Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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PON1 hydrolyzes the oxons of several organophosphorous insecticides (e.g. paraoxon, diazoxon and chlorpyrifos-oxon) and metabolizes lipid peroxides of low density lipoproteins (LDL) and HDL. As such, PON1 plays a relevant role in determining susceptibility of organophosphate toxicity and cardiovascular disease. The objective of this study was to determine associations of PON1 status (i.e. genotype and activity levels) with atherosclerosis (ATH) in individuals from the Southeastern United States. An additional objective was to determine whether PON1 genotype and/or PON1 activity levels influence the capacity of PON1 to metabolize chlorpyrifos-oxon (CPO) at a relatively low concentration. Data indicated increasing PON1 activity assessed by hydrolysis of phenyl acetate is associated with decreased odds of ATH. Furthermore, neither PON1 genotype nor PON1 activity levels influence capacity of PON1 to metabolize CPO at a relatively low concentration.
Start Page: 71
ISSN/ISBN: 9781267059482
Keywords: Paraoxonase
Keywords: Chlorpyrifos-oxon
Keywords: Atherosclerosis
Keywords: 0383:Surgery
Keywords: Organophosphates
Keywords: 0383:Toxicology
Keywords: Pon1
Keywords: Health and environmental sciences
Keywords: 0307:Molecular biology
Keywords: Health disparities
Keywords: Biological sciences
Paraoxonase
Atherosclerosis
Chlorpyrifos-oxon
912870368
Organophosphates
Pon1
0383: Toxicology
66569
0383: Surgery
n/a
Health disparities
English
0307: Molecular biology
Coombes, Ryan Hunter
2548830561
Copyright ProQuest, UMI Dissertations Publishing 2011
9781267059482
2011
Health and environmental sciences
1502713
2012-01-03
Biological sciences
63822891 English

245. Coppola, L. ; Comitini, F.; Casucci, C.; Milanovic, V.; Monaci, E.; Marinozzi, M.; Taccari, M.; Ciani, M., and Vischetti, C. Fungicides degradation in an organic biomixture: impact on microbial diversity. 2011; 29, (1): 99-106.


Rec #: 58309
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Biological systems are being developed all over EU countries to protect water-bodies from pesticide contamination at farm level. A laboratory experiment was carried out to test the efficiency of a mixture of compost and straw in bio-degrading different mixtures of fungicides usually applied in vineyards. At the same time the effects of fungicide applications on microbial community of biomixture were also evaluated. Results showed that the biomixture had a good capability of degrading pesticides. Indeed, at the end of the experiment (112 days), the concentration of most of the pesticides was close to complete degradation. Denaturing gradient gel electrophoresis (DGGE) analysis showed an evident modification. of microbial diversity after the addition of fungicides. However, at the end of degradation process, no significant changes in the composition of microbial community were seen. In this specific substrate used in the biomixture, yeast flora and ascomycete filamentous fungi seemed to be involved in the degradation activity.
Keywords: RIBOSOMAL-RNA GENE, PHANEROCHAETE-CHRYSOSPORIUM, FERMENTATION, BIOBEDS,
ISI Document Delivery No.: 859LF

246. Corlett, P. R.; Frith, C. D., and Fletcher, P. C. From Drugs to Deprivation: a Bayesian Framework for Understanding Models of Psychosis.


