Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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diuron, the fungicide chlorothalonil, and the insecticide permethrin for marine and estuarine species. Permethrin was the most toxic pesticide to marine and estuarine crustaceans. Diuron was the most toxic pesticide to algae, and chlorothalonil was most toxic to early life stages of molluscs and other invertebrates. Toxicity data (96 h LC50/EC50 values) were analyzed using a probability distribution on the ranked toxicity values and 10th centile values were calculated based on different groups of species and for all species combined. Our results indicate that an assessment of risk based on smaller taxonomic groups can be informative, especially for pesticides of less specific modes of action such as chlorothalonil. Published by Elsevier Ltd.
Keywords: Risk assessment, Acute toxicity, Pesticides, Estuarine species
ISI Document Delivery No.: 983UA

313. Delpuech, J. M.; Dupont, C., and Allemand, R. Decrease in Fecundity Induced by Interspecific Mating Between Two Trichogramma Parasitoid Species. 2010; 103, (2): 308-313.


Rec #: 59049
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
Abstract: Abstract: Trichogramma are used for the biological control of numerous pests. For Trichogramma, as for other insects, the specificity of matings is ensured by several barriers that prevent copulation attempts between insects from different species. We have recently shown that insecticides may totally suppress species recognition that occurs from pheromonal communications between two Tri-chogramtna species, a sublethal effect that will increase mating attempts between two different species. In this work, we have assessed the fitness cost of such interspecific matings and demonstrate that they are very costly for females. After an interspecific mating, females can generate only males because fertilized eggs degenerate (Trichogramma are haplo-diploid species; males are issued from unfertilized eggs and females from fertilized eggs). The resulting offspring are reduced in number by more than half, corresponding to the missing progeny from fertilized eggs. After an interspecific mating, the fecundity of females cannot be restored even if females subsequently mate intraspecifically. These results highlight the strong fitness cost of any event that would decrease the specificity of matings in Trichogramma. Because Trichogramma are key species regulating insect populations, these effects must be considered in the context of sustainable development.
Keywords: Trichogramma evanescens, Trichogramma semblidis, biological control,
ISI Document Delivery No.: 576SX

314. Demirda-Ramazan; Yerlikaya, Emrah; Aksakal, Erc++ment; K++frevio-lu, +űmer Irfan, and Ekinci, Deniz. Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes. 2012 Sep; 34, (2): 218-222.


Rec #: 5690
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: The objective of this study was to assess the inhibitory effects of six commonly used pesticides, cyhalothrin, cypermethrin, dichlorvos, methamidophos, chlorpyrifos and methylparathion, on the pH regulatory enzyme carbonic anhydrase (CA) of Dicentrarchus labrax (European Seabass) liver (dCA) and bovine erythrocytes (bCA). Results of the study showed that the pesticides displayed quite variable inhibition profiles with KI values ranging from 0.376 to 26.164 ++M against dCA, and from 1.174 to 53.281 ++M against bCA. Methylparathion was the most effective inhibitor for both enzymes. Overall data show that all of the tested pesticides inhibit both dCA and bCA at low concentrations indicating that indiscriminate use of these pesticides might cause disruption of acid base regulation resulting in animal deaths. Our results also point out that susceptibility to these pesticides varies among CAs from different organisms. CA/ Purification/ Organophosphate/ Pesticide/ Inhibition

315. Dengiz, Orhan; Ozcan, Hesna; Koksal, Eselim; Baskan, Oguz; Kosker, Yakup, and Dengiz, Orhan. Sustainable Natural Resource Management and Environmental Assessment in the Salt Lake (Tuz Golu) Specially Protected Area. 2010 Feb; 161, (1-4): 327-342.


