Is this redundant? This was mentioned in the section on non-neuronal plasticity and perhaps should merely be elaborated more in that section there are two studies that might be discussed in more detail either in that section or here. Tj's ensheathment paper fits in this discussion. The point of putting it here is by way of a segue into a discussion of the tendency to ignore non neuronal (or even nonsynaptic) changes. THIS HAS BEEN DONE
THESE CONCEPTS SEEMS TO GO WITH THIS SECTION:
Synaptic specificity supported by “synaptic tag” that is localized and protein-synthesis independent (Frey and Morris, 1997). Fits concept of metaplasticity in that history of synapse (even sub optimal stimulation patterns) pre-disposes synapse to subsequent modification.
Could consider integrating notion of differential parameters necessary/sufficient to induce LTP (emphasize model of learning, not that it is equivalent or necessary for) in multiple areas of the brain. That one type of stimulus does not result in the same effect in numerous areas of the brain suggests (obviously) differential make-up of that area and surely different mechanisms. This notion would simply parallel our argument of different “types of plasticity” (as defined anatomically), with physiological correlates (Yun, et al., 2002); (Trepel and Racine, 1998). I AM NOT SURE MORE IS NEEDED
IS THIS THE VENUE TO EVEN BRING UP FRAGILE X/FMRP????
I AGREE WITH YOU THAT THE ANSWER IS NO
On the Horizon: A Role for Protein Synthesis at the synapse
Since the first report of morphological evidence for protein synthesis at the synapse (Steward & Levy, 1992) there has been a growing body of literature investigating this phenomenon. Some forms of synaptic and dendritic protein synthesis have been shown to be activated by metabotropic glutamate receptors (mGluR) in some cases (e.g., Weiler & Greenough, 1993; Weiler et al., 1994, 1997; Eberwine PNAS-still in press?) and by NMDA receptors as well (Sheetz et al., 2000). Proteins synthesized at synapses include the fragile X protein FMRP and calcium/calmodulin-dependent protein kinase II (CAMKII). FMRP has also been shown to be necessary for the mGluR-dependent synthesis, which is not observed in FMR1 knockout mice (cite Spangler abstract). Plasticity-inducing forms of electrical stimulation have been shown to trigger the transcription and transport of mRNA for the protein ARC to dendritic sites of stimulation, where it is translated (Steward and Worley references). mGluR1 activation, ARC synthesis and CAMKII activity have been proposed to be involved in various forms of plasticity (Huber/Bear work; Steward; Mary Kennedy), although details of the specific functions of synaptic or dendritic protein synthesis are still under investigation. Do you think we need to say anything more here? The chapter is really not "about" this, and I am not sure (but open to suggestions) what additional data makes sense to include.
In summary, brain plasticity appears to be a phenomenon that is not restricted to elements that are neuron-specific. In fact, it could be argued that neuronal plasticity is but a small fraction of the overall changes that occur in response to experience and that we are just beginning to understand the importance of these other forms of brain plasticity. A big waving of our hands to and draw grand conclusions, followed by speculations on direction…..
CHAPTER WORKING NOTES:
MSVs—Kara; TJ; specialized synaptic morph changes.
Tissue cultures lacking astrocytes—how good a model? Lack of synapse formation in cultures without astrocytes (Ullian, et al., 2001). Moreover, even when synapses do form, they are functionally immature. Obvious implications on studies of “synaptic plasticity” in vitro. NOT SURE WE HAVE TIME FOR THIS NOR IS THIS NECESSARILY CONSISTENT WITH UNDERLYING THEME OF THE PAPER.
Lack of astro part of ECM. Lack of basis for TPA, other actions probably involved in synaptogenesis. MMP3, MMP6, MMP9 (Metalomatrix proteins), stromolysin, gelatinase. Roles of Astros, ECM, TPA, etc. in synaptogenesis; adhesions; rec aggregation DEFINITELY NOT ENOUGH TIME FOR THIS.
