Do laboratory results concerning high-viscosity glass-ionomers versus amalgam for tooth restorations indicate similar effect direction and magnitude than that of controlled clinical trials? A meta-epidemiological study

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Do laboratory results concerning high-viscosity glass-ionomers versus amalgam for tooth restorations indicate similar effect direction and magnitude than that of controlled clinical trials? - A meta-epidemiological study
Steffen Mickenautsch, Veerasamy Yengopal
File S1: Simple PubMed of the dental literature published

between 2009 - 2014


Silver amalgam

Database searched



MeSH search terms

“Glass Ionomer Cements”

“Dental Amalgam”

Date of search

27 August 2014

27 August 2014

Number of full citations



Number of citations of clinical studies



Number of citations of laboratory studies



Laboratory/Clinical study ratio



Citations of clinical studies

1/1: Gomes GM, Gomes OM, Gomes JC, Loguercio AD, Calixto AL, Reis A. Evaluation of different restorative techniques for filling flared root canals: fracture resistance and bond strength after mechanical fatigue. J Adhes Dent. 2014 Jun;16(3):267-76. doi: 10.3290/j.jad.a31940. PubMed PMID: 24779026.
2/2: Cakmak F, Turk T, Karadeniz EI, Elekdag-Turk S, Darendeliler MA. Physical properties of root cementum: part 24. Root resorption of the first premolars after 4 weeks of occlusal trauma. Am J Orthod Dentofacial Orthop. 2014 May;145(5):617-25. doi: 10.1016/j.ajodo.2013.12.027. PubMed PMID: 24785926.
3/3: Ding YJ, Yao H, Wang GH, Song H. A randomized double-blind placebo-controlled study of the efficacy of Clinpro XT varnish and Gluma dentin desensitizer on dentin hypersensitivity. Am J Dent. 2014 Apr;27(2):79-83. PubMed PMID: 25000665.
4/4: Casagrande L, Dalpian DM, Ardenghi TM, Zanatta FB, Balbinot CE, García-Godoy F, De Araujo FB. Randomized clinical trial of adhesive restorations in primary molars. 18-month results. Am J Dent. 2013 Dec;26(6):351-5. PubMed PMID: 24640441.
5/5: Koyuturk AE, Ozmen B, Tokay U, Tuloglu N, Sari ME, Sonmez TT. Two-year follow-up of indirect posterior composite restorations of permanent teeth with excessive material loss in pediatric patients: a clinical study. J Adhes Dent. 2013 Dec;15(6):583-90. doi: 10.3290/j.jad.a30897. PubMed PMID: 24278962.
6/6: Santamaria MP, da Silva Feitosa D, Casati MZ, Nociti FH Jr, Sallum AW, Sallum EA. Randomized controlled clinical trial evaluating connective tissue graft plus resin-modified glass ionomer restoration for the treatment of gingival recession associated with non-carious cervical lesion: 2-year follow-up. J Periodontol. 2013 Sep;84(9):e1-8. doi: 10.1902/jop.2013.120447. Epub 2013 Jan 31. PubMed PMID: 23368948.
7/7: Bonifácio CC, Hesse D, Raggio DP, Bönecker M, van Loveren C, van Amerongen WE. The effect of GIC-brand on the survival rate of proximal-ART restorations. Int J Paediatr Dent. 2013 Jul;23(4):251-8. doi: 10.1111/j.1365-263X.2012.01259.x. Epub 2012 Aug 14. PubMed PMID: 22891625.
8/8: Campus G, Carta G, Cagetti MG, Bossù M, Sale S, Cocco F, Conti G, Nardone M, Sanna G, Strohmenger L, Lingström P; Italian Experimental Group on Oral Health. Fluoride concentration from dental sealants: a randomized clinical trial. J Dent Res. 2013 Jul;92(7 Suppl):23S-8S. doi: 10.1177/0022034513484329. Epub 2013 May 20. PubMed PMID: 23690357.
9/9: Hilton TJ, Ferracane JL, Mancl L; Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NWP). Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial. J Dent Res. 2013 Jul;92(7 Suppl):16S-22S. doi: 10.1177/0022034513484336. Epub 2013 May 20. PubMed PMID: 23690353; PubMed Central PMCID: PMC3706175.
10/10: Blatz MB, Mante FK, Saleh N, Atlas AM, Mannan S, Ozer F. Postoperative tooth sensitivity with a new self-adhesive resin cement--a randomized clinical trial. Clin Oral Investig. 2013 Apr;17(3):793-8. doi: 10.1007/s00784-012-0775-4. Epub 2012 Jul 11. PubMed PMID: 22782256.
11/11: Guler C, Yilmaz Y. A two-year clinical evaluation of glass ionomer and ormocer based fissure sealants. J Clin Pediatr Dent. 2013 Spring;37(3):263-7. PubMed PMID: 23855170.
12/12: Havale R, Anegundi RT, Indushekar K, Sudha P. Clinical and radiographic evaluation of pulpotomies in primary molars with formocresol, glutaraldehyde and ferric sulphate. Oral Health Dent Manag. 2013 Mar;12(1):24-31. PubMed PMID: 23474578.
13/13: Ferreira JM, Pinheiro SL, Sampaio FC, Menezes VA. Use of glass ionomer cement containing antibiotics to seal off infected dentin: a randomized clinical trial. Braz Dent J. 2013;24(1):68-73. PubMed PMID: 23657417.
14/14: Corralo DJ, Maltz M. Clinical and ultrastructural effects of different liners/restorative materials on deep carious dentin: a randomized clinical trial. Caries Res. 2013;47(3):243-50. doi: 10.1159/000345648. Epub 2013 Jan 19. PubMed PMID: 23343804.
15/15: Maltz M, Jardim JJ, Mestrinho HD, Yamaguti PM, Podestá K, Moura MS, de Paula