Rec #: 48099
Keywords: MODELING
Notes: Chemical of Concern: CPY
Abstract: Abstract: The Salt Lake Specially Protected Area is a unique ecosystem for both agricultural activities and natural life in Turkey. In the present study, an attempt was made to develop a conceptual land use strategy and methodology, taking into account ecological factors for regional development in the Salt Lake Specially Protected Area. A detailed Geographic Information System (GIS) analysis was done to create a comprehensive database including land use, land suitability, and environmental factors (soil, climate, water quality, fertilizing status, and heavy metal and pesticide pollution). The results of the land suitability survey for agricultural use showed that, while 62.6% of the study area soils were classified as best and relatively good, about 15% were classified as problematic and restricted lands, only 22.2% of the study area soils were not suitable for agricultural uses. However, this is not enough to derive maximum benefit with minimum degradation. Therefore, environmental factors and ecological conditions were combined to support this aim and to protect the ecosystem. Excessive irrigation practices, fertilizer and pesticide application, and incorrect management practices all accelerate salinization and degradation. In addition to this, it was found that a multi-layer GIS analysis made it easy to develop a framework for optimum land use and could increase the production yield preserving the environmental conditions. Finally, alternative management and crop patterns were undertaken to sustain this unique ecosystem, considering water, soil, climate, land use characteristics, and to provide guidance for planners or decision makers.
Keywords: Land Use
Keywords: Turkey, Tuz L.
Keywords: Ecosystems
Keywords: Degradation
Keywords: Climates
Keywords: Pollution Abstracts; Sustainability Science Abstracts; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environmental Engineering Abstracts; Meteorological & Geoastrophysical Abstracts
Keywords: Turkey
Keywords: AQ 00003:Monitoring and Analysis of Water and Wastes
Keywords: Environmental Studies
Keywords: Salts
Keywords: SW 1030:Use of water of impaired quality
Keywords: Agricultural Chemicals
Keywords: Assessments
Keywords: Pesticides
Keywords: Geographical Information Systems
Date revised - 2010-02-01
Language of summary - English
Location - Turkey, Tuz L.; Turkey
Pages - 327-342
ProQuest ID - 809953729
SubjectsTermNotLitGenreText - Land Use; Salts; Agricultural Chemicals; Degradation; Assessments; Ecosystems; Pesticides; Climates; Geographical Information Systems; Turkey, Tuz L.; Turkey
Last updated - 2012-08-02
Corporate institution author - Dengiz, Orhan; Ozcan, Hesna; Koksal, ESelim; Baskan, Oguz; Kosker, Yakup
DOI - OB-74e9f985-02a4-4f33-bb65mfgefd101; 12597280; 0167-6369; 1573-2959 English

316. DeNoyelles, F. Jr.; Dewey, S. L.; Huggins, D. G., and Kettle, W. D. Aquatic Mesocosms in Ecological Effects Testing: Detecting Direct and Indirect Effects of Pesticides. 1994: 577-603.


Rec #: 1690
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (24D,24DXY,ATZ,CBF,CBL,CPY,CYP,CuS,DCA,DDVP,DFZ,MP,PCP,PMR,PPZ,PRO,SZ), NO REVIEW (24D,24DXY,ATZ,CBF,CBL,CPY,CYP,CuS,DCA,DDVP,DFZ,MP,PCP,PMR,PPZ,PRO,SZ)
Notes: Chemical of Concern: 24D,24DXY,ATZ,AsO3Na,CBF,CBL,CPY,CYP,CuS,DCA,DDVP,DFZ,MP,MXC,PCP,PMR,PPZ,PRO,SZ

317. Deribe, Ermias; Rosseland, Bjoern Olav; Borgstroem, Reidar; Salbu, Brit; Gebremariam, Zinabu; Dadebo, Elias; Norli, Hans Ragnar; Eklo, Ole Martin, and Deribe, Ermias. Bioaccumulation of Persistent Organic Pollutants (Pops) in Fish Species From Lake Koka, Ethiopia: the Influence of Lipid Content and Trophic Position. 2011 Dec 1; 410-411, 136-145.