Rec #: 50749
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: INTRODUCTION: Various experimental manipulations, usually involving drug administration, have been used to produce symptoms of psychosis in healthy volunteers. Different drugs produce both common and distinct symptoms. A challenge is to understand how apparently different manipulations can produce overlapping symptoms. We suggest that current Bayesian formulations of information processing in the brain provide a framework that maps onto neural circuitry and gives us a context within which we can relate the symptoms of psychosis to their underlying causes. This helps us to understand the similarities and differences across the common models of psychosis.
ABSTRACT: MATERIALS AND METHODS: The Bayesian approach emphasises processing of information in terms of both prior expectancies and current inputs. A mismatch between these leads us to update inferences about the world and to generate new predictions for the future. According to this model, what we experience shapes what we learn, and what we learn modifies how we experience things.
ABSTRACT: DISCUSSION: This simple idea gives us a powerful and flexible way of understanding the symptoms of psychosis where perception, learning and inference are deranged. We examine the predictions of the cognitive model in light of what we understand about the neuropharmacology of psychotomimetic drugs and thereby attempt to account for the common and the distinctive effects of NMDA receptor antagonists, serotonergic hallucinogens, cannabinoids and dopamine agonists.
ABSTRACT: CONCLUSION: By acknowledging the importance of perception and perceptual aberration in mediating the positive symptoms of psychosis, the model also provides a useful setting in which to consider an under-researched model of psychosis-sensory deprivation.
MESH HEADINGS: Animals
MESH HEADINGS: Antipsychotic Agents/pharmacology/therapeutic use
MESH HEADINGS: Bayes Theorem
MESH HEADINGS: Humans
MESH HEADINGS: *Models, Biological
MESH HEADINGS: Psychoses, Substance-Induced/etiology/*physiopathology
MESH HEADINGS: Psychotic Disorders/*physiopathology eng

247. Cormier, C. M.; Au, K. S., and Northrup, H. A 10 Bp Deletion Polymorphism and 2 New Variations in the Glut1 Gene Associated With Meningomyelocele.


Rec #: 51529
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: We sought to examine the diversity and extent of sequence variations in GLUT1 in patients with myelomeningocele (MM) and to identify variations conferring risk of MM. Sequences of the 10 exons and exon-intron boundaries of GLUT1 for 96 patients with MM (48 Caucasians and 48 Mexican Americans) were determined by direct sequencing of DNA. Two new variants were identified. One is located within intron 7 (c.972+17t>a), 17 bases from exon 7. The other is within exon 8 (c.1016T>C) and results in an amino acid change at isoleucine 339 (p.Ile339Thr). A 10 base pair (bp) deletion within intron 9 was genotyped for 457 patients with MM and showed it to be more common in Caucasian MM patients than in Caucasian controls (P = .02). The physiologic role of the 2 newly identified variants in the GLUT1 gene and the 10 bp deletion associated with risk of MM in Caucasian patients is under investigation.
MESH HEADINGS: Cohort Studies
MESH HEADINGS: European Continental Ancestry Group/genetics
MESH HEADINGS: Genetic Association Studies/methods
MESH HEADINGS: Glucose Transporter Type 1/*genetics
MESH HEADINGS: Humans
MESH HEADINGS: Meningomyelocele/diagnosis/*genetics
MESH HEADINGS: Mexican Americans/genetics
MESH HEADINGS: *Polymorphism, Single Nucleotide
MESH HEADINGS: *Sequence Deletion eng

248. Coscolla, Clara; Castillo, Mercedes; Pastor, Agustin; Yusa, Vicent, and Coscolla, Clara. Determination of 40 Currently Used Pesticides in Airborne Particulate Matter (Pm 10) by Microwave-Assisted Extraction and Gas Chromatography Coupled to Triple Quadrupole Mass Spectrometry. 2011 May 5; 693, (1-2): 72-81.


