Identification of 23 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs Supplementary Table Table S1 Additional 95 active compounds with an ic



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Identification of 23 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs
Supplementary Table

Table S1 Additional 95 active compounds with an IC50 of 10 to 30 µM, SI<10 fold, or without FDA approval for human use that block Ebola VLP entry into HeLa cells

Drug Name

Block Ebola VLP entry

Cytotoxicity

Selectivity

Approved Indication

 

IC50 (M)

Max. Inh. (%)

IC50 (M)

Index (fold)

 



















Tazobactam*

0.273

83

> 500

> 1833

Antimicrobial (beta-lactamas inhibitor)

Pivoxil Sulbactam*

1.72

90

> 500

> 291

Antimicrobial (beta-lactamas inhibitor)

Dipyrithione

1.88

82

> 500

> 266

Fungicide

Triparanol

3.06

96

24.3

8

Antilipemic

Malachite Green Chloride

3.43

95

43.2

13

Antiinfective Agent

Methylbenzethonium Chloride

3.85

69

24.3

6

Anti-Ulcerogenic

Perhexiline

3.85

102

24.3

6

Antianginal

Mequitazine

3.85

97

27.3

7

Antihistamine / Anticholinergic

Perphenazine

4.32

94

27.3

6

Antipsychotic

(S)-(+)-Niguldipine Hydrochloride

4.32

92

> 500

> 116

Calcium Channel Blocker

Amindocate

4.32

79

> 500

> 116

NA

Ebastine

4.32

99

12.2

3

Antihistamine

Mk-2206

4.32

99

250

58

NA

Bepridil

4.85

101

21.7

4

Anti-Anginal

Fluspirilene

4.85

103

27.3

6

Antipsychotic

Proadifen Hydrochloride

4.85

89

27.3

6

Inhibitor Of Cytochrome P450 Enzymes

Thioridazine..Hcl

4.85

98

27.3

6

Antipsychotic

Nitromersol

4.85

96

17.2

4

Antiseptic / Disinfectant

Clocapramine

4.85

100

30.6

6

Antipsychotic

Difeterol

5.44

99

30.6

6

NA

Pamicogrel

5.44

60

> 500

> 92

Anti-Platelet-Aggregation (Experimental)

Fluoperazine Dihydrochloride

5.44

90

30.6

6

Antipsychotic

Oxethazaine

6.11

70

34.3

6

Anesthetic

Fendiline

6.11

86

27.3

4

Calcium Channel Blocker.

Rimcazole Dihydrochloride

6.11

98

34.3

6

Antipsychotic

Indocate

6.11

86

> 500

> 82

NA

Astemizole

6.85

102

27.3

4

Antihistamine

Ftormetazine

6.85

92

30.6

4

NA

Sertindole

6.85

104

43.2

6

Antipsychotic

Vanoxeamine

7.69

100

21.7

3

Cardiac Arrhythmias

Octoclothepin Maleate Salt

7.69

99

27.3

4

NA

Desloratadine

7.69

106

27.3

4

Allergies

Cinacalcet Hydrochloride

7.69

71

43.2

6

Hyperparathyroidism

Odanacatib

7.69

66

> 500

> 65

Osteoporosis / Bone Metastasis (Experimental)

L-Alpha-Acetyl-N-Normethadol

7.96

102

63.2

8

NA

Lidoflazine

8.63

100

27.3

3

Antiarrhythmic

Methiothepin Maleate

8.63

99

34.3

4

Antipsychotic

Duloxetine Hydrochloride

8.63

95

30.6

4

Antidepressant

Tandutinib

8.63

92

> 500

> 58

Anticancer (Experimental)