Rec #: 47009
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: The concentrations and bioaccumulation of persistent organic pollutants (POPs) were determined in four fish species from Lake Koka, Ethiopia, representing 2-3 levels in the food chain of the lake. Dichlorodiphenyltrichloroethanes (DDTs), endosulfans, polychlorinated biphenyls (PCBs) and chlorpyrifos were identified, with DDTs as the most predominant pesticide, with concentration ranging from 0.05 to 72.53ngg-1 wet weight (ww). All fish tissue samples collected from different species of the lake contained residues of DDTs. The maximum level of DDTs was found in the fattiest, African sharptooth catfish (Clarias gariepinus) sampled from the lake, with a mean concentration of 15.15ngg-1ww. The significant (P<0.05) relationship between concentrations of DDTs and delta 15N indicates that DDTs biomagnified in the food web of the lake. The 4,4'-DDE to 4,4'-DDT ratio in Oreochromis niloticus (0.6) and Cyprinus carpio (0.5) were below 1, indicating ongoing use of DDTs in the study area and recent exposure of these fish species.
Keywords: persistent organic pollutants
Keywords: Lipids
Keywords: Clarias gariepinus
Keywords: Lakes
Keywords: Ethiopia
Keywords: Bioaccumulation
Keywords: Cyprinus carpio
Keywords: Meteorological & Geoastrophysical Abstracts; Environment Abstracts; Pollution Abstracts
Keywords: DDT
Keywords: Pesticides
Keywords: Africa
Keywords: Fish
Keywords: Nitrogen isotopes
Keywords: PCB compounds
Keywords: food webs
Keywords: Oreochromis niloticus
Date revised - 2011-12-01
Language of summary - English
Location - Ethiopia; Africa
Number of references - 4
Pages - 136-145
ProQuest ID - 911159387
SubjectsTermNotLitGenreText - Nitrogen isotopes; Lakes; Bioaccumulation; persistent organic pollutants; Lipids; Pesticides; DDT; Fish; food webs; PCB compounds; Cyprinus carpio; Clarias gariepinus; Oreochromis niloticus; Ethiopia; Africa
Last updated - 2012-09-24
British nursing index edition - Science of the Total Environment [Sci. Total Environ.]. Vol. 410-411, pp. 136-145. 1 Dec 2011.
Corporate institution author - Deribe, Ermias; Rosseland, Bjoern Olav; Borgstroem, Reidar; Salbu, Brit; Gebremariam, Zinabu; Dadebo, Elias; Norli, Hans Ragnar; Eklo, Ole Martin
DOI - 5e0c305a-3431-406c-9d2bcsamfg201; 16077657; 0048-9697
Alexander J., Frà ̧yland L., Hemre G.I., Jacobsen B.K., Lund E., Meltzer H.M. A comprehensive assessment of fish and other seafood in the Norwegian diet.
FAO. "Prevention and disposal of obsolete and banned pesticides stocks." 5th FAO Consultation meeting.
FLDP. "Lake Fisheries Development Project." Phase II.Final Report.
Gebre-Mariam, Z, Gebre-Mariam, Z 2002 "The Ethiopian Rift Valley Lakes: Major threats and strategies for conservation" ETHIOPIAN RIFT VALLEY LAKES 259-271 English

318. Desai, P.; Patlolla, R. R., and Singh, M. Interaction of Nanoparticles and Cell-Penetrating Peptides With Skin for Transdermal Drug Delivery.


Rec #: 50429
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Topical or transdermal drug delivery is challenging because the skin acts as a natural and protective barrier. Therefore, several methods have been examined to increase the permeation of therapeutic molecules into and through the skin. One approach is to use the nanoparticulate delivery system. Starting with liposomes and other vesicular systems, several other types of nanosized drug carriers have been developed such as solid lipid nanoparticles, nanostructured lipid carriers, polymer-based nanoparticles and magnetic nanoparticles for dermatological applications. This review article discusses how different particulate systems can interact and penetrate into the skin barrier. In this review, the effectiveness of nanoparticles, as well as possible mode of actions of nanoparticles, is presented. In addition to nanoparticles, cell-penetrating peptide (CPP)-mediated drug delivery into the skin and the possible mechanism of CPP-derived delivery into the skin is discussed. Lastly, the effectiveness and possible mechanism of CPP-modified nanocarriers into the skin are addressed.
MESH HEADINGS: Administration, Cutaneous
MESH HEADINGS: Animals
MESH HEADINGS: Cell-Penetrating Peptides/*administration &
MESH HEADINGS: dosage/chemistry
MESH HEADINGS: Drug Carriers/chemistry
MESH HEADINGS: Drug Delivery Systems/*methods
MESH HEADINGS: Humans
MESH HEADINGS: Lipids/chemistry
MESH HEADINGS: Liposomes/*pharmacokinetics
MESH HEADINGS: Nanoparticles/*administration &
MESH HEADINGS: dosage/chemistry
MESH HEADINGS: Pharmaceutical Preparations/administration &
MESH HEADINGS: dosage/chemistry
MESH HEADINGS: Rats
MESH HEADINGS: *Skin/anatomy &
MESH HEADINGS: histology/metabolism eng

319. Desneux, N.; Decourtye, A., and Delpuech, J. M. The Sublethal Effects of Pesticides on Beneficial Arthropods. desne001@umn.edu//: 2007; 52, 81-106.