LM. Partial removal of carious dentine: a multicenter randomized controlled trial and 18-month follow-up results. Caries Res. 2013;47(2):103-9. doi: 10.1159/000344013. Epub 2012 Nov 28. PubMed PMID: 23207420.

16/16: Santamaria MP, Casati MZ, Nociti FH Jr, Sallum AW, Sallum EA, Aukhil I, Wallet SM, Shaddox LM. Connective tissue graft plus resin-modified glass ionomer restoration for the treatment of gingival recession associated with non-carious cervical lesions: microbiological and immunological results. Clin Oral Investig. 2013 Jan;17(1):67-77. doi: 10.1007/s00784-012-0690-8. Epub 2012 Feb 29. PubMed PMID: 22373777.
17/17: Chen Xx, Liu Xg. Clinical comparison of Fuji VII and a resin sealant in children at high and low risk of caries. Dent Mater J. 2013;32(3):512-8. PubMed PMID: 23719016.
18/18: Nosrat A, Seifi A, Asgary S. Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Int J Paediatr Dent. 2013 Jan;23(1):56-63. doi: 10.1111/j.1365-263X.2012.01224.x. Epub 2012 Feb 6. PubMed PMID: 22309243.
19/19: Bezerra AC, Novaes RC, Faber J, Frencken JE, Leal SC. Ion concentration adjacent to glass-ionomer restorations in primary molars. Dent Mater. 2012 Nov;28(11):e259-63. doi: 10.1016/ Epub 2012 Sep 20. PubMed PMID: 22999372.
20/20: Zhi QH, Lo EC, Lin HC. Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. J Dent. 2012 Nov;40(11):962-7. doi: 10.1016/j.jdent.2012.08.002. Epub 2012 Aug 11. PubMed PMID: 22892463.
21/21: Perdigão J, Dutra-Corrêa M, Saraceni SH, Ciaramicoli MT, Kiyan VH. Randomized clinical trial of two resin-modified glass ionomer materials: 1-year results. Oper Dent. 2012 Nov-Dec;37(6):591-601. doi: 10.2341/11-415-C. Epub 2012 Jul 7. PubMed PMID: 22770485.
22/22: Jongsma LA, Kleverlaan CJ, Feilzer AJ. Clinical success and survival of indirect resin composite crowns: results of a 3-year prospective study. Dent Mater. 2012 Sep;28(9):952-60. doi: 10.1016/ Epub 2012 May

18. PubMed PMID: 22608959.

23/23: Huth KC, Hajek-Al-Khatar N, Wolf P, Ilie N, Hickel R, Paschos E. Long-term effectiveness of four pulpotomy techniques: 3-year randomised controlled trial. Clin Oral Investig. 2012 Aug;16(4):1243-50. doi: 10.1007/s00784-011-0602-3. Epub 2011 Aug 13. PubMed PMID: 21842145.
24/24: Andrade AK, Duarte RM, Silva FD, Batista AU, Lima KC, Pontual ML, Montes MA. Clinical evaluation of nanofill and nanohybrid composite in Class I restorations: a 12-month randomized trial. Gen Dent. 2012 Jul-Aug;60(4):e255-62. PubMed PMID: 22782061.
25/25: Roshan NM, Sakeenabi B. Anxiety in children during occlusal ART restorations in primary molars placed in school environment and hospital dental setup. J Clin Pediatr Dent. 2012 Summer;36(4):349-52. PubMed PMID: 23019830.

