Appendix G. Trials Pending Assessment Table Trials Pending Assessment



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Table 1. Trials Pending Assessment

Study Reference

Study Name

Location

N

Intervention Description

Relevant Outcomes

2013 Status

Annweiler C, Fantino B, Parot-Schinkel E, Thiery S, Gautier J, Beauchet O. Alzheimer’s disease-input of vitamin D with mEmantine essay (AD-IDEA) trial: study protocol for a randomized controlled trial. Trials 2011, 12:230. PMID: 22014101.
Annweiler C, Beauchet O. Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D. Drugs & Aging 2012 Feb 1;29(2):81-91. PMID: 22233455.

AD-IDEA

FRA

120

Vitamin D 100,000 IU every 4 weeks

ADAS-cog, MMSE, Frontal Assessment Battery, TMT part A and B, ADAL, IADL, Timed Up and GO, Five Time Sit-to-Stand

In progress

Barnes DE, Chesney M. Preventing loss of independence through exercise (PLIE) – pilot. San Francisco: University of California San Francisco.

PLIE

US

16

Integrative exercise program

ADCS-ADL, QOL-AD, SF-36, falls, ADAS-cog, adverse effects

In progress

Barnes DE. The Mental Activity and eXercise trial for seniors. San Francisco: University of California San Francisco.

MAX

US

126

(IG1) Aerobic exercise

(IG2) Computer-based mental activity training



Cognitive function

Completed June 2011, no publications

Belleville S, Hudon C. Measuring the impact of cognitive and psychosocial interventions in patients with mild cognitive impairment. Montreal: Centre de Recherche de l’Institut Universitair de Geriatrie de Montreal.

NR

CAN

162

(IG1) Cognitive training

(IG2) Psychosocial intervention



Memory tests, ADLs, MMQ, GDS, GAI, well-being

In progress

Blumenthal JA. ENLIGHTEN: Exercise and NutritionaL Interventions for cognitive and Cardiovasulare HealTh ENhancement. Durham, NC: Duke University.

ENLIGHTEN

US

160

(IG1) Aerobic exercise

(IG2) DASH diet



(IG3) Aerobic exercise and DASH diet

Executive function (e.g., Digit symbol, trail making test, Stroop test, etc.)

In progress

Boustani M. Indiana University Dementia Screening Trial (IU-CHOICE). Indianapolis, IN: IU Center for Aging Research, 2011. PMID: None.

IU-CHOICE

US

4000

Memory Impairment Screen (MIS)

HRQL, PHQ, anxiety, health care use, advanced care planning

In progress

Boxer AL. Memantine (10mg BID) for the frontal and temporal subtypes of frontotemporal dementia; [Official title] A prospective, randomized, multi-center, double-blind, 26 week, placebo-controlled trial of memantine (10mg BID) for the frontal and temporal subtypes of frontotemporal dementia. ClinicalTrials.gov [www.clinicaltrials.gov], 2007. PMID: None.

NR

NR

140

Memantine 10mg BID

Neuropsychiatric Inventory; Clinical Global Impression Change (CGIC); MMSE; FAQ; UCSF FTD-Neuropsychological Test Battery

Completed December 2012, no publications

Burns J. Dose response study of aerobic exercise in older adults. Kansas: University of Kansas Medical Center Research Institute.

NR

US

100

50%, 100% and 150% aerobic exercise program

Cognitive function, memory tests

In progress

Burns J. Pilot study of aerobic exercise in early Alzheimer’s disease. Kansas: University of Kansas Medical Center Research Institute.

NR

US

80

Aerobic exercise

Cognitive function, daily function and behavior

In progress

Carrie I, van Kan GA, Gillette-Guyonnet S, et al. Recruitment strategies for preventive trials. The MAPT study (MultiDomain Alzheimer Preventive Trial). Journal of Nutrition, Health & Aging 2012 Apr;16(4):355-9. PMID: 22499458.

NR

FRA

1680

(IG1) Omega-3 supplementation

(IG2) Omega-3 + multi-domain intervention (exercise, cognitive training)

(IG3) Multi-domain intervention


Cognitive function

In progress

Carter J. A randomised placebo-controlled trial of polyunsaturated omega-3 fatty acid (PFA), in the treatment of dementia; a pilot study. ISRCTN Register, 2006. PMID: None.

NR

UK

50

Polyunsaturated omega-3 fatty acid (PFA)

Cognition (MMSE); quality of life (QOL-AD); general health (GHQ-12)

In progress

Chipman KA. Making memory better for seniors with mild cognitive impairment. Nova Scotia: Capital District Health Authority.

