Curriculum vitae sergei A. Nedospasov, Ph. D., D. Sci. Permanent laboratory of Molecular Immunology professional



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CURRICULUM VITAE
Sergei A. NEDOSPASOV, Ph.D., D.Sci.
PERMANENT Laboratory of Molecular Immunology

PROFESSIONAL Engelhardt Institute of Molecular Biology

ADDRESS Russian Academy of Sciences

32 Vavilov street

Moscow 119991, Russia

tel: +7 499 135 9964

FAX: +7 499 135 1405

E-mail: sergei.nedospasov@gmail.com


ALTERNATIVE AG Entzundungsbiologie

PROFESSIONAL Deutsches Rheuma Forschungszentrum

ADDRESS Chariteplatz 1

10117 Berlin

Germany

tel. +49 30 28 46 06 77



FAX: +49 30 28 46 06 03

E-mail: nedospasov@drfz.de


EDUCATION AND SCIENTIFIC DEGREES

1959-1969 Primary, secondary, high school (Moscow, Russia).

1970-1976 Moscow Institute of Physics and Technology, Department of Molecular Biophysics.

1976-1979 Ph.D. program in Molecular Biology, Institute of Molecular Biology USSR Academy of Sciences, Moscow USSR

(mentors: A. Varshavsky 1976-1977, G. Georgiev - 1977-1979)

1976 Degree awarded: MS (Biophysics)

1980 Degree awarded: Candidate of Sciences (Molecular Biology) (Ph.D.)

1990 Degree awarded: Doctor of Sciences (Molecular Biology) (D.Sci.), similar to German second degree (Habilitation)


BRIEF CHRONOLOGY OF EMPLOYMENT

1975-1976 Research Technician, Institute of Molecular Biology, USSR Academy of Sciences, Moscow

1978-1982 Junior Staff Scientist, Institute of Molecular Biology, USSR Academy of Sciences, Moscow

1982-1983 Postdoctoral Fellow, Swiss Institute for Experimental

Cancer Research, Lausanne, Switzerland

1983-1986 Staff Scientist, Institute of Molecular Biology, USSR Academy of Sciences, Moscow

1986 Visiting Scientist, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

1986-1987 Senior Investigator, Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow

1987-1991 Co-head, Unit of Eukaryotic Gene Expression, Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow

1991-1993 Special Volunteer (part time), Laboratory of Molecular Immunoregulation

BRMP, NCI-FCRDC, Frederick, MD

1991-1999 Group leader, Cytokine Molecular Biology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow

1993-2006 Principal Scientist, BRP, SAIC Frederick,

and Principal Investigator, National Cancer Institute, Frederick, MD.

1995-1998 Leading Staff Scientist, Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

1999-date Professor and Head, Laboratory of Molecular Immunology

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

2005-date Head, AG Entzundungsbiologie, Deutsches Rheuma-Forschungszentrum

Berlin, Germany

HONORS AND OTHER SPECIAL SCIENTIFIC RECOGNITION

1991 Investigator Award, Cancer Research Institute (New York)

1995-2000 International Research Scholar, Howard Hughes Medical Institute (regional grant program)

1996 Research grant from Volkswagen Foundation (with A. Nordheim).

1997-2002 Fellowship Committee, International Union Against Cancer (Geneva)

1998 Professor of Molecular Biology

2000 Peregrinus Award from Berlin-Brandenburg Academy of Sciences

2000-date International Research Scholar, Howard Hughes Medical Institute (Parasitology and Infectious Diseases)

2003 Elected Associate Member of the Russian Academy of Sciences

2005 Helmholtz-Humboldt Award (Germany)



REVIEWER/EDITORIAL ACTIVITIES

1994-1998 Contributing Editor, Journal of Inflammation

1996-2003 Executive Editor, Immunology Letters

2003-date Editorial Board, Russian Journal of Immunology

2003-date Editorial Board, Immunology Letters

2006-date Editorial Board, Molecular Biology (Moscow)




PROFESSIONAL SOCIETIES

Russian Society of Biochemistry and Molecular Biology.

Russian Society of Immunologists

International Cytokine Society

American Association of Immunologists

German Society of Immunologists


RESEARCH INTERESTS

Innate immunity, functions of cytokines in vivo, genetic predisposition to disease and cancer, genetic knockout technology, cancer antigens, regulation of transcription.



TEACHING AND EDUCATIONAL ACTIVITIES

1997-2000 Co-organizer of the Special Educational Program of the Belozersky Institute (Moscow State University) in Biochemistry, Molecular and Cell Biology, and Immunology.

2000-date Director, Special Educational Program "Oncoimmunology” at Moscow State University and the Russian Academy of Sciences.

Website: www.oncoimmunology.ru.

2005-date Director, Graduate Program "Molecular immunology” at Moscow State University and the Russian Academy of Sciences.

Website: www.molimmunology.ru.


ACTIVE GRANT SUPPORT

Howard Hughes Medical Institute

European Union FP6 Program

Russian Foundation for Basic Research

Russian Academy of Sciences

Deutsches Forschungsgemeinschaft


LIST OF PUBLICATIONS:

  1. Varshavsky A.J., Nedospasov S.A., Bakayev V.V., Bakayeva T.G. and Georgiev G.P. Histone-like proteins in the purified E.Coli deoxyribonucleoprotein. Nucleic Acids Res. 1977. 4, 2725-2744.

  2. Varshavsky A.J., Nedospasov S.A., Schmatchenko V.V., Bakayev V.V., Chumakov P.M., and Georgiev G.P. Compact form of SV40 minichromosome is resistant to nuclease: possible implications to chromatin structure. Nucleic Acids Res. 1977. 4, 3303-3325.

  3. Varshavsky A.J., Bakayev V.V., Nedospasov S.A., and Georgiev G.P. On the structure of eukaryotic, prokaryotic and viral chromatin. Cold Spring Harbor Symposia in Quantitative Biology. 1978. Vol. 42, pp. 457-473. Georgiev G.P., Nedospasov S.A., and Bakayev V.V. Supranucleosomal levels of chromatin organization. In: "The Cell Nucleus" (H. Busch, ed.) 1978, Vol. 6, pp. 3-39, Academic Press, New York.

  4. Nedospasov S.A., Bakayev V.V., Georgiev G.P. Presence of histone H1 in SV40 virions isolated from the nuclei of infected cells. Proc. Acad. Sci USSR. (Dokl. Akad. Nauk SSSR) 1978. 241, 485-488.

  5. Nedospasov S.A., Bakayev V.V., and Georgiev G.P. Chromosome of the mature SV40 virions contains H1 histone. Nucleic Acids Res. 1978. 5, 2847-2860.

  6. Belintsev B.N., Gagua A.V., and Nedospasov S.A. Effect of superhelicity on the double helix twist angle in DNA. Nucleic Acids Res. 1979. 6, 983-992.

