Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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In vitro metabolism of DEHP by subcellular fractions of human brain, intestine, kidney, liver, lung, skin, testis, rat liver and recombinant CYP isoforms of human and rat was investigated using LC-MS/MS. DEHP was rapidly hydrolyzed to mono(2-ethylhexyl) phthalate (MEHP) in 12 microsomal/cytosolic fractions of selected 7 human organs and rat liver but not in microsomal fractions of human brain and human female skin. MEHP was metabolized to CYP-mediated oxidative and dealkylated metabolites in human and rat liver and at a lower rate in human intestine. Measurable amounts of mono(2-ethyl-5-hydroxyhexyl) phthalate (5-OH MEHP), mono(2-ethyl-5-oxohexyl) phthalate (5-Oxo MEHP), mono(2-ethyl-5-carboxypentyl) phthalate (5-carboxy MEPP), mono(2-carboxymethyl-hexyl) phthalate (2-carboxy MMHP) and phthalic acid (PA) were formed by human liver fractions. Human CYP2C9*1, CYP2C19 and rat CYP2C6 were the major CYP isoforms producing 5-OH MEHP and 5-Oxo MEHP metabolites; however, only human CYP2C9*1 and 2C9*2 produced 5-carboxy MEPP from MEHP. Additionally, human CYP3A4 and rat CYP3A2 were the primary enzymes for PA production via heteroatom dealkylation of MEHP. Percent total normalized rates (%TNR) by CYP2C9*1 in human liver microsomes (HLM) were 94%, 98% and 100%, respectively, for 5-OH MEHP, 5-Oxo MEHP, 5-carboxy MEPP, and 76% for PA production by CYP3A4. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords: DEHP, In vitro metabolism, Human tissues, Rat tissues, Cytochrome P450,
ISI Document Delivery No.: 902DU

232. Chowdhury, Alamgir Zaman; Jahan, Salina Akter; Islam, Mohammad Nazrul; Moniruzzaman, Mohammed; Alam, Mohammad Khorshed; Zaman, Mohammad a; Karim, Nurul, and Gan, Siew Hua. Occurrence of Organophosphorus and Carbamate Pesticide Residues in Surface Water Samples From the Rangpur District of Bangladesh. 2012 Jul; 89, (1): 202-7.