NR

CAN

40

Cognitive training

Rivermead Behavioral Memory Test, CVLT, MMQ, GDS, MAI, MPI, Zarit Burden

NR

Chodosh J. SCAN memory program evaluation study. Los Angeles: VA Greater Los Angeles Healthcare System.

SMPES

US

500

Dementia care management including assessment, education, counseling, referrals and telephone followup

Healthcare use, BPI, FAQ, HRQOL, caregiver burden and depression

Completed March 2012, no publications

Choi SH. Efficacy study of cognitive intervention in amnestic mild cognitive impairment. South Korea: Inha University.

NR

SKO

279

(IG1) Group-based cognitive training

(IG2) Home-based cognitive training



Memory tests (e.g., Stroop recall test), MMSE, CDR-SB, QoL, GDS

In progress

Cyarto EV, Cox KL, Almeida OP, Flicker L, Ames D, Byrne G, Hill KD, Beer CD, LoGiudice D, Appadurai K, Irish M, Renehan E, Lautenschlager NT. The Fitness for the Ageing Brain Study II (FABS II): Protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease. Trials 2010; 11:120. PMID: 21143943.

Fitness for the Ageing Brain Study II (FABS II)

AUS

230

3 components: PA program; behavioral intervention package; phone monitoring.

Asked to do 150 min/week of moderate PA.

Given education material about AD.


Geriatric Depression Scale – 15 item; Cambridge Contextual Reading Test; Alzheimer’s disease Assessment Scale – Cognitive Section; Standardized Mini-Mental State Examination; Clinical Dementia Rating Scale; Quality of Life – AD; Neuropsychiatric Inventory; Instrumental Activities of Daily Living; Activities of Daily Living; Short Form-36 version 2 (SF-36v2); Zarit Burden Interview.

In progress

Cyarto EV, Lautenschlager NT, Desmond PM, et al. Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial. BMC Psychiatry 2012 Oct 11;12(1):167. PMID: 23050829.

NR

AUS

156

Physical activity, Modification of the Fitness for Ageing Brain study intervention

Cognitivtion, physical function, physical activity

In progress

Dartigues JF. Efficacy assessment of three non-pharmacological therapies in Alzheimer’s disease. Bordeaux, France: University Hospital Bordeaux.

NR

FRA

800

(IG1) Group-based cognitive training

(IG2) Reminiscence therapy

(IG3) “Made to measure” program (physician chooses either IG1 or IG2)


ADAS-cog, MADRS, MMSE, behavioral disturbaces

Completed December 2012, no publications

Dartigues JF. Efficacy of care management in Alzheimer patients. Bordeaux, France: University Hospital Bordeaux.

NR

FRA

400

Care management (home visits from social worker and regular telephone followups)

NPI, MMSE, CDS, MADRS, QoL, Zarit burden, institutionalization

Competed December 2011, no publications

Dwolatzky T. Computerized personal interventions for Alzheimer’s patients. Israel: Shaare Zedek Medical Center.

NR

ISR

159

(IG1) Reminiscence therapy (personalized computer program); (IG2) Cognitive training

Cognitive function

Completed September 2012, no publications

Dysken M. A randomized clinical trial of vitamin E and memantine in Alzheimer’s disease. Minneapolis, MN: Department of Veteran Affairs.

NR

US, PR

620

(IG1) Vitamin E

(IG2) Memantine



ADCS-ADL

Completed September 2012, no publications

Elizabeth C. Evaluation of a psycho-educational group programme for dementia care-givers. National Research Register, 2000.

NR

UK

NR

8 week psycho-educational group program

Beck depression inventory; Beck anxiety inventory; carers burden inventory; short anxiety screening test

In progress

Farb NAS. Cognitive activation therapy for MCI: a randomized control study. Ontario: Rothman Research Institute.

FarbMCI2012

CAN

30

Computer-based cognitive activation training (Luminosity) and mindfulness-based stress reduction

Memory, executive function, well-being

In progress

Floeel A. Effects of dietary interventions on the brain in mild cognitive impairment. Berlin, Germany: Charite University.

NR

GER

330

Omega-2 supplementation

ADAS-cog

Completed December 2012, no publications

Forstmeier S, Maerchke A, Savaskan E, Roth T. Cognitive-behavioral treatment for mild Alzheimer’s patients and their caregivers. Germany: University of Zurich.

