Curriculum vitae arnold I. Caplan



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CURRICULUM VITAE
ARNOLD I. CAPLAN
PERSONAL
Born: January 5, 1942 Married: July 4, 1965 Children: Aaron M. Caplan

Chicago, Illinois Bonita W. Caplan Rachel C. Uram



EDUCATION
Illinois Institute of Technology, Chicago, Illinois 60616, 1959 to 1963.

B.S., Chemistry, 1963; spent 1½ years working for Dr. A. E. Martell, Chairman, Chemistry Department, on the chelative structure of reduced glutathione.


The Johns Hopkins University Medical School, Baltimore, Maryland 21205, 1963 to 1967.

1963-1966, Ph.D., Physiological Chemistry; during the first year of graduate school, participated in a research project, "The Effects of Sr++ on Swelling and ATP-Linked Contraction of Mitochondria," under the supervision of Dr. Albert L. Lehninger. Thesis work, under the supervision of Dr. J. W. Greenawalt, was concerned with the separation, identification and characterization of the inner and outer mitochondrial membranes. This entailed a combined electron microscopic and biochemical approach.

1966-1967, Postdoctoral Fellow with Dr. C. R. Hackenbrock, Department of Anatomy; research was concerned with an investigation of the ultrastructure of isolated, intact mitochondria during various metabolic states. The observations obtained were used to elaborate the general thesis of the ultrastructural basis for energy transfer.
Brandeis University, Waltham, Massachusetts 02154, 1967 to 1969.

1967-1968, Postdoctoral Fellow with Dr. N. O. Kaplan, Graduate Department of Biochemistry; in collaboration with Dr. E. Zwilling of the Biology Department, investigation of the effects of nicotinamide-antagonized teratogens on cartilage and muscle development in both in vitro and in vivo systems.

1968-1969, Postdoctoral Fellow with Dr. E. Zwilling, Department of Biology; continuation of work initiated during the previous year.
WORK HISTORY
Case Western Reserve University, Cleveland, Ohio 44106, 1969 to Present.

1981-Present Professor, Department of Biology.

Director, Cellular and Molecular Basis of Aging Training Program (ended 2007).


1986-Present Director, Skeletal Research Center.

Professor of General Medical Sciences (Oncology).


2005- Present Professor of Biomedical Engineering.
2004-2011 Professor of Pathology.
1989-2000 Professor of Physiology and Biophysics.
1984-1985 Erna and Jakob Michael Visiting Professor, Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel.

1981-1988 Professor, Developmental Genetics and Anatomy.
1976-1977 (Josiah Macy, Jr. Faculty Scholar Award), Sabbatical Leave, Faculte de Medecine de Strasbourg, Institute de Chimie Biologique, 67085 Strasbourg CEDEX, France. In the laboratory of Prof. Pierre Chambon, research involved investigation of chromatin structure and function, especially as related to molecular details of the relationship between poly (ADP-ribose) and other chromatin constituents.

August 2016



Case Western Reserve University - Continued
1975-1981 Associate Professor, Departments of Biology and Anatomy; Co-Director, Developmental Biology Center; Research involved elucidation of the factors controlling muscle, bone and cartilage development in chick limb mesodermal cells. A working hypothesis was suggested that the local metabolic environment had a profound effect on the choice mechanism(s) governing mesodermal cell differentiation into particular phenotypic pathways.
1975-1991 Co-Director, Cellular and Molecular Biology Training Program.

1973 (Research Career Development Award) Leave of Absence as Visiting Professor, Department of Biochemistry and Biophysics, University of California Medical School, San Francisco, California 94122. In collaboration with Dr. Brian J. McCarthy, investigation into the basis of gene selectivity.
1969-1975 Assistant Professor, Departments of Biology and Anatomy (Medical School).

HONORS/AWARDS


  1. Lifetime Achievement Award, National Center for Regenerative Medicine, August 2015

  2. Inaugural Member of the “Pioneers of Innovation” chosen by the Advocacy Committee of the Orthopaedic Research Society, March 2014

  3. Honorary Alumni of the Year Award, School of Med., Case Western Reserve University, September 2013

  4. TERMIS-NA 2010 Inaugural Lifetime Achievement Award, December 2010

  5. Elected Fellow: College of Fellows of the American Institute for Medical and Biological Engineering, Instillation, February 2010.