Rec #: 42669
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: We report the presence of organophosphorus and carbamate residues in 24 surface water samples and five ground water samples from Pirgacha Thana, Rangpur district, Bangladesh using high-performance liquid chromatography. A number of samples of surface water from paddy fields were found to contain chlorpyriphos, carbofuran and carbaryl at concentrations ranging from 0-1.189, 0-3.395 and 0-0.163 ÎĽg/L, respectively. Surface water from the lakes had chlorpyriphos, carbofuran and carbaryl at concentrations ranging from 0.544-0.895, 0.949-1.671 and 0-0.195 ÎĽg/L, respectively. This result indicates that the general public living in the area of Rangpur is at high risk of pesticide exposure from contaminated waters in the environment.[PUBLICATION ABSTRACT]
Keywords: Agriculture
Keywords: Lakes -- chemistry
Keywords: Organophosphorus Compounds -- analysis
Keywords: Carbofuran -- analysis
Keywords: Carbofuran
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Humans
Keywords: Pesticide Residues
Keywords: Carbaryl
Keywords: Carbaryl -- analysis
Keywords: Environmental Studies
Keywords: Environmental Monitoring
Keywords: Carbamates -- analysis
Keywords: Organophosphorus Compounds
Keywords: Carbamates
Keywords: Water Pollutants, Chemical
Keywords: Pesticide Residues -- analysis
Keywords: Bangladesh
Copyright - Springer Science+Business Media, LLC 2012
Language of summary - English
Location - Bangladesh
Pages - 202-7
ProQuest ID - 1020039293
Document feature - References
SubjectsTermNotLitGenreText - Bangladesh
Last updated - 2012-10-05
Place of publication - New York
Corporate institution author - Chowdhury, Alamgir Zaman; Jahan, Salina Akter; Islam, Mohammad Nazrul; Moniruzzaman, Mohammed; Alam, Mohammad Khorshed; Zaman, Mohammad A; Karim, Nurul; Gan, Siew Hua
DOI - 2685220351; 69774282; 108019; BVCX; 22526994; SPVLBVCX128891641
APHA (1995) Standard methods for the examination of water and waste water, 19th edn. Washington DC, pp 1-30, 40-175
Aziz, J. A., Aziz, J. A. 2005 "Management of source and drinking-water quality in Pakistan." Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 11 5/6 1087-1098
Bagchi S, Azad A, Alomgir ZC, Uddin MA, Al-Reza SM, Rahman A (2009) Quantitative analysis of pesticide residues in some pond water samples of Bangladesh. Asian J Water Environ Pollut 6:27-30
Bakore, N., John, P., and Bhatnagar, P.: Organochlorine pesticide residues in wheat and drinking water samples from Jaipur, Rajasthan, India, Environ. Monit. Assess., 98, 381-389, 2004.
Bortoluzzi EC, Rheinheimer DS, Gonc ̧alves CS, Pellegrini JBR, Maroneze AM (1987) Manual of pesticide residue analysis, vol 1, Pesticide Commission, Weinheim, New York, VCH, pp 297-307
DFG (1987) Manual of pesticide residue analysis. Pesticide Commission, Weinheim, New York 1:297-307
EPA, US Environmental Protection Agency (1984) Health and environmental effects profile for carbaryl. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH., EPA/600/x-84/155
EPA, US Environmental Protection Agency (1999) Integrated risk information system (IRIS) on Carbaryl National Center for Environmental Assessment, Office of Research and Development, Washington, DC
Gan J (2002) Pesticide and groundwater quality. Published in PesticideWise by University of California, Riverside Cooperative Extension in the World Wide
Goad RT, Goad JT, Atieh BH, Gupta RC (2004) Carbofuran-induced endocrine disruption in adult male rats. Toxicol Mech Methods 14:233-239
Hayat K, Ashfaq M, Ashfaq U, Saleem MA (2011) Determination of pesticide residues in blood samples of villagers involved in pesticide application at District Vehari (Punjab), Pakistan. Afr J Environ Sci Tech 4:666-684
Hunt, D T E, Wilson, A L 1986 "The chemical analysis of water: general principles and techniques" Royal Society of Chemistry. London, , 2nd ed., (39358) 683
Iram, Shazia, Ahmad, Iftikhar 2009 "ANALYSIS OF PESTICIDES RESIDUES OF RAWAL AND SIMLY LAKES" Pakistan Journal of Botany 41 4 1981-1987
Khatun MZ, Haque SM, Islam MN, Khatoon JA, Hossain MA (2008) Presence of organophosphorous pesticide in surface water in Dhaka city. J Sub Agric Res Dev 6:506-511
Kin CM, Huat TG, Kumari A (2006) Method development for the determination of pesticide residues in vegetables and fruits by using solid-phase microextraction. M J Chem B 8:067-071
Mavrikou, Sophie, Flampouri, Kelly 2008 "Assessment of organophosphate and carbamate pesticide residues in cigarette tobacco with a novel cell biosensor" Sensors (Peterborough, NH) 8 4 2818-2832
MOLTO, J. C., PICO, Y. 1991 "Determination of triazines and organophosphorus pesticides in water samples using solid-phase extraction" Journal of chromatography 555 1-2 137-145
Rahman MM (2000) Pestcides: their uses and problems in context of Bangladesh. Paper presented at the National Workshop on conventional and nuclear Technique for Pesticide Residues studies in Food and Environment at IFRB, 15-19 October, AERE, Savar, Bangladesh, pp 1-25
Rauh, Virginia A., Garfinkel, Robin 2006 "Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children" Pediatrics 118 6 E1845-E1859
Wilson, P. Chris, Foos, Jane Ferguson 2006 "Survey of carbamate and organophosphorous pesticide export from a South Florida (USA) agricultural watershed: Implications of sampling frequency on ecological risk estimation" Environmental Toxicology & Chemistry 25 11 2847-2852 English

233. Chowdhury, M. A. Z.; Banik, S.; Uddin, B.; Moniruzzaman, M.; Karim, N., and Gan, S. H. Organophosphorus and Carbamate Pesticide Residues Detected in Water Samples Collected from Paddy and Vegetable Fields of the Savar and Dhamrai Upazilas in Bangladesh. 2012; 9, (9): 3318-3329.