  7. Nedospasov S.A., and Georgiev G.P. Non-random cleavage of SV40 DNA in the compact chromosome and free in solution by micrococcal nuclease. Biochem. Biophys. Res. Commun. 1980. 92, 523-539.

  8. Bakayev V.V., and Nedospasov S.A. SV40 specific nucleoprotein complexes: heterogeneity and composition. Virology. 1981. 109, 244-259.

  9. Georgiev G.P., Bakayev V.V., Nedospasov S.A., Razin S., and Mantieva V. Studies on chromatin. Mol. Cell. Biochem. 1981. 40, 29-49.

  10. Nedospasov S.A., Shakhov A.N., and Georgiev G.P. Nucleosomal structure of SV40 minichromosomes as revealed by micrococcal nuclease action. FEBS Lett. 1981. 125, 35-38.

  11. Bakayev V.V., Nedospasov S.A., Georgiev G.P. Structural organization of the SV40 chromosomes. I. Heterogeneity and composition of the viral nucleoprotein complexes at different stages of lytic infection. Mol. Biol. 1981. 15, 939-949.

  12. Chuvpilo S.A., Nedospasov S.A., Shakhov A.N., Georgiev G.P. Analysis of nucleosome alignment by molecular cloning: mapping of core-particle positions in the minichromosome of Simian Virus 40. Proc. Acad. Sci. USSR (Dokl. Akad. Nauk SSSR). 1982. 267, 1268-1272.

  13. Shakhov A.N., Nedospasov S.A., and Georgiev G.P. DNAase II as a probe to sequence specific chromatin organization: preferential cleavage at 72 bp modulator sequence of SV40. Nucleic Acids Res. 1982. 10, 3951-3965.

  14. Nedospasov S.A., Shakhov A.N., Sahli R. Structural and functional organization of the SV40 chromosomes. II. Characterization of the viral genome with a deletion in the regulatory region. Mol. Biol. 1984. 18, 1091-1099.

  15. Nedospasov S.A., Shakhov A.N., Georgiev G.P. Structural and functional organization of the SV40 chromosomes. III. Nucleosomal organization of the "free" minichromosomes. Mol. Biol. 1984. 18, 1099-1110.

  16. Shakhov A.N., Nedospasov S.A., Georgiev G.P. Structural and functional organisation of the SV40 chromosomes. IV. Specific organization of the regulatory sequences of the SV40 in the minichromosome. Mol. Biol. 1985. 19, 926-935.

  17. Nedospasov S.A., Shakhov A.N., Kushnirov V.V. Nucleotide sequence of the Simian virus 40 (strain SV40-M). In: Molecular Biology of Viruses (Zhdanov V.M., Yershov F.I., ed.). 1985. pp. 187-192. Moscow.

  18. Nedospasov S.A., Shakhov A.N., Turetskaya R.L., Mett V.A., Georgiev G.P., Dobrynin V.N., Korobko V.G. Molecular cloning of the genes, coding for human tumor necrosis factors: tandem arrangement of alpha and beta genes in a short segment (6 kb) of the human genome. Proc. Acad. Sci. USSR. (Dokl. Akad. Nauk SSSR). 1985. 285, 1487-1490.

  19. Golovanov E.I., and Nedospasov S.A. An effective approach to the identification of subclones of a DNA of known nucleotide sequence. Comp. Appl. Biosci. 1986. 2, 297-299.

  20. Nedospasov S.A., Shakhov A.N., Turetskaya R.L., Mett V.A., Georgiev G.P., Korobko V.G., Dobrynin V.N., Filippov S.A., Bystrov N.S., Boldyreva E.F., Chuvpilo S.A., Chumakov A.M., Shingarova L.Y., and Ovchinnikov Yu.A. Tandem arrangement of the genes coding for tumor necrosis factor (TNF-) and lymphotoxin (TNF-) in human genome. Cold Spring Harbor Symposia in Quantitative Biology. 1986. Vol. 51, pp.611-625.

  21. Nedospasov S.A., Hirt B., Shakhov A.N., Dobrynin V.N., Kawashima E., and Jongeneel C.V. The genes coding for tumor necrosis factor (TNF-) and lymphotoxin (TNF-) are tandemly arranged on the chromosome 17 of the mouse. Nucleic Acids Res. 1986. 14, 7713-7725.

  22. Spies T., Morton C.C., Nedospasov S.A., Fiers W., Pious D., and Strominger J.L. Genes for the tumor necrosis factors  and  are linked to the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 1986. 83, 8699-8702.

  23. Muller U., Jongeneel C.V., Nedospasov S.A., Fisher Lindall K., and Steinmetz M. Tumor necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex. Nature, 1987. 325, 265-267.

  24. Semon D., Kawashima E., Jongeneel C.V., Shakhov A.N., and Nedospasov S.A. Nucleotide sequence of murine TNF locus including TNF- (tumor necrosis factor) and TNF- (lymphotoxin) genes. Nucleic Acids Res., 1987, 15, 9083-9084.

  25. Shakhov A.N., and Nedospasov S.A. Molecular cloning of the genes, coding for tumor necrosis factors: nucleotide sequence of the mouse TNF- gene. Bioorg. Chem. 1987. 13, 701-705.

  26. Prassolov V.S., Turetskaya R.L., Nedospasov S.A., Chumakov P.M., Shakhov A.N. Use of retroviral vectors for expression of intron-containing chromosomal genes: production of biologically active human tumor necrosis factor (lymphotoxin) Proc. Acad. Sci. USSR (Dokl. Akad. Nauk SSSR) 1988. 300, 1498-1501.

  27. Shakhov A.N., Kuprash D.V., Turetskaya R.L., Azizov M.M., Andreyeva A.V., Nedospasov S.A. Cloning and structural analysis of the genes, coding for the rabbit tumor necrosis factor and lymphotoxin. Mol. Biol. 1989. 23, 1743-1750.

  28. Jongeneel C.V., Nedospasov S.A., Plaetinck G., Naquet P., and Cerottini J.-C. Expression of the tumor necrosis factor locus is not necessary for the cytolytic activity of T lymphocytes. J. Immunol. 1988. 140, 1916-1922.

  29. Nedospasov S.A., Turetskaya R.L., and Shakhov A.N. Cloning and characterization of the rabbit lymphotoxin (TNF-) gene and its tight linkage to the gene coding for tumor necrosis factor. Nucleic Acids Res. 1988. 16, 3112.

  30. Shakhov A.N., Turetskaya R.L., Nedospasov S.A. Cloning and structural analysis of the complementary DNA for human neuroleukin gene. Proc. Acad. Sci. USSR. (Dokl. Akad. Nauk SSSR) 1988. 303, 1273-1276.

  31. Nedospasov S.A., Turetskaya R.L., Mett V.L., Shakhov A.N. Mapping of genomic locus, containing tumor necrosis factor genes by indirect end labeling with synthetic oligonucleotides. Bioorg. chem. 1989, 15, 990-993.