26/26: Phonghanyudh A, Phantumvanit P, Songpaisan Y, Petersen PE. Clinical evaluation of three caries removal approaches in primary teeth: a randomised controlled trial. Community Dent Health. 2012 Jun;29(2):173-8. PubMed PMID: 22779380.

27/27: Vigolo P, Mutinelli S. Evaluation of zirconium-oxide-based ceramic single-unit posterior fixed dental prostheses (FDPs) generated with two CAD/CAM systems compared to porcelain-fused-to-metal single-unit posterior FDPs: a 5-year clinical prospective study. J Prosthodont. 2012 Jun;21(4):265-9. doi: 10.1111/j.1532-849X.2011.00825.x. Epub 2012 Feb 19. PubMed PMID: 22339945.
28/28: Chen X, Du MQ, Fan MW, Mulder J, Huysmans MC, Frencken JE. Caries-preventive

effect of sealants produced with altered glass-ionomer materials, after 2 years. Dent Mater. 2012 May;28(5):554-60. doi: 10.1016/ Epub 2012 Jan 31. PubMed PMID: 22300651.

29/29: Shetty RM, Bhat S, Mehta D, Srivatsa G, Shetty YB. Comparative analysis of postcementation hypersensitivity with glass ionomer cement and a resin cement: an in vivo study. J Contemp Dent Pract. 2012 May 1;13(3):327-31. PubMed PMID: 22918005.
30/30: Ulusu T, Odabaş ME, Tüzüner T, Baygin O, Sillelioğlu H, Deveci C, Gökdoğan FG, Altuntaş A. The success rates of a glass ionomer cement and a resin-based fissure sealant placed by fifth-year undergraduate dental students. Eur Arch Paediatr Dent. 2012 Apr;13(2):94-7. PubMed PMID: 22449810.
31/31: Corbacho de Melo MM, Cardoso MG, Faber J, Sobral A. Risk factors for periodontal changes in adult patients with banded second molars during orthodontic treatment. Angle Orthod. 2012 Mar;82(2):224-8. doi: 10.2319/030911-172.1. Epub 2011 Sep 7. PubMed PMID: 21899378.
32/32: Baracco B, Perdigão J, Cabrera E, Giráldez I, Ceballos L. Clinical evaluation of a low-shrinkage composite in posterior restorations: one-year results. Oper Dent. 2012 Mar-Apr;37(2):117-29. doi: 10.2341/11-179-C. Epub 2012 Feb 7. PubMed PMID: 22313275.
33/33: Dos Santos VE Jr, de Vasconcelos FM, Ribeiro AG, Rosenblatt A. Paradigm shift in the effective treatment of caries in schoolchildren at risk. Int Dent J. 2012 Feb;62(1):47-51. doi: 10.1111/j.1875-595X.2011.00088.x. PubMed PMID: 22251037.
34/34: Antonson SA, Antonson DE, Brener S, Crutchfield J, Larumbe J, Michaud C, Yazici AR, Hardigan PC, Alempour S, Evans D, Ocanto R. Twenty-four month clinical evaluation of fissure sealants on partially erupted permanent first molars: glass ionomer versus resin-based sealant. J Am Dent Assoc. 2012 Feb;143(2):115-22. Erratum in: J Am Dent Assoc. 2012 Apr;143(4):336. PubMed PMID: 22298552.

35/35: Dhar V, Chen H. Evaluation of resin based and glass ionomer based sealants placed with or without tooth preparation-a two year clinical trial. Pediatr Dent. 2012 Jan-Feb;34(1):46-50. PubMed PMID: 22353457.

36/36: De Menezes Abreu DM, Leal SC, Mulder J, Frencken JE. Dental anxiety in 6-7-year-old children treated in accordance with conventional restorative treatment, ART and ultra-conservative treatment protocols. Acta Odontol Scand. 2011 Nov;69(6):410-6. doi: 10.3109/00016357.2011.572561. Epub 2011 Apr 27. PubMed PMID: 21524172.
37/37: Dere H, Ozdogan F, Ozcan KM, Selcuk A, Ozcan I, Gokturk G. Comparison of glass ionomer cement and incus interposition in reconstruction of incus long process defects. Eur Arch Otorhinolaryngol. 2011 Nov;268(11):1565-8. doi: 10.1007/s00405-010-1454-1. Epub 2011 Feb 22. PubMed PMID: 21340562.
38/38: Maghrabi AA. Effect of dentin sealers on postoperative sensitivity of complete cast crowns cemented with glass ionomer cement. J Prosthodont. 2011 Jul;20(5):385-90. doi: 10.1111/j.1532-849X.2011.00724.x. Epub 2011 May 31. PubMed PMID: 21627710.
39/39: Ibiyemi O, Bankole OO, Oke GA. Survival rates of two atraumatic restorative treatment (ART) types in occlusal carious permanent teeth after two years. Afr J Med Med Sci. 2011 Jun;40(2):127-34. PubMed PMID: 22195380.
40/40: Nazir M, Walsh T, Mandall NA, Matthew S, Fox D. Banding versus bonding of