  6. Honorary Member: Stem Cell Research Italy, 2010

  7. The Genzyme Life-Time Achievement Award given by the International Cartilage Repair Society, October, 2007

  8. The Marshall Urist Award for Excellence in Tissue Regeneration Research presented by the Orthopaedic Research Society, February 1999.

  9. The Elizabeth Winston Lanier Award given by the American Academy of Orthopaedic Surgeons as part of their 1990 Kappa Delta Awards conferred on February 8, 1990.

  10. The Erna and Jakob Michael Visiting Professorship; The Weizmann Institute of Science, Israel, 1984-85.

  11. Josiah Macy Faculty Scholar Award, 1976-1977.

  12. National Institutes of Health Career Development Award, 1971-1976.

  13. American Cancer Society Postdoctoral Fellowship, 1967-1969.


COMMERCIAL INTERESTS
1. President and Founder, Skeletech, Inc.; 1989-1992.

2. Founder, Chief Scientific Officer, Member of Board of Directors, Osiris Therapeutics, Inc. 1992-1997.

3. Founder, Arnold Caplan and associates, aCa, consulting group; 1996-Present

4. Founder, Cell Targeting, Inc., 2004-2011

5. Consultant, Chief Scientific Officer, Orthocyte a subsidiary of BioTime, Inc.

6. Founder, CellBank Technologies, LLP, 2011-Present


Residence: Business:

1 Stratford Court Skeletal Research Center

Beachwood, Ohio 44122 Department of Biology

216-450-1299 Case Western Reserve University

2080 Adelbert Road, MSC 118

Cleveland, Ohio 44106-7080

Office: 216-368-3562

Lab: 216-368-2777; Fax: 216-368-4077

Email: arnold.caplan@case.edu


PUBLICATIONS
http://www.ncbi.nlm.nih.gov/sites/myncbi/1zEcdPwCyfoAl/bibliography/47858974/public/?sort=date&direction=ascending
1965

1. AI Caplan and E Carafoli. The Effects of Sr++ on Swelling and ATP-Linked Contraction of Mitochondria. Biochem Biophys Acta 104:317-329 (1965).



1966

2. AI Caplan and JW Greenawalt. Biochemical and Ultrastructural Properties of Osmotically Lysed Rat Liver Mitochondria. J Cell Biol 31:455-472 (1966).


1968

3. AI Caplan and JW Greenawalt. The Effects of Osmotic Lysis on the Oxidative Phosphorylation and Compartmentation of Rat Liver Mitochondria. J Cell Biol 36:15-31 (1968).

4. AI Caplan, E Zwilling and NO Kaplan. 3-Acetylpyridine: Effects In Vitro Related to Teratogenic Activity in Chick Embryos. Science 160:1009-1010 (1968).
1969

5. CR Hackenbrock and AI Caplan. Ion-Induced Ultrastructural Transformations in Isolated Mitochondria. J Cell Biol 42:221-234 (1969).


1970

6. AI Caplan. Effects of the Nicotinamide-Sensitive Teratogen 3-Acetylpyridine on Chick Limb Cells in Culture. Exp Cell Res 62:341-355 (1970).


1971

7. AI Caplan. The Teratogenic Action of the Nicotinamide Analogs 3-Acetylpyridine and 6-Aminonicotinamide on Developing Chick Embryos. J Exp Biol 178:351-358 (1971).


1972

8. AI Caplan. Effects of a Nicotinamide-Sensitive Teratogen 6-Aminonicotinamide on Chick Limb Cells in Culture. Exp Cell Res 70:185-195 (1972).

9. AI Caplan. The Effects of the Nicotinamide-Sensitive Teratogen 3-Acetylpyridine on Chick Limb Mesodermal Cells in Culture: Biochemical Parameters. J Exp Zool 180:351-362 (1972).