CBTAC

GER

124

Cognitive behavioral therapy including goal setting, psychoeducation, cognitive restructuring, caregiver training and psychosocial interventions

NPI, B-ADL, SCI, AES, CES-D, STAI, STAXI, SF-12, Zarit CBI, SCI for caregiver

In progress

Gates NJ, Valenzuela M, Sachdez PS, Singh NA, Baune BT, Brodaty H, et al. Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomized double blind, sham controlled, longitudinal trial. BMC Geriatrics 2011; 11:19. PMID: 21510896.

SMART

AUS

120

Cognitive training and progressive resistance training

ADAS-cog, IADLs, well-being, quality of life, neuropsychological test scores

Methods paper published 2011

Gaugler JE, Mittelman M. Comprehensive support for Alzheimer’s disease caregivers. Minneapolis, MN: University of Minnesota Clinical and Translational Science Institute

NR

US

161

Enhanced counseling and support for caregivers

Nursing home/institutional placement, caregiver stress, depression and social support

Completed January 2012, no publications

Gertz H. German adaptation of REACH II. Germany: University of Leipzig.

DeREACH

GER

158

“Resources to Enhance Alzheimer’s Caregivers Health – second edition” for caregivers

Zarit CBI, PHQ, SF-12

In progress

Hasselbalch SG. Effect of physical exercise in Alzheimer’s patients. Denmark: Rigshospital.

NR

DEN

192

Moderate intensity physical exercise

Symbol digit modalities test, NPI, ADAS-cog

In progress

Heuser I, Frolich L. Trial of simvastatin in amnestic mild cognitive impairment patients. Berlin: Charity University.

SIMaMCI

GER

640

Simvastatin

ADAS-cog, FCSRT score

In progress

Hill C. Aerobic exercise training in mild cognitive impairment. Dallas, TX: University of Texas Southwestern Medical Center.

NR

US

204

Moderate intensity endurance exercise training

Cognitive function

In progress

Holfhoff V. Effectiveness of home-based occupational therapy for dementia. Germany: Dresden University of Technology.

ERGODEM

GER

200

Home-based occupational therapy

ADAS-ADL, cognitive function, behavioral problems, caregiver burden

Completed January 2011, no publications

Janssen Research and Development. A double-blind, placebo-controlled, 2-year study of galantamine used to treat patients with mild to moderate Alzheimer’s disease.

NR

US

2051

Galantamine 8-24 mg/d

MMSE, DAD

In progress

Jenson M. The effect of cognitive function as measured by repeated cognitive measures after 12 weeks treatment with donepezil. AstraZeneca

NR

CAN, PER, POL, SWA

155

Donepezil

ADCS-CGIC, NTB, ADAS-cog, CogState computerized neurological test battery

Completed January 2011, no publications

Kivipelto M, Laatikainen TK, Soininen HS, Tuomilehto J, Strandberg TE, Sulkava R, et al. Finnish geriatric intervention study to prevent cognitive impairment and disability. Finland: National Institute for Health and Welfare.

FINGER

FIN

1200

Lifestyle counseling including guided aerobic exercise and muscle training, cognitive training, nutritional guidance

Neuropsychological test battery, Stroop and Trail Making Tests, ADCS-ADS, RAND-36

In progress

Kolassa I. Sensory-cognitive and physical fitness training in mild cognitive impairment. Germany: University of Konstanz.

NR

GER

100

(IG1) Auditory discrimination training; (IG2) physical fitness

ADAS-cog

Completed June 2012, no publications

Krikorian R. Omega-3 and blueberry supplementation in age-related cognitive decline. Cincinnati, OH: University of Cincinnati.

NR

US

140

Omega-3 fatty acid

Memory tests, GDS, GAI

In progress

Laakkonen ML, Holtta EH, Savikko N, et al. Psychosocial group intervention to enhance self-management skills of people with dementia and their caregivers: study protocol for a randomized controlled trial. Trials 2012;13:133. PMID: 22871107.

NR

FIN

160

Psychosocial intervention

HRQoL (15D and SCQ), depression, cognitiveion, GHQ-12, CES-D, caregiver coping

In progress

Laks J. Physical exercise as an additional treatment for Alzheimer disease. Rio de Janiero: Federal University of Rio de Janiero.

NR

BRA

60

Aerobic exercise

CAMCOG, trail making test, physical function

In progress

Le Duff F. Physical training and cognitive activity on the mild cognitive impairment patient. Nice, France: Centre Hospitalier Universitaire de Nice.