first permanent molars: a multi-centre randomized controlled trial. J Orthod. 2011 Jun;38(2):81-9. doi: 10.1179/14653121141308. PubMed PMID: 21677099.

41/41: Kemoli AM, Opinya GN, van Amerongen WE, Mwalili SM. Two-year survival rates of proximal atraumatic restorative treatment restorations in relation to glass ionomer cements and Postrestoration meals consumed. Pediatr Dent. 2011 May-Jun;33(3):246-51. PubMed PMID: 21703078.
42/42: Tagliaferro EP, Pardi V, Ambrosano GM, Meneghim Mde C, da Silva SR, Pereira AC. Occlusal caries prevention in high and low risk schoolchildren. A clinical trial. Am J Dent. 2011 Apr;24(2):109-14. PubMed PMID: 21698991.
43/43: De Moor RJ, Stassen IG, van 't Veldt Y, Torbeyns D, Hommez GM. Two-year clinical performance of glass ionomer and resin composite restorations in xerostomic head- and neck-irradiated cancer patients. Clin Oral Investig. 2011 Feb;15(1):31-8. doi: 10.1007/s00784-009-0355-4. Epub 2009 Dec 8. PubMed PMID: 19997859.
44/44: Liu H, Zhou Q, Qin M. Mineral trioxide aggregate versus calcium hydroxide for pulpotomy in primary molars. Chin J Dent Res. 2011;14(2):121-5. PubMed PMID: 22319753.

45/45: Rinke S, Schäfer S, Roediger M. Complication rate of molar crowns: a practice-based clinical evaluation. Int J Comput Dent. 2011;14(3):203-18. English, German. PubMed PMID: 22141230.

46/46: de Andrade AK, Duarte RM, Medeiros e Silva FD, Batista AU, Lima KC, Pontual ML, Montes MA. 30-Month randomised clinical trial to evaluate the clinical performance of a nanofill and a nanohybrid composite. J Dent. 2011 Jan;39(1):8-15. doi: 10.1016/j.jdent.2010.09.005. Epub 2010 Oct 1. PubMed PMID: 20888884.
47/47: Trairatvorakul C, Itsaraviriyakul S, Wiboonchan W. Effect of glass-ionomer cement on the progression of proximal caries. J Dent Res. 2011 Jan;90(1):99-103. doi: 10.1177/0022034510381265. Epub 2010 Sep 21. PubMed PMID: 20858776.
48/48: Deepa G, Shobha T. A clinical evaluation of two glass ionomer cements in primary molars using atraumatic restorative treatment technique in India: 1 year follow up. Int J Paediatr Dent. 2010 Nov;20(6):410-8. doi:

10.1111/j.1365-263X.2010.01067.x. PubMed PMID: 20642467.

49/49: Orhan AI, Oz FT, Orhan K. Pulp exposure occurrence and outcomes after 1- or 2-visit indirect pulp therapy vs complete caries removal in primary and permanent molars. Pediatr Dent. 2010 Jul-Aug;32(4):347-55. PubMed PMID: 20836956.
50/50: Bjørndal L, Reit C, Bruun G, Markvart M, Kjaeldgaard M, Näsman P, Thordrup M, Dige I, Nyvad B, Fransson H, Lager A, Ericson D, Petersson K, Olsson J, Santimano EM, Wennström A, Winkel P, Gluud C. Treatment of deep caries lesions in adults: randomized clinical trials comparing stepwise vs. direct complete excavation, and direct pulp capping vs. partial pulpotomy. Eur J Oral Sci. 2010 Jun;118(3):290-7. doi: 10.1111/j.1600-0722.2010.00731.x. PubMed PMID: 20572864.
51/51: Alves dos Santos MP, Luiz RR, Maia LC. Randomised trial of resin-based restorations in Class I and Class II beveled preparations in primary molars: 48-month results. J Dent. 2010 Jun;38(6):451-9. doi: 10.1016/j.jdent.2010.02.004. Epub 2010 Feb 25. PubMed PMID: 20188783.
52/52: Mendonça JS, Neto RG, Santiago SL, Lauris JR, Navarro MF, de Carvalho RM. Direct resin composite restorations versus indirect composite inlays: one-year results. J Contemp Dent Pract. 2010 May 1;11(3):025-32. PubMed PMID: 20461321.
53/53: van Dijken JW, Pallesen U. Fracture frequency and longevity of fractured resin composite, polyacid-modified resin composite, and resin-modified glass ionomer cement class IV restorations: an up to 14 years of follow-up. Clin Oral Investig. 2010 Apr;14(2):217-22. doi: 10.1007/s00784-009-0287-z. Epub 2009 Jun 6.