Incorporate Harris, Matus, Segal. Motility and shape issues. Put together a model, slow accumulation of synapses via overproduction-selection as a basis for the stable long-term substrate of memory; plus fast shape changes, PSD size, perfs, interpret multiple synapses from local and wiring diagram view. DONE TO AN EXTENT, NIX THIS SECTION?
Abraham, W.C. and Tate, W.P. (1997) Metaplasticity: a new vista across the field of synaptic plasticity. Prog Neurobiol, 52: 303-323.
Aguayo, A.J., David, S. and Bray, G.M. (1981) Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents. J Exp Biol, 95: 231-240.
Andersen, P. and Soleng, A. (1998) Long-term potentiation and spatial training are both associated with the generation of new excitatory synapses. Brain Res., 26: 353-359.
Araque, A., Parpura, V., Sanzgiri, R.P. and Haydon, P.G. (1998) Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons. Eur J Neurosci, 10: 2129-2142.
Araque, A., Parpura, V., Sanzgiri, R.P. and Haydon, P.G. (1999) Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci, 22: 208-215.
Atwood, H.L. and Wojtowicz, J.M. (1999) Silent synapses in neural plasticity: current evidence. Learn Mem, 6: 542-571.
Bailey, C.H. and Chen, M. (1988) Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7. Proc Natl Acad Sci U S A, 85: 9356-9359.
Bar, T. (1980) The Vascular System of the Cerebral Cortex, Springer, Berlin.
Benes, F.M., Turtle, M., Khan, Y. and Farol, P. (1994) Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch Gen Psychiatry, 51: 477-484.
Bennett, E.L., Diamond, M.C., Krech, D. and Rosenzweig, M.R. (1964) Chemical and anatomical plasticity of brain. Science, 146: 610-619.
Bezzi, P., Vesce, S., Panzarasa, P. and Volterra, A. (1999) Astrocytes as active participants of glutamatergic function and regulators of its homeostasis. Adv. Exp. Med. Biol., 468: 69-80.
Black, J.E., Isaacs, K.R., Anderson, B.J., Alcantara, A.A. and Greenough, W.T. (1990) Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci U S A, 87: 5568-5572.
Black, J.E., Parnisari, R., Eichbaum, E. and Greenough, W.T. (1986) Morphological effects of housing environment and excersize on cerebral cortex and cerebellum of old rats. Society for Neuroscience Abstracts, 12: 1579.
Black, J.E., Polinsky, M. and Greenough, W.T. (1989) Progressive failure of cerebral angiogenesis supporting neural plasticity in aging rats. Neurobiol Aging, 10: 353-358.
Black, J.E., Sirevaag, A.M. and Greenough, W.T. (1987) Complex experience promotes capillary formation in young rat visual cortex. Neurosci Lett, 83: 351-355.
Blakemore, W.F. and Keirstead, H.S. (1999) The origin of remyelinating cells in the central nervous system. J Neuroimmunol, 98: 69-76.
Bliss, T.V. and Lomo, T. (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol, 232: 331-356.
Briones, T., Shah, P., Juraska, J. and Greenough, W.T. (1999) Effects of prolonged exposure to and subsequent removal from a complex environment on corpus callosum myelination in the adult rat. Society for Neuroscience Abstracts, 25: 638.
Briones, T.L., Klintsova, A.Y. and Greenough, W.T. (In preparation) Stability of synaptic plasticity induced by complex environment exposure in the adult rat visual cortex. .
Bruck, W., Schmied, M., Suchanek, G., Bruck, Y., Breitschopf, H., Poser, S., Piddlesden, S. and Lassmann, H. (1994) Oligodendrocytes in the early course of multiple sclerosis. Ann Neurol, 35: 65-73.
Bruneau, R., Zook, A., Walters, D., Nolan, B.C., Cooper, N., Freeman, J.H. and Kleim, J.A. (2001) Synaptogenesis within anterior interpositus nucleus following eyeblink conditioning. Society for Neuroscience Abstracts, 27: 1689.