Rec #: 2000
Keywords: REVIEW
Call Number: NO REVIEW (AZD,CPY,CYH,CYP,DM,DMT,ES,FNT,FPN,IMC,LCYT,MP,TUZ)
Notes: EcoReference No.: 99528
Chemical of Concern: AZD,CPY,CYH,CYP,DM,DMT,ES,FNT,FPN,IMC,LCYT,MP,TUZ

320. Deziel, Nicole C; Viet, Susan M; Rogers, John W; Camann, David E; Marker, David a; Heikkinen, Maire Sa; Yau, Alice Y; Stout, Daniel M; Dellarco, Michael, and Deziel, Nicole C. Comparison of Wipe Materials and Wetting Agents for Pesticide Residue Collection From Hard Surfaces. 2011 Sep 15; 409, (20): 4442-4448.


Rec #: 47119
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Different wipe materials and wetting agents have been used to collect pesticide residues from surfaces, but little is known about their comparability. To inform the selection of a wipe for the National Children's Study, the analytical feasibility, collection efficiency, and precision of Twillwipes wetted with isopropanol (TI), Ghost Wipes (GW), and Twillwipes wetted with water (TW), were evaluated. Wipe samples were collected from stainless steel surfaces spiked with high and low concentrations of 27 insecticides, including organochlorines, organophosphates, and pyrethroids. Samples were analyzed by GC/MS/SIM. No analytical interferences were observed for any of the wipes. The mean percent collection efficiencies across all pesticides for the TI, GW, and TW were 69.3%, 31.1%, and 10.3% at the high concentration, respectively, and 55.6%, 22.5%, and 6.9% at the low concentration, respectively. The collection efficiencies of the TI were significantly greater than that of GW or TW (p<0.0001). Collection efficiency also differed significantly by pesticide (p<0.0001) and spike concentration (p<0.0001). The pooled coefficients of variation (CVs) of the collection efficiencies for the TI, GW, and TW at high concentration were 0.08, 0.17, and 0.24, respectively. The pooled CV of the collection efficiencies for the TI, GW, and TW at low concentration were 0.15, 0.19, and 0.36, respectively. The TI had significantly lower CVs than either of the other two wipes (p=0.0008). Though the TI was superior in terms of both accuracy and precision, it requires multiple preparation steps, which could lead to operational challenges in a large-scale study.
Keywords: Feasibility studies
Keywords: Insecticides
Keywords: Organochlorine compounds
Keywords: P 9999:GENERAL POLLUTION
Keywords: ENA 09:Land Use & Planning
Keywords: Organophosphates
Keywords: Pesticide residues
Keywords: Pollution Abstracts; Environment Abstracts
Keywords: Steel
Keywords: Pyrethroids
Keywords: Children
Keywords: Environmental Studies
Date revised - 2012-01-01
Language of summary - English
Pages - 4442-4448
ProQuest ID - 889685985
SubjectsTermNotLitGenreText - Feasibility studies; Insecticides; Organochlorine compounds; Organophosphates; Pesticide residues; Steel; Pyrethroids; Children
Last updated - 2012-08-02
Corporate institution author - Deziel, Nicole C; Viet, Susan M; Rogers, John W; Camann, David E; Marker, David A; Heikkinen, Maire SA; Yau, Alice Y; Stout, Daniel M; Dellarco, Michael
DOI - OB-27574729-9056-4022-b043csamfg201; 15619618; 0048-9697 English

321. Dhillon, a S; Tarbutton, G L; Levin, J L; Plotkin, G M; Lowry, L K; Nalbone, J T; Shepherd, S, and Dhillon, A S. Pesticide/Environmental Exposures and Parkinson's Disease in East Texas. 2008; 13, (1): 37-48.