10. AI Caplan. Comparison of the Capacity of Nicotinamide and Nicotinic Acid to Relieve the Effects of Muscle and Cartilage Teratogens in Developing Chick Embryos. Dev Biol 28:344-351 (1972).

11. AI Caplan. The Site and Sequence of Action of 6-Aminonicotinamide in Causing Bone Malformations of Embryonic Chick Limb and Its Relationship to Normal Development. Dev Biol 28:71-83 (1972).
1973

12. AI Caplan and S Koutroupas. The Control of Muscle and Cartilage Development in the Chick Limb: The Role of Differential Vascularization. J Embryol Exp Morph. 29:571-583 (1973).

13. AI Caplan and AC Stoolmiller. Control of Chondrogenic Expression in Mesodermal Cells of Embryonic Chick Limb. Proc Natl Acad Sci 70:1712-1717 (1973).
1974

14. MJ Rosenberg and AI Caplan. Nicotinamide Adenine Dinucleotide Levels in Cells of Developing Chick Limbs: Possible Control of Muscle and Cartilage Development. Dev Biol 38:157-164 (1974).


1975

15. MJ Rosenberg and AI Caplan. Nicotinamide Adenine Dinucleotide Levels in Chick Limb Mesodermal Cells In Vitro: Effects of 3-Acetylpyridine and Nicotinamide. J Embryol Exp Morph 33:947-956 (1975).



16. AI Caplan and MJ Rosenberg. Interrelationship Between Poly(Adenosine Diphosphoribose) Synthesis, Intracellular NAD Levels, and Muscle or Cartilage Differentiation from Embryonic Chick Limb Mesodermal Cells. Proc Natl Acad Sci 72:1852-1857 (1975).

17. AI Caplan and MJ Rosenberg. The Control of Chondrogenic and Myogenic Expression in Chick Limb Mesodermal Cells. In: Extracellular Matrix Influences on Gene Expression, Ed. H.C. Slavkin and R. Greulich, Academic Press, New York, pp. 47-55 (1975).

18. AI Caplan. Biochemical Influences on Organ and Tissue Differentiation. In: 7th Mead Johnson Symposium in Perinatal and Developmental Medicine: Clinical and Biological Aspects of Malformation, Ed. R.S. Bloom, J.C. Sinclair and J.B. Warshaw, pp. 38-53 (1975).
1976

19. VC Hascall, TR Oegema, M Brown and AI Caplan. Isolation and Characterization of Proteoglycans from Avian Embryonic Limb Bud Chondrocytes Grown In Vitro. J Biol Chem 251:3511-3519 (1976).

20. P Osdoby and AI Caplan. The Possible Differentiation of Osteogenic Elements In Vitro from Chick Limb Mesodermal Cells: I. Morphological Evidence. Dev Biol 52:283-299 (1976).

21. CP Ordahl and AI Caplan. Transcriptional Diversity in Myogenesis. Dev Biol 54:61-72 (1976).

22. CP Ordahl, TR Johnson and AI Caplan. Sheared DNA Fragment Sizing: Comparison of Techniques. Nucl Acids Res 3:2985-2999 (1976).

23. AI Caplan. Simplified Procedure for Preparing Myogenic Cells for Culture. J Embryol Exp Morph 36:175-181 (1976).


1977

24. S DeLuca, D Heinegard, VC Hascall, JH Kimura and AI Caplan. Chemical and Physical Changes in Proteoglycans During Development of Chick Limb Bud Chondrocytes Grown In Vitro. J Biol Chem 252:6600-6608 (1977).

25. AI Caplan. Muscle, Cartilage and Bone Development and Differentiation from Chick Limb Mesenchymal Cells. In: Vertebrate Limb and Somite Morphogenesis. Ed. DA Ede, JR Hinchliffe and M Balls, Cambridge University Press, Cambridge, England, pp. 199-213 (1977).
1978

26. AI Caplan. Molecular Basis for Limb Morphogenesis. In: 5th International Conference on Birth Defects, Ed. J Littlefield and J DeGrouchy, Excerp. Medica. pp. 208-220 (1978).

