

  17. Tsunoda I, Kuang, L-Q, Theil DJ and Fujinami RS. (2000). Antibody association with a novel model for primary progressive multiple sclerosis: Induction of relapsing-remitting and progressive forms of EAE in H2S mouse strains. Brain Pathol. 10 (3): 402-418.

  18. Libbey JE, McCright IJ, Tsunoda I, Wada Y and Fujinami RS. (2001). Peripheral nerve protein, P0, as a potential receptor for Theiler’s murine encephalomyelitis virus. J. NeuroVirol. 7 (2): 97-104.

  19. Tsunoda I, Wada Y, Libbey JE, Cannon TS, Whitby FG and Fujinami RS. (2001). Prolonged gray matter disease without demyelination caused by Theiler’s murine encephalomyelitis virus with a mutation in VP2 puff B. J. Virol. 75 (16): 7494-7505.

  20. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2001). Viruses can silently prime for and trigger central nervous system autoimmune disease. J. NeuroVirol. 7 (3): 220-227.

  21. Libbey JE, Tsunoda I and Fujinami RS. (2002). Altered cell growth and morphology in a BHK-21 cell mutant that lacks a receptor for Theiler’s murine encephalomyelitis virus (TMEV). Virology 294 (1): 85-93.

  22. McCright IJ, Tsunoda I and Fujinami RS. (2002). Mutation in loop I of VP1 of Theiler’s virus delays viral RNA release into cells and enhances antibody-mediated neutralization: A mechanism for the failure of persistence by the mutant virus. J. NeuroVirol. 8 (2): 100-110.

  23. Tsunoda I, Kuang L-Q and Fujinami RS. (2002). Induction of autoreactive CD8+ cytotoxic T cells during Theiler’s murine encephalomyelitis virus infection: Implications for autoimmunity. J. Virol. 76 (24): 12834-12844.

  24. Wang M, Libbey JE, Tsunoda I and Fujinami RS. (2003). Modulation of immune system function by measles virus infection. II. Infection of B cells leads to the production of a soluble factor that arrests uninfected B cells in G0/G1. Viral. Immunol. 16 (1): 45-56.

  25. Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2003). Axonal injury heralds virus induced demyelination. Am. J. Pathol. 162 (4): 1259-1269.

  26. Tsunoda I, Lane TE, Blackett J and Fujinami RS. (2004). Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult. Scler. 10 (1): 26-34.

  27. Tsunoda I, Kuang L-Q, Igenge IZM and Fujinami RS. (2005). Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation, J. Neuroimmunol. 160 (1-2): 122-34.

  28. Tsunoda I, Kuang L-Q, Kobayashi-Warren M and Fujinami RS. (2005). Central nervous system pathology caused by autoreactive CD8+ T cell clones following virus infection. J. Virol. 79 (23): 14640-14646.

  29. Tsunoda I, Libbey JE, Kuang L-Q, Terry EJ and Fujinami RS. (2005). Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am. J. Pathol. 167 (6): 1631-1646.

  30. Tsunoda I, Libbey JE, Kobayashi-Warren M and Fujinami RS (2006). IFN-γ production and astrocyte recognition by autoreactive T cells induced by Theiler’s virus infection: role of viral strains and capsid proteins. J. Neuroimmunol. 172 (1-2): 85-93.

  31. Carlson NG, Hill KE, Tsunoda I, Fujinami RS and Rose JW. (2006). The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. J. Neuroimmunol. 174 (1-2): 21-31.

  32. Libbey JE, Peterson LK, Tsunoda I and Fujinami RS. (2006). Monoclonal MOG-reactive autoantibody from progressive EAE has the characteristics of a natural antibody. J. Neuroimmunol. 173 (1-2): 135-145.

  33. Tsunoda I, Tanaka T, Terry EJ and Fujinami RS. (2007). Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: When can axonal injury be beneficial? Am. J. Pathol. 170 (1): 214-226.

  34. Libbey JE, Tsunoda I, Whitton JL and Fujinami RS. (2007). Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler’s murine encephalomyelitis virus. J. Virol. 81 (6): 3009-3011.

  35. Peterson LK, Tsunoda I, Masaki T and Fujinami RS. (2007). Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis. J. Neuroimmunol. 183 (1-2): 69-80.