NR

FRA

36

(IG1) Physical training + cognitive activity

(IG2) Physical training alone



Cognitive function

In progress

Liu-Ambrose T, Eng J, Boyd J, Hsiung R, Jacova C, Feldman H, Brasher P, Lee P. PROMOTE: Promotion of the mind through exercise. British Columbia: University of British Columbia.

PROMOTE

CAN

70

Aerobic-based exercise training

ADCS-ADL, ADAS-cog

Completed December 2012, no publications

Luchsinger J, Mittleman M, Mejia M, Silver S, Lucero RJ, Ramierez M, et al. The Northern Manhattan Caregiver Intervention Project: a randomized trial testing the effectiveness of a dementia caregiver intervention in Hispanics in New York City. BMJ Open 2012;2:e001941. PMID: 22983877.

NYUCI

US

160

Caregiver intervention addressing psychosocial and economic stressors

GDS, Zaris Caregiver burden

Methods paper published 2012

Markham C. The talking sense communication programme for dementia carers. United Kingdom: University of Portsmouth.

NR

UK

60

The Talking Sense manual including individualized communication development; addresses caregivers knowledge, skills and behavior

Caregiver HADS, QOL

In progress

Masera F. A trial to support caregivers of patients with dementia in Italy: the UP-TECH project. Italy: Istituot Naxionale di Ricovero e Cura per Anziani.

UP-TECT

ITA

900

(IG1) Case manager providing counseling and telephone followups (UP protocol)

(IG2) Case manager providing counseling, telephone followups, and other assistive technologies (UP-TECH)



Caregiver burden inventory, days spent at home by patient, QOL

In progress

Montero-Odasso M, Wells LJ, Borrie MJ, Speechley M. Can cognitive enhancers reduce the risk of fs in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial. BMC Neurology 2009; 9:42. PMID: 19674471.

NR

CAN

140

Rx: 5mg donepezil for 1 mo; Rx: increased to 10mg donepezil (per standard treatment)

Attention measured w/ the Digit Span Test; Executive function using the Trail Making Test, parts A & B; Reduction of number falls: The total number of falls by mo. 6 (T2) & proportion of participants who fall are also secondary outcome measures to be evaluated.

In progress

Nichols LO. Testing the effectiveness of telephone support for dementia caregivers. Memphis, TN: Department of Veterans Affairs.

CONNECT

US

154

Telephone support over the course of year

General well-being and caregivers level of distress

In progress

Orrell M, Yates LA, Burns A, et al. Individual Cognitive Stimulation Therapy for dementia (iCST): study protocol for a randomized controlled trial. Trials 2012 Sep 22;13(1):172. PMID: 22998983.

NR

UK

306

Individual cognitive stimulation therapy

ADAS-cog, QoL-AD, SF-12 for caregiver quality of life

In progress

Pandita-Gunawardena D. An audit to examine the effectiveness of information and counselling strategies in relieving caregiver stress in caregivers of patients with dementia. ISRCTN Register, 2005. PMID: None

NR

UK

100

Enhanced carer counselling

Zait Burden interview

In progress

Pitkala KH, Raivio MM, Laakkonen ML, Tilvis RS, Kautiainen H, Strandberg TE. Exercise rehabilitation on home-dwelling patients with Alzheimer's disease--a randomized, controlled trial. Study protocol. Trials 2010; 11:92. PMID: 20925948.

NR

SWE

210

Intervention 1: Home-based physical exercise/rehab.

Intervention 2: Day rehab centre-based physical exercise/rehab.



CDR; MMSE; Verbal flow, clock drawing test; FIM; NPI; Cornell depression scale; Falls & fractures; Use of health & social services, admission to permanent institutional care, mortality; Zarit burden scale; GDS; RAND-36; QOL

In progress

Pond CD, Brodaty H, Stocks NP, et al. Ageing in general practice (AGP) trial: a cluster randomised trial to examine the effectiveness of peer education on GP diagnostic assessment and management of dementia. BMC Family Practice 2012;13:12.

AGP

AUS

200 patients, 160 GPs

Two education sessions from GP or nurse providing information about dementia and individualized feedback

GPCOG, CAMCOG, MMSE, GDS, WHOQOL-BREF, BDI, GPAQ, ADL

In progress

Pot AM. [Public title] Effectiveness of an e-Mental Health intervention for family caregivers of people with dementia; [Official/Scientific title] Effectiveness of an eHealth intervention on psychological well-being, feelings of burden and perceived health of family caregivers of people with dementia. WHO Portal/ICTRP [http://apps.who.int/trialsearch], 2009. PMID: None.