Rec #: 58089
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Several types of organophosphorous and carbamate pesticides have been used extensively by the farmers in Bangladesh during the last few decades. Twenty seven water samples collected from both paddy and vegetable fields in the Savar and Dhamrai Upazilas in Bangladesh were analyzed to determine the occurrence and distribution of organophosphorus (chlorpyrifos, malathion and diazinon) and carbamate (carbaryl and carbofuran) pesticide residues. A high performance liquid chromatograph instrument equipped with a photodiode array detector was used to determine the concentrations of these pesticide residues. Diazinon and carbofuran were detected in water samples collected from Savar Upazila at 0.9 mu g/L and 198.7 mu g/L, respectively. Malathion was also detected in a single water sample at 105.2 mu g/L from Dhamrai Upazila. Carbaryl was the most common pesticide detected in Dhamrai Upazila at 14.1 and 18.1 mu g/L, while another water sample from Dhamrai Upazila was contaminated with carbofuran at 105.2 mu g/L. Chlorpyrifos was not detected in any sample. Overall, the pesticide residues detected were well above the maximum acceptable levels of total and individual pesticide contamination, at 0.5 and 0.1 mu g/L, respectively, in water samples recommended by the European Economic Community (Directive 98/83/EC). The presence of these pesticide residues may be attributed by their intense use by the farmers living in these areas. Proper handling of these pesticides should be ensured to avoid direct or indirect exposure to these pesticides.
Keywords: pesticides, organophosphorus, carbamate, HPLC
ISI Document Delivery No.: 012XP

234. Chrisman, J. D.; Koifman, S.; Sarcinelli, P. D.; Moreira, J. C.; Koifman, R. J., and Meyer, A. Pesticide sales and adult male cancer mortality in Brazil. 2009; 212, (3): 310-321.


Rec #: 58099
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: In Brazil, where the use of pesticide grows rapidly, studies that evaluate the impact of pesticide exposure on cancer incidence and mortality are very scarce. In this study, we evaluated the degree of correlation between pesticide sales in 1985 in eleven Brazilian states and cancer mortality rates during 1996-1998. Information of all cancer deaths occurred in men 30-69 years old from 1996 to 1998 were collected from National Mortality System. Single and multiple linear regression coefficients were obtained to assess the relationship between per capita sales of pesticides in 1985, specific-site cancer mortality rates (prostate, soft tissue, larynx, leukemia, lip, esophagus, lung, pancreas, bladder, liver, testis, stomach, brain, non-Hodgkin's lymphoma, and multiple myeloma) during 1996-1998, and several covariates. In addition, states were stratified into three groups according to tertiles of pesticides sales and cancer mortality rate ratios (MRR) were then calculated using first tertile as reference. Finally, a factor analysis was performed to reveal unapparent relationships between pesticide use and cancer mortality. Pesticide sales showed statistically significant correlation with the mortality rates for the cancers of prostate (r = 0.69; p = 0.019), soft tissue (r = 0.71; p = 0.015), leukemia (r = 0.68; p = 0.021), lip (r = 0.73; p = 0.010), esophagus (r = 0.61; p = 0.046), and pancreas (r = 0.63; p = 0.040). Moderate to weak correlations were observed for the cancers of larynx, lung, testis, bladder, liver, stomach, brain, and NHL and multiple myeloma. In addition, correlation between pesticide sales and specific-site cancer mortality rates was reinforced by multiple regression analysis. For all specific-sites, cancer mortality rates were significantly higher in the states of moderate (2nd tertile) and high (3rd tertile) pesticide sales, with MRR ranging from 1.11 to 5.61. Exploring hidden relationships between pesticide sales and cancer mortality in Brazil, through a factor analysis, revealed that affluence; public policies and lifestyle behaviors may explain almost 70% of the variance of the studied association. The results suggest that population exposure to pesticides in the 1980s in some Brazilian States may have been associated with selected cancer sites observed a decade later. (C) 2008 Elsevier GrnbH. All rights reserved.
Keywords: Pesticides, Cancer mortality, Brazil, Ecological study
ISI Document Delivery No.: 432JP

235. Chuang, J. C. and Wilson, N. K. Multiresidue analysis of organophosphate and pyrethroid pesticides in duplicate-diet solid food by pressurized liquid extraction. 2011; 46, (1): 41-50.


