Evidence Table 58. Interventions listed in detail for all studies



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Evidence Table 58. Interventions listed in detail for all studies

Author Year

Supplement:

Latin or other names used in this study for the supplement

Supplement Composition

Is purity of the supplement reported?

Is the supplement licensed in the region used?

Does the paper report where the supplement was manufactured?

Have storage conditions for the supplement been reported?

Is the origin of the supplement reported?

What subtype of the supplement was administered?

Are nutrient levels or biomarkers of the supplement reported?

Abdul 20101

Echinacea

E. angustifolia and E. purpurea

600 mg of E. angustifolia roots and 675 mg of E. purpurea root;

No

NR

QLD, Australia

No

roots of E. angustifolia and E. purpurea

NA

Echinacea alkamide content in plasma

Aruna 20072

Gingko biloba

NR

NR

No

NR

 

No

No

NA

No

Avogaro 19743

Niacin

nicotinic acid

NR

No

NR

 

No

No

NR

No

Balestrieri 19964

Fish oils/marine oils

ethylester

85% n-3 fatty acids (EPA + DHA ratio 1:1)

No

NR

Esapent-Carlo Erba, Milano Italy

No

No

NR

No

Barbagallo 19995

Vitamin E

NR

NR

No

NR

 

No

No

NR

plasma vit E

Bays 20097

Omega-3 (EPA, DHA or both)

Lovaza

NR

No

NR

 No

No

No

NA

No

Bays 20106

Omega-3 (EPA, DHA or both)

P-OM3 (omega-3-acid ethyl esters)

465mg EHA;375mgDHA

No

NR

 No

No

No

NA

No

Bender 19988

Fish oils/marine oils

MaxEPA

NR

No

NR

 

No

No

NR

No

Bordia 19989

Garlic

NR

NR

No

NR

 

No

Peeled garlic clves were crushed, extracted in ethyl acetate, the solvent evaporated and the resultant oil dissolved in soy oil. The oil extract of garlic was encapsulated. Each capsule contained oil equivalent of 1g raw garlic.

NR

No




Evidence Table 58. Interventions listed in detail for all studies (continued)

Author Year

Supplement:

Latin or other names used in this study for the supplement

Supplement Composition

Is purity of the supplement reported?

Is the supplement licensed in the region used?

Does the paper report where the supplement was manufactured?

Have storage conditions for the supplement been reported?

Is the origin of the supplement reported?

What subtype of the supplement was administered?

Are nutrient levels or biomarkers of the supplement reported?

Budoff 200410

Garlic

Aged Garlic Extract (AGE), Kyolic

NR

No

NR

 

No

No

NR

No

Caso 200711

Supp 1: Coenzyme Q10
Supp 2: Vitamin E

Supp 1: Q-Sorb softgel
Supp 2: NR

Supp 1: NA
Supp 2: NA

Supp 1: No
Supp 2: No

Supp 1: NR
Supp 2: NR

Supp 1: NY, USA
Supp 2: NY, USA

Supp 1: No
Supp 2: No

Supp 1: No
Supp 2: No

Supp 1: NA
Supp 2: NA

Supp 1: No
Supp 2: No

Chan 200212

Fish oils/marine oils

Omacor

45% EPA and 39% EHA

No

Yes

Oslo, Norway

No

No

NA

measurements of plasma EPA and DHA levels

d'Arcangues 200413

Vitamin E

Evion

NA

tablets returned to the Merck laboratories for retesting at the end of the trial and their stability over the course of the study was confirmed

NR

Germany

No

No

NA

No

Davidson 199715

Fish oils/marine oils

NR

The Omega FA content of 7.2g of the marine oil supplements used was 3.6g EPA: DHA ratio = 1.5

No

NR

SuperEPA 1200, Advanced Nutritional Technoligy, Inc., Dublin California

No

No

NR

No

Davidson, 200714

Omega-3 (EPA, DHA or both)

omega 3-acid ethyl esters (P-OM3)

465mg EPA; 375mg DHA

No

NR

New Jersey, USA

No

No

NA

No

De, Caterina 200216

Vitamin E

NA

NA

No

NR

Switzerland

No

No

NA

plasma vit E

Dehmer 198817

Omega-3 (EPA, DHA or both)