27. JH Kimura, P Osdoby, AI Caplan and VC Hascall. Electron Microscopic and Biochemical Studies of Proteoglycan Polydispersity in Chick Limb Bud Chondrocyte Cultures. J Biol Chem 253:4721-4729 (1978).

28. JE Zull, S Krug, D Abel and AI Caplan. Development of Parathyroid Hormone and Calcitonin-Activated Adenylate Cyclases in the Embryonic Limb and in Cultured Cells from Embryonic Chick Limb. Proc Natl Acad Sci 75:3871-3875 (1978).

29. S DeLuca, AI Caplan and VC Hascall. Biosynthesis of Proteoglycans by Chick Limb Bud Chondrocytes. J Biol Chem 253:4713-4720 (1978).

30. AI Caplan and CP Ordahl. Irreversible Gene Repression Model for Control of Development. Science 201:120-130 (1978).

31. JE Saffitz and AI Caplan. Separation of Transcriptively Active and Inactive Chromatin: Agarose Gel Chromatography. Biochem Biophys Acta 520:368-375 (1978).

32. AI Caplan, MG Ord and LA Stocken. Chromatin Structure Through the Cell Cycle: Studies With Regenerating Rat Liver. Biochem J 174:475-483 (1978).



  1. JE Saffitz and AI Caplan. Hydroxylapatite Thermal Fractionation of Chromatin and DNA. Biochem 17:3480-3486 (1978).




34. JE Saffitz and AI Caplan. Attempted Separation of Transcriptively Active and Inactive Chromatin by Hydroxylapatite Thermal Chromatography. Biochem 17:3487-3495 (1978).

35. CP Ordahl and AI Caplan. High Diversity in the Polyadenylated RNA Populations of Embryonic Myoblasts. J Biol Chem 253:7683-7691 (1978).



  1. JH Kimura and AI Caplan. Identification of Glycogen as the Major Xylose Acceptor in Polysomal Preparations from Chick Embryo Cartilage Cultures. Arch Biochem Biophys 191:687-697 (1978).


1979

37. AI Caplan, C Neidergang, H Okazaki and P Mandel. Poly(ADP-ribose) Levels as a Function of Chick Limb Mesenchymal Cell Development as Studied In Vitro and In Vivo. Dev Biol 72:102-109 (1979).

38. P Osdoby and AI Caplan. Osteogenesis in Cultures of Limb Mesenchymal Cells. Dev Biol 73:84-102 (1979).

39. LS Lohmander, VC Hascall and AI Caplan. Effects of 4-Methyl Umbelliferyl-ß-D-Xylopyranoside on Chondrogenesis and Proteoglycan Synthesis in Chick Limb Bud Mesenchymal Cell Cultures. J Biol Chem 254:10551-10561 (1979).

40. JH Kimura, P Osdoby, AI Caplan and VC Hascall. Electron Microscopic Examination of Isolated Proteoglycan Aggregates. In: Glycoconjugate Research, Vol. I, Ed. JO Gregory, RW Jeanloz, Academic Press, New York, pp. 189-192 (1979).

41. AI Caplan, C Neidergang, H Okazaki and P Mandel. Poly(ADP-ribose) Polymerase: Self-ADP-ribosylation, the Stimulation by DNA and the Effects on Nucleosome Formation and Stability. Arch Biochem Biophys 198:60-69 (1979).

42. LS Lohmander, VC Hascall and AI Caplan. Effects of ß-D-Xyloside on Chondrogenesis and Proteoglycan Synthesis in Chick Limb Bud Cell Cultures. In: Proc. of 2nd Munich Symposium on Biology of Connective Tissue: Biology of the Articular Cartilage in Heath and Disease, (1979).
1980

43. AI Caplan and VC Hascall. Structure and Development Changes in Proteoglycans. In: Dilatation of the Uterine Cervix, Ed. F Naftolin and PG Stubblefield, Raven Press, New York, pp. 79-98 (1980).

44. P Osdoby and AI Caplan. Scanning Electron Microscopy of In Vitro Osteogenesis. Calcif Tiss Intl 30:43-50 (1980).

45. S DeLuca, LS Lohmander, B Nilsson, VC Hascall and AI Caplan. Proteoglycans from Chick Limb Bud Chondrocyte Cultures: Keratan Sulfate and Oligosaccharides which Contain Mannose and Sialic Acid. J Biol Chem 255:6077-6083 (1980).