  32. Nedospasov S.A., Shakhov A.N., Georgiev G.P. Analysis of nucleosome positioning by indirect end labeling and molecular cloning. In: Methods in Enzymology (P.M. Wassarman and R.D. Kornberg, ed) Academic Press, N.Y. 1989. Vol. 170. pp. 408-420.

  33. Nedospasov S.A., Shakhov A.N., and Hirt B. Control region of SV40 minichromosomes is preferentially cleaved by single-strand specific S1 nuclease. J. Biomol. Struct. Dyn. 1989. 6, 907-913.

  34. Seregina T.M., Mekshenkov M.I., Turetskaya R.L., and Nedospasov S.A. An autocrine growth factor constitutively produced by a human lymphoblastoid B-cell line is serologically related to lymphotoxin (TNF-). Mol. Immunol. 1989. 26,339-342.

  35. Jongeneel C.V., Shakhov A.N., Nedospasov A.N., and Cerottini J.-C. Molecular control of tissue-specific expression at the mouse TNF locus. Eur. J. Immunol. 1989. 19, 549-553.

  36. Shakhov A.N., Collart M., Vassalli P., Nedospasov S.A., and Jongeneel C.V. B-type enhancers are involved in LPS-mediated transcriptional activation of the tumor necrosis factor a gene in primary macrophages. J. Exp. Med. 1990. 171, 35-48.

  37. Shakhov A.N., Kuprash D.V., Azizov M.M. Jongeneel C.V., and Nedospasov S.A. Structural analysis of the rabbit TNF locus, containing the genes encoding TNF- (lymphotoxin) and TNF- (tumor necrosis factor) Gene. 1990. 95, 215-221.

  38. Shakhov A.N., Turetskaya R.L., Kuprash D.V., Nedospasov S.A., Collart M., Drouet C., and Jongeneel C.V. Sequences involved in the regulation of TNF gene expression. In: Molecular and Cellular Biology of Cytokines (J.J. Oppenheim, C.A. Dinarello, M. Kluger, ed.), pp. 25-30, Wiley-Liss, 1990.

  39. Turetskaya R.L., Kuprash D.V., Udalova I.A., Azizov M.M. and Nedospasov S.A. Molecular cloning and characterization of the chromosomal copy of the human gene encoding receptor for tumor necrosis factors. Proc. Acad. Sci. USSR (Dokl. Akad. Nauk SSSR) 1990. 315, 1475-1478.

  40. Turetskaya R.L., Udalova I.A., Kuprash D.V., Terskikh A.V., and Nedospasov S.A. Cloning and characterization of the human genome locus containing the gene encoding second type (75 kD) receptor for tumor necrosis factor and lymphotoxin. Proc. Acad. Sci. USSR (Dokl. Akad. Nauk SSSR) 1991. 320, 1258-1262.

  41. Zverev, V.V., Shakhov A.N., Nedospasov S.A., Pugach A.V., Sidorov, E., and Cloning and expression of the CD4 receptor gene from human T-lymphocytes in Escherichia coli. Mol. Gen. Mikrobiol. Virusol. 1991. 1: 16-18.

  42. Nedospasov S.A., Udalova I.A., Kuprash D.V., and Turetskaya R.L. DNA sequence polymorphism at the human TNF locus. Numerous TNF/LT alleles tagged by two closely linked microsatellites in the upstream region of lymphotoxin (TNF-) gene. J. Immunol. 1991. 147, 1053-1059.

  43. Jongeneel C.V., Briant L., Udalova I.A., Sevin. A., Nedospasov S.A. and Cambon-Thomsen A. Extensive genetic polymorphism in the human necrosis factor region and relation to extended HLA haplotypes. Proc. Natl. Acad. Sci USA. 1991. 88, 9717-9721.

  44. Udalova I.A., Turetskaya R.L., Kuprash D.V. and Nedospasov S.A. An STS in the human TNF locus located at 6p21.3. Nucleic Acids Res. 1991, 4784.

  45. Kuprash D.V. and Nedospasov S.A. Transcription factors of NF-kB/rel family significantly bend DNA at the site of binding. Proc. Acad. Sci. USSR (Dokl. Akad. Nauk SSSR), 1992, 322, 421-426.

  46. Azizov M.M., Ulyanov A.V., Kuprash D.V., Shakhov A.N., Gavin I.M. and Nedospasov S.A. Preparation and characterization of a mononucleosomal library from human cell chromatin and its use for nucleosome reconstitution studies. Proc. Acad. Sci. USSR (Dokl. Akad. Nauk SSSR), 1992, 322, 415-420.

  47. Nedospasov, S.A., Shakhov, A.N., Kuprash, D.V., Udalova, I.A., Azizov M.M., Seregina T.M., Mekshenkov M.I. and Turetskaya R.L. Genes, encoding tumor necrosis factors: genome organization, polymorphism and expression. in: Modern Trends in Human Leukemia IX (R.Neth, ed.) Springer-Verlag, Berlin, 1992, pp. 175-183.

  48. Kuprash, D.V., Turetskaya, R.L., Boldin, M.P., Udalova, I.A., Kistanova, E.M., Smirnova, J.B., and Nedospasov, S.A. Structure and regulation of tumor necrosis factor genes at genomic loci. In: Tumor Necrosis Factor and Related Cytokines. (W. Fiers, W. Buurman, ed.) Karger, Basel, 1993, pp. 19-26.

  49. Udalova, I.A., Nedospasov, S.A., Webb, G.C., Chaplin, D.D. and Turetskaya, R.L. Highly informative typing of the human TNF locus using 6 polymorphic markers. Genomics, 1993, 16, 180-186.

  50. Abraham, L.J., Marley, J.V., Nedospasov, S.A, Cambon-Thomsen A, Crouau-Roy B, Dawkins RL, and Giphart MJ. Microsatellite, restriction fragment-length polymorphism, and sequence-specific oligonucleotide typing of the tumor necrosis factor region. Comparisons of the 4AOHW cell panel. Hum. Immunol. 1993, 38, 17-23.

  51. Nedospasov, S.A., Udalova, I.A., Smirnova, J.B., Kuprash, D.V., Zharkov, V.G., and Turetskaya, R.L. Genetic polymorphism at the human TNF locus: ethnic bias in the distribution of TNFab alleles. Proc. Russ. Acad. Sci. (Dokl. Akad. Nauk) 1993, 331, 504-508.

  52. Alimzhanov, M.B., Kuprash, D.V., Turetskaya, R.L., Osipovich, O.A., Borodulina, O., Ossovskaya, V., Chumakov, P.M., and Nedospasov, S.A. Cloning and characterization of a murine gene gadd45 induced by DNA damage. Proc. Russ. Acad. Sci. (Dokl. Akad. Nauk) 1993, 336, 788-791.