Rec #: 46259
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population.
Keywords: Historical account
Keywords: Farms
Keywords: Cigarettes
Keywords: Parkinson's disease
Keywords: risk reduction
Keywords: X 24380:Social Poisons & Drug Abuse
Keywords: Insecticides
Keywords: Rotenone
Keywords: Fluoride
Keywords: farms
Keywords: Cigarette smoking
Keywords: Toxicology Abstracts; CSA Neurosciences Abstracts; Environment Abstracts; Health & Safety Science Abstracts
Keywords: alcohols
Keywords: Cadmium
Keywords: N3 11027:Neurology & neuropathology
Keywords: Fluorides
Keywords: Occupational exposure
Keywords: Paraquat
Keywords: Alcohol
Keywords: Etiology
Keywords: Data processing
Keywords: H 1000:Occupational Safety and Health
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Neurodegenerative diseases
Keywords: Movement disorders
Keywords: Pesticides
Keywords: lumber
Keywords: Fish
Keywords: USA, Texas
Date revised - 2010-07-01
Language of summary - English
Location - USA, Texas
Pages - 37-48
ProQuest ID - 745641885
SubjectsTermNotLitGenreText - Etiology; Data processing; Farms; Parkinson's disease; Chlorpyrifos; Neurodegenerative diseases; Insecticides; Movement disorders; Rotenone; Fluoride; Pesticides; Cigarette smoking; alcohols; Cadmium; Paraquat; Occupational exposure; Alcohol; Historical account; Cigarettes; risk reduction; farms; lumber; Fish; Fluorides; USA, Texas
Last updated - 2011-12-14
British nursing index edition - Journal of Agromedicine [J. Agromed.]. Vol. 13, no. 1, pp. 37-48. 2008.
Corporate institution author - Dhillon, A S; Tarbutton, G L; Levin, J L; Plotkin, G M; Lowry, L K; Nalbone, J T; Shepherd, S
DOI - MD-0013819520; 13135254; 1059-924X English

322. Diamanti-Kandarakis, E.; Bourguignon, J. P.; Giudice, L. C.; Hauser, R.; Prins, G. S.; Soto, A. M.; Zoeller, R. T., and Gore, A. C. Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. 2009; 30, (4): 293-342.


Rec #: 1820
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (ATZ,As,CPY,DZ,PMR,VCZ), NO REVIEW (ATZ,As,CPY,DZ,PMR,VCZ)
Notes: Chemical of Concern: ATZ,As,BPA,CPY,DDE,DDT,DES,DMBA,DXN,DZ,EPRN,HCCH,MXC,PCB,PMR,PPCP,PRN,TBT,TCC,TCDD,VCZ

323. Dias, J. C. and Jemmio, A. [About an Insecticidal Paint for Controlling Triatoma Infestans, in Bolivia].


Rec #: 80069
Keywords: NON-ENGLISH
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Preliminary evaluations of an insecticidal paint based on diazinon, chlorpyrifos and pyriproxyfen in a micro-encapsulated formulation (Inesfly 5A IGR) have shown that it has effective and persistent activity against Triatoma infestans inside homes and in areas surrounding homes, in a highly infested region of the Bolivian Chaco. Furthermore, the evaluations have highlighted that the product presents good handling characteristics and gives a good appearance to houses and outhouses that have been treated, and that its acceptance among the population and the local sanitary authorities is excellent. This encourages new investigations and the use of the product on a larger scale and against other vector species for Chagas disease.
MESH HEADINGS: Animals
MESH HEADINGS: Chagas Disease/prevention &
MESH HEADINGS: control
MESH HEADINGS: Chlorpyrifos
MESH HEADINGS: Consumer Satisfaction
MESH HEADINGS: Diazinon
MESH HEADINGS: Humans
MESH HEADINGS: *Insect Vectors
MESH HEADINGS: *Insecticides
MESH HEADINGS: *Paint
MESH HEADINGS: Pyridines
MESH HEADINGS: Time Factors
MESH HEADINGS: *Triatoma por. Sobre uma pintura inseticida para o controle de Triatoma infestans, na Bol¡via.

324. Diaz-Gomez, O.; Lagunes-Tejeda, A.; Sanchez-Arroyo, H., and Alatorre-Rosas, R. Susceptibility of Plutella xylostella L. to Synthetic Organic Insecticides (Susceptibilidad de Plutella xylostella L. a Insecticidas Organosinteticos). 1994; 19, (1): 83-88(SPA) (ENG ABS).