1981

46. AI Caplan. Embryological Development: Evolutionary History, Genetic Bias and Cellular Environment Control the Flow of Developmental Events. J Col Sci Teach 10:226-230; 289-293 (1981).

47. AI Caplan. Studies on the Role of NAD and Poly(ADP-ribose) in the Control of the Differentiation and Development of Embryonic Chick Limb Cells. In: Novel ADP-Ribosylation of Regulatory Enzymes and Proteins, Ed. T Sigamura and M Smulson, Elsevier, North Holland, pp. 315-324 (1981).

48. RL Stevens, SP Nissley, JH Kimura, M Rechler, AI Caplan and VC Hascall. Effects of Insulin and Multiplication-Stimulating Activity on Proteoglycan Biosynthesis in Chondrocytes from the Swarm Rat Chondrosarcoma. J Biol Chem 256:2045-2052 (1981).




49. AI Caplan. The Molecular Control of Muscle and Cartilage Development. In: 39th Annual Symposium of the Society for Developmental Biology, Ed. S Subtelney and U Abbott, Alan R. Liss, Inc., New York, pp. 37-68 (1981).

50. P Osdoby and AI Caplan. First Bone Formation in Embryonic Chick Limbs. Dev Biol 86:147-156 (1981).

51. P Osdoby and AI Caplan. Characterization of a Bone-Specific Alkaline Phosphatase in Cultures of Chick Limb Mesenchymal Cells. Dev Biol 86:136-146 (1981).

52. JE Zull, K Youngman and AI Caplan. The Development of Hormonal Responses of Cultured Embryonic Chick Limb Mesenchymal Cells. Dev Biol 86:61-68 (1981).


1982

53. K von der Mark, P Osdoby and AI Caplan. Effect of 4-Methyl Umbelliferyl-ß-D-Xyloside on Collagen Synthesis in Chick Limb Bud Mesenchymal Cell Cultures. Dev Biol 90:24-30 (1982).

54. MJ Katz, RJ Lasek, P Osdoby, JR Whittaker and AI Caplan. Bolton-Hunter Reagent as a Vital Stain for Developing Systems. Dev Biol 90:419-429 (1982).

55. DA Carrino and AI Caplan. Isolation and Preliminary Characterization of Proteoglycans Synthesized by Skeletal Muscle. J Biol Chem 257:14145-14154 (1982).

56. BW Cherney, RJ Midura and AI Caplan. Poly(ADP-ribose) and the Differentiation of Embryonic Tissue. In: ADP-Ribosylation Reactions: Biology and Medicine, Ed. O Hayaishi and K Ueda, Academic Press, New York, pp. 389-406 (1982).

57. CP Ordahl, T Cooper, C Ovitt, J Fornwald, AI Caplan and A Calman. Structure and Developmental Regulation of Muscle-Regulated Gene Sets. In: Cold Spring Harbor Symposium, Muscle Development: Molecular and Cellular Control. Ed. ML Pearson and HF Epstein (1982).

58. R Shogren, AM Jamieson, J Blackwell, DA Carrino and AI Caplan. Light Scattering Studies of Chick Limb Bud Proteoglycans. J Biol Chem 257:8627-8629 (1982).

59. P Osdoby, MC Martini and AI Caplan. Isolated Osteoclasts and Their Presumed Progenitor Cells, the Monocyte, in Culture. J Exp Biol 224:331-344 (1982).

60. MC Martini, P Osdoby and AI Caplan. Adhesion of Osteoclasts and Monocytes to Developing Bone. J Exp Biol 224:345-354 (1982).
1983

61. SJ Hunter and AI Caplan. The Control of Cartilage Differentiation. In: Cartilage, Vol. II, Development and Differentiation, Ed. BK Hall, Academic Press, New York, pp. 87-120 (1983).