Camel, J.E., Withers, G.S. and Greenough, W.T. (1986) Persistence of visual cortex dendritic alterations induced by postweaning exposure to a "superenriched" environment in rats. Behav Neurosci, 100: 810-813.
Carlin, R.K. and Siekevitz, P. (1983) Plasticity in the central nervous system: do synapses divide? Proc Natl Acad Sci U S A, 80: 3517-3521.
Castellucci, V.F., Carew, T.J. and Kandel, E.R. (1978) Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica. Science, 202: 1306-1308.
Chang, F.L. and Greenough, W.T. (1982) Lateralized effects of monocular training on dendritic branching in adult split-brain rats. Brain Res, 232: 283-292.
Comery, T.A., Shah, R. and Greenough, W.T. (1995) Differential rearing alters spine density on medium-sized spiny neurons in the rat corpus striatum: evidence for association of morphological plasticity with early response gene expression. Neurobiol Learn Mem, 63: 217-219.
Comery, T.A., Stamoudis, C.X., Irwin, S.A. and Greenough, W.T. (1996) Increased density of multiple-head dendritic spines on medium-sized spiny neurons of the striatum in rats reared in a complex environment. Neurobiol Learn Mem, 66: 93-96.
Connor, J.R., Melone, J.H., Yuen, A.R. and Diamond, M.C. (1981) Dendritic length in aged rats' occipital cortex: an environmentally induced response. Exp Neurol, 73: 827-830.
Coq, J.O. and Xerri, C. (1998) Environmental enrichment alters organizational features of the forepaw representation in the primary somatosensory cortex of adult rats. Exp Brain Res, 121: 191-204.
Dani, J.W., Chernjavsky, A. and Smith, S.J. (1992) Neuronal activity triggers calcium waves in hippocampal astrocyte networks. Neuron, 8: 429-440.
Devor, M. and Wall, P.D. (1978) Reorganisation of spinal cord sensory map after peripheral nerve injury. Nature, 276: 75-76.
Diamond, M., Huang, W. and Ebner, F. (1994) Laminar comparison of somatosensory cortical plasticity. Science, 265: 1885-1888.
Diamond, M.C., Krech, D. and Rosenzweig, M.R. (1964) The effects of an enriched environment on the histology of the rat cerebral cortex. Journal of Comparative Neurology, 123: 111-120.
Diamond, M.C., Law, F., Rhodes, H., Lindner, B., Rosenzweig, M.R., Krech, D. and Bennett, E.L. (1966) Increases in cortical depth and glia numbers in rats subjected to enriched environment. J Comp Neurol, 128: 117-126.
Doubell, T.P. and Stewart, M.G. (1993) Short-term changes in the numerical density of synapses in the intermediate and medial hyperstriatum ventrale following one-trial passive avoidance training in the chick. Journal of Neuroscience, 13: 2230-2236.
Engert, F. and Bonhoeffer, T. (1999) Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature, 399: 66-70.
Faggin, B.M., Nguyen, K.T. and Nicolelis, M.A.L. (1997) Immediate and simultaneous sensory reorganization at cortical and subcortical levels of the somatosensory system. Proceedings of the National Academy of Sciences (USA), 94: 9428-9433.
Fiala, J.C., Allwardt, B. and Harris, K.M. (2002) Dendritic spines do not split during hippocampal LTP or maturation. Nat Neurosci, 5: 297-298.
Floeter, M.K. and Greenough, W.T. (1979) Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys. Science, 206: 227-229.
Frey, U. and Morris, R.G. (1997) Synaptic tagging and long-term potentiation. Nature, 385: 533-536.
Friedlander, M.J., Martin, K.A. and Wassenhove-McCarthy, D. (1991) Effects of monocular visual deprivation on geniculocortical innervation of area 18 in cat. J Neurosci, 11: 3268-3288.
Geinisman, Y., Berry, R.W., Disterhoft, J.F., Power, J.M. and Van der Zee, E.A. (2001) Associative learning elicits the formation of multiple-synapse boutons. J Neurosci, 21: 5568-5573.