  53. Kuprash, D.V., Alimzhanov, M.B., Pokholok, D.K., Kozlov, S.V., Novobrantseva, T.I., Turetskaya, R.L., and Nedospasov S.A. Characterization of the locus from murine chromosome 17, containing three genes of TNF family, including the gene for transmembrane subunit of lymphotoxin (LT-). Proc. Russ. Acad. Sci. (Dokl. Akad. Nauk), 1994, 337, 658-661.

  54. Ohmori, Y., Tebo, J., Nedospasov, S.A., and Hamilton, T.A. B binding activity in a murine macrophage-like cell line: Sequence-specific differences in B binding and transcriptional activation functions. J. Biol. Chem. 1994, 269, 17684-17690.

  55. Marincola, F.M., Shamamian, P., Alexander, R.B., Gnarra, J.R., Turetskaya, R.L., Nedospasov, S.A., Simonis, T.B., Taubenberger, J.K., Yanelli, J., Mixon, A., Restifo, N.P., Herlyn, M., and Rosenberg, S.A. Loss of HLA haplotype and B locus down-regulation in melanoma cell lines. J. Immunol. 1994. 153, 1225-1237.

  56. Pokholok, D.K., Maroulakou, I.G., Kuprash, D.V., Alimzhanov, M.B., Kozlov, S.V., Novobrantseva, T.I., Turetskaya, R.L., Green, J.E., and Nedospasov S.A. Cloning and in situ transcriptional analysis of the murine lymphotoxin-beta (LT-) gene. Proc. Natl. Acad. Sci. USA 1995, 92, 674-678.

  57. Kuprash, D.V., Rice, N.R., and Nedospasov, S.A. Homodimer of p50 (NFkB1) does not introduce a substantial directed bend into DNA according to three different experimental assays. Nucleic Acids Res. 1995, 23, 427-433.

  58. Kuprash, D.V, Udalova, I.A., Turetskaya, R.L., Rice, N.R. and Nedospasov, S.A. Conserved B element located downstream of Tumor Necrosis Factor a gene: distinct NF-B binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene, 1995, 11, 97-106.

  59. Biragyn, A., and Nedospasov, S.A. Lipopolysaccharide-induced expression of TNF-a gene in the macrophage cell line ANA-1 is regulated at the level of transcription processivity. J. Immunol. 1995, 155, 674-683.

  60. Monos, D.S., Kamoun, M., Udalova, I.A., Csanky, E., Turetskaya, R.L., Smirnova, J.B., Cizman, B., Feng, H.S., Zharkov V.G.,Gasser, D., Zmijewski, C.M., Spielman, R.S., and Nedospasov, S.A. Genetic polymorphism in the human TNF region in insulin-dependent diabetes melittus: linkage disequilibrium of TNFab microsatellites with HLA-extended haplotypes. Hum. Immunol. 1995, 44, 70-79.

  61. Udalova, I.A., Turetskaya, R.L., Kuprash, D.V., and Nedospasov, S.A. Two steps in LPS-induced transcriptional activation of the human TNF gene in macrophages: Role of NF-B/Rel family. Proc. Russ. Acad. Sci. (Dokl. Akad. Nauk), 1995, 342, 413-417.

  62. Zverev, V.V., Sidorov, A.V., Nedospasov, S.A., Maliushova, V.V., Udalova, I.A., Andzhaparizde, O.G. and Blinov, V.M. Nucleotide sequence of two exons of the human T-lymphocyte CD4 receptor gene. Vopr. Virusol. 1995, 40: 100-102.

  63. Turetskaya, R.L., Varfolomeev, E.E., Lopukhina, A.A., Udalova, I.A., Kuprash, D.V., Krasylnikov, A.N., Chaplin, D.D., and Nedospasov, S.A. Polymorphic marker in the human TNF receptor (p75) gene: application for study of association with disease. Proc. Russ. Acad. Sci. (Dokl. Akad. Nauk), 1996, 351: 558-560.

  64. Stuber, F., Udalova, I.A., Book, M., Drutskaya, L.N., Kuprash, D.V., Turetskaya, R.L., Schade, F.U., and Nedospasov, S.A. The -308 TNF polymorphism is not associated with survival in severe sepsis and is unrelated to LPS-inducibility of the human TNF promoter. J. Inflam.1996, 46, 42-50.

  65. Kuprash, D.V., Osipovich, O.A., Pokholok, D.K., Alimzhanov, M.B., Biragyn, A., Turetskaya, R.L. and Nedospasov, S.A. Functional Analysis of the Lymphotoxin- promoter. Sequence requirements for PMA activation. 1996, J. Immunol. 156, 2465-2472.

  66. Alimzhanov M.B., Kuprash D.V., Kosco-Vilbois M.H., Luz A., Turetskaya R.L., Tarakhovsky A., Rajewsky K., Nedospasov S.A., and Pfeffer K. Abnormal development of secondary lymphoid tissues in lymphotoxin -deficient mice. Proc. Natl. Acad. Sci. USA, 1997, 94, 2117-2122.

  67. Schroeder H.W.Jr., Zhu Z-B , Campbell D.R., Berny S., Nedospasov S.A., Turetskaya R.L., Atkinson T.P., Go R.C.P., Cooper M.D., Volanakis J.E. Susceptibility locus for IgA deficiency and Common Variable Immunodeficiency in the HLA -DR3, -B8, -A1 haplotype. Mol. Medicine. 1998. 4, 72-86.

  68. Udalova, I.A., Knight, J.C., Vidal, V., Nedospasov, S.A. and Kwiatkowski D. Complex NFB interactions at the distal tumor necrosis factor promoter region in human monocytes. J. Biol. Chem. 1998. 273, 21178-21186.

  69. Baer M., Dillner A., Schwartz R.C., Sedon C., Nedospasov S.A. and Johnson P.F. TNF alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-B p50. 1998. Mol. Cell. Biol. 18, 5678-5689.

  70. Kaijel E.L., van Krugten M.V., Brinkman B.M.N., Huizinga T.W.J., van der Straaten T., Hazes J.M.W., Ziegler-Heitbrock H.W.L., Nedospasov S.A., Breedveld F.C. and Verweij C.L. Functional analysis of the human tumor necrosis factor (TNF promoter polymorphism related to joint damage in rheumatoid arthritis. 1998. Mol. Medicine 4, 724-733.

  71. Tumanov A.V., Nedospasov S.A., and Turetskaya R.L. Chromatin organization in the tumor necrosis factor/lymphotoxin gene locus: correlation with tissue-specific expression. Mol. Biol. 1998. 32, 98-102.

  72. Korobko VG., Boitchenko V.E., Kuprash D.V., Turetskaya R.L., and Nedospasov S.A. Heterologous expression of murine LT alpha and LT beta and generation of antibodies to LT beta. Bioorg. Chem. 1999, 25, 350-354.

  73. Baer, M., Nedospasov, S., and Johnson, P.F. Attenuation of tumor necrosis factor alpha gene transcription in macrophages by an autocrine factor. Cold Spring Harbor Symposia on Quantitative Biology .1999, Vol. 64, pp. 437-444.