Rec #: 58119
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: An analytical method was developed for determining organophosphate pesticides (OPP) and pyrethroid pesticides (PYR) in duplicate-diet solid food. The method consisted of pressurized liquid extraction (PLE) with dichloromethane followed by cleanup with gel permeation and solid phase extraction columns and gas chromatography/mass spectrometry (GC/MS) analysis. Quantitative recoveries (73-117 %) of the target pesticides were obtained for spiked duplicate-diet food samples. The percent standard deviation (% RSD) of replicate food samples was within +/- 20 %. Another method was developed for determining a common OPP metabolite, 3, 5, 6-trichloro-2-pyridinol (TCP) in duplicate-diet food. The method consisted of a PLE with methanol followed by liquid-liquid partitioning, derivatization, and GC/MS analysis. Recoveries of TCP ranged from 83 to 101 % for spiked duplicate-diet food samples. The % RSD of replicate food samples was within +/- 15 %. The results confirmed that these methods are reliable and robust, and that they can be used in routine analysis. In addition, a storage stability study for a common OPP, chlorpyrifos (CPF), in solid food samples was performed. The fortified 15N-13C-labeled CPF was stable over 16 mo storage at -20 degrees C in the dark. The developed analytical methods were successfully applied to 278 duplicate-diet food samples from preschool children, demonstrating that these methods are robust and suitable for routine analysis in future exposure monitoring studies.
Keywords: Duplicate-diet food, organophosphate pesticide, pyrethroid pesticide,
ISI Document Delivery No.: 733MV

236. Chuang, Jane C; Wilson, Nancy K, and Chuang, Jane C. Multiresidue Analysis of Organophosphate and Pyrethroid Pesticides in Duplicate-Diet Solid Food by Pressurized Liquid Extraction. 2010 Nov; 45, (8): 868-877.