Geinisman, Y., deToledo-Morrell, L. and Morrell, F. (1991) Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities. Brain Res, 566: 77-88.
Geinisman, Y., Morrell, F. and de Toledo-Morrell, L. (1989) Perforated synapses on double-headed dendritic spines: a possible structural substrate of synaptic plasticity. Brain Res, 480: 326-329.
Geinisman, Y., Morrell, F. and de Toledo-Morrell, L. (1990) Increase in the relative proportion of perforated axospinous synapses following hippocampal kindling is specific for the synaptic field of stimulated axons. Brain Res, 507: 325-331.
Gilbert, C.D. (1992) Horizontal integration and cortical dynamics. Neuron, 9: 1-13.
Gilbert, C.D. and Wiesel, T.N. (1979) Morphology and intracortical projections of functionally characterized neurones in the cat visual cortex. Nature, 280: 120-125.
Globus, A., Rosenzweig, M.R., Bennett, E.L. and Diamond, M.C. (1973) Effects of differential experience on dendritic spine counts in rat cerebral cortex. J Comp Physiol Psychol, 82: 175-181.
Gould, E., Beylin, A., Tanapat, P., Reeves, A. and Shors, T.J. (1999) Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci, 2: 260-265.
Green, E.J., Greenough, W.T. and Schlumpf, B.E. (1983) Effects of complex or isolated environments on cortical dendrites of middle-aged rats. Brain Res, 264: 233-240.
Greenough, W.T., Juraska, J.M. and Volkmar, F.R. (1979) Maze training effects on dendritic branching in occipital cortex of adult rats. Behav Neural Biol, 26: 287-297.
Greenough, W.T., Larson, J.R. and Withers, G.S. (1985) Effects of unilateral and bilateral training in a reaching task on dendritic branching of neurons in the rat motor-sensory forelimb cortex. Behav Neural Biol, 44: 301-314.
Greenough, W.T., McDonald, J.W., Parnisari, R.M. and Camel, J.E. (1986) Environmental conditions modulate degeneration and new dendrite growth in cerebellum of senescent rats. Brain Res, 380: 136-143.
Greenough, W.T., Volkmar, F.R. and Juraska, J.M. (1973) Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat. Exp Neurol, 41: 371-378.
Greenough, W.T., West, R.W. and DeVoogd, T.J. (1978) Subsynaptic plate perforations: changes with age and experience in the rat. Science, 202: 1096-1098.
Hart, B. and Risley, T.R. (1995) Meaningful Differences in the Everyday Experience of Young American Children, Brookes Publishing, Baltimore.
Hatton, G.I. (1997) Function-related plasticity in hypothalamus. Annu Rev Neurosci, 20: 375-397.
Hebb, D.O. (1949) The organization of behavior, Wiley, New York.
Hubel, D.H., Wiesel, T.N. and LeVay, S. (1977) Plasticity of ocular dominance columns in monkey striate cortex. Philos Trans R Soc Lond B Biol Sci, 278: 377-409.
Hymovitch, B. (1952) The effects of experimental variations on problem-solving in the rat. J. Comp. Physio. Psycho., 45: 313-321.
Jacobs, K.M. and Donoghue, J.P. (1991) Reshaping the cortical motor map by unmasking latent intracortical connections. Science, 251: 944-947.
Jones, D.G. and Calverley, R.K. (1991) Frequency of occurrence of perforated synapses in developing rat neocortex. Neurosci Lett, 129: 189-192.
Jones, T.A. (1999) Multiple synapse formation in the motor cortex opposite unilateral sensorimotor cortex lesions in adult rats. J Comp Neurol, 414: 57-66.
Jones, T.A., Chu, C.J., Grande, L.A. and Gregory, A.D. (1999) Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci, 19: 10153-10163.
Jones, T.A. and Greenough, W.T. (1996) Ultrastructural evidence for increased contact between astrocytes and synapses in rats reared in a complex environment. Neurobiol Learn Mem, 65: 48-56.