MaxEPA

3.2g EPA 2.2g DHA in 18 capsules

No

NR

Michigan

No

No

NA

No

Desideri 200318

Vitamin E

alpha-tocopherol

NR

No

NR

Roche Molecular Biochemicals, Milan, Italy

No

No

NR

Plasma Vit E concentrations were measured by HPLC according to the well-estalished method of Lee et al. Plamsa vitamin E leveers were expressed both in absolute concentrations and as the ratio of Vitmain E / (total cholesterol + triglycerdies)

Di, Spirito 200819

Omega-3 (EPA, DHA or both)

P-OM3, Lovaza

465 mg of the ethyl ester of eicosapentaenoic acid and 375 mg of the ethyl ester of docosahexaenoic acid

No

NR

North Carolina US

No

No

NA

No

Duffy 200120

Vitamin E

NR

NR

No

NR

Victoria, Australia

No

No

Acetylcholine for vasomotion study; Sodium nitroprusside to assess response to endothelial-independent vasodilator

tocopherol measured by high-performance liquid chromatography

Eritsland 199621

Fish oils/marine oils

Omacor

Each soft gelatin capsule contains 1 g of fatty acids (51% eicosapentaenoic acid C20:5n-3 and 32% docosahexaenoic acid C22:6n-3 ethyl esters) and 3.7 mg o-tocopherol as an antioxidant.

No

NR

Pronova AS, Oslo, Norway

No

No

NR

No

Eritsland 199621

Fish oils/marine oils

Omacor

each capsule contained 1 gram fatty acids (51% EPA and 32% DHA) and 3.7 mg alpha-tocopherol

No

NR

Pronova AS, Oslo, Norway

No

fish oil

NR

No

Eritsland 199621

Fish oils/marine oils

n-3 fatty acids

each capsule contained 1 gram fatty acids (51% EPA and 32% DHA) and 3.7 mg alpha-tocopherol

No

NR

Norway

No

fish oil

NR

No

Ferraro 200922

Fish oils/marine oils

PUFA

85% EPA + DHA

No

NR

 

No

No

NA

No

Gardner 2007 23

Gingko biloba

EGb 761

24% Ginkgo flavone glycosides and 6% terpene lactones

No

NR

Springville, Utah by Nature's Way

No

No

NA

No

Garg 199524

Gingko biloba

Ginkgo Biloba Extract

NR

No

NR

 

No

No

NR

No

Glynn 200725

Vitamin E

alpha-tocopherol

NR

No

NR

 

No

No

NR

No

Gosai 200826

Omega-3 (EPA, DHA or both)

P-OM3

465 mg of the ethyl ester eicosapentaenoic acid and 375 mg of the ethyl ester docosahexaenoic acid

No

Yes

North Carolina, US

No

No

NA

No

Govil 197927

Magnesium

magnesium hydroxide solution

NA

No

NR

 

No

No

NR

serum magnesium

Hansen 199329

Fish oils/marine oils

fish oil ethyl ester (K-85)

EPA to DHA ratio 1.90

94% n-3 fatty acids

NR

Pronova A/S, Oslo, Norway)

No

No

NR

No

Hajda, J28(2010)

Garlic extract

GaliPure

GarliPure®, 600mgcaplets from Natrol®, CA, USA

containing gamma glutamylcysteines 12,000µg, 4800µg alliin, 3900µg sulfur and 3800µg thiosulfinates resulting in a allicin yield 3600µg



No

Yes

Yes, USA

No

Yes

NA

No

Howe 1994 30

Fish oils/marine oils

Lipitac Forte

NR

No

NR

Marker Pharma, Sydney Australia

No

No

NR

No

Isley 200731

Supp 1: Omega-3 (EPA, DHA or both)
Supp 2: Niacin

Supp 1: Omacor
Supp 2: NR

Supp 1: 85% eicosapentaenoic (EPA) plus docosahexaenoic acids (DHA)
Supp 2: NA

Supp 1: No
Supp 2: No

Supp 1: NR
Supp 2: NR

Supp 1: Norway
Supp 2: NY, USA

Supp 1: No
Supp 2: No

Supp 1: No
Supp 2: No

Supp 1: NA
Supp 2: NA

Supp 1: No
Supp 2: No

Jiang 2004 33

Ginseng

Panax ginseng

8.93 mg ginsenosides as ginsenoside Rg1

No

NR

 