Metixene Hydrochloride

8.63

104

30.6

4

Anticholinergic

Triflupromazine Hydrochloride

9.68

95

43.2

4

Antipsychotic

Drofenine Hydrochloride

9.68

94

> 500

> 52

NA

Thenalidine

9.68

88

> 500

> 52

Antihistamine

Mosapramine

9.68

103

43.2

4

Antipsychotic

Buprenorphine

9.87

79

35.0

4

Anti-Addictive

Pimozide

10.9

113

34.3

3

Antipsychotic

Prochlorperazine

10.9

103

27.3

3

Antipsychotic

Homochlorcyclizine..2Hcl

10.9

95

250

23

Antihistamine

Carbetapentane Citrate

10.9

88

> 500

> 46

Antitussive

Lapatinib

10.9

91

17.2

2

Anticancer

Zanapezil Fumerate

10.9

91

> 500

> 46

NA

Rescimetol

10.9

91

> 500

> 46

NA

Bamipine

10.9

95

> 500

> 46

Antihistamine

Nebivolol Hydrochloride

10.9

91

27.3

3

Hypertension

Proscillaridin A

10.9

60

0.0

0

Congestive Heart Failure / Cardiac Arrhythmia

Chlorprothixene Hydrochloride

12.2

96

43.2

4

Antipsychotic

Protryptyline Hydrochloride

12.2

98

250

21

Antidepressant

Metergoline

12.2

95

34.3

3

Antipsychoactive

Propiverine Hydrochloride

12.2

98

250

21

Anticholinergic

Amoxapine

13.7

103

> 500

> 37

Antidepressant

Benzydamine Hydrochloride

13.7

92

> 500

> 37

Anti-Inflammatory

Dimethisoquin Hydrochloride

13.7

80

250

18

Antipruritic

Tioconazole

13.7

92

250

18

Antifungal

Sarpogrelate

13.7

101

> 500

> 37

Diabetes Mellitus

Halofantrine

13.7

93

> 500

> 37

Antimalaria

Monatepil

13.7

93

> 500

> 37

Antihypertensive

Methadone Hydrochloride

14.1

104

> 500

> 37

Anti-Addictive

Amitriptyline Hydrochloride

15.3

99

> 500

> 33

Antidepressant

Promazine Hydrochloride

15.3

94

250

16

Antipsychotic

Trimipramine Maleate

15.3

97

> 500

> 33

Antidepressant

Pimethixene Maleate

15.3

93

> 500

> 33

Antihistamine / Anticholinergic

(S)-(+)-Dimethindene Maleate

15.3

90

> 500

> 33

Antihistamine / Anticholinergic

Cantharidin

15.3

103

250

16

Blister Agent

Roxindole Hydrochloride

15.3

90

> 500

> 33

Schizophrenia

Canertinib

15.3

98

250

16

Anticancer (Experimental)

Dopexamine

15.3

74

> 500

> 33

Adrenergic Beta-Agonists

Butriptyline

15.3

96

> 500

> 33

Antidepressant

Cyproheptadine Hydrochloride

17.2

96

> 500

> 29

Antihistamine

Trihexyphenidyl Hydrochloride

17.2

97

> 500

> 29

Antiparkinsonian

Diphenidol Hydrochloride

17.2

84

> 500

> 29

Antiemetic

Carvedilol

17.2

89

43.2

3

Adrenergic Alpha-1 Receptor Antagonists

Orphenadrine Hydrochloride

19.3

92

> 500

> 26

Parkinsonism

Diphenylpyraline Hydrochloride

19.3

88

> 500

> 26

Antihistamine

Bromperidol

19.3

93

250

13

Antipsychotic

Ami-193

19.3

76

> 500

> 26

5-Ht2A, 5-Ht1A, And D2 Receptor Antagonist

Mesoridazine Besylate

19.3

94

> 500

> 26

Phenothiazine

Ipenoxazone Hydrochloride

19.3

76

> 500

> 26

NA

Dibucaine Hydrochloride

21.7

92

> 500

> 23

Anesthetics

Tomoxetine Hydrochloride

21.7

87

> 500

> 23

Attention Deficit-Hyperactivity Disorder

Dasatinib

21.7

100

> 500

> 23

Anticancer

Premethadone

22.1

87

> 500

> 23

NA

Sulconazole Nitrate

24.3

76

30.6

1

Antifungal

Octylonium Bromide

24.3

71

43.2

2

Antimuscarinic

Axitinib

27.3

61

30.6

1

Anticancer

*These beta-lactamase inhibitors most likely inhibited the reporter enzyme instead of VLP entry.


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