Rec #: 47319
Keywords: CHEM METHODS
Notes: Chemical of Concern: CPY
Abstract: Abstract: A confirmatory and sensitive procedure has been developed for the determination of 40 currently used pesticides (CUPs) in airborne particulate matter (PM 10) at trace level. The proposed method includes extraction of PM 10-bound pesticides by microwave-assisted extraction (MAE) followed by a gel permeation chromatography (GPC) clean-up and determination by GC-MS/MS. The injection mode and the main parameters in MS/MS were optimized. The matrix effect was also evaluated. Recoveries ranged from 70 to 120% except for pyrimethanil and pirimicarb. The limit of quantification (LOQ) ranged from 1.32 to 39.47 pg m[super]-3, when air volumes of 760 m[super]3 were collected. The method was applied to 38 samples collected from a rural station belonging to the atmospheric monitoring network of the Regional Valencia Government (Spain) during April-June 2010. Eighteen out of 40 pesticides investigated were found in at least one sample (bifenthrin, chlorothalonil, chlorpyriphos-e, chlorpyriphos-m, clorpropham, diazinon, dicofol, diphenylamine, fipronil, fludioxonil, folpet, malathion, metalaxyl, penconazole, quinoxyfen, triadimefon, trifluralin, and vinclozoline), with concentrations ranging from 1.32 to 625.80 pg m[super]-3.
Keywords: Chromatography
Keywords: Spain
Keywords: Mass spectrometry
Keywords: Particulates
Keywords: Atmospheric circulation-oceanic circulation coupled models
Keywords: Malathion
Keywords: M2 551.510.42:Air Pollution (551.510.42)
Keywords: Environment Abstracts; Meteorological & Geoastrophysical Abstracts
Keywords: Gas chromatography
Keywords: fipronil
Keywords: Spain, Valencia
Keywords: Pesticides
Keywords: Trifluralin
Keywords: ENA 01:Air Pollution
Keywords: Rural areas
Date revised - 2011-06-01
Language of summary - English
Location - Spain; Spain, Valencia
Pages - 72-81
ProQuest ID - 874193418
SubjectsTermNotLitGenreText - Gas chromatography; Chromatography; Mass spectrometry; Atmospheric circulation-oceanic circulation coupled models; fipronil; Pesticides; Trifluralin; Particulates; Malathion; Rural areas; Spain; Spain, Valencia
Last updated - 2012-03-29
British nursing index edition - Analytica Chimica Acta [Anal. Chim. Acta]. Vol. 693, no. 1-2, pp. 72-81. 5 May 2011.
Corporate institution author - Coscolla, Clara; Castillo, Mercedes; Pastor, Agustin; Yusa, Vicent
DOI - e178a357-ab57-46a8-8b21csaobj201; 14977508; 0003-2670 English

249. Coscolla, Clara; Colin, Patrice; Yahyaoui, Abderrazak; Petrique, Olivier; Yusa, Vicent; Mellouki, Abdelwahid; Pastor, Agustin, and CoscollA, Clara. Occurrence of Currently Used Pesticides in Ambient Air of Centre Region (France). 2010 Oct; 44, (32): 3915-3925.


Rec #: 47669
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Ambient air samples were collected, from 2006 to 2008 at three rural and two urban sites in Centre Region (France) and analyzed for 56 currently used pesticides (CUPs), of which 41 were detected. The four CUPs most frequently detected were the herbicides trifluralin, acetochlor and pendimethalin and the fungicide chlorothalonil, which were found with frequencies ranging between 52 and 78%, and with average concentrations of 1.93, 1.32, 1.84 and 12.15ngma3, respectively. Among the detected pesticides, concentrations of eight fungicides (spiroxamine, fenpropimorph, cyprodinil, tolyfluanid, epoxiconazole, vinchlozolin, fluazinam, fludioxinil), two insecticides (propargite, ethoprophos), and one herbicide (oxyfluorfen) are, to our knowledge, reported for the first time in the literature. The majority of the CUPs showed a seasonal trend, with most of the detections and the highest concentrations occurring during the spring and early summer. The most important pesticides detected were related to arable crops and fruit orchards, the main cultures in this region, highlighting the fact that the main sources come from local applications. Minor differences were found in the profiles of pesticides within rural areas and between rural and urban areas.
Keywords: P 0000:AIR POLLUTION
Keywords: Herbicides
Keywords: Environmental Studies
Keywords: France
Keywords: Sulfur dioxide
Keywords: Pesticides
Keywords: Fungicides
Keywords: Air sampling
Keywords: M2 551.5:General (551.5)
Keywords: summer
Keywords: Trifluralin
Keywords: Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Environment Abstracts
Keywords: Seasonal variations
Keywords: pendimethalin
Keywords: ENA 01:Air Pollution
Keywords: Rural areas
Date revised - 2011-10-01
Language of summary - English
Location - France
Pages - 3915-3925
ProQuest ID - 811148145
SubjectsTermNotLitGenreText - Fungicides; Rural areas; Sulfur dioxide; Pesticides; Air sampling; Trifluralin; summer; Herbicides; pendimethalin; Seasonal variations; France
Last updated - 2011-12-08
Corporate institution author - CoscollA, Clara; Colin, Patrice; Yahyaoui, Abderrazak; Petrique, Olivier; YusA, Vicent; Mellouki, Abdelwahid; Pastor, Agustin
DOI - OB-5898967e-37e0-4e37-99c0csaobj202; 13637768; 1352-2310 English