  36. Tsunoda I, Terry EJ, Marble BJ, Lazarides E, Woods C and Fujinami RS. (2007). Modulation of experimental allergic encephalomyelitis by VLA-2 blockade. Brain Pathol. 17 (1): 45-55.

  37. Tsunoda I, Libbey JE and Fujinami RS. (2007). Sequential polymicrobial infections lead to CNS inflammatory disease: Possible involvement of bystander activation in heterologous immunity. J. Neuroimmunol. 188 (1-2): 22-33.

  38. Tsunoda I, Libbey JE and Fujinami RS. (2007). TGF-β suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler’s virus. J. Neuroimmunol. 190 (1-2): 80-89.

  39. Tsunoda I, Tanaka T, Saijoh Y and Fujinami RS. (2007). Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration. Am. J. Pathol. 171 (5): 1563-1575.

  40. Peterson LK, Tsunoda I and Fujinami RS. (2008). Role of CD5+ B-1 cells in EAE pathogenesis. Autoimmunity 41 (5): 353-362.

  41. Peterson LK, Tsunoda I, Libbey JE and Fujinami RS. (2008). Role of B:T cell ratio in suppression of clinical signs: a model for silent MS. Exp. Mol. Pathol. 85 (1): 28-39.

  42. Peterson LK, Masaki T, Wheelwright SR, Tsunoda I and Fujinami RS. (2008). Cross-reactive myelin antibody induces renal pathology. Autoimmunity, 41 (7): 526-36.

  43. Theil DJ, Libbey LE, Rodriguez F, Whitton JL, Tsunoda I, Derfuss TJ and Fujinami RS.  (2008). Targeting myelin proteolipid protein to the MHC class I pathway by ubiqitination modulates the course of experimental autoimmune encephalomyelitis.  J. Neuroimmunol., 204 (1-2): 92-100.

  44. Tsunoda I, Tanaka T and Fujinami RS. (2008). Regulatory role of CD1d in neurotropic virus infection. J. Virol., 82 (20): 10279-10289.

  45. Tsunoda I, Libbey JE and Fujinami RS. (2009). Theiler's murine encephalomyelitis virus attachment to the gastrointestinal tract is associated with sialic acid binding. J. NeuroVirol., 15 (1): 81-89.

  46. Tsunoda I, Tanaka T, Taniguchi M and Fujinami RS. (2009). Contrasting roles for V14+ NKT cells in a viral model for multiple sclerosis. J. NeuroVirol., 15 (1): 90-98.

  47. Greenlee JE, Clawson SA, Hill KE, Wood BL, Tsunoda I and Carlson NG. (2010). Purkinje cell death after uptake of anti-Yo antibodies in cerebellar slice cultures. J Neuropathol Exp Neurol., 69 (10): 997-1007.

  48. Libbey JE, Cusick MF, Tsunoda I and Fujinami RS. (2012). Antiviral CD8+ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice. J NeuroVirol., 18 (2): 127-137.

  49. Tsunoda I, Libbey JE and Fujinami RS. (2012). Immunization with Structural and Non-Structural proteins of Theiler's murine encephalomyelitis virus alters demyelinating disease. J. NeuroVirol., 18 (2): 127-137.

  50. Libbey JE, Tsunoda I and Fujinami RS. (2012). Role of interleukin-17 in a prime/challenge model of multiple sclerosis. J. NeuroVirol., 18 (6): 471-478.

  51. Karlsson F, Martinez NE, Gray L, Zhang S, Tsunoda I and Grisham MB. (2013). Therapeutic evaluation of ex vivo-generated vs. natural regulatory T-cells in a mouse model of chronic gut inflammation. Inflamm Bowel Dis., 19 (11): 2282-2294.

  52. Sato F, Martinez NE, Shahid M, Rose JW, Carlson NG and Tsunoda I. (2013). Resveratrol exacerbates both autoimmune and viral models for multiple sclerosis. Am. J. Pathol., 183 (5): 1390-1396.

  53. Chaitanya GV, Omura S, Sato S, Martinez NE, Minagar A, Ramanadhan M, Guttman BW, Zivadinov R, Tsunoda I and Alexander JS. (2013). Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature. J. Neuroinflammation, 10 (1): 125.