PubMed PMID: 19504133.

54/54: Târcă T, Bădescu A, Topoliceanu C, Lăcătuşu S. [Clinical and microbiological

study regarding surface antibacterial properties of bioactive dental materials]. Rev Med Chir Soc Med Nat Iasi. 2010 Apr-Jun;114(2):536-41. Romanian. PubMed PMID: 20700999.

55/55: Lutfi AN, Kannan TP, Fazliah MN, Jamaruddin MA, Saidi J. Proliferative activity of cells from remaining dental pulp in response to treatment with dental materials. Aust Dent J. 2010 Mar;55(1):79-85. doi: 10.1111/j.1834-7819.2009.01185.x. PubMed PMID: 20415916.
56/56: Sly EG, Kaplan AE, Missana L. Clinical evaluation of glass ionomer for pit and fissure sealing of fully erupted molars. Acta Odontol Latinoam. 2010;23(1):3-7. PubMed PMID: 20645635.
57/57: Santiago SL, Passos VF, Vieira AH, Navarro MF, Lauris JR, Franco EB. Two-year

clinical evaluation of resinous restorative systems in non-carious cervical lesions. Braz Dent J. 2010;21(3):229-34. PubMed PMID: 21203706.

58/58: Płuciennik-Stronias M, Sakowska D, Krzemiński Z, Piatowska D. [Influence of topical fluoridation of glass ionomer cements on inhibitory activity on cariogenic bacteria]. Med Dosw Mikrobiol. 2010;62(4):369-74. Polish. PubMed PMID: 21473102.
59/59: Ertugrul F, Cogulu D, Ozdemir Y, Ersin N. Comparison of conventional versus colored compomers for class II restorations in primary molars: a 12-month clinical study. Med Princ Pract. 2010;19(2):148-52. doi: 10.1159/000273077. Epub 2010 Feb 4. PubMed PMID: 20134179.
60/60: Shi L, Wang X, Zhao Q, Zhang Y, Zhang L, Ren Y, Chen Z. Evaluation of packable and conventional hybrid resin composites in Class I restorations: three-year results of a randomized, double-blind and controlled clinical trial. Oper Dent. 2010 Jan-Feb;35(1):11-9. doi: 10.2341/09-027CR. PubMed PMID: 20166406.
61/61: Baseggio W, Naufel FS, Davidoff DC, Nahsan FP, Flury S, Rodrigues JA. Caries-preventive efficacy and retention of a resin-modified glass ionomer cement and a resin-based fissure sealant: a 3-year split-mouth randomised clinical trial. Oral Health Prev Dent. 2010;8(3):261-8. PubMed PMID: 20848004.
62/62: Duque C, Negrini Tde C, Sacono NT, Spolidorio DM, de Souza Costa CA, Hebling

J. Clinical and microbiological performance of resin-modified glass-ionomer liners after incomplete dentine caries removal. Clin Oral Investig. 2009 Dec;13(4):465-71. doi: 10.1007/s00784-009-0304-2. Epub 2009 Jun 23. PubMed PMID: 19548010.

63/63: Kemoli AM, van Amerongen WE, Opinya G. Influence of the experience of operator and assistant on the survival rate of proximal ART restorations: two-year results. Eur Arch Paediatr Dent. 2009 Dec;10(4):227-32. PubMed PMID: 19995507.

64/64: Wolfart S, Harder S, Eschbach S, Lehmann F, Kern M. Four-year clinical results of fixed dental prostheses with zirconia substructures (Cercon): end abutments vs. cantilever design. Eur J Oral Sci. 2009 Dec;117(6):741-9. doi: 10.1111/j.1600-0722.2009.00693.x. PubMed PMID: 20121939.