Jones, T.A. and Greenough, W.T. (In Press) Behavioral experience-dependent plasticity of glial-neuronal interactions. In: A. Volterra, P. Magistretti and P.G. Haydon (Ed.^Eds.), Glia in Synaptic Transmission, Oxford University Press, Oxford, UK, .
Jones, T.A., Hawrylak, N. and Greenough, W.T. (1996) Rapid laminar-dependent changes in GFAP immunoreactive astrocytes in the visual cortex of rats reared in a complex environment. Psychoneuroendocrinology, 21: 189-201.
Jones, T.A., Kleim, J.A. and Greenough, W.T. (1996) Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: a quantitative electron microscopic examination. Brain Res, 733: 142-148.
Jones, T.A., Klintsova, A.Y., Kilman, V.L., Sirevaag, A.M. and Greenough, W.T. (1997) Induction of multiple synapses by experience in the visual cortex of adult rats. Neurobiol Learn Mem, 68: 13-20.
Juraska, J.M., Greenough, W.T., Elliott, C., Mack, K.J. and Berkowitz, R. (1980) Plasticity in adult rat visual cortex: an examination of several cell populations after differential rearing. Behav Neural Biol, 29: 157-167.
Juraska, J.M. and Kopcik, J.R. (1988) Sex and environmental influences on the size and ultrastructure of the rat corpus callosum. Brain Res, 450: 1-8.
Kempermann, G., Brandon, E.P. and Gage, F.H. (1998) Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr Biol, 8: 939-942.
Kempermann, G., Kuhn, H.G. and Gage, F.H. (1998) Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci, 18: 3206-3212.
Kioussi, C. and Gruss, P. (1996) Making of a Schwann. Trends Genet, 12: 84-86.
Kleim, J.A., Barbay, S., Cooper, N.R., Hogg, T.M., Reidel, C.N., Remple, M.S. and Nudo, R.J. (2002) Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol Learn Mem, 77: 63-77.
Kleim, J.A., Barbay, S. and Nudo, R.J. (1998) Functional reorganization of the rat motor cortex following motor skill learning. J Neurophysiol, 80: 3321-3325.
Kleim, J.A., Bruneau, R., Remple, M., Soroka, N. and Cooper, N. (2001) Forelimb strength training leads to increased synapse number within the ventral spinal cord of the rat. Society for Neuroscience Abstracts, 27.
Kleim, J.A., Cooper, N.R. and VandenBerg, P. (2002) Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res., In Press.
Kleim, J.A., Lussnig, E., Schwarz, E.R., Comery, T.A. and Greenough, W.T. (1996) Synaptogenesis and Fos expression in the motor cortex of the adult rat after motor skill learning. J Neurosci, 16: 4529-4535.
Kleim, J.A., Pipitone, M.A., Czerlanis, C. and Greenough, W.T. (1998) Structural stability within the lateral cerebellar nucleus of the rat following complex motor learning. Neurobiol Learn Mem, 69: 290-306.
Kleim, J.A., Swain, R.A., Armstrong, K.A., Napper, R.M., Jones, T.A. and Greenough, W.T. (1998) Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning. Neurobiol Learn Mem, 69: 274-289.
Kleim, J.A., Vij, K., Ballard, D.H. and Greenough, W.T. (1997) Learning-dependent synaptic modifications in the cerebellar cortex of the adult rat persist for at least four weeks. J Neurosci, 17: 717-721.
Kleim, J.A., Vij, K., Kelly, J.L., Ballard, D.H. and Greenough, W.T. (In revision) The persistence of training-induced astrocytic hypertrophy within the cerebellar cortex. .
Liu, S., Qu, Y., Stewart, T.J., Howard, M.J., Chakrabortty, S., Holekamp, T.F. and McDonald, J.W. (2000) Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci U S A, 97: 6126-6131.
Lund, R.D. (1965) Uncrossed visual pathways of hooded and albino rats. Science, 149: 1506-1507.
Lynch, G., Deadwyler, S. and Cotman, G. (1973) Postlesion axonal growth produces permanent functional connections. Science, 180: 1364-1366.