Rec #: 43799
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: An analytical method was developed for determining organophosphate pesticides (OPP) and pyrethroid pesticides (PYR) in duplicate-diet solid food. The method consisted of pressurized liquid extraction (PLE) with dichloromethane followed by cleanup with gel permeation and solid phase extraction columns and gas chromatography/mass spectrometry (GC/MS) analysis. Quantitative recoveries (73-117 %) of the target pesticides were obtained for spiked duplicate-diet food samples. The percent standard deviation (% RSD) of replicate food samples was within plus or minus 20 %. Another method was developed for determining a common OPP metabolite, 3, 5, 6-trichloro-2-pyridinol (TCP) in duplicate-diet food. The method consisted of a PLE with methanol followed by liquid-liquid partitioning, derivatization, and GC/MS analysis. Recoveries of TCP ranged from 83 to 101 % for spiked duplicate-diet food samples. The % RSD of replicate food samples was within plus or minus 15 %. The results confirmed that these methods are reliable and robust, and that they can be used in routine analysis. In addition, a storage stability study for a common OPP, chlorpyrifos (CPF), in solid food samples was performed. The fortified 15N-13C-labeled CPF was stable over 16 mo storage at -20 degree C in the dark. The developed analytical methods were successfully applied to 278 duplicate-diet food samples from preschool children, demonstrating that these methods are robust and suitable for routine analysis in future exposure monitoring studies.
Keywords: Mass Spectrometry
Keywords: Pollution monitoring
Keywords: SW 3050:Ultimate disposal of wastes
Keywords: Environment Abstracts; Water Resources Abstracts; Pollution Abstracts
Keywords: Organophosphates
Keywords: Agricultural wastes
Keywords: Mass spectrometry
Keywords: Metabolites
Keywords: Solids
Keywords: P 6000:TOXICOLOGY AND HEALTH
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Storage
Keywords: Chlorpyrifos
Keywords: Foods
Keywords: Agricultural Chemicals
Keywords: Organophosphorus Pesticides
Keywords: Analytical Methods
Keywords: Pesticides
Keywords: Monitoring
Keywords: Pyrethroids
Date revised - 2011-03-01
Language of summary - English
Number of references - 28
Pages - 868-877
ProQuest ID - 856764903
SubjectsTermNotLitGenreText - Chlorpyrifos; Storage; Pollution monitoring; Organophosphates; Agricultural wastes; Pesticides; Mass spectrometry; Metabolites; Pyrethroids; Mass Spectrometry; Foods; Organophosphorus Pesticides; Agricultural Chemicals; Analytical Methods; Solids; Monitoring
Last updated - 2012-12-14
British nursing index edition - Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes [J. Environ. Sci. Health, Pt. B: Pestic., Food Contam., Agric. Wastes]. Vol. 45, no. 8, pp. 868-877. Nov 2010.
Corporate institution author - Chuang, Jane C; Wilson, Nancy K
DOI - b25f3514-d4e6-4254-a339mfgefd107; 14060674; 0360-1234; 1532-4109
(1996) Food Quality Protection Act of 1996, Public Law, 104-170, August 3
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Agency of Toxic Substances and Disease Registry (1997) Toxicological Profile for Chlorpyrifos. U.S. Public Health Service, NTIS PB98-103088, Agency of Toxic Substances and Disease Registry, Atlanta, GA
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Hunter, R. E. (2010) Jr.; Riederer, A.M.; Ryan, P.B. Method for the determination of organophosphorus and pyrethroid pesticides in food via gas chromatography with electron-capture detection. J. Agric Food Chem., 58, pp. 1396-1402.
Lu, C. , Bravo, R. , Caltabiano, L. M. , Irish, R. M. , Weerasekera, G. and Barr, D. B. (2005) The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments. J Toxicol Environ Health A., 13, pp. 209-227.
Misita, M. , Schrock, M. , Tracy, K. and Tabor, J. (2003) Simultaneous extraction of PCDD/PCDF and PCBs using accelerated solvent extraction for sediment, tissue, and sludge matrices. Organohalogen Compounds, 60, pp. 37-40.
Morgan, M. , Sheldon, L. , Croghan, C. , Jones, P. , Chuang, J. C. and Wilson, N. K. (2007) An observational study of 127 preschool children at their homes and daycare centers in Ohio: Environmental pathways to cis- and trans-permethrin exposure. Environmental Research, 104, pp. 266-274.
Morgan, M. , Sheldon, L. , Croghan, C. , Chuang, J. C. , Lordo, R. , Wilson, N. K. , Lyu, C. , Brinkman, M. , Morse, N. , Chou, Y. L. , Hamilton, C. , Finegold, J. , Hand, K. and Gordon, S. M. (2004) A pilot study of children's total exposure to persistent pesticides and other persistent organic pollutants (CTEPP), EPA/600/R-041/193, USEPA National Exposure Research Laboratory, Research Triangle Park, NC
Morgan, M. K. , Sheldon, L. S. , Croghan, C. , Jones, P. , Robertson, G. L. , Chuang, J. C. , Wilson, N. K. and Lyu, C. (2005) Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments. J Expo Anal Environ Epidemiol., 15, pp. 297-309.
Morgan, M. K. , Sheldon, L. S. , Jones, P. , Croghan, C. , Chuang, J. C. and Wilson, N. K. The reliability of using urinary biomarkers to estimate children's exposures to chlorpyrifos and diazinon, J Expo Sci. and Environ Epidemiol
National Research Council (1993) Pesticides in the Diets of Infants and Children, National Academy Press, Washington D.C.
Racke, K. D. , Steele, K. P. , Yoder, R. N. , Dick, W. A. and Avidov, E. (1996) Factors affecting the hydrolytic degradation of chlorpyrifos in soil. J. Agric. Food Chem., 44, pp. 1582-1592.
Racke, K. D. (1993) Environmental fate of chlorpyrifos. Rev. Environ. Contam. Toxicol., 131, pp. 1-150.
Richter, B. E. , Jones, B. A. , Ezzell, J. L. and Porter, N. L. (1996) Accelerated solvent extraction: a new technique for sample preparation. Anal. Chem., 68, pp. 1033-1039.
Saito, K. , Sjodin, A. , Sandau, C. D. , Davis, M. D. , Nakazawa, H. , Matsuki, Y. and Patterson, D. G. (2004) Jr. Development of a accelerated solvent extraction and gel permeation chromatography analytical method for measuring persistent organohalogen compounds in adipose and organ tissue analysis. Chemosphere, 57, pp. 373-381.
Shafer, T. J. , Meyer, D. A. and Crofton, K. M. (2005) Developmental neuro-toxicity of pyrethroid insecticides: critical review and future research needs. Environ Health Perspect., 113, pp. 123-136.
USEPA (1997) Exposure Factors Handbook, pp. EPA 600/P-95/002Fa-c, 1997, U.S. Environmental Protection Agency, Office of Health and Environmental Assessment. Washington, DC
Vonderheidea, A. P. , Boyd, B. , Ryberg, A. , Yilmaz, E. and Hieber, T. (2009) E.; Kauffman, P.E.; Garris, S.T.; Morgan, J.N. Analysis of permethrin isomers in composite diet samples by molecularly imprinted solid-phase extraction and isotope dilution gas chromatography-ion trap mass spectrometry. Journal of Chromatography A., 1216, pp. 4663-4640.
Wang, P. , Zhang, Q. , Wang, Y. , Wang, T. , Li, X. , Ding, L. and Jiang, G. (2010) Evaluation of Soxhlet extraction, accelerated solvent extraction, and microwave-assisted extraction for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers in soil and fish samples. Analtica Chimica Acta, 663, pp. 43-48.
Wilson, N. K. , Chuang, J. C. , Lyu, C. W. , Menton, R. and Morgan, M. R. (2003) Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. J Expo Anal Environ Epidemiol, 13, pp. 187-202.
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237. Chui, L.; Couturier, M. R.; Chiu, T.; Wang, G.; Olson, A. B.; Mcdonald, R. R.; Antonishyn, N. A.; Horsman, G., and Gilmour, M. W. Comparison of Shiga Toxin-Producing Escherichia Coli Detection Methods Using Clinical Stool Samples.