65/65: Kemoli AM, van Amerongen WE. Influence of the cavity-size on the survival rate of proximal ART restorations in primary molars. Int J Paediatr Dent. 2009 Nov;19(6):423-30. doi: 10.1111/j.1365-263X.2009.01013.x. Epub 2009 Sep 1. PubMed

PMID: 19732191.

66/66: Malkhassian G, Manzur AJ, Legner M, Fillery ED, Manek S, Basrani BR, Friedman S. Antibacterial efficacy of MTAD final rinse and two percent chlorhexidine gel medication in teeth with apical periodontitis: a randomized double-blinded clinical trial. J Endod. 2009 Nov;35(11):1483-90. doi: 10.1016/j.joen.2009.08.003. Epub 2009 Sep 18. PubMed PMID: 19840635.
67/67: Oba AA, Dülgergil T, Sönmez IS, Doğan S. Comparison of caries prevention with glass ionomer and composite resin fissure sealants. J Formos Med Assoc. 2009 Nov;108(11):844-8. doi: 10.1016/S0929-6646(09)60415-0. PubMed PMID: 19933027.
68/68: Burrow MF, Banomyong D, Harnirattisai C, Messer HH. Effect of glass-ionomer cement lining on postoperative sensitivity in occlusal cavities restored with resin composite--a randomized clinical trial. Oper Dent. 2009 Nov-Dec;34(6):648-55. doi: 10.2341/08-098-C. PubMed PMID: 19953773.
69/69: Daou MH, Tavernier B, Meyer JM. Two-year clinical evaluation of three restorative materials in primary molars. J Clin Pediatr Dent. 2009 Fall;34(1):53-8. PubMed PMID: 19953810.
70/70: Santamaria MP, Ambrosano GM, Casati MZ, Nociti Júnior FH, Sallum AW, Sallum EA. Connective tissue graft plus resin-modified glass ionomer restoration for the treatment of gingival recession associated with non-carious cervical lesion: a randomized-controlled clinical trial. J Clin Periodontol. 2009 Sep;36(9):791-8.

doi: 10.1111/j.1600-051X.2009.01441.x. Epub 2009 Jul 7. PubMed PMID: 19594663.

71/71: Wilson TG Jr. The positive relationship between excess cement and peri-implant disease: a prospective clinical endoscopic study. J Periodontol. 2009 Sep;80(9):1388-92. doi: 10.1902/jop.2009.090115. PubMed PMID: 19722787.
72/72: Khairallah C, Hokayem A. [Long-term clinical evaluation of 2 dental materials used for the preparation of esthetic inlays]. Odontostomatol Trop. 2009 Sep;32(127):5-13. French. PubMed PMID: 20441124.

1/1: Kisakol G. Dental amalgam implantation and thyroid autoimmunity. Bratisl Lek Listy. 2014;115(1):22-4. PubMed PMID: 24471898.
2/2: McCracken MS, Gordan VV, Litaker MS, Funkhouser E, Fellows JL, Shamp DG, Qvist V, Meral JS, Gilbert GH; National Dental Practice-Based Research Network Collaborative Group. A 24-month evaluation of amalgam and resin-based composite restorations: Findings from The National Dental Practice-Based Research Network. J Am Dent Assoc. 2013 Jun;144(6):583-93. PubMed PMID: 23729455; PubMed Central PMCID: PMC3694730.
3/3: Gilbert GH, Gordan VV, Funkhouser EM, Rindal DB, Fellows JL, Qvist V, Anderson G, Worley D; National Dental PBRN Collaborative Group. Caries treatment in a dental practice-based research network: movement toward stated evidence-based treatment. Community Dent Oral Epidemiol. 2013 Apr;41(2):143-53. doi: 10.1111/cdoe.12008. Epub 2012 Oct 5. PubMed PMID: 23036131; PubMed Central PMCID: PMC3811014.
4/4: Martin J, Fernandez E, Estay J, Gordan VV, Mjor IA, Moncada G. Minimal invasive treatment for defective restorations: five-year results using sealants. Oper Dent. 2013 Mar-Apr;38(2):125-33. doi: 10.2341/12-062C. Epub 2012 Jul 11. PubMed PMID: 22788726.
5/5: Maltz M, Jardim JJ, Mestrinho HD, Yamaguti PM, Podestá K, Moura MS, de Paula LM. Partial removal of carious dentine: a multicenter randomized controlled trial

and 18-month follow-up results. Caries Res. 2013;47(2):103-9. doi: 10.1159/000344013. Epub 2012 Nov 28. PubMed PMID: 23207420.

6/6: Bracher AK, Hofmann C, Bornstedt A, Hell E, Janke F, Ulrici J, Haller B, Geibel MA, Rasche V. Ultrashort echo time (UTE) MRI for the assessment of caries lesions. Dentomaxillofac Radiol. 2013;42(6):20120321. doi: 10.1259/dmfr.20120321. Epub 2013 Feb 18. PubMed PMID: 23420857; PubMed Central PMCID: PMC3667523.
7/7: Tüzüner T, Alacam A, Altunbas DA, Gokdogan FG, Gundogdu E. Clinical and radiographic outcomes of direct pulp capping therapy in primary molar teeth following haemostasis with various antiseptics: a randomised controlled trial. Eur J Paediatr Dent. 2012 Dec;13(4):289-92. PubMed PMID: 23270285.

8/8: Maserejian NN, Hauser R, Tavares M, Trachtenberg FL, Shrader P, McKinlay S. Dental composites and amalgam and physical development in children. J Dent Res. 2012 Nov;91(11):1019-25. doi: 10.1177/0022034512458691. Epub 2012 Sep 12. PubMed

PMID: 22972857; PubMed Central PMCID: PMC3525131.
9/10: Maserejian NN, Trachtenberg FL, Hauser R, McKinlay S, Shrader P, Bellinger DC. Dental composite restorations and neuropsychological development in children: treatment level analysis from a randomized clinical trial. Neurotoxicology. 2012 Oct;33(5):1291-7. doi: 10.1016/j.neuro.2012.08.001. Epub 2012 Aug 14. PubMed PMID: 22906860; PubMed Central PMCID: PMC3470777.
10/11: Naimi-Akbar A, Svedberg P, Alexanderson K, Ekstrand J, Sandborgh-Englund G. Reliance on social security benefits by Swedish patients with ill-health attributed to dental fillings: a register-based cohort study. BMC Public Health. 2012 Aug 30;12:713. doi: 10.1186/1471-2458-12-713. PubMed PMID: 22935213; PubMed Central PMCID: PMC3487969.
11/12: Yaman E, Görken F, Pinar Erdem A, Sepet E, Aytepe Z. Effects of folk medicinal plant extract Ankaferd Blood Stopper(®) in vital primary molar pulpotomy. Eur Arch Paediatr Dent. 2012 Aug;13(4):197-202. PubMed PMID: 22883359.
12/13: Maserejian NN, Trachtenberg FL, Hauser R, McKinlay S, Shrader P, Tavares M, Bellinger DC. Dental composite restorations and psychosocial function in children. Pediatrics. 2012 Aug;130(2):e328-38. doi: 10.1542/peds.2011-3374. Epub 2012 Jul 16. PubMed PMID: 22802599; PubMed Central PMCID: PMC3408688.
13/14: Neelakantan P, Rao CV, Indramohan J. Bacteriology of deep carious lesions underneath amalgam restorations with different pulp-capping materials--an in vivo analysis. J Appl Oral Sci. 2012 Mar-Apr;20(2):139-45. PubMed PMID: 22666827; PubMed Central PMCID: PMC3894753.
14/15: Overton JD, Sullivan DJ. Early failure of Class II resin composite versus Class II amalgam restorations placed by dental students. J Dent Educ. 2012 Mar;76(3):338-40. PubMed PMID: 22383602.
15/16: Geier DA, Carmody T, Kern JK, King PG, Geier MR. A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels: a further assessment of the Casa Pia Children's Dental Amalgam Trial. Hum Exp Toxicol. 2012 Jan;31(1):11-7. doi: 10.1177/0960327111417264. Epub 2011 Jul 29. PubMed PMID: 21803780.
16/17: Thygesen LC, Flachs EM, Hanehøj K, Kjuus H, Juel K. Hospital admissions for neurological and renal diseases among dentists and dental assistants occupationally exposed to mercury. Occup Environ Med. 2011 Dec;68(12):895-901. doi: 10.1136/oem.2010.064063. Epub 2011 Apr 20. PubMed PMID: 21508427.
17/18: De Menezes Abreu DM, Leal SC, Mulder J, Frencken JE. Dental anxiety in 6-7-year-old children treated in accordance with conventional restorative treatment, ART and ultra-conservative treatment protocols. Acta Odontol Scand. 2011 Nov;69(6):410-6. doi: 10.3109/00016357.2011.572561. Epub 2011 Apr 27. PubMed PMID: 21524172.