NR

NETH

150

e-Mental Health intervention, called ‘Dementie de Baas’ (‘Mastery over Dementia’). The intervention cosist of 8 lessons & a booster session (follow-up). Working principles are psycho education, cognitive behavioral therapy, problem solving behavior, assertiveness training & relaxation therapy. Participants are in contact w/ a professional counselor (digital coach) who gives them feedback.

Depressive symptoms(CES-D); anxiety(HADS); caregiver stress (RPBMC); feelings of burden (SPICC);subjective health; quality of life; use of care services

In progress

Prick AE. [Public title] Effect of a training program on dementia and caregiving; [Scientific title] A training program for people with dementia and their family caregivers: a randomized controlled trial. Netherlands Trial Register [www.trialregsiter.nl], 2009. PMID: None.
Prick AE, de LJ, Scherder E, et al. Home-based exercise and support programme for people with dementia and their caregivers: study protocol of a randomised controlled trial. BMC Public Health 2011;11:894. PMID: 22117691.


NR

NETH

312 (156 dyads)

The goal of the exercise training program is that people with dementia will exercise actively during at least 30 minutes a day. The exercises will include balance, strength training, aerobic/endurance activities & flexibility training. In addition the caregiver will learn how to cope w/ the demented person, will be advised in dementia & the consequences & pleasure activities w/ the patient will be stimulated.

People w/ dementia: Physical health (SIP & SF36); Cognition (neuropsychological research)

Caregivers: Physical health (GHQ-12); mood (CES-D); stress (RMBPC & cortisol)



In progress

Rigaud AS. Web-based psycho-educational program to support carers in Alzheimer’s patients. Paris: Hospital Broca la Collegiale Memory Clinic.

DIAPASON

FRA

80

Web-based psycho-educational program, lifestyle counseling

Caregiver stress, Zarit CBI, BDI, RCSE

In progress

Rovner BW, Casten RJ, Hegel MT, Leiby BE.

Preventing cognitive decline in older African Americans with mild cognitive impairment: design and methods of a randomized controlled trial. Comt Clin Trials 2012; 33:712-20. PMID: 22406101.



NR

US

200

Manual-based behavioral treatment including goal-setting, activity scheduling, task assignments, identifying avoidant behaviors and rating accomplishments

Episodic member, ADAS neuropsychology tests

Methods paper published 2012

Sadavoy J. Screening for mental health concerns for at-risk community living Chinese seniors. Canada: Mount Sinai Hospital, 2007. PMID: None.

NR

CAN

100

Participants screened for depression and cognitive impairment; only half receive screening results

Health care planning

Not yet recruiting

Saxton J. Cognitive assessment of elderly primary care patients. Pittsburgh, PA: University of Pittsburgh, 2011. PMID: None.

NR

US

524

Patient screened for cognitive impairment; only half of physician received results

Health care planning, cognitive outcomes

Completed August 2012, no publications

Shinto L. Lipoic acid and omega-3 fatty acids for Alzheimer’s disease. Portland, OR: Oregon Health and Science University.

NR

US

100

Omega-3 fatty acids

ADAS-cog, ADL

In progress

Sicari R, Berardi N. Train the brain – cognitive and physical training for slowing dementia. Italy: Institute of Clinical Physiology, National Research Council.

Train the Brain (TTB)

ITA

160

Physical activity (aerobics, muscle training, balance, flexibility) and cognitive training

Cognitive function

In progress

Thyrian JR. Intervention study to improve life and care for people with dementia and their caregivers in primary care. Germany: German Center for Neurodegenerative Diseases.

DelpHi

GER

1000

Home visits by Dementia Care Manager to provide care management, counseling and support caregivers

QoL-AD, BIZA-D, NPI, BSI, PHS

In progress

van den Dungen P, Moll van Charante EP, van Marwijk HW, et al. Case-finding of dementia in general practice and effects of subsequent collaborative care; design of a cluster RCT. BMC Public Health 2012;12:609. PMID: 22863299.

NR

NETH

162

Case finding and collaborative care

QoL-AD, EQ5D, MH5, GHQ-12, SSCQ

In progress

Volkers KM, Scherder EJ. The effect of regular walks on various health aspects in older people with dementia: Protocol of a randomized-controlled trial. BMC Geriatrics 2011; 11:38. PMID: 21827648.

