Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos

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amino acid residues 96-110, play an important role in neurite outgrowth and neural cell differentiation. In the current study, we evaluated the developmental abnormalities caused by administration of exogenous APP(96-110) in sea urchin embryos and larvae, which, like the developing mammalian brain, utilize acetylcholine and other neurotransmitters as morphogens; effects were compared to those of beta-amyloid 1-42 (Abeta42), the neurotoxic APP fragment contained within neurodegenerative plaques in Alzheimer's Disease. Although both peptides elicited dysmorphogenesis, Abeta42 was far more potent; in addition, whereas Abeta42 produced abnormalities at developmental stages ranging from early cleavage divisions to the late pluteus, APP(96-110) effects were restricted to the intermediate, mid-blastula stage. For both agents, anomalies were prevented or reduced by addition of lipid-permeable analogs of acetylcholine, serotonin or cannabinoids; physostigmine, a carbamate-derived cholinesterase inhibitor, was also effective. In contrast, agents that act on NMDA receptors (memantine) or alpha-adrenergic receptors (nicergoline), and that are therapeutic in Alzheimer's Disease, were themselves embryotoxic, as was tacrine, a cholinesterase inhibitor from a different chemical class than physostigmine. Protection was also provided by agents acting downstream from receptor-mediated events: increasing cyclic AMP with caffeine or isobutylmethylxanthine, or administering the antioxidant, a-tocopherol, were all partially effective. Our findings reinforce a role for APP in development and point to specific interactions with neurotransmitter systems that act as morphogens in developing sea urchins as well as in the mammalian brain.
Keywords: 2921-88-2
Keywords: Animals
Keywords: Drug Interactions
Keywords: Sea Urchins -- drug effects
Keywords: Serotonin -- analogs & derivatives
Keywords: amyloid beta-protein (1-42)
Keywords: Chlorpyrifos -- pharmacology
Keywords: 50-67-9
Keywords: Acetylcholine -- metabolism
Keywords: Peptide Fragments
Keywords: Acetylcholine -- analogs & derivatives
Keywords: Cannabinoids
Keywords: Amyloid beta-Peptides
Keywords: Peptide Fragments -- pharmacology
Keywords: Amyloid beta-Peptides -- pharmacology
Keywords: Amyloid beta-Protein Precursor -- pharmacology
Keywords: Serotonin -- metabolism
Keywords: Time Factors
Keywords: Amyloid beta-Protein Precursor
Keywords: Larva -- drug effects
Keywords: 51-84-3
Keywords: Serotonin -- pharmacology
Keywords: Dose-Response Relationship, Drug
Keywords: Cannabinoids -- metabolism
Keywords: Embryo, Nonmammalian
Keywords: Cannabinoids -- pharmacology
Keywords: Serotonin
Keywords: Chlorpyrifos
Keywords: 0
Keywords: Cannabinoids -- agonists
Keywords: Acetylcholine