  74. Endres R., Alimzhanov M.B., Plitz T., Fuetterer A., Kosco-Vilbois M.H., Nedospasov S.A., Rajewsky K., and Pfeffer K. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and Tumor Necrosis Factor by B cells. 1999. J. Exp. Med. 189, 159-168.

  75. Kuprash D.V., Udalova I.A., Turetskaya R.L., Kwiatkowski D., Rice N.R. and Nedospasov S.A. Similarity and differences between human and murine TNF promoters in their response to LPS. 1999. J. Immunol. 162, 4045-4052.

  76. Ito D., Back T.C., Shakhov A.N., Wiltrout R.H., and Nedospasov S.A. Mice with a targeted mutation in Lymphotoxin-exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment. 1999. J. Immunol. 163, 2809-2915.

  77. Wedel, A., Frankenberger, M., Sulski, G., Petersmann, I., Kuprash, D., Nedospasov, S. and Ziegler-Heitbrock H.W.L. 1999. Role of p52 (NF-kB2) in LPS tolerance in a human B cell line. Biological Chemistry, 380: 1193-1199.

  78. Ye J., Ding M., Zhang X., Rojanasakul Y., Nedospasov S., Vallyathan V., Castranova V., and Shi X. Induction of TNF-alpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions. 1999. Mol Cell Biochem. 198:193-200.

  79. Kuprash D.V. Alimzhanov M.B., Tumanov A.V., Rajewsky K., Anderson A.O., Pfeffer K. and Nedospasov S.A. Establishment of spleen microarchitecture, but not organogenesis of lymph nodes requires cooperation of Tumor Necrosis Factor and Lymphotoxin  1999. J. Immunol. 163 : 6575-6580.

  80. Shakhov, A.N., Rubtsov, A.V., Lyakhov, I.G., Tumanov, A.V., and Nedospasov S.A. SPLASH, a novel member of phospholipase A2 family, is downregulated in mutant mice with lymphotoxin deficiency.2000. Genes and Immunity, 1: 191-199.

  81. Eskdale, J., Armstrong, C., Turetskaya, R.L., Kuprash, D.V., Nedospasov S.A. and Gallagher, G. Genetic typing of human p55 TNF receptor gene (CD120a) based on a microsatellite marker. 2000. Genes and Immunity, 1: 228-230.

  82. Shakhov A.N., Lyakhov I.G., Tumanov, A.V., Rubtsov A.V., Drutskaya, L.N., Marino M.J. and Nedospasov S.A. Gene profiling approach in the analysis of Lymphotoxin and TNF deficiencies. 2000. J. Leuk. Biol., 68: 151-157.

  83. Lagarkova M.A., BoitchenkoV.E., Kashkarova U.A., Mescheryakov A.A. and Nedospasov S.A. Human cortactin as putative cancer antigen. 2000. Oncogene, 19: 5204-5207.

  84. Boitchenko, V.E., Korobko, V.G., Prassolov, V.S., Kravchenko V.V., Kuimov A.N., Turetskaya, R.L., Kuprash, D.V. and Nedospasov S.A. Detection of murine LT and LT in eukaryotic cells using polyclonal antibodies. 2000. Russ. J. Immunol. 5, 259-266.

  85. Drize N.N., Drutskaya M.S., Gerasimova L.P., Manakova T.E., Chertkov J.L., Turetskaya R.L., Kuprash D.V. and Nedospasov S.A. Contrasting differences in hematopoietic systems in mice deficient in Tumor Necrosis Factor and Lymphotoxin-alpha. Bull. Exp. Biol. Med. 2000, 130, 76-79.

  86. Boitchenko, V.E., Alimzhanov, M.B., Turetskaya, Rühlmann, A.R. Nordheim, A., Kuprash, D.V., and Nedospasov S.A. Comparison of LT and LTtranscription in B and T cell lines, primary T cells and human tissues. Mol. Biol. 2001, 35, 1-8.

  87. Drutskaya, M.S., Kuprash, D.V., Nedospasov, S.A., Chertkov, J.L., and Drize N.I. Hematopoiesis in mice with TNF deficiency: alterations observed in long-term bone marrow cultures. Bull. Exp. Biol. Med. 2001, 131:150-152.

  88. Shakhov, A.N., Nedospasov S.A. Expression profiling in knockout mice: Lymphotoxin versus Tumor Necrosis Factor in the maintenance of splenic microarchitecture. Cytokines and Growth Factors Reviews. 2001, 12, 107-119.

  89. Le, Y.Y., Gong, W.H., Tiffany, H.L., Tumanov, A.V., Nedospasov, S.A., Shen, W.P., Dunlop, N.M., Gao, J.L., Murphy, P.M., Oppenheim, J.J., and Wang, J.M. Amyloid  activates a G-protein-coupled chemoattractant receptor, FPR-like-1. 2001. J. Neurosci 21, 123.

  90. Kuimov A.N., Kuprash D.V., Petrov V.N., Vdovichenko K.K.,Scanlan M.J., Jongeneel C.V., Lagarkova M.A. and Nedospasov, S.A. Cloning and characterization of TNKL, a member of the tankyrase gene family. 2001. Genes and Immunity, 2, 52-55.

  91. Boitchenko, V.E., Kuprash, D.V. Nordheim, A., Rühlmann, A. and Nedospasov, S.A. Cyclosporin A blocks PMA and ionomycin activated lymphotoxin expression in human T cell lines. 2001. Russ. J. Immunol. 6, 9-16.

  92. Shakhov A.N., Leufgen, H., Drutskaya, L.N., Kuprash, D.V. and Nedospasov, S.A. Transcriptional regulation of the gene encoding p40, a component of IL12 and IL23, in murine macrophages. 2001. Russ. J. Immunol. 6, 357-366.

  93. Hehlgans, T., Stölcker, B., P. Stopfer, Müller, P., Cernaianu, G. Guba, M., Steinbauer, M., Nedospasov, S.A., Pfeffer, K. and Männel, D.N. Lymphotoxin- receptor immune interaction promotes tumor growth by inducing angiogenesis. 2002. Cancer Res. 62, 4034-4040.

  94. Kuprash, D.V., Boitchenko, V.E., Yarovinsky, F.O., Rice N.R., Nordheim, A., Rühlmann, A. and Nedospasov S.A. Cyclosporin A blocks the expression of lymphotoxin-, but not lymphotoxin- in human peripheral blood cells. 2002. Blood 100, 1721-1727.

  95. Soloviev, A., Schwarz, E.M., Kuprash, D.V., Nedospasov, S.A., Puzas, J.E., Rosier, R.N., O'Keefe, R.J. The role of p105 protein in NFB activation in ANA-1 murine macrophages following stimulation with titanium particles. 2002. J Orthop Res. 20, 714-422.