Rec #: 600
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (AZ,CPY,ES,FNV,PMR)
Notes: Chemical of Concern: AZ,CPY,ES,FNV,PMR

325. Ding, G. D.; Wang, P.; Tian, Y.; Zhang, J.; Gao, Y.; Wang, X. J.; Shi, R.; Wang, G. Q., and Shen, X. M. Organophosphate Pesticide Exposure and Neurodevelopment in Young Shanghai Children. 2012; 46, (5): 2911-2917.


Rec #: 59139
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: A large amount of organophosphate pesticides (OPs) is used throughout China. Animal studies have suggested that even moderate doses are toxic to neurodevelopment, but there are a few studies in humans. We investigated both the urinary levels of OP metabolites in children and their relationship with child neurodevelopment. Participating 301 young children (23-25 months of age) were recruited from two community hospitals in Shanghai between February and October 2008. We measured five nonspecific dialkyl phosphate (DAP) metabolite levels of OPs in the children's urine and examined their association with the children's developmental quotients (DQs) based on the Gesell Developmental Schedules (GDS). The creatinine-adjusted geometric means (GMs) of OP metabolites in urine samples were 11.27 mu g/g for DMP; 6.99 mu g/g for DMTP; 7.96 mu g/g for DEP; 14.19 mu g/g for DETP; and 4.55 mu g/g for DEDTP. The children had relatively higher levels of OP urinary metabolites compared with those reported in developed countries, no association was found between child urinary levels of OP metabolites and any of the DQ scores. However, our results should be interpreted with caution, and more studies of children living in China are warranted given the relatively high levels of child OP urinary metabolites in Shanghai.
Keywords: MEXICAN-AMERICAN CHILDREN, CHLORPYRIFOS, ASSOCIATION, METABOLITES,
ISI Document Delivery No.: 902FJ

326. Ding, S. J.; Carr, J.; Carlson, J. E.; Ton, L.; Xue, W. H.; Li, Y. F.; Schopfer, L. M.; Li, B.; Nachon, F.; Asojo, O.; Thompson, C. M.; Hinrichs, S. H.; Masson, P., and Lockridge, O. Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. 2008; 21, (9): 1787-1794.


Rec #: 59149
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Tyrosine 411 of human albumin is an established site for covalent attachment of 10-fluoroethoxyphosphinyl-N-biotinamidopentyldecanamide (FP-biotin), diisopropylfluorophosphate, chlorpyrifos oxon, soman, sarin, and dichlorvos. This work investigated the hypothesis that other residues in albumin could be modified by organophosphorus agents (OP). Human plasma was aggressively treated with FP-biotin; plasma proteins were separated into high and low abundant portions using a proteome partitioning antibody kit, and the proteins were digested with trypsin. The FP-biotinylated tryptic peptides were isolated by binding to monomeric avidin beads. The major sites of covalent attachment identified by mass spectrometry were Y138, Y148, Y401, Y411, Y452, S232, and S287 of human albumin. Prolonged treatment of pure human albumin with chlorpyrifos oxon labeled Y138, Y150, Y161, Y401, Y411, and Y452. To identify the most reactive residue, albumin was treated for 2 h with DFP, FP-biotin, chlorpyrifos oxon, or soman, digested with trypsin or pepsin, and analyzed by mass spectrometry. The most reactive residue was always Tyr 411. Diethoxyphosphate-labeled Tyr 411 was stable for months at pH 7.4. These results will be useful in the development of specific antibodies to detect OP exposure and to engineer albumin for use as an OP scavenger.
Keywords: HUMAN-SERUM-ALBUMIN, GLUTATHIONE-S-TRANSFERASE, MASS-SPECTROMETRY, HUMAN
ISI Document Delivery No.: 349IU

327. Ding, Y. P. ; Landrum, P. F.; You, J.; Harwood, A. D., and Lydy, M. J. Use of solid phase microextraction to estimate toxicity: Relating fiber concentrations to body residues-part II. 2012; 31, (9): 2168-2174.


Rec #: 59169
Keywords: MODELING
Notes: Chemical of Concern: CPY
Abstract: Abstract: In the companion paper, solid phase
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