18/19: Sjursen TT, Lygre GB, Dalen K, Helland V, Laegreid T, Svahn J, Lundekvam BF, Björkman L. Changes in health complaints after removal of amalgam fillings. J Oral Rehabil. 2011 Nov;38(11):835-48. doi: 10.1111/j.1365-2842.2011.02223.x. Epub 2011 Apr 23. PubMed PMID: 21517933; PubMed Central PMCID: PMC3229679.
19/20: Samir AM, Aref WM. Impact of occupational exposure to elemental mercury on some antioxidative enzymes among dental staff. Toxicol Ind Health. 2011 Oct;27(9):779-86. doi: 10.1177/0748233710397420. Epub 2011 Mar 22. PubMed PMID: 21427135.
20/21: Malekafzali B, Shekarchi F, Asgary S. Treatment outcomes of pulpotomy in primary molars using two endodontic biomaterials. A 2-year randomised clinical trial. Eur J Paediatr Dent. 2011 Sep;12(3):189-93. PubMed PMID: 22077689.
21/22: Gordan VV, Riley JL 3rd, Blaser PK, Mondragon E, Garvan CW, Mjör IA. Alternative treatments to replacement of defective amalgam restorations: results of a seven-year clinical study. J Am Dent Assoc. 2011 Jul;142(7):842-9. PubMedPMID: 21719808.
22/23: Geier DA, Carmody T, Kern JK, King PG, Geier MR. A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children's dental amalgam trial. Biometals. 2011 Apr;24(2):215-24. doi: 10.1007/s10534-010-9387-0. Epub 2010 Nov 5. PubMed PMID: 21053054.
23/24: Erdem AP, Guven Y, Balli B, Ilhan B, Sepet E, Ulukapi I, Aktoren O. Success rates of mineral trioxide aggregate, ferric sulfate, and formocresol pulpotomies: a 24-month study. Pediatr Dent. 2011 Mar-Apr;33(2):165-70. PubMed PMID: 21703067.
24/25: Fernández EM, Martin JA, Angel PA, Mjör IA, Gordan VV, Moncada GA. Survival rate of sealed, refurbished and repaired defective restorations: 4-year follow-up. Braz Dent J. 2011;22(2):134-9. PubMed PMID: 21537587.
25/26: Alptekin T, Ozer F, Unlu N, Cobanoglu N, Blatz MB. In vivo and in vitro evaluations of microleakage around Class I amalgam and composite restorations. Oper Dent. 2010 Nov-Dec;35(6):641-8. doi: 10.2341/10-065-L. PubMed PMID: 21180003.
26/27: Ahrari F, Nojoomian M, Moosavi H. Clinical evaluation of bonded amalgam restorations in endodontically treated premolar teeth: a one-year evaluation. J Contemp Dent Pract. 2010 Oct 14;11(5):009-16. PubMed PMID: 20978719.
27/28: de Oliveira MT, Pereira JR, Ghizoni JS, Bittencourt ST, Molina GO. Effects from exposure to dental amalgam on systemic mercury levels in patients and dental school students. Photomed Laser Surg. 2010 Oct;28 Suppl 2:S111-4. doi: 10.1089/pho.2009.2656. Epub 2010 Oct 7. PubMed PMID: 20929387.
28/29: Ansari G, Ranjpour M. Mineral trioxide aggregate and formocresol pulpotomy of primary teeth: a 2-year follow-up. Int Endod J. 2010 May;43(5):413-8. doi: 10.1111/j.1365-2591.2010.01695.x. PubMed PMID: 20518934.
29/30: Simratvir M, Singh N, Chopra S, Thomas AM. Efficacy of 10% Povidone Iodine in children affected with early childhood caries: an in vivo study. J Clin Pediatr Dent. 2010 Spring;34(3):233-8. PubMed PMID: 20578661.
30/31: Gupta M, Pandit IK, Srivastava N, Gugnani N. Comparative evaluation of 2% sodium fluoride iontophoresis and other cavity liners beneath silver amalgam restorations. J Indian Soc Pedod Prev Dent. 2010 Apr-Jun;28(2):68-72. doi: 10.4103/0970-4388.66738. PubMed PMID: 20660970.
31/32: Daou MH, Tavernier B, Meyer JM. Two-year clinical evaluation of three restorative materials in primary molars. J Clin Pediatr Dent. 2009 Fall;34(1):53-8. PubMed PMID: 19953810.
32/67. Sonmez D(1), Duruturk L. Success rate of calcium hydroxide pulpotomy in primary molars restored with amalgam and stainless steel crowns. Br Dent J. 2010 May 8;208(9):E18; discussion 408-9. doi: 10.1038/sj.bdj.2010.446.

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