  96. Tumanov, A.V., Kuprash, D.V., Lagarkova, M.A., Abe, K., Shakhov, A.N., Drutskaya. L.N., Stewart C.L., Chervonsky, A.V. and Nedospasov, S.A. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. 2002. Immunity 17, 239-250.

  97. Koroleva E.P., Lagarkova, M.A., Mesheryakov, A.A., Scanlan M.J., Old, L.J., Nedospasov S.A., and Kuprash, D.V., Serological identification of antigens associated with renal cell carcinoma. 2002. Russ. J. Immunol. 7, 229-238.

  98. Radko, B., Boitchenko, V.E., Nedospasov, S.A. and Korobko, V.G. Characterization of the variable light and heavy chain genes of high-affinity monoclonal antibody against human Tumor Necrosis Factor. 2002. Russ. J. Immunol. 7, 371-374.

  99. Kuprash D.V. Alimzhanov M.B., Tumanov A.V., Shakhov, A.N., Grivennikov S.I., Marino, M.W., Turetskaya, R.L., Anderson A.O., Rajewsky K., Pfeffer K. and Nedospasov S.A. Redundancy in TNF and LT signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single knockout mice. 2002. Mol. Cell Biol. 22: 8626-8634.

  100. Lagarkova, M.A., Koroleva, E.P., Kuprash D.V., Boitchenko, V.E., Kashkarova, U.A., Nedospasov S.A. and Shebzukhov, Yu. V. Evaluation of humoral response to cancer antigens in patients using recombinant expression-based serological mini-arrays (SMARTA). 2003. Immunol. Lett. 85, 71-74.

  101. Abe, K., Yarovinsky, F., Murakami, T., Ito, D., Tumanov, A.V., Pfeffer, K., Shakhov, A.N., Drutskaya, L.N., Kuprash, D.V., Komschlies, K.L., and Nedospasov, S.A. Distinct role of TNF/LT subfamily of cytokines in the development and recruitment of dendritic cells. 2003. Blood 101, 1477-1483.

  102. Hur, G.M., Lowis, J., Yang, Q., Lin, Y., Nakano, H., Nedospasov, S. and Liu, Z.-G. The death domain kinase RIP has an essential role in DNA damage-induced NF-B activation. Genes and Dev. 2003, 17, 873-882.

  103. Nedospasov, S.A., Grivennikov, S.I. and Kuprash, D.V. Physiological role of TNF and TNFR superfamilies, as assessed by genetic knockouts. In: Cytokine Knockouts. 2nd edition (Fantuzzi, G., ed.), Humana Press, 2003, pp. 439-460.

  104. Tumanov, A.V. Kuprash, D.V. and Nedospasov, S.A., Role of lymphotoxin in the development and maintenance of secondary lymphoid tissues. Cytokines and Growth Factors Reviews. 2003. 14: 275-288.

  105. Tumanov, A.V. Grivennikov, S.I., Shakhov A.N., Rybtsov, S.A., Koroleva, E.P., Takeda, J., Nedospasov, S.A., and Kuprash, D.V. Dissecting the role of Lymphotoxin in lymphoid organs by conditional targeting. Immunol. Reviews. 2003, 195, 106-116.

  106. Nedospasov S.A. Tumor Necrosis Factor and Lymphotoxin: molecular genetics, regulation and physiological role. Genetika. 2003, 39: 207-214.

  107. Koroleva, E.P., Lagarkova, M.A., Khlgatyan, S.V., Shebzukhov Yu.V., Mesheryakov, A.A., Lichinitser, M.R., Nedospasov, S.A. and Kuprash, D.V. Serological evaluation of the repertoire of human cancer antigens and autoantigens. Mol. Biol. 2004, 38: 233-238.

  108. Nedospasov, S.A., Kuprash, D.V. Cytokine, cytokine receptors and intracellular signalling. In: Carcinogenesis. (Zaridze, D. ed.), 2004. Medicine (Moscow)., pp. 158-168.

  109. Nedospasov, S.A., Lavrik, I.N. Mechanisms of the programmed cell death mediated by the "death receptors". In: Carcinogenesis. (Zaridze, D. ed.), 2004, Medicine (Moscow), pp. 168-179.

  110. Shakhov, A.N., Rybtsov, S.A., Tumanov, A.V., Shulenin, S., Kuprash, D.V., Dean, M., and Nedospasov, S.A. SMUCKLER/TIM-4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur. J. Immunol. 2004, 34: 494-503.

  111. Lin, Y., Choski, S., Shen, H.-M., Yang, Q-F., Hur, G.-M., Kim, Y.S., Tran, J.T., Nedospasov, S.A., and Liu, Z.-G. TNF induced non-apoptotic cell death requires RIP mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 2004, 279:10822-10828.

  112. Tumanov, A.V., Kuprash, D.V., Nedospasov, S.A. and Chervonsky, A.V. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer’s patches. J. Immunol. 2004, 173:86-91.

  113. Nedospasov, S.A. Dissecting Lymphotoxin functions by using Cre-LoxP knockout technology. CCR Frontiers in Science 2004. 3: 1-2.

  114. Grivennikov, S.I., Tumanov, A.V., Liepinsh, D.J., Kruglov, A.A., Marakusha, B.I., Shakhov, A.N., Murakami, T., Drutskaya, L.N., Förster, I., Clausen, B.E., Tessarollo, L., Ryffel, B., Kuprash, D.V., and Nedospasov, S.A. Distinct and non-redundant in vivo functions of TNF produced by T cells and macrophages/ neutrophils: protective and deleterious effects. Immunity 2005, 22: 93-104.

  115. Cataisson, C., Pearson, A.J., Torgerson, S., Nedospasov, S.A. and Yuspa, S.H. PKCmediated chemotaxis of neutrophils requires NFB activity but is independent of TNF signaling in mouse skin in vivo. J. Immunol. 2005, 174: 1686-1692.

  116. Kim, Y.-S., Nedospasov, S.A., and Liu, Z.-G. TRAF2 is a key effector molecule of LIGHT-Lymphotoxin  Receptor signaling. Mol. Cell. Biol. 2005, 25: 2130-2137.

  117. Shebzukhov, Yu.V., Koroleva, E.P., Khlgatian, S.V., Kuz’mina, K.E., Radko, B.V., Longpre, F., Lagarkova, M.A., Kadachigova, T.S., Gurova, O.V., Mescheryakov, A.A., Lichinitser, M.R., Knuth, A., Jager, E., Kuprash, D.V., and Nedospasov, S.A. Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients Int. J. Cancer. 2005, 117: 800-806.

  118. Komarova, E.A., Krivokrysenko, V., Wang, K., Neznanov, N., Chernov, M.V., Komarov, P.G., Brennan, M.-L., Golovkina, T.V., Rokhlin, O., Kuprash, D.V., Nedospasov, S.A., Hazen, S.R., Feinstein, E., and Gudkov, A.V. p53 is a suppressor of inflammatory response in mice. FASEB J. 2005, 19: 1030-1032.

