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D. Additional Procedures for Work with Substances of Known High Chronic Toxicity

All of the procedures and precautions described in the preceding section should be followed when working with substances known to have high chronic toxicity. In addition, when such substances are to be used in quantities in excess of a few milligrams to a few grams (depending on the hazard posed by the particular substance), the additional precautions described below should also be used. A substance that has caused cancer in humans or has shown high carcinogenic potency in test animals (but for which a regulatory standard has not been issued by OSHA) will generally require the use of these additional procedures. However, this determination will also depend on other factors, such as the physical form and the volatility of the substance, the kind and duration of exposure, and the amount of material to be used. Besides strong carcinogens, substances in the high chronic toxicity category include potent reproductive toxins and certain heavy metal compounds such as dimethylmercury and nickel carbonyl. See Section VII-A for a more detailed discussion of the identification of substances with high chronic toxicity.

(1) Approvals
Permission must be obtained from your research supervisor prior to any work with substances of known high chronic toxicity. It is the supervisor's responsibility to approve all plans for experimental operations and waste disposal.
(2) Restrict access to areas where substances of high chronic toxicity are being used and stored
Any volatile substances having high chronic toxicity should be stored in a ventilated storage area in a secondary tray or container having sufficient capacity to contain the material should the primary container accidentally break. All containers of substances in this category should have labels that identify the contents and include a warning such as the following: WARNING! HIGH CHRONIC TOXICITY or CANCER SUSPECT AGENT. Storage areas for substances in this category should be designated areas (see Part VII.B), and special signs should be posted if a special toxicity hazard exists. With the exception of materials that require refrigeration, substances of high chronic toxicity should be stored in areas maintained under negative pressure with respect to surrounding areas (e.g., fume hoods).
All experiments with and transfers of such substances or mixtures containing such substances should be done in a designated area such as an efficient laboratory hood. When a negative pressure glove box in which work is done through attached gloves is used, the ventilation rate in the glove box should be at least two volume changes per hour, the pressure should be at least 0.5 in. of water lower than that of the external environment, and the exit gases should be passed through a trap or HEPA filter. Positive-pressure glove boxes are normally used to provide an inert anhydrous atmosphere. If these glove boxes are used with highly toxic compounds, then the box should be thoroughly checked for leaks before each use. If gases are vented from a glove box, they should be passed through a suitable trap or filter or directly into the hood system. Laboratory vacuum pumps used with substances having high chronic toxicity should be protected by high-efficiency scrubbers or HEPA filters and vented into an exhaust hood. Motor-driven vacuum pumps are recommended because they are easy to decontaminate. (Note: decontamination of a vacuum pump should be carried out in an exhaust hood). Designated areas should be clearly marked with a conspicuous sign reading: DESIGNATED AREA FOR USE OF PARTICULARLY HAZARDOUS SUBSTANCESAUTHORIZED PERSONNEL ONLY. Only authorized and instructed personnel should be allowed to work in or have access to such designated areas.
(3) Wear suitable protective apparel
Proper gloves should be worn when transferring or otherwise handling substances or solutions of substances having high chronic toxicity (see Prudent Practices, pp. 158-160). Two gloves should generally be worn on each hand. In the event of an accident, the outer, contaminated gloves can then be removed and the researcher can immediately take steps to deal with the accident. To avoid contamination of the general laboratory environment, protective gloves should be removed when leaving a designated area (e.g., to answer the telephone). In some cases, the laboratory worker or the research supervisor may deem it advisable to use other protective apparel such as an apron of reduced permeability covered by a disposable coat. Extreme precautions such as these might be taken, for example, when handling large amounts of certain heavy metals and their derivatives or compounds known to be potent carcinogens. After working with such substances, laboratory workers should remove any protective apparel that has been used and thoroughly wash hands, forearms, face, and neck. If disposable apparel or absorbent paper liners have been used, these items should generally be placed in a closed and impervious container that should then be labeled in some manner such as the following: CAUTION: CONTENTS CONTAMINATED WITH SUBSTANCES OF HIGH CHRONIC TOXICITY. Nondisposable protective apparel should be thoroughly washed, and containers of disposable apparel and paper liners should be incinerated.
(4) Protect the environment and dispose of waste materials properly
Surfaces on which high-chronic-toxicity substances are handled should be protected from contamination by using chemically resistant trays or pans that can be decontaminated after the experiment or by using dry, absorbent, plastic-backed paper that can be disposed of after use.
Wastes and other contaminated materials from an experiment involving substances of high chronic toxicity should be collected, together with the washings from flasks, and either decontaminated chemically or placed in closed, suitably labeled containers for incineration. If chemical decontamination is to be used, a method should be chosen that can reasonably be expected to convert essentially all of the toxic materials into nontoxic materials. For example, residues and wastes from experiments in which -propiolactone, bis(chloromethyl)ether, or methyl chloromethyl ether have been used should be treated for 10 min with concentrated aqueous ammonia. In the event that chemical decontamination is not feasible, wastes and residues should be placed in an impermeable container that should be closed and labeled in some manner such as the following: CAUTION: COMPOUNDS OF HIGH CHRONIC TOXICITY or CAUTION: CANCER SUSPECT AGENT. In general, liquid wastes containing such compounds should be placed in glass or (usually preferable) polyethylene bottles half filled with vermiculite and these should be transported in plastic or metal pails of sufficient capacity to contain the material in case of accidental breaking of the primary container. Consult the Health & Safety Programs Unit (777-5269) for instructions on the disposal of contaminated waste materials.
Normal laboratory work should not be resumed in an area that has been used for work with substances of high chronic toxicity until it has been adequately decontaminated. Work surfaces should be thoroughly washed and rinsed. If experiments have involved the use of finely divided solid materials, dry sweeping should not be done. In such cases, surfaces should be cleaned by wet mopping or by use of a vacuum cleaner equipped with a high efficiency particulate air (HEPA) filter. All equipment (e.g., glassware, vacuum traps, and containers) that is known or suspected to have been in contact with substances of high chronic toxicity should be washed and rinsed before they are removed from the designated area.
(5) Be prepared for accidents
Be prepared for the release of a substance of high chronic toxicity by formulating a contingency plan to deal with any accident that may occur. The Health & Safety Programs Unit (777-5269) can provide assistance in preparing these contingency plans. Make sure that the necessary equipment and materials are on hand to deal with possible accidents before beginning work with substances of high chronic toxicity.
(6) Medical Surveillance
If you anticipate being involved in continued experimentation with a substance of high chronic toxicity (i.e., if you regularly use toxicologically significant quantities of such a substance three times a week), then a qualified physician at the Occupational Health Services (777-3472) should be consulted to determine whether it is advisable to establish a regular schedule of medical surveillance or biological monitoring. See Part IX for a further discussion of medical surveillance.

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