No

No

NA

No

Jiang 200532

Supp 1: Gingko biloba
Supp 2: Ginger

Supp 1: Tavonin
Supp 2: NR

Supp 1: 2000mg of Ginkgo biloba leaf, 9.6 mg of ginkgo‚ avonglycosides, 2.4 mg of ginkgolides and bilobalide
Supp 2: each capsule containing extract equivalent to 0.4 g of ginger rhizome powder

Supp 1: No
Supp 2: No

Supp 1: NR
Supp 2: NR

Supp 1: Germany
Supp 2: Australia

Supp 1: No
Supp 2: No

Supp 1: gingko leaf, avonglycosides and ginkgolides and bilobalide
Supp 2: NR

Supp 1: NA
Supp 2: NA

Supp 1: No
Supp 2: No

Kaul 199234

Fish oils/marine oils

Maxepa

1.8g EPA; 1.2g DHA

No

NR

Hull, UK

No

No

NA

No

Kim 201035

Gingko biloba

NA

204% glycosidic flavonoids + 6% terpenoids

No

NR

Korea

No

No

NA

No

Lee 200836

Ginseng

P. ginseng

NR

The quality was tested according to the Korea Food & Drug Administration and hospital standards (ginsenoside Rb1>0.20%, Rg1>0.10%)

NR

Korea

No

Root was air dried and crushed materials were added to distilled water, and extraction was performed by heating the solution for 4 hours at 100°C

NA

No

Liu 200337

Fish oils/marine oils

Eskimo-3

18% eicosapentaenoic acid (EPA, 20:5n-3), 12% docosahexaenoic acid (DHA, 22:6n-3) and a total of 38% of long-chain omega-3 fatty acids and is stabilized by a mixture of natural antioxidants, Pufanox, such as vitamins C and E and lecithin.

No

NR

Cardinova, Uppsala, Sweden

No

No

NR

No

Lungershausen 199438

Fish oils/marine oils

Omacor

1.9g EPA; 1.5g DHA

No

NR

Oslo, Norway

No

No

NR

No

Mabuchi 2007 39

Coenzyme Q10

NA

NA

No

NR

Kaneka Co., Osaka, Japan

No

No

NA

No

Macan200640

Garlic

Kyolic (Aged Garlic Extract)

NR

No

NR

Wakunaga of America, Mission Viejo California

No

No

NR

No

Maki 200841

Omega-3 (EPA, DHA or both)

P-OM3

NR

No

NR

New Jersey

No

No

NA

No

Manuel 200442

Vitamin E

d-alpha-tocopherol

NR

No

NR

Omega Pharma, NV, Nazareth, Belgium

No

No

NR

serum vit E

Mauro 200343

Gingko biloba

NR

containing 24% ginkgo flavone glycosides

Verification of the flavone content and a general fingerprint of the chemical constituents ethanolic, reversedphase high-performance liquid chromatography (HPLC) assay using UV detection according to a previously described procedure

NR

California

No

leaf extract

NA

No

McDowell 199444

Vitamin E

RRR-alpha-tocopherol

NR

No

NR

Henkel Corporation, Cork, Ireland

No

No

NR

serum alpha-tocopherol

McKenney, 200645

Omega-3 (EPA, DHA or both)

Omacor

NR

No

NR

New Jersey, US

No

No

NA

No

Meyer 200746

Supp 1: Omega-3 (EPA, DHA or both)
Supp 2: Omega-3 (EPA, DHA or both)

Supp 1: DHA
Supp 2: DHA

Supp 1: 7% EPA, 27% DHA
Supp 2: 7% EPA, 27% DHA

Supp 1: No
Supp 2: No

Supp 1: NR
Supp 2: NR

 Supp 1: No
Supp 2: No

Supp 1: No
Supp 2: No

Supp 1: No
Supp 2: No

Supp 1: NA
Supp 2: NA

Supp 1: No
Supp 2: No

Micheletta 200447

Vitamin E

alpha-tocopherol

NR

No

NR

 

No

No

NA

serum vit E

Miyamoto 200448

Vitamin E

alpha-tocopherol acetate

NR

No

NR

 

No

No

NR

No

Mohammed Abdul 200849

Garlic

Garliplex 2000

equivalent to 3.71mg of allicin

No

NR

Australia

No

garlic bulb

NA

No

Motoyama 199850

Vitamin E

Alpha-tocopherol acetate

NR

No

NR

 