Rec #: 50509
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: Molecular diagnostic tools capable of identifying Shiga toxin-specific genetic determinants in stool specimens permit an unbiased approach to detect Shiga toxin-producing Escherichia coli (STEC) in clinical samples and can indicate when culture-based isolation methods are required. It is increasingly recognized that clinically relevant STEC are not limited to the singular O157 serotypes, and therefore diagnostic assays targeting toxin-encoding determinants must be able to account for any genetic variation that exists between serotypes. In this study conventional PCR and four real-time PCR assays (HybProbe, TaqMan, SYBR Green, and LUX) targeting the stx1 and stx2 Shiga toxin coding sequences were used to identify STEC in enriched stool samples (n = 36) and a panel of O157 and non-O157 strains (n = 64). PCR assays targeting stx1 and stx2 had variable specificity and sensitivity values with enriched stool samples. Molecular assays using DNA from pure cultures revealed that some primers were not sensitive to all stx2 variants. This evaluation concluded that the TaqMan-based probes were most appropriate in high throughput clinical diagnostic laboratories in consideration of cost, turn around time, and assay performance.
MESH HEADINGS: Biological Assay
MESH HEADINGS: Feces/*microbiology
MESH HEADINGS: Humans
MESH HEADINGS: Polymerase Chain Reaction/economics/*methods
MESH HEADINGS: Sensitivity and Specificity
MESH HEADINGS: Shiga Toxin 1/genetics
MESH HEADINGS: Shiga Toxin 2/genetics
MESH HEADINGS: Shiga-Toxigenic Escherichia coli/*genetics/*isolation &
MESH HEADINGS: purification
MESH HEADINGS: Time Factors eng

238. Coble, J; Thomas, K W; Hines, C J; Hoppin, Ja; Dosemeci, M; Curwin, B; Lubin, J H; Freeman, Leb; Blair, a; Sandler, D P; Alavanja, Mcr, and Coble, J. An Updated Algorithm for Estimation of Pesticide Exposure Intensity in the Agricultural Health Study. 2011 Dec; 8, (12): 4608-4622.


Rec #: 42989
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: An algorithm developed to estimate pesticide exposure intensity for use in epidemiologic analyses was revised based on data from two exposure monitoring studies. In the first study, we estimated relative exposure intensity based on the results of measurements taken during the application of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) (n = 88) and the insecticide chlorpyrifos (n = 17). Modifications to the algorithm weighting factors were based on geometric means (GM) of post-application urine concentrations for applicators grouped by application method and use of chemically-resistant (CR) gloves. Measurement data from a second study were also used to evaluate relative exposure levels associated with airblast as compared to hand spray application methods. Algorithm modifications included an increase in the exposure reduction factor for use of CR gloves from 40% to 60%, an increase in the application method weight for boom spray relative to in-furrow and for air blast relative to hand spray, and a decrease in the weight for mixing relative to the new weights assigned for application methods. The weighting factors for the revised algorithm now incorporate exposure measurements taken on Agricultural Health Study (AHS) participants for the application methods and personal protective equipment (PPE) commonly reported by study participants.
Keywords: Chlorpyrifos
Keywords: Insecticides
Keywords: Urine
Keywords: H 5000:Pesticides
Keywords: Pesticides
Keywords: Sprays
Keywords: 2,4-Dichlorophenoxyacetic acid
Keywords: Herbicides
Keywords: gloves
Keywords: Health & Safety Science Abstracts
Keywords: Protective equipment
Date revised - 2012-06-01
Language of summary - English
Pages - 4608-4622
ProQuest ID - 1020840104
SubjectsTermNotLitGenreText - Chlorpyrifos; Insecticides; Urine; Pesticides; Sprays; 2,4-Dichlorophenoxyacetic acid; Herbicides; gloves; Protective equipment
Last updated - 2012-12-14
British nursing index edition - International Journal of Environmental Research and Public Health [Int. J. Environ. Res. Public Health]. Vol. 8, no. 12, pp. 4608-4622. Dec 2011.
Corporate institution author - Coble, J; Thomas, K W; Hines, C J; Hoppin, JA; Dosemeci, M; Curwin, B; Lubin, J H; Freeman, LEB; Blair, A; Sandler, D P; Alavanja, MCR
DOI - MD-0018314470; 16435120; 1660-4601 English

239. Cole, T. B.; Jansen, K.; Park, S.; Li, W. F.; Furlong, C. E., and Costa, L. G. The Toxicity of Mixtures of Specific Organophosphate Compounds is Modulated by Paraoxonase 1 Status. Department of Medicine and Genome Sciences, University of Washington, Seattle, WA, USA,//: 2009; 660, 47-60.