NR

NETH

175

Daily 30 minute walk, 5 times a week under supervision.

MMSE Eight words test; Rule shift cards; Key search; Digit span (forward & backward); Face recognition; Picture recognition; Category fluency test; Visual memory span (forward & backward); Picture completion; Stroop task; GDS; QoL - Qualidem; Katz index

In progress

Whitlatch CJ, Judge K, Zarit SH, Femia E. Dyadic Intervention for Family Caregivers and Care Receivers in Early-Stage Dementia. The Gerontologist 2006; 46(5):688-694. PMID: 17050761.

Early Diagnosis Dyadic Intervention (EDDI)

US

34 dyads

9 sessions

Objectives: Increase understanding of care preferences/ values of ea. dyad member; discuss/ practice effective communication; discuss discrepancies in care preferences/ expectations; increase dyad’s knowledge of available services; explore emotional significance/ relationship issues brought on by the illness for both care partners.



NR

In progress, Baseline

Abbreviations: AD = Alzheimer’s disease, ADAS-CGIC = Alzheimer’s Disease Assesment Scale-Clinical Global Impression of Change; ADAS-Cog = Alzheimer’s Disease Assesment Scale-Cognitive subscale; ADCS-ADS = Alzheimer’s Disease Cooperative Study-AIDS Dementia Complex; ADL = activites of daily living; AES = Apathy Evaluation Scale; AUS = Austrailia; B-ADL = Bayer-Activities of Daily Living Scale; BID = twice daily; BIZA = Berlin Inventory of Caregivers’ Burden with Dementia Patients; BPI = Brief Pain Inventory; BRA = Brazil; BSI = British Standards Institute; CAMCOG = Cambridge Cognitive Examination; CAN = Canada; CDR-SB = Clinical Dementia Rating-Sum of Boxes; CES-D = Center for Epidemiologic Studies-Depression scale; CGIC = Clinical Global Impression of Change; CVLT = California Verbal Learning Test; DAD = Disability Assesment for Dementia; DASH = Division of Adolescent and School Health; DEN = Denmark; EQ5D = European Quality of Life-5 Dimensions; FAQ = frequently asked questions; FIN = Finland, FIM = Functional Independence Measure; FRA = France; FTD = Frontotemporal Dementia; GAF = Global Assesment of Functioning; GDS = Geriatric Depression Scale; GER = Germany; GHQ-12 = 12-item General Health Questionnaire; GP(s) = general practitioner(s); GPAQ = General Practitioner Alzheimer Questionnaire; HADS = Hospital Anxiety and Depression Scale; IADL = instrumental activities of daily living; IG = intervention group; IN = Indiana; ISR = Israel; ITA = Italy; MADRS = Montgomery-Asberg Depression Rating Scale; MAI = Multilevel Assesment Inventory; MHS = mental health specialist; MIS = Memory Impairment Screen; MMQ = Multifactorial Memory Questionnaire; MMSE = Mini-Mental State Examination; MPI = Multidimensional Prognostic Index; mo = month; N = number; NETH = Netherlands; NPI = Neuropsychiatric Inventory; NR = not reported; NTVB = Neuropsychological Test Battery; PA = physical activity; PER = Peru; PHQ = Patient Health Questionnaire; PHS = public health services; PMID = PubMed Identifier; POL = Poland, PR = Puerto Rico; QOL = quality of life; QOL-AD = Quality of Life-Alzheimer’s Disease; RAND-36 = RAND-36 measure of Health-Related Quality of Life; RCSE = Revised scale for Caregiving Self-Efficacy; RMBPC = Revised Memory & Behavior Problem Checklist; Rx = prescription; SAF = South Africa; SCI = subjective cognitive impact; SCQ = Social Communication Questionnaire; SF-12 = Medical Outcomes Study 12-Item Short Form Health Survey; SF-36(v2) = Medical Outcomes Study 36-Item Short Form Health Survey (version 2); SIP = Sickness Impact Profile; SKO = South Korea; SSCQ = Short Sense of Competence Questionnaire; STAI = State-Trait Anxiety Inventory; STAXI = State-Trait Anger Expression Inventory; SWE = Sweden; TMT = Trail Making Test; T2 = timepoint 2; UK = United Kingdom; WHOQOL-BREF = World Health Organization Quality of Life Assessment-abbreviated.

Screening for Cognitive Impairment Kaiser Permanente Research Affiliates EPC


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