No

No

NR

Measurement of flow-dependent vasodilation and blood sampling for assaysof thiobarbituric acid reactive substances (TBARS) and alpha-tocopherol weire performed before and 4 weeks after treatment

Mueller 1991 51

Omega-3 (EPA, DHA or both)

Promega

8 g of omega-3 fatty acids and 3.5 g of eicosapentaenoic

No

NR

New Jersey, US

No

No

NA

No

Napoli 1998 52

Vitamin E

DL-alpha-tocopherol

NR

No

NR

Walgreen Co., Deerfield Illinois

No

No

NR

No

Neil, HAW

Omega-3 (EPA, DHA or both)

NR

EPA=46%, DHA=38%

No

NR

Yes

No

No

NA

No

Nordoy 2000 54

Omega-3 (EPA, DHA or both)

Omacor

EHA=49%, DHA=39%

No

NR

 

No

No

NR

No

Nordøy 200355

Omega-3 (EPA, DHA or both)

Omacor

ethyl esters of eicosapentaenoic acid (EPA) 45% and docosahexaenoic acid (DHA) 39%

No

NR

Pronova, A/S, Lysaker, Norway

No

No

NR

No

Paolisso 1992 57

Magnesium

MAG2

NR

No

NR

Lyrca Synthelabo, Italy

No

No

magnesium pidolate

erythrocyte magnesium

Paolisso 199556

Vitamin E

DL-a-tocopherol acetate/d

NA

No

NR

Milan, Italy

No

No

NA

No

Playford 200358

Coenzyme Q10

NR

NR

No

NR

Blackmores, Australia

No

No

NR

Serum CoQ was assayed by reverse-phase HPLC plasma fibrinogen by Clauss reaction adn homocysteine by immunoassay.

Reyes 198459

Magnesium

Slow Mag

2.63 mmol Mg2+

No

NR

 

No

No

magnesium chloride

No

Roth 200960

Omega-3 (EPA, DHA or both)

prescription Omega-3

NR

No

Yes

Ovaza (Omacor)- US

No

No

NA

No

Sconce 200761

Vitamin K

phytomenadione

20:80 ethanol odeionized water solution

stability and quality control checks

NR

United Kingdom

No

No

NA

plasma vit K

Steiner 199562

Vitamin E

alpha-tocopherol

NR

No

NR

 

No

No

NR

serum concentration of alpha-tocopherol

Sutken 200663

Vitamin E

NR

NR

No

NR

 

No

No

NR

Vit E was measured in serum samples that were isolated and were determined according to the Hashim's method.

Svaneborg 200264

Fish oils/marine oils

NR

NR

No

NR

Pronova Biocare, Norway, delivered as Pikasol by Lube, Denmark

No

No

NR

platelet levels of EPA & DHA

Tankanow 200365

Hawthorn

Crataegus

one tablet contained 450 mg dry extract of hawthorn leaves with flowers standardized to 84.3 mg of oligomeric procyanidines

No

NR

Germany

No

hawthorn leaves with flowers

NA

No

Watson 199966

Coenzyme Q10

Coenzyme Q

NR

No

NR

Health World Limited, Brisbane, Australia

No

No

NR

Plasma levels of Coenzyme Q

Wirell 199467

Magnesium

Magnesiocard

NR

No

NR

Tutzing Germany

No

No

magnesium aspartate hydrochloride

serum magnesium, also in urine

Wolf 200668

Gingko biloba

EGb761

NA

No

NR

Germany

No

dry extract from gingko biloba leaves

NA

No

Yamamoto 199569

Omega-3 (EPA, DHA or both)

Epadel

NR

No

NR

Mochido Pharmacy, Japan

No

No

NR

plasma EPA levels

Young 200770

Coenzyme Q10

Q-Gel

NR

No

NR

 

No

No

NR

total plasma levels of CoQ10

Yuan 200471

Ginseng

Panax quinquefolius

total ginsenoside content was 5.19%

The constituent split was as follows: ginsenoside Rb1 , 1.93%; Rb2 , 0.20%; Rc, 0.61%; Rd, 0.42%; Re, 1.68%; and Rg1 , 0.35%

NR

Wisconsin US

No

root of American ginseng

NA

No


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