  54. Alexander JS, Prouty L, Tsunoda I, Ganta CV and Minagar A. (2013). Venous endothelial injury in central nervous system diseases. BMC Medicine, 11:219.

  55. Martinez NE, Karlsson F, Sato F, Kawai E, Omura S, Grisham MB, Minagar A and Tsunoda I. (2014). Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis.  Brain Pathol., 24 (5): 436-51. PMID: 24417588

  56. Fernando V, Omura S, Martinez NE, Sato F, Kawai E, Elliott SF, Takahashi S, Yoh K, and Tsunoda I. (2014). Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int. J. Mol. Sci., 15: 1700-1717.

  57. Omura S, Kawai E, Sato F, Martinez NE, Chaitanya GV, Rollyson P, Cvek U, Trutschl M, Alexander JS, and Tsunoda I. (2014). Bioinformatics multivariate analysis determined a set of phase-specific biomarker candidates in a novel mouse model for viral myocarditis. Circ. Cardiovasc. Genet., 7: 444-454. PMID: 25031303

  58. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Jaskowski TD, and Carlson NG. (2014). Neuronal uptake of anti-Hu antibody but not anti-Ri antibody leads to cell death in brain slice cultures. J. Neuroinflammation, 11(1): 160. PMID: 25228406

  59. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2014) RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis in novel Th17-biased transgenic mice. J. Neuroimmunol., 276: 142-149. PMID: 25288300

  60. Sato F, Omura S, Kawai E, Martinez NE, Acharya MM, Reddy PC, Chaitanya GV, Alexander JS and Tsunoda I. (2014). Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler’s virus infection. Cell. Immunol., 292 (1-2): 85-93.

  61. Kawai E, Sato F, Omura S, Martinez NE, Reddy PC, Taniguchi M., and Tsunoda I. (2015). Organ-specific protective role of NKT Cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain. J. Neuroimmunol., 278 (1-2):174-784. PMID: 25434008

  62. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2015). Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav. Immun., 43: 86-97. PMID:25046854

  63. Becker F, Potepalov S, Shehzahdi R, Bernas M, Witte M, Abreo F, Traylor J, Orr WA, Tsunoda I, Alexander JS. (2015). Downregulation of FoxC2 increased susceptibility to experimental colitis: Influence of lymphatic drainage function? Inflamm. Bowel Dis., 21 (6): 1282-96. PMID:25822012

  64. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, and Carlson NG. (2015). Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One, 10 (4):e0123446. PMID: 25885452

  1. Al-Kofahi M, Becker F, Gavins FNE, Woolard M, Tsunoda I, Wang Y, Ostanin D, Zawieja DC, Muthuchamy M, von der Weid PY, and Alexander JS. (2015). IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with involvement of cyclooxygenase-2 and prostaglandin E2. Br. J. Pharmacol. 172 (16): 4038-51. PMID: 25989136

  2. Alexander JS, Chervenak R, Weinstock-Guttman B, Tsunoda I, Ramanthan M, Martinez N, Sato F, Chaitanya GV, Minagar A, Monceaux C, McGee J, Jennings MH, Becker F, Cvek U, Trutschl M, and Zivadinov R. (2015). Blood circulating microparticle species in relapsing-remitting and secondary progressive multiple sclerosis. A case-control, cross sectional study with conventional MRI and advanced iron content imaging outcomes. J Neurol. Sci. 355 (1-2): 84-9. PMID: 26073484

  3. Becker F, Kurmaeva, E, Gavins FNE, Stevenson EV, Navratil AR, Jin L, Tsunoda I, Orr AW, Alexander JS, and Ostanin DV. (2016). A critical role for monocytes/macrophages during intestinal inflammation-associated lymphangiogenesis. Inflamm. Bowel Dis.  221326-1345. PMID: 26950310

  4. Kanai K, Park A-M, Yoshida H, Tsunoda I, and Yoshie O. (2017). IL-35 suppresses lipopolysaccharide-induced airway eosinophilia in EBI3-defieicent mice. J. Immunol. 198 (1), 119-121.

  5. Sato F, Kawai E, Martinez NE, Omura S, Park A-M, Takahashi S, Yoh K, and Tsunoda I. (2017). T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection. Sci. Rep. in press.

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