• Major pathogen of domesic herbivores that come in contact with
Pathogenesis and Clinical feature:
Acquired by the entry of spores through injured skin incutaneous anthrax, or mucus membrane in intestinal anthrax, or inhalation of spores in the lung while handling skin and hides
Specimen: Fluid or pus from skin lesion, Blood, sputum
Smear: Non-capsulated gram-positive rods with centrally
located spores from culture
Large capsulated gram-positive rods without spores from primary specimen.
Culture: Grows aerobically in ordinary media over wide range of temperature. Non-hemolytic ,large, dense, grey-white irregular colonies with colony margin of “Medussa Head” or“curled-hair lock” appearance due to composition of parallel chaining of cells
Gelatin-stab culture: Gelatin liquefactionGrowth along the track of the wire with lateral spikes longest near the surface Providing “inverted fur tree”appearance.
Serology: ELISA has been developed to measure antibodies to edema toxin and lethal toxin
Positive result: 4-fold change or single titer > 1:32