Keywords: Embryonic Development -- drug effects
Keywords: Sea Urchins -- growth & development
Date completed - 2009-01-13
Date created - 2008-10-20
Date revised - 2012-12-20
Language of summary - English
Pages - 503-509
ProQuest ID - 69691552
SuppNotes - Cites: Neurosci Biobehav Rev. 2003 Sep;27(4):351-63[12946688]; Cites: Brain Res Bull. 2008 Jan 31;75(1):94-100[18158101]; Cites: Curr Alzheimer Res. 2005 Jan;2(1):37-45[15977988]; Cites: EMBO J. 2005 Dec 7;24(23):3996-4006[16252002]; Cites: Neurosci Lett. 2006 Sep 1;404(3):342-6[16837132]; Cites: Toxicology. 2006 Oct 3;227(1-2):173-83[16956707]; Cites: Prog Neurobiol. 2007 May;82(1):11-32[17428603]; Cites: Environ Health Perspect. 2007 Sep;115(9):1306-13[17805420]; Cites: J Neurosci. 2007 Dec 26;27(52):14459-69[18160654]; Cites: J Embryol Exp Morphol. 1970 Jun;23(3):549-69[4394387]; Cites: Exp Cell Res. 1970 Sep;62(1):102-17[4394736]; Cites: J Embryol Exp Morphol. 1968 Aug;20(1):119-28[5687734]; Cites: J Neurosci. 1994 Apr;14(4):2117-27[8158260]; Cites: J Neurochem. 1997 Oct;69(4):1389-97[9326267]; Cites: Toxicol Appl Pharmacol. 1997 Oct;146(2):227-36[9344890]; Cites: J Neurosci. 1998 Feb 15;18(4):1240-9[9454834]; Cites: Crit Rev Neurobiol. 1998;12(3):177-204[9847054]; Cites: Environ Health Perspect. 1999 Feb;107 Suppl 1:59-64[10229707]; Cites: Environ Health Perspect. 1999 Feb;107 Suppl 1:65-9[10229708]; Cites: Brain Res. 1999 Aug 28;839(2):313-22[10519055]; Cites: Perspect Dev Neurobiol. 1998;5(4):469-80[10533532]; Cites: Neurosci Behav Physiol. 2000 Jan-Feb;30(1):53-62[10768372]; Cites: Biol Psychiatry. 2001 Feb 1;49(3):221-32[11230873]; Cites: Environ Health Perspect. 2001 Jul;109(7):651-61[11485862]; Cites: Neuroscience. 2002;111(3):649-56[12031351]; Cites: Ann N Y Acad Sci. 2002 Jun;965:473-8[12105122]; Cites: Prog Neurobiol. 2003 May;70(1):1-32[12927332]; Cites: Environ Health Perspect. 2003 Nov;111(14):1730-5[14594623]; Cites: Brain Res Bull. 2004 Mar 1;63(1):57-63[15121239]; Cites: Toxicol Sci. 2004 Dec;82(2):545-54[15342957]; Cites: Neurochem Res. 2005 Jun-Jul;30(6-7):825-37[16187217]; Cites: J Neurobiol. 2006 Apr;66(5):476-87[16470685]; Cites: J Neurosci. 2006 Jul 5;26(27):7212-21[16822978]; Cites: Exp Gerontol. 2006 Oct;41(10):1007-13[16930903]; Cites: Methods Enzymol. 2006;412:234-55[17046662]; Cites: Science. 2006 Nov 10;314(5801):941-52[17095691]; Cites: Brain Res Bull. 2007 Sep 28;74(4):221-31[17720543]; Cites: Chem Res Toxicol. 2004 Aug;17(8):983-98[15310231]
Last updated - 2013-01-19
British nursing index edition - Neurotoxicology and teratology, November 2008, 30(6):503-509
Corporate institution author - Buznikov, Gennady A; Nikitina, Lyudmila A; Seidler, Frederic J; Slotkin, Theodore A; Bezuglov, Vladimir V; Milosević, Ivan; Lazarević, Lidija; Rogac, Ljubica; Ruzdijić, Sabera; Rakić, Ljubisa M
DOI - MEDL-18565728; 18565728; NIHMS75298; PMC2579926; 0892-0362 eng