Rec #: 2740
Keywords: REVIEW
Call Number: NO REVIEW (CPYO,DZ,MLO)
Notes: Chemical of Concern: CPYO,DZ,MLO

240. Collins, G. B.; Bengtson, D. A., and Moore, J. C. Characterization of Reference Artemia III for Marine Toxicological Studies. 1991: 315-323.


Rec #: 570
Keywords: NO CONC,NO DURATION
Call Number: NO CONC (CPY), NO DURATION (CPY)
Notes: Chemical of Concern: CPY

241. Colodner, K. J. and Feany, M. B. Glial Fibrillary Tangles and Jak/Stat-Mediated Glial and Neuronal Cell Death in a Drosophila Model of Glial Tauopathy.


Rec #: 50409
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: A subset of neurodegenerative tauopathies is characterized by abundant filamentous inclusions of hyperphosphorylated tau in both neurons and glia. Although the contribution of neuronal tau to behavioral changes and neuronal loss in neurodegenerative diseases has been studied extensively, the functional consequences of tau deposition in glial cells have been less well characterized. To investigate the role of abnormal tau accumulation and aggregation in glial cells, we created a Drosophila model of glial tauopathy by expressing human wild-type tau in adult fly glial cells. Glial expression of tau resulted in robust aggregation of phosphorylated tau into fibrillary inclusions similar to human glial tangles. Tangle formation was accompanied by shortened lifespan and age-dependent apoptotic cell death of both glia and neurons. Genetic manipulation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling modified toxicity of glial tau. We also identified a synergistic interaction of combined tau expression in neurons and glial cells. In summary, we present a genetically tractable model of glial fibrillary tau tangle formation and identify JAK/STAT signaling as mediating the death of both glia and neurons in this model.
MESH HEADINGS: Animals
MESH HEADINGS: Animals, Genetically Modified
MESH HEADINGS: Cell Death/genetics/physiology
MESH HEADINGS: *Disease Models, Animal
MESH HEADINGS: Drosophila melanogaster/genetics
MESH HEADINGS: Humans
MESH HEADINGS: Janus Kinases/genetics/*physiology
MESH HEADINGS: Neurofibrillary Tangles/genetics/*metabolism/pathology
MESH HEADINGS: Neuroglia/*enzymology/*pathology
MESH HEADINGS: Neurons/metabolism/pathology
MESH HEADINGS: STAT Transcription Factors/genetics/*physiology
MESH HEADINGS: Signal Transduction/genetics/physiology
MESH HEADINGS: Tauopathies/*enzymology/etiology/*pathology eng

242. Colovic, M.; Krstic, D.; Petrovic, S.; Leskovac, A.; Joksic, G.; Savic, J.; Franko, M.; Trebse, P., and Vasic, V. Toxic effects of diazinon and its photodegradation products. 2010; 193, (1): 9-18.


Rec #: 58229
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: The toxic effects of diazinon and its irradiated Solutions were investigated using cultivated human blood cells (lymphocytes and erythrocytes) and skin fibroblasts. Ultra Performance Liquid Chromatography (UPLC)-UV/VIS system was used to monitor the disappearance of starting diazinon during 115-min photodegradation and formation of its by-products (diazoxon and 2-isopropyl-6-methyl-4-pyrimidinol (IMP)) as a function of time Dose-dependent AChE and Na(+)/K(+)-ATPase inhibition by diazinon was obtained for all investigated cells Calculated IC(50) (72 h) values, in M, were 7 5 x 10(-6)/3 4 x 10(-5), 8.7 x 10(-5)/6.6 x 10(-5), and 3 0 x 10(-5)/4 6 x 10(-5) for fibroblast, erythrocyte and lymphocyte AChE/Na(+)/K(+)-ATPase, respectively. Results obtained for reference commercially purified target enzymes indicate similar sensitivity of AChE towards diazinon (IC(50) (20 min)-7.8 x 10(-5) M). while diazinon concentrations below 10 mM did not noticeably affect Na(+)/K(+)-ATPase activity Besides, diazinon and IMP induced increasing incidence of micronuclei (via clastogenic mode of action) in a dose-dependent manner up to 2 x 10(-6) M and significant inhibition of cell proliferation and increased level of malondialdehyde at all investigated concentrations Although after 15-min diazinon irradiation formed products do not affect purified commercial enzymes activities, inhibitory effect of irradiated solutions on cell enzymes increased as a function of time exposure to UV light and resulted in significant reduction of AChE (LIP to 28-45%) and Na(+)/K(+)-ATPase (up to 35-40%) at the end of irradiation period Moreover, photodegradation treatment strengthened prooxidative properties of diazinon as well as its potency to induce cytogenetic damage (C) 2009 Elsevier Ireland Ltd All rights reserved.
Keywords: Diazinon, Photodegradation, Acetylcholinesterase, Na(+)/K(+)-ATPase,
ISI Document Delivery No.: 569QC

