Fellow-Head and Neck Division, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, ny



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CURRICULUM VITAE
______________________________

Joseph A. Califano, III, M.D.



Current Appointments

Professor, Head and Neck Division, Division of Head and Neck Cancer Research, Department of Otolaryngology-Head and Neck Surgery, Department of Oncology, Johns Hopkins University, Baltimore, MD


Personal Data
Department of Otolaryngology-Head and Neck Surgery

Johns Hopkins Hospital

601 North Caroline Street, 6th Floor

Baltimore, MD 21287-0910



jcalifa@jhmi.edu
410-955-6420

410-955-8510 (fax)


Education and Training
1985, B.A., Chemistry, Amherst College, Amherst, Massachusetts,
1993, M.D., Harvard Medical School, Boston, Massachusetts
1993- 1994, Intern, General Surgery, Johns Hopkins Hospital, Baltimore, Maryland
1994-1999, Resident, Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland
1994-1996, Research Training in Otolaryngology NIH grant T32, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland

1999-2000, Fellow-Head and Neck Division, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY



PROFESSIONAL EXPERIENCE
2000-2003, Assistant Professor, Head and Neck Division, Division of Head and Neck Cancer Research, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD
2002-3, Assistant Professor, Department of Oncology, Johns Hopkins Hospital, Baltimore,
2003-2007, Associate Professor, Head and Neck Division, Division of Head and Neck Cancer Research, Department of Otolaryngology-Head and Neck Surgery, Department of Oncology, Johns Hopkins Hospital, Baltimore, MD
2007-present, Professor, Head and Neck Division, Division of Head and Neck Cancer Research, Department of Otolaryngology-Head and Neck Surgery, Department of Oncology, Johns Hopkins Hospital, Baltimore, MD
2009-present, Research Director, Milton J. Dance Head and Neck Cancer Center, Greater Baltimore Medical Center, Baltimore, MD
RESEARCH ACTIVITIES
Peer Reviewed Publications

ORIGINAL SCIENCE


1. Wellstein, A, Zugamaier G, Califano JA III, Kern F, Paik S, Lippman ME. Tumor Growth Dependent on Kaposi’s Sarcoma-derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate. Journal of the National Cancer Institute, 1995; 83(10):716-720.
2. Cairns P, Polascik TJ, Eby Y, Tokino K,Califano J, Merlo A, Mao L, Herath J ,Jenkins R, Westra W , Rutter JL, Buckler A, Gabrielson E, Tockman M, Cho KR, Hedrick L, Bova GS, Issacs W, Schwab D, Sidransky D. Frequency of Homozygous Deletion at p16/CDKN2 in Primary Human Tumors. Nature Genetics.1995; 11(2):210-212
3. Johns M III, Westra, WH, Califano JA, Eisele D, Koch WM, Sidransky D. Allelotype of Salivary Gland Tumors. Cancer Research. 1996; 56:1151-1154
4. Califano J, van der Riet,P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D. A Genetic Progression Model for Head and Neck Cancer: Implications for Field Cancerization. Cancer Research. 1996; 56:2488-2492
5. Reed A, Califano J, Cairns P, Westra WH, Jones R, Koch W, Ahrendt S, Eby Y, Sewell D, Nawroz H, Bartek J, Sidransky D High Frequency of p16CDKN2/MTS-1/INK4A Inactivation in Head and Neck Squamous Cell Carcinoma. Cancer Research. 1996; 56:3630-3633
6. Califano JA, Johns MM III, Westra, WH, Lango M, Eisele D, Saji, M, Zeiger MA, Udelsman R, Koch WM, Sidransky D. An Allelotype of Papillary Thyroid Cancer. International Journal of Cancer. 1996; 69:442-444
7. Califano J, Ahrendt S, Meininger G, Koch W, Westra WH, Sidransky D. Detection of Telomerase Activity in Oral Rinses from Head and Neck Squamous Cell Cancer Patients. Cancer Research. 1996; 56:5720-22
8. Lee DJ, Koch WM, Yoo G, Lango M, Reed A, Califano J, Brennan JA, Westra WH, Zahurak M, Sidransky D. The Impact of Chromosome 14q Loss on Survival in Primary Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research. 1997; 3:501-505
9. Ahrendt SA, Yang SC, Wu L, Westra WH, Jen J, Califano JA, Sidransky D. Comparison of Oncogene Mutation Detection and Telomerase Activity for the Molecular Staging of Non-Small Cell Lung Cancer . Clinical Cancer Research. 1997; 3(7):1207-1214
10. Califano J, Eisele DW. Benign Salivary Gland Tumors. Otolaryngologic Clinics of North America. 1999; 32(5):861-73
11. Califano J, Leong P, Koch W, Eisenberger C, Sidransky D, Westra WH. Second Esopghageal Tumors in Patients with Head and Neck Squamous Cell Carcinoma: An Assessment of Clonal Relationships. Clinical Cancer Research. 1999; 5:1862-1867
12. Califano J, Westra WH, Koch W, Meininger G, Reed A, Yip L, Boyle JO, Lonardo F, Sidransky D. Unknown Primary Head and Neck Squamous Cell Carcinoma: Molecular Identification of the Site of Origin. J Natl Cancer Inst. 1999; 91(7):599-604
13. Califano, J, Miller S, Frodel J. Treatment of Occipital Acne Keloidalis by Excision Followed by Secondary Intention Healing. Arch Facial Plast Surg. 1999; 1(4):308-11
14.Califano J, Westra WH, Meininger G, Corio R, Koch W, Sidransky D. Genetic Progression and Clonal Relationship of Recurrent Premalignant Head and Neck Lesions. Clin Cancer Res. 2000; 6(2):347-52
15. Califano J, Koch W, Sidransky D, Westra WH. Inverted Sinonasal Papilloma: a Molecular Genetic Appraisal of its Putative Status as a Precursor to Squamous Cell Carcinoma. Am J Pathol. 2000; 156(1):333-7
16. Shah SI, Yip L, Greenberg B, Califano JA, Chow J, Eisenberger CF, Lee DJ, Sewell DA, Reed AL, Lango M, Jen J, Koch WM, Sidransky D. Two distinct regions of loss on chromosome arm 4q in primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2000; 126(9):1073-6
17. Spafford MF, Koch WM, Reed AL, Califano JA, Xu LH, Eisenberger CF, Yip L, Leong PL, Wu L, Liu SX, Jeronimo C, Westra WH, Sidransky D. Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis. Clin Cancer Res. 2001; 7(3):607-12 2001
18. Rosas SLB, Koch W, Carvalho MGC, Wu L, Califano J, Westra W, Jen J, Sidransky D. Promoter Hypermethylation Patterns of p16, MGMT and DAP-kinase in Tumors and Saliva of Head and Neck Cancer Patients. Cancer Research. 2001; 61(3):939-42, 2001
19. Patturajan M, Nomoto S, Sommer M, Fomenkov A, Hibi K, Zangen R, Poliak N, Califano J, Trink B, Ratovitski E, Sidransky D. Np63 induces -catenin nuclear accumulation and signaling. Cancer Cell. 2002; 1:1-11
20. Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidranksy D, Califano J. Real time quantitative PCR demonstrates low prevalence of human papillomavirus inpremalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002; 8(5):1203-9
21. Ha PK, Tong BC, Westra WH, Sanchez-Cespedes M, Parella P, Zahurak M, Sidransky D, Califano J. Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. Clincal Cancer Research. 2002; (7):2260-5
22. Ansari-Lari MA, Hoque MO, Califano JA, Westra WH. Immunohistochemical p53 expression patterns in sarcomatoid carcinomas of the upper respiratory tract. Am J Surg Pathol. 2002; (8):1024-31
23. Ha P, Califano, J. Molecular Biology of Laryngeal Cancer. Otolaryngology Clinics of North America. 2002; Oct;35(5):993-1012
24. Patturajan M, Nomoto S, Sommer M, Fomenkov A, Hibi K, Zangen R, Poliak N,

Califano J, Trink B, Ratovitski E, Sidransky D. DeltaNp63 induces beta-catenin nuclear accumulation and signaling. Cancer Cell. 2002; May;1(4):369-79
25. Ha PK, Pilkington TA, Westra WH, Sciubba J, Sidransky D, Califano J. Progression of Microsatellite Instability from Premalignant Lesions to Tumors of the Head and Neck. International Journal of Cancer. 2002; Dec 20;102(6):615-7
26.Earnest L, Byrne P, Califano J. Massive facial angiofibroma in a patient with tuberous sclerosis. Otolaryngol Head Neck Surg. 2003; Jan;128(1):151-3
27.Califano J, Cordeiro PG, Disa JJ, Hidalgo DA, DuMornay W, Bilsky MH, Gutin PH, Shah JP, Kraus DH. Anterior Cranial Base Reconstruction Using Free Tissue Transfer: Changing Trends. Head Neck. 2003; Feb;25(2):89-96

28.Tong, BC, Ha PK, Dhir K, Xing M, Westra WH, Sidransky D, Califano J. Mitochondrial DNA Alterations in Thyroid Cancer. Journal of Surgical Oncology. 2003; Mar 82(3):170-3

29. Xing M, Usadel H, Cohen Y, Tokumaru Y, Guo Z, Westra WB, Tong BC, Tallini G, Udelsman R, Califano JA, Ladenson PW, Sidransky D. Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. Cancer Res. 2003; May 1;63(9):2316-21


30. Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z,

Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B. DeltaNp63alpha and TAp63alpha Regulate Transcription of Genes with Distinct Biological Functions in Cancer and Development. Cancer Res. 2003; May 15;63(10):2351-7


31 Ha P, Benoit N, Yochem R, Sciubba J, Zahurak M, Sidransky D, Pevsner J, Westra WH, Califano J. A Transcriptional Progression Model for Head and Neck Cancer. Clinical Cancer Research. 2003; Aug 1;9(8):3058-64
32. Minhas, K, Singh B, Jiang W, Sidransky D, Califano J. Spindle Assembly Checkpoint Defects and Chromosomal Instability in Head and Neck Squamous Cell Carcinoma. International Journal of Cancer. 2003; Oct 20;107(1):46-52

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