62. P Osdoby, MC Martini and AI Caplan. The Development of Long Bones of the Limb: Cell and Matrix Interactions of Osteoclasts and Monocytes. In: Limb Development and Regeneration, Part B, Ed. RO Kelly, PF Goetinck and JA MacCabe, Alan R. Liss, Inc., New York, pp. 229-238 (1983).

63. DM Jargiello and AI Caplan. The Fluid Flow Dynamics in the Developing Chick Wing. In: Limb Development and Regeneration, Part A, Ed. JF Fallon and AI Caplan, Alan R. Liss, Inc., New York, pp. 143-154 (1983).

64. DA Carrino and AI Caplan. Proteoglycans Produced by Skeletal Muscle In Vitro and In Vivo. In: Limb Development and Regeneration, Part B, Ed. RO Kelly, PF Goetinck and JA MacCabe, Alan R. Liss, Inc., New York, pp. 379-390 (1983).

65. AI Caplan, GT Syftestad and P Osdoby. The Development of Bone and Cartilage in Tissue Culture. J Clin Ortho Rel Res. 174:243-263 (1983).

66. DM Jargiello and AI Caplan. The Establishment of Vascular-Derived Micro-Environments in the Developing Chick Wing. Dev Biol 97:364-374 (1983).

67. DP Lennon, P Osdoby, DA Carrino, BM Vertel and AI Caplan. Isolation and Characterization of Chondrocytes and Non-Chondrocytes from High-Density Chick Limb Bud Cell Cultures. J Craniofac Genet Develop Biol 3:235-251 (1983).

68. DA Carrino, DP Lennon and AI Caplan. Extracellular Matrix and the Maintenance of the Differentiated State: Proteoglycans Synthesized by Replated Chondrocytes and Non-Chondrocytes. Dev Biol 99:132-144 (1983).

69. AI Caplan, MY Fiszman and HM Eppenberger. Molecular and Cell Isoforms During Development. Science 221:921-927 (1983).

70. RL Shogren, J Blackwell, AM Jamieson, DA Carrino, DG Pechak and AI Caplan. Light-Scattering Studies of Chick Limb Bud Proteoglycan Aggregate. J Biol Chem 258:8627-8629 (1983).

1984

71. AI Caplan. Cartilage. Scientific American 251:84-94 (1984).

72. DA Carrino, DG Pechak and AI Caplan. Characterization of Proteoglycans which are Synthesized During Skeletal Muscle Development. In: Developmental Processes in Normal and Diseased Muscle, Ed. H Eppenberger and J-C Perriard: Vol. 9 of Experimental Biology and Medicine, Ed. A Wolsky, S Karger, Publishers, Basel, Switzerland, pp. 80-86 (1984).

73. GT Syftestad and AI Caplan. A Fraction from Extracts from Demineralized Bone Stimulates the Conversion of Mesenchymal Cells into Chondrocytes. Dev Biol 104:348-356 (1984).

74. GT Syftestad and AI Caplan. Effects of Osteoinductive Bone Matrix Extracts on the Transition of Mesenchymal Cells into Chondrocytes. Calc Tiss Intl 36:625-627 (1984).


  1. DA Carrino and AI Caplan. Isolation and Partial Characterization of High-Buoyant-Density Proteoglycans Synthesized In Ovo by Embryonic Chick Skeletal Muscle and Heart. J Biol Chem 259:12419-12430 (1984).


1985

76. DA Carrino and AI Caplan. Isolation and Characterization of Proteoglycans Synthesized In Ovo by Embryonic Chick Cartilage and New Bone. J Biol Chem 260:122-127 (1985).

77. AI Caplan. The Vasculature and Limb Development. Cell Diff 16:1-11 (1985).

78. DG Pechak, DA Carrino and AI Caplan. Electron Microscopic Characterization of Chick Embryonic Skeletal Muscle Proteoglycans. J Cell Biol 100:1767-1776 (1985).

79. RF Drushel, DG Pechak and AI Caplan. The Anatomy, Ultrastructure and Fluid Dynamics of the Developing Vasculature of the Embryonic Chick Wing Bud. Cell Diff 16:13-28 (1985).