250. Coscolla, Clara; Yusa, Vicent; Beser, M Isabel; Pastor, Agustin, and Coscolla, Clara. Multi-Residue Analysis of 30 Currently Used Pesticides in Fine Airborne Particulate Matter (Pm 2.5) By Microwave-Assisted Extraction and Liquid Chromatography-Tandem Mass Spectrometry. 2009 Dec 18; 1216, (51): 8817-8827.


Rec #: 44419
Keywords: CHEM METHODS
Notes: Chemical of Concern: CPY
Abstract: Abstract: A confirmatory and rapid procedure has been developed for the determination of 30 currently used pesticides (CUP) in fine airborne particulate matter (PM 2.5) at trace level. The proposed method includes extraction of PM 2.5-bound pesticides by microwave-assisted extraction (MAE) followed by a direct injection into LC-MS/MS. The main parameters affecting the MAE extraction (time, temperature and volume of solvent) were optimised using statistical design of experiments (DoE). The matrix effect was also evaluated. Recoveries ranged from 72 to 109% and the limit of quantification (LoQ) was 32.5 pg m super(-3) for chlorpyrifos, 13.5 pg m super(-3) for fenhexamid, imazalil and prochloraz, and 6.5 pg m super(-3) for the rest of pesticides, when air volumes of 760 m super(3) were collected. The method was applied to 54 samples collected from three stations of the atmospheric monitoring network of the Regional Valencia Government (Spain) during April-July 2009. Nineteen out of 30 pesticides investigated were found in at least one sample: omethoate, carbendazim, acetamiprid, thiabendazole, malathion, flusilazole, metalaxyl, azoxystrobin, iprovalicarb, myclobutanil, tebuconazole, triflumizole, cyprodinil, tebufenpyrad, buprofezin, pyriproxyfen, hexythiazox, flufenoxuron and fenazaquin. The measured concentrations ranged from 6.5 to 1208 pg m super(-3). To our knowledge, 11 of the pesticides detected have been reported for the first time in ambient air.
Keywords: P 0000:AIR POLLUTION
Keywords: Chromatography
Keywords: Spain
Keywords: Solvents
Keywords: Temperature
Keywords: Statistical analysis
Keywords: Mass spectrometry
Keywords: Particulates
Keywords: Malathion
Keywords: Chlorpyrifos
Keywords: M2 551.510.42:Air Pollution (551.510.42)
Keywords: Pollution Abstracts; Meteorological & Geoastrophysical Abstracts
Keywords: Spain, Valencia
Keywords: Pesticides
Keywords: Atmospheric monitoring
Date revised - 2010-03-01
Language of summary - English
Location - Spain; Spain, Valencia
Pages - 8817-8827
ProQuest ID - 21337999
SubjectsTermNotLitGenreText - Chromatography; Statistical analysis; Mass spectrometry; Chlorpyrifos; Pesticides; Temperature; Solvents; Particulates; Atmospheric monitoring; Malathion; Spain; Spain, Valencia
Last updated - 2012-03-29
British nursing index edition - Journal of Chromatography A [J. Chromatogr.]. Vol. 1216, no. 51, pp. 8817-8827. 18 Dec 2009.
Corporate institution author - Coscolla, Clara; Yusa, Vicent; Pastor, Agustin
DOI - MD-0011340607; 11309966; 0021-9673 English

251. Costa, L. G.; Giordano, G.; Cole, T. B.; Marsillach, J., and Furlong, C. E. Paraoxonase 1 (PON1) as a Genetic Determinant of Susceptibility to Organophosphate Toxicity. 2013; PRESS, 8 p.


Rec #: 2730
Keywords: REVIEW
Call Number: NO REVIEW (CPY,CPYO,DZ)
Notes: Chemical of Concern: CPY,CPYO,DZ,EPRN,PRN

252. Costa, Michael D; Freitas, Mayara L; Soares, Felix Alexandre Antunes; Carratu, Vanessa Santana; Brandao, Ricardo, and Costa, Michael D. Potential of Two New Oximes in Reactivate Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphate Compounds: an in Vitro Study. 2011 Dec; 25, (8): 2120-2123.


Rec #: 43009
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Organophosphate (OP) compounds exert inhibition on cholinesterase (ChE) activity by irreversibly binding to the catalytic site of the enzyme. Oximes are compounds generally used to reverse the ChE inhibition caused by OP agents. In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion. Oximes used clinically (obidoxime and pralidoxime) were used as positive control. For this study, human blood (erythrocytes for AChE determination and plasma for BChE determination) was used and different concentrations of oximes (1-100 mu M) were tested. The concentrations of OP used were based on the IC50 for AChE and BChE. Results demonstrated that obidoxime was more effective in reactivate the AChE inhibition induced by OP compounds. However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE. For BChE reactivation, none of evaluated oximes achieved positives rates of reactivation, been obidoxime able to reactivate malathion-inhibited BChE only in 24% at the highest concentration. We conclude that both newly developed oximes seem to be promising reactivators of OP-inhibited AChE.
Keywords: obidoxime
Keywords: Acetylcholinesterase
Keywords: Erythrocytes
Keywords: Enzymes
Keywords: organophosphates
Keywords: Cholinesterase
Keywords: Malathion
Keywords: Chlorpyrifos
Keywords: Blood
Keywords: oximes
Keywords: Active sites
Keywords: X 24330:Agrochemicals
Keywords: Toxicology Abstracts
Keywords: Diazinon
Date revised - 2011-12-01
Language of summary - English
Pages - 2120-2123
ProQuest ID - 911163686
SubjectsTermNotLitGenreText - Chlorpyrifos; Blood; obidoxime; Acetylcholinesterase; oximes; Erythrocytes; Enzymes; organophosphates; Active sites; Cholinesterase; Diazinon; Malathion
Last updated - 2012-03-29
British nursing index edition - Toxicology In Vitro [Toxicol. In Vitro]. Vol. 25, no. 8, pp. 2120-2123. Dec 2011.
Corporate institution author - Costa, Michael D; Freitas, Mayara L; Carratu, Vanessa Santana; Brandao, Ricardo
DOI - 24e28ee8-bec7-47cf-9ab4csamfg201; 16058565; 0887-2333 English

253. Cotelle, S. ; Testolin, R. C.; Foltete, A. S.; Bossardi-Rissardi, G.; Silveira, R. A., and Radetski, C. M. Genotoxicity potential of a new natural formicide. 2012; 19, (3): 628-635.


Rec #: 58349
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: Background, aim, and scope Assessment of environmental impacts from pesticide utilization should include genotoxicity studies, where the possible effects of mutagenic/genotoxic substances on individuals are assessed. In this study, the genotoxicity profile of the new formicide Macex (R) was evaluated with two genotoxicity tests, namely, the micronucleus test with mouse bone marrow and Vicia faba, and a mutagenicity test using the Ames Salmonella assay. Materials and methods The bacterial reverse mutation test (Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535), the Vicia root tip and mouse micronucleus tests were conducted according to published protocols. Results In the range of the formicide
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