Maletic-Savatic, M., Malinow, R. and Svoboda, K. (1999) Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science, 283: 1923-1926.
Meshul, C.K., Seil, F.J. and Herndon, R.M. (1987) Astrocytes play a role in regulation of synaptic density. Brain Res, 402: 139-145.
Moser, M.B., Trommald, M. and Andersen, P. (1994) An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses. Proc Natl Acad Sci U S A, 91: 12673-12675.
Muller, T., Grosche, J., Ohlemeyer, C. and Kettenmann, H. (1993) NMDA-activated currents in Bergmann glial cells. Neuroreport, 4: 671-674.
Nilsson, M., Perfilieva, E., Johansson, U., Orwar, O. and Eriksson, P.S. (1999) Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory. J Neurobiol, 39: 569-578.
Nudo, R.J., Milliken, G.W., Jenkins, W.M. and Merzenich, M.M. (1996) Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci, 16: 785-807.
Plautz, E.J., Milliken, G.W. and Nudo, R.J. (2000) Effects of repetitive motor training on movement representations in adult squirrel monkeys: role of use versus learning. Neurobiol Learn Mem, 74: 27-55.
Raisman, G. and Field, P.M. (1973) A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei. Brain Res, 50: 241-264.
Ramon y Cajal, S. (1893) New findings about the histological structure of the central nervous system. Archiv fur Anatomie und Physiologie (Anatomie): 319-428.
Remple, M.S., Bruneau, R.M., VandenBerg, P.M., Goertzen, C. and Kleim, J.A. (2001) Sensitivity of cortical movement representations to motor experience: evidence that skill learning but not strength training induces cortical reorganization. Behav Brain Res, 123: 133-141.
Rioult-Pedotti, M.-S., Friedman, D., Hess, G. and Donoghue, J. (1998) Strengthening of horizontal cortical connections following skill learning. Nature Neuroscience, 1: 230-234.
Rouach, N., Glowinski, J. and Giaume, C. (2000) Activity-dependent neuronal control of gap-junctional communication in astrocytes. J Cell Biol, 149: 1513-1526.
Rowan, R.A. and Maxwell, D.S. (1981) Patterns of vascular sprouting in the postnatal development of the cerebral cortex of the rat. Am J Anat, 160: 247-255.
Salm, A.K. (2000) Mechanisms of glial retraction in the hypothalamo-neurohypophysial system of the rat. Exp Physiol, 85: 197S-202S.
Sapolsky, R.M. (1996) Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion. Stress, 1: 1-19.
Schousboe, A., Westergaard, N., Sonnewald, U., Petersen, S.B., Yu, A.C. and Hertz, L. (1992) Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA. Prog Brain Res, 94: 199-211.
Seress, L., Abraham, H., Paleszter, M. and Gallyas, F. (2001) Granule cells are the main source of excitatory input to a subpopulation of GABAergic hippocampal neurons as revealed by electron microscopic double staining for zinc histochemistry and parvalbumin immunocytochemistry. Exp Brain Res, 136: 456-462.
Shao, Y. and Sutin, J. (1992) Expression of adrenergic receptors in individual astrocytes and motor neurons isolated from the adult rat brain. Glia, 6: 108-117.
Shelton, M.K. and McCarthy, K.D. (1999) Mature hippocampal astrocytes exhibit functional metabotropic and ionotropic glutamate receptors in situ. Glia, 26: 1-11.
Sirevaag, A.M., Black, J.E. and Greenough, W.T. (1991) Astrocyte hypertrophy in the dentate gyrus of young male rats reflects variation of individual stress rather than group environmental complexity manipulations. Exp Neurol, 111: 74-79.
Sirevaag, A.M., Black, J.E., Shafron, D. and Greenough, W.T. (1988) Direct evidence that complex experience increases capillary branching and surface area in visual cortex of young rats. Brain Res., 471: 299-304.
Sirevaag, A.M. and Greenough, W.T. (1985) Differential rearing effects on rat visual cortex synapses. II. Synaptic morphometry. Brain Res., 351: 215-226.