171. Byford, R. L.; Lockwood, J. A.; Smith, S. M.; Harmon, C. W.; Johnson, C. C.; Luther, D. G.; Morris, H. F. Jr., and Penny, A. J. Insecticide Residues in Cattle Treated with a Cypermethrin, Chlorpyrifos, Piperonyl Butoxide-Impregnated Ear Tag. 1986; 37, (5): 692-697.

Rec #: 490
Keywords: NO CONC
Call Number: NO CONC (CPY,CYP,PPB)
Notes: Chemical of Concern: CPY,CYP,PPB

172. Cacciatore, Luis Claudio; Kristoff, Gisela; Verrengia Guerrero, Noemi R; Cochon, Adriana C, and Cacciatore, Luis Claudio. Binary Mixtures of Azinphos-Methyl Oxon and Chlorpyrifos Oxon Produce in Vitro Synergistic Cholinesterase Inhibition in Planorbarius Corneus. 2012 Jul; 88, (4): 450-458.

Rec #: 38699
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: In this study, the cholinesterase (ChE) and carboxylesterase (CES) activities present in whole organism homogenates from Planorbarius corneus and their in vitro sensitivity to organophosphorous (OP) pesticides were studied. Firstly, a characterization of ChE and CES activities using different substrates and selective inhibitors was performed. Secondly, the effects of azinphos-methyl oxon (AZM-oxon) and chlorpyrifos oxon (CPF-oxon), the active oxygen analogs of the OP insecticides AZM and CPF, on ChE and CES activities were evaluated. Finally, it was analyzed whether binary mixtures of the pesticide oxons cause additive, antagonistic or synergistic ChE inhibition in P. corneus homogenates. The results showed that the extracts of P. corneus preferentially hydrolyzed acetylthiocholine (AcSCh) over propionylthiocholine (PrSCh) and butyrylthiocholine (BuSCh). Besides, AcSCh hydrolyzing activity was inhibited by low concentrations of BW284c51, a selective inhibitor of AChE activity, and also by high concentrations of substrate. These facts suggest the presence of a typical AChE activity in this species. However, the different dose-response curves observed with BW284c51 when using PrSCh or BuSCh instead of AcSCh suggest the presence of at least another ChE activity. This would probably correspond to an atypical BuChE. Regarding CES activity, the highest specific activity was obtained when using 2-naphthyl acetate (2-NA), followed by 1-naphthyl acetate (1-NA); p-nitrophenyl acetate (p-NPA), and p-nitrophenyl butyrate (p-NPB). The comparison of the IC50 values revealed that, regardless of the substrate used, CES activity was approximately one order of magnitude more sensitive to AZM-oxon than ChE activity. Although ChE activity was very sensitive to CPF-oxon, CES activity measured with 1-NA, 2-NA, and p-NPA was poorly inhibited by this pesticide. In contrast, CES activity measured with p-NPB was equally sensitive to CPF-oxon than ChE activity. Several specific binary combinations of AZM-oxon and CPF-oxon caused a synergistic effect on the ChE inhibition in P. corneus homogenates. The degree of synergism tended to increase as the ratio of AZM-oxon to CPF-oxon decreased. These results suggest that synergism is likely to occur in P. corneus snails exposed in vivo to binary mixtures of the OPs AZM and CPF.
Keywords: Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE)
Date revised - 2012-08-01
Language of summary - English
Pages - 450-458
ProQuest ID - 1020844906
Last updated - 2012-11-06
British nursing index edition - Chemosphere [Chemosphere]. Vol. 88, no. 4, pp. 450-458. Jul 2012.
Corporate institution author - Cacciatore, Luis Claudio; Kristoff, Gisela; Verrengia Guerrero, Noemi R; Cochon, Adriana C
DOI - 9b113754-62b3-47fe-9514csamfg201; 16792851; 0045-6535 English

173. Caceres, Tanya; Megharaj, Mallavarapu; Venkateswarlu, Kadiyala; Sethunathan, Nambrattil; Naidu, Ravi, and Caceres, Tanya. Fenamiphos and Related Organophosphorus Pesticides: Environmental Fate and Toxicology. 2010; 205, 117-162.

Rec #: 44379
Notes: Chemical of Concern: CPY
Abstract: Abstract: Organophosphorus (OP) compounds are among the most common chemical classes used in crop and livestock protection and account for an estimated 34% of worldwide insecticide sales (Singh and Walker 2006). During the last 60 yr, approximately 150 different OP chemicals have been used to protect crops, livestock, and human health (Casida and Quistad 2004). In recent years, the OP compounds have been the most widely used group of insecticides in Australia. In addition to fenamiphos (nematicide), isofenphos, and coumaphos (insecticides), the most commonly used OP pesticides include parathion methyl, chlorpyrifos, dimethoate, and profenfos. Approximately 500 t of OP-active ingredients comprising about 30 distinct compounds have been used annually in Australia for many years (Australian Academy of Technological Sciences and Engineering 2002).
Keywords: Chlorpyrifos
Keywords: fenamiphos
Keywords: Pesticides (organophosphorus)
Keywords: Insecticides
Keywords: Coumaphos
Keywords: Dimethoate
Keywords: X 24330:Agrochemicals
Keywords: Toxicology Abstracts
Keywords: Crops
Keywords: Parathion
Keywords: Livestock
Date revised - 2010-03-01
Language of summary - English
Pages - 117-162
ProQuest ID - 21395145
SubjectsTermNotLitGenreText - Chlorpyrