Dawson et al., 2015. Supplementary Information



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Dawson et al., 2015. Supplementary Information

Table S1. Blood glucose and tracer parameters in the 2-deoxyglucose imaging experiment






Wild-type

Disc1tr Hemi

Saline

Ketamine

Saline

Ketamine

Plasma 14C concentration (nCi/ml)

23.98 ± 1.36

27.85 ± 2.05

24.69 ± 3.69

26.84 ± 1.26

Plasma Glucose concentration (mmol/L)

9.31 ± 0.43

10.43* ± 0.39

9.12 ± 0.18

10.29* ± 0.53

Whole Brain Average 14C concentration (WBAv [nCi/mg])

127.59 ± 6.53

131.92 ± 11.10

157.74 ± 22.68

123.86 ± 9.65

WBAv : Plasma 14C ratio

5.39 ± 0.35

4.75 ± 0.31

7.43 ± 2.15

4.65 ± 0.34

Data shown as mean ± S.E.M. While ketamine treatment significantly increases the plasma glucose concentration this does not significantly impact on the ability of the tracer to enter the brain, as supported by no significant alterations in the WBAv:14C Plasma ratio. In addition, genotype does not significantly affect blood glucose and tracer levels, the WBAv 14C concentration or the WBAv: Plasma 14C ratio. *denotes p<0.05 significant difference from saline-treated animals (main treatment effect, 2-way ANOVA).


Prefrontal Cortex




Mesolimbic




Hippocampus

Anterior Prelimbic Cortex (aPrL)




Ventral Tegmental Area (VTA)




Dorsal Subiculum (DSub)

Frontal Association Area (FRA)




Nucleus Accumbens Core (NacC)




Cornu Ammonis 1 (CA1)

Dorsolateral Orbital Cortex (DLO)




Nucleus Accumbens Shell (NacS)




Cornu Ammonis 2 (CA2)

Medial Orbital Cortex (MO)




Basal Ganglia




Cornu Ammonis 3 (CA3)

Lateral Orbital Cortex (LO)




Ventromedial Striatum (VMST)




Dentate Gyrus (DG)

Medial Prelimbic Cortex (Layer 1, [mPrL1])




Dorsolateral Striatum (DLST)




Molecular Layer (ML)

Medial Prelimbic Cortex (Layer 2, [mPrL2])




Globus Pallidus (GP)




Multimodal

Medial Prelimbic Cortex (Layer 3, [mPrL3])




Substantia Nigra pars Reticulata (SNR)




Habenula (Hab)

Cortex




Substantia Nigra pars Compacta (SNC)




Mamillary Body (MB)

Cingulate Cortex (Cg1)




Amygdala




Corpus Callosum (CC)

Primary Motor Cortex (M1)




Basolateral Amygdala (BLA)




Septum/Diagonal Band of Broca (DB)

Piriform Cortex (Piri)




Central Amygdala (CeA)




Lateral Septum (LS)

Insular Cortex (Ins)




Medial Amygdala (MeA)




Medal Septum (MS)

Somatosensory Cortex (SSCTX)




Auditory




Horizontal Limb of DB (HDB)

Retrosplenial Cortex (RSC)




Inferior Colliculus (IC)




Vertical Limb of DB (VDB)

Thalamus




Medial Geniculate (MG)







Anteromedial Thalamus (AMthal)




Auditory Cortex (AudC)







Anteroventral Thalamus (AVthal)




Neuromodulatory







Mediodorsal Thalamus (MDthal)




Dorsal Raphe (DR)







Centromedial Thalamus (CMthal)




Median Raphe (MR)







Centrolateral Thalamus (CLthal)




Ventral Tegmental Nucleus (VTg)







Ventrolateral Thalamus (VLthal)




Dorsal Tegmental Nucleus (DTg)







Ventromedial Thalamus (VMthal)




Locus Coeruleus (LC)







Nucleus Reuniens (Re)













Dorsal Reticular Thalamus (dRT)













Ventral Reticualr Thalamus (vRT)












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