  119. Kuprash, D.V., Tumanov, A.V., Grivennikov, S.I., Kruglov, A.A., Koroleva, E.P., Drutskaya, M.S., Shakhov, A.N., Southon, E., Tessarollo, L., and Nedospasov, S.A. Novel tumor necrosis factor knockout mice that lack Peyer's patches. Eur J. Immunol. 2005, 35: 1592-1600.

  120. Shebzukhov, Yu.V., Koroleva, E.P., Khlgatian, S.V., Lagarkova, M.A., Mescheryakov, A.A., Lichinitser, M.R., Karbach J., Jager, E., Kuprash, D.V., and Nedospasov, S.A. Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU therapy. Immun. Lett. 2005, 100: 88-93.

  121. Drutskaya, M.S., Ortiz, M., Liepinsh, D.J., Kuprash, D.V., Nedospasov, S.A. and Keller, J.R. Inhibitory effects of Tumor Necrosis Factor on hematopoiesis seen in vitro are translated to increased numbers of both committed and multipotent progenitors in TNF-deficient mice. Exp. Hematol. 2005, 33: 1348-1356.

  122. Welniak, L.A. Kuprash, D.V., Tumanov, A.V., Panoskaltsis-Mortari, A., Blazar, B.R., Sun, K., Nedospasov, S.A., and Murphy, W.J. Peyer’s patches are not required for acute lethal graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation. Blood. 2006, 107: 410-412.

  123. Wright, H.V., Bailey, D., Kashyap, M., Drutskaya, M.S., Nedospasov, S.A., and Ryan, J.J. IL-3-mediated TNF production is necessary for mast cell development. J. Immunol. 2006 176: 2114-2121.

  124. Liepinsh, D.J., Grivennikov, S.I., Lagarkova, M.A., Drutskaya, M.S., Klarmann, K.D., Lockett, S.J., McAuliffe, M., Tessarollo, L., Keller, J.R., Kuprash, D.V. and Nedospasov, S.A. Novel Lymphotoxin  knockout mice with unperturbed TNF expression: reassessing LT biological functions. Mol. Cell. Biol. 2006, 26, 4214-4225.

  125. Grivennikov, S.I., Kuprash, D.V., Liu, Z-G., and Nedospasov, S.A. Intracellular signals and events activated by cytokines of TNF superfamily: from simple paradigms to complex mechanisms. Int. Rev. Cytol. 2006, 252: 129-161.

  126. Junt, T., Harris, N., Tumanov, A.V., Heikenwalder, M., Zeller, N., Kuprash, D.V., Aguzzi, A., Ludewig, B., Nedospasov, S.A., and Zinkernagel, R.M. Lymphotoxin-beta expression governs immunity at two distinct levels. Eur. J. Immunol. 2006, 36: 2061-2075.

  127. Cui, C.-Y., Hashimoto, T., Grivennikov, S.I., Piao, Y., Nedospasov, S.A., and Schlessinger, D. Ectodysplasin activates the lymphotoxin-β pathway for hair follicle differentiation. Proc. Natl. Acad. Sci. USA 2006, 103 :9142-9147.

  128. Grivennikov, S.I., Nedospasov, S.A. TNF produced by distinct types of leukocytes: the good and the bad. CCR Frontiers in Science 2006. 5: 3-6.

  129. Togbe, D., Grivennikov, S.I., Couillin, I., Maillet, I., Jacobs, M., Maret, M., Fick, L., Nedospasov, S.A., Quesniaux,V.F.J., Schnyder, B., and Schnyder-Candrian, S. T cell-derived TNF down-regulates the acute airway response to endotoxin. Eur. J. Immunol. 2007, 37: 768-779.

  130. Nedospasov, S.A., Kuprash, D.V. Oncoimmunology: some fundamental problems of cancer immunotherapy. Mol. Biol. 2007, 41: 355-368.

  131. Kashkin, K.N., Khlgatyan, S.V., Gurova, O.V., Kuprash, D.V., and Nedospasov, S.A. New mutations in the human p53 gene – a regulator of the cell cycle and carcinogenesis. Biochemistry (Mosc.) 2007, 72: 282-292.

  132. Jacobs, M., Togbe, D., Fremond, C., Samarina, A., Allie, N., Botha, T., Carlos, D., Parida, S.K., Grivennikov, S., Nedospasov, S.A., Monteiro, A., Le Bert, M., Quesniaux, V., and Ryffel, B. Tumor necrosis factor is critical to control tuberculosis infection. Microbes Infect. 2007, 9: 624-628.

  133. Shebzukhov, Yu.V., Belousov, P.V., Khlgatian, S.V., Sazykin, A.Iu., Kuprash, D.V., and Nedospasov, SA. Contemporary molecular-biological methods of cancer diagnostics and monitoring based on the humoral immune response to
    tumor-associated antigens. Mol Gen Mikrobiol Virusol. 2007, 2: 3-6.

  134. Belousov, P.V., Shebzukhov, Yu.V., Kuprash, D.V., and Nedospasov, S.A. Paraneoplastic neurological syndromes and onconeural antibodies in experimental and clinical oncoimmunology. Mol Gen Mikrobiol Virusol. 2007, 2: 6-13.

  135. Shebzukhov, Yu.V., Koroleva, E.P., Khlgatian, S.V., Belousov, P.V., Sazykin A.Yu., Kadachigova, T.S., Pomerantseva, E.A., Lagarkova, M.A., Nedospasov, S.A. and Kuprash, D.V., RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity. Cancer Lett. 2007, 255:255-262.

  136. Cui, C.Y., Kunisada, M., Esibizione, D., Grivennikov, S.I., Piao, Y., Nedospasov, S.A., and Schlessinger, D. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet. 2007, 16: 2583-2590.

  137. Rebholz, B., Haase, I., Eckelt, B., Paxian, S., Flaig, M.J., Ghoreschi, K., Nedospasov, S.A., Mailhammer, R., Debey-Pascher, S., Schultze, J.L., Weindl, G., Forster, I., Huss, R., Stratis, A., Ruzicka, T., Rocken ,M., Pfeffer, K., Schmid, R.M., and Rupec, R.A. Crosstalk between keratinocytes and adaptive immune cells in an IkappaB-alpha protein-mediated inflammatory disease of the skin. Immunity 2007, 27: 296-307.

  138. Magez, S., Radwanska, M., Drennan, M., Fick, L., Allie N., Jacobs M, Nath Boral, T., Nedospasov S.A. , Ryffel B., Brombacher, F., and De Baetselier, P. TNFRp55 signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide mediated T. Congolese parasite killing. J. Infect. Dis. 2007, 196: 954-962.

  139. Jungbeck, M., Stopfer, P., Bataille, F., Nedospasov, S.A., Männel, D.N., and Hehlgans, T. Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation- opposite functions for surface lymphotoxin expressed by T and B lymphocytes. Mol. Immunol. 2008, 45: 34-41.