Sirevaag, A.M. and Greenough, W.T. (1987) Differential rearing effects on rat visual cortex synapses. III. Neuronal and glial nuclei, boutons, dendrites, and capillaries. Brain Res., 424: 320-332.
Sirevaag, A.M. and Greenough, W.T. (1991) Plasticity of GFAP-immunoreactive astrocyte size and number in visual cortex of rats reared in complex environments. Brain Res., 540: 273-278.
Smit, A.B., Syed, N.I., Schaap, D., van Minnen, J., Klumperman, J., Kits, K.S., Lodder, H., van der Schors, R.C., van Elk, R., Sorgedrager, B., Brejc, K., Sixma, T.K. and Geraerts, W.P. (2001) A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature, 411: 261-268.
Sorra, K.E., Fiala, J.C. and Harris, K.M. (1998) Critical assessment of the involvement of perforations, spinules, and spine branching in hippocampal synapse formation. J Comp Neurol, 398: 225-240.
Szeligo, F. and Leblond, C.P. (1977) Response of the three main types of glial cells of cortex and corpus callosum in rats handled during suckling or exposed to enriched, control and impoverished environments following weaning. J Comp Neurol, 172: 247-263.
Tanzi, E. (1893) Facts and inductions in current histology of the nervous system. Rivista sperimentale di freniatria e medicina legale delle mentali alienazioni, 19: 419-472.
Toni, N., Buchs, P.A., Nikonenko, I., Bron, C.R. and Muller, D. (1999) LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature, 402: 421-425.
Trachtenberg, J.T. and Stryker, M.P. (2001) Rapid Anatomical Plasticity of Horizontal Connections in the Developing Visual Cortex. J Neurosci, 21: 3476-3482.
Trachtenberg, J.T., Trepel, C. and Stryker, M.P. (2000) Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex. Science, 287: 2029-2032.
Trepel, C. and Racine, R.J. (1998) Long-term potentiation in the neocortex of the adult, freely moving rat. Cereb Cortex, 8: 719-729.
Turner, A.M. and Greenough, W.T. (1985) Differential rearing effects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron. Brain Res, 329: 195-203.
Ullian, E.M., Sapperstein, S.K., Christopherson, K.S. and Barres, B.A. (2001) Control of synapse number by glia. Science, 291: 657-661.
van Praag, H., Kempermann, G. and Gage, F.H. (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci, 2: 266-270.
Volkmar, F.R. and Greenough, W.T. (1972) Rearing complexity affects branching of dendrites in the visual cortex of the rat. Science, 176: 1145-1147.
Wallace, C.S., Kilman, V.L., Withers, G.S. and Greenough, W.T. (1992) Increases in dendritic length in occipital cortex after 4 days of differential housing in weanling rats. Behav Neural Biol, 58: 64-68.
Wesa, J.M., Chang, F.L., Greenough, W.T. and West, R.W. (1982) Synaptic contact curvature: effects of differential rearing on rat occipital cortex. Brain Res, 256: 253-257.
West, M.J. (1999) Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci, 22: 51-61.
West, R.W. and Greenough, W.T. (1972) Effect of environmental complexity on cortical synapses of rats: preliminary results. Behav Biol, 7: 279-284.
Withers, G.S. and Greenough, W.T. (1989) Reach training selectively alters dendritic branching in subpopulations of layer II-III pyramids in rat motor-somatosensory forelimb cortex. Neuropsychologia, 27: 61-69.
Yakovlev, P. and Lecours, A. (1967) The myelinogenetic cycles of regional maturation of the brain. In: A. Minkowski (Ed.^Eds.), Regional Development of the Brain Early in Life, Blackwell Scientific Publications Inc, Boston, Mass, pp. 3-70.
Yun, S.H., Mook-Jung, I. and Jung, M.W. (2002) Variation in effective stimulus patterns for induction of long-term potentiation across different layers of rat entorhinal cortex. J Neurosci, 22: RC214.