243. Conn, S. J. ; Gilliham, M.; Athman, A.; Schreiber, A. W.; Baumann, U.; Moller, I.; Cheng, N. H.; Stancombe, M. A.; Hirschi, K. D.; Webb, A. A.; Burton, R.; Kaiser, B. N.; Tyerman, S. D., and Leigh, R. A. Cell-Specific Vacuolar Calcium Storage Mediated by Cax1 Regulates Apoplastic Calcium Concentration, Gas Exchange, and Plant Productivity in Arabidopsis.


Rec #: 50259
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
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ABSTRACT: The physiological role and mechanism of nutrient storage within vacuoles of specific cell types is poorly understood. Transcript profiles from Arabidopsis thaliana leaf cells differing in calcium concentration ([Ca], epidermis < 10 mM versus mesophyll >60 mM) were compared using a microarray screen and single-cell quantitative PCR. Three tonoplast-localized Ca(2+) transporters, CAX1 (Ca(2+)/H(+)-antiporter), ACA4, and ACA11 (Ca(2+)-ATPases), were identified as preferentially expressed in Ca-rich mesophyll. Analysis of respective loss-of-function mutants demonstrated that only a mutant that lacked expression of both CAX1 and CAX3, a gene ectopically expressed in leaves upon knockout of CAX1, had reduced mesophyll [Ca]. Reduced capacity for mesophyll Ca accumulation resulted in reduced cell wall extensibility, stomatal aperture, transpiration, CO(2) assimilation, and leaf growth rate; increased transcript abundance of other Ca(2+) transporter genes; altered expression of cell wall-modifying proteins, including members of the pectinmethylesterase, expansin, cellulose synthase, and polygalacturonase families; and higher pectin concentrations and thicker cell walls. We demonstrate that these phenotypes result from altered apoplastic free [Ca(2+)], which is threefold greater in cax1/cax3 than in wild-type plants. We establish CAX1 as a key regulator of apoplastic [Ca(2+)] through compartmentation into mesophyll vacuoles, a mechanism essential for optimal plant function and productivity.
MESH HEADINGS: Antiporters/genetics/*metabolism
MESH HEADINGS: Arabidopsis/genetics/*metabolism
MESH HEADINGS: Arabidopsis Proteins/genetics/*metabolism
MESH HEADINGS: Calcium/*metabolism
MESH HEADINGS: Cation Transport Proteins/genetics/*metabolism
MESH HEADINGS: Cell Wall/metabolism
MESH HEADINGS: Gene Expression Profiling
MESH HEADINGS: Gene Expression Regulation, Plant
MESH HEADINGS: Mutagenesis, Insertional
MESH HEADINGS: Mutation
MESH HEADINGS: Oligonucleotide Array Sequence Analysis
MESH HEADINGS: Phenotype
MESH HEADINGS: Plant Leaves/cytology/metabolism
MESH HEADINGS: Plant Stomata/metabolism
MESH HEADINGS: RNA, Plant/genetics
MESH HEADINGS: Single-Cell Analysis
MESH HEADINGS: Vacuoles/*metabolism eng

244. Coombes, Ryan Hunter and Chambers, Janice E. Hydrolysis of Organophosphate and Model Substrates in African American and Caucasian Southerners by Serum Paraoxonase-1 (Pon1) and Its Relationship to Atherosclerosis. 2011: (UMI# 1502713 ).


Rec #: 51649
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Paraoxonase-1 (PON1) is a high density lipoprotein (HDL)-associated enzyme displaying esterase and lactonase activity.
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