  140. Schneider, K., Lowendorf, A., De Trez, C., Fulton, J., Rhode, A., Shumway, H., Ha, S-W., Patterson, G., Pfeffer, K., Nedospasov, S.A., Ware, C. and Benedict, C. Lymphotoxin-beta mediated crosstalk between B cells and stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host & Microbe 2008, 3: 67-76.

  141. Shebzukhov, Yu.V., Lavrik, I.N., Karbach J., Khlgatian, S.V., Koroleva, E.P., Belousov, P.V., Kashkin, K.N., Knuth, A., Jager, E., Chi, N.-W., Kuprash, D.V., and Nedospasov, S.A. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. Cancer Immunol. Immunother. 2008. 57: 871-881.

  142. Kuprash, D.V., Qin, J., Ito, D., Grivennikov, S.I., Abe, K., Drutskaya, L.N., Blankenstein, T., and Nedospasov, S.A. Ablation of TNF or Lymphotoxin signaling and the frequency of spontaneous tumors in p53 deficient mice. Cancer Lett. 2008, 268: 70-75.

  143. Heikenwalder, M., Prinz, M., Zeller, N., Lang, K.S., Junt, T., Rossi, S., Tumanov, A.V., Schmidt, H., Priller, J., Flatz, L., Rülicke,T., McPherson, A., Hollaender, G., Nedospasov S.A., and Aguzzi A. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am. J. Pathol. 2008, 172: 1555-1570.

  144. Belousov, P.V., Kuprash, D.V., Sazykin, A.Y., Khlgatyan, S.V., Shebzukhov, Y.V., and Nedospasov, S.A. Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors. Biochemistry (Mosc.) 2008, 73: 562-572.

  145. Nedospasov, S.A. 2007 Nobel Prize winners in Physiology and Medicine. Biochemistry (Mosc.) 2008, 73: 234-235.

  146. Kruglov, A.A., Kuchmiy, A., Grivennikov, S.I., Tumanov, A.V. Kuprash, D.V., and Nedospasov, S.A. Physiological functions of Tumor Necrosis Factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factors Rev. 2008, 19: 231-244.

  147. Galimov, A.R., Kruglov, A.A., Bolsheva, N.L., Yurkevich, O.Y., Liepinsh, D.J., Mufazalov, I.A., Penkov, D.A., Kuprash, D.V., and Nedospasov, S.A. Chromosomal localization and molecular organization of genomic segments, containing human TNF/LT locus, in transgenic mice. Mol. Biol. 2008, 42: 1-10.

  148. Nedospasov, S.A. and Kuprash, D.V. Tumor Necrosis Factor and lymphotoxin: physiological functions, role in cytokine and anti-cytokine therapy. Russian Journal of AIDS, Cancer and Public Health. 2008, 12:64-71.

  149. Tumanov, A.V., Koroleva, E.P., Christiansen, P.A., Khan, M.A., Ruddy, M.J., Burnette, B., Papa, S., Franzoso, G., Nedospasov, S.A., Fu, Y.-X., and Anders, R.A. T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology, 2009, 136: 694-704.

  150. Efimov, G.A., Kruglov, A.A., Tillib, S.V., Kuprash, D.V. and Nedospasov, S.A. Tumor Necrosis Factor and the consequences of its ablation in vivo. Mol. Immunol. 2009, (in press).

  151. Plagmann, I., Chalaris, A., Kruglov, A.A., Nedospasov, S.A., Rosenstiel, P.,Rose-John, S., and Scheller, J. Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing capacity of human TNF. J. Biotechnol. 2009, in press.

  152. Efimov, G.A., Sazykin, A.Yu., Kruglov, A.A., Kuprash, D.V., and Nedospasov, S.A. Single-chain antibodies recognizing and neutralizing human TNF. Russ. J. Immunol. 2009 (in press).

  153. Belousov, P.V., Kuprash, D.V., Nedospasov, S.A., and Shebzukhov, Yu.V. Perspectives of applications of autoantibodies to tumor-associated antigens as cancer biomarkers. Curr. Mol. Medicine 2009 (in press).  

  154. Mufazalov, I.A., Penkov, D.N., Chernyak, B.V., Pletjushkina, O.Y., Vyssokikh, M.Y. , Chertkova, R.V. , Kirpichnikov, M.P., Dolgikh, D.A., Kruglov, A.A., Kuprash, D.V., Skulachev V.P. and Nedospasov, S.A. Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome C gene. Mol. Biol. 2009 (in press).

  155. Liepinsh, D.J., Kruglov, A.A., Galimov, A.R., Shebzukhov, Yu.V., Tumanov A.V., Grivennikov, S.I., Drutskaya, M.S., Feigenbaum, L., Shakhov, A.N., Kuprash, D.V., and Nedospasov, S.A. Thymic athrophy due to homeostatic overexpression of TNF/LT cytokines. Eur. J. Immunol. 2009 (on revision).

  156. Haybaeck, J., Zeller, N., Wolf, M.J., Wagner, U., Kurrer, M.O., Bremer, J., Weber, A., Iezzi, G., Graf, R., Clavien, P.-A., Thimme, R., Blum, H., Nedospasov, S.A., Karin, M., Kopf, M., Aguzzi, A., and Heikenwalder, M. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell (on revision).

  157. Conrad, U., Plagmann, I., Kruglov, A.A., Nedospasov, S.A., Rose-John, S., and Scheller, J. An anti-TNF single domain antibody produced in transgenic plants shows improved serum half life and is effective TNF-mediated toxicity. (submitted).

  158. Tumanov, A.V., Grivennikov, S.I., Kruglov, A.A., Shebzukhov, Y.V., Piao, Y., Cui, C.-Y., Kuprash, D.V., and Nedospasov, S.A. Cellular source and molecular form of TNF specifies its distinct function in the development and maintenance of secondary lymphoid tissues (in preparation).

  159. Grivennikov S.I., Allie N., Jacobs M, Shebzukhov, Yu.V., Yeremeev, V.V., Fremond C, Togbe D., Noulin, N., Fick, L., Kuprash, D.V., Quesniaux, V., Nedospasov, S.A., and Ryffel, B. Critical role of TNF produced by T cells in resistance to tuberculosis. (in preparation).

  160. Sun, K., Li, M., Wilkins, D.E.C., Redelman, D., Panoskaltsis-Mortari, A., Sayers, T., Nedospasov, S.A., Taub, D.D., Blazar, B.R., Welniak, L.A., and Murphy, W.J. Opposing role of TNFand Interferon- on IL-17 induction and outcome after allogeneic bone marrow transplantation (in preparation).

  161. De Trez, C, Fukuyama, S., Jacquin, C., Fulton, J., Schneider, K., Norris, P., Nedospasov, S.A., Pfeffer, K., and Ware, C.F. Lymphoid tissue inducer cells control CD8α- dendritic cell homeostasis via the Lymphotoxin-β receptor pathway (in preparation).


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