80. AI Caplan. Poly(ADP-ribose)Synthetase and Cell Differentiation. In: ADP-Ribosylation of Proteins, Ed. F Althaus, H Hilz and S Shall, Springer-Verlag, Berlin, pp. 388-396 (1985).

81. GT Syftestad, M Weitzhandler and AI Caplan. Isolation and Characterization of Osteogenic Cells Derived from First Bone of the Embryonic Tibia. Dev Biol 110:275-283 (1985).

82. DA Carrino, M Weitzhandler and AI Caplan. Proteoglycans Synthesized During the Cartilage to Bone Transition. In: The Chemistry and Biology of Mineralized Tissues, Ed. WT Butler, Ebsco Media, Inc., Birmingham, Alabama, pp. 197-208 (1985).

83. RJ Midura, BW Cherney and AI Caplan. The Relationship of Nicotinamide Adenine Dinucleotide to the Chondrogenic Differentiation of Limb Mesenchymal Cells. Dev Biol 111:232-242 (1985).

84. BW Cherney, RJ Midura and AI Caplan. Poly(ADP-ribose) Synthetase and Chick Limb Mesenchymal Cell Differentiation. Dev Biol 112:115-125 (1985).



  1. GT Syftestad, PA Lucas and AI Caplan. The In Vitro Chondrogenic Response of Limb Bud Mesenchyme to a Water-Soluble Fraction Prepared from Demineralized Bone Matrix. Differentiation 29:230-237 (1985).


1986

86. DA Carrino and AI Caplan. Proteoglycan Synthesis During Skeletal Muscle Development. In: Molecular Biology of Muscle Development, UCLA Symposia on Molecular and Cellular Development, Vol. 29, Ed. C Emerson, DA Fischman, B Nadal-Ginard and MAQ Siddiqui, Alan R. Liss, Inc., New York, pp. 117-132 (1986).

87. MJ Kujawa, DG Pechak, MY Fiszman and AI Caplan. Hyaluronic Acid Bonded to Cell Culture Surfaces Inhibits the Program of Myogenesis. Dev Biol 113:10-16 (1986).

88. H Ohno, J Blackwell, AM Jamieson, DG Pechak, DA Carrino and AI Caplan. Structure of Native Proteoglycan Aggregates from Chick Limb Bud Chondrocytes. Biopolymers 25:931-946 (1986).

89. MJ Kujawa and AI Caplan. Hyaluronic Acid Bonded to Cell Culture Surfaces Stimulates Chondrogenesis in Stage 24 Limb Mesenchyme Cell Cultures. Dev Biol 114:504-518 (1986).

90. AI Caplan. Molecular and Cellular Differentiation of Muscle, Cartilage and Bone in the Developing Limb. In: Progress in Developmental Biology Part B, Progress in Clinical and Biological Research. Vol. 217B, Ed. HC Slavkin, Alan R. Liss, Inc., New York, pp. 307-318 (1986).

91. MJ Kujawa, DA Carrino and AI Caplan. Substrate-Bonded Hyaluronic Acid Exhibits a Size-Dependent Stimulation of Chondrogenic Differentiation of Stage 24 Limb Mesenchymal Cells in Culture. Dev Biol 114:519-528 (1986).

92. AI Caplan. The Extracellular Matrix is Instructive. BioEssays 5:129-132 (1986).

93. PA Lucas, GT Syftestad and AI Caplan. Partial Isolation and Characterization of a Chemotactic Factor from Adult Bone for Mesenchymal Cells. Bone 7:365-371 (1986).

94. H Ohno, J Blackwell, AM Jamieson, DA Carrino and AI Caplan. Calibration of the Relative Molecular Mass of Proteoglycan Subunit by Column Chromatography on Sepharose CL-2B. Biochem J 235:553-557 (1986).

95. DG Pechak, MJ Kujawa and AI Caplan. Morphological and Histological Events During First Bone Formation in Embryonic Chick Limbs. Bone 7:441-458 (1986).


  1. DG Pechak, MJ Kujawa and AI Caplan. Morphology of Bone Development and Bone Remodeling in Embryonic Chick Limbs. Bone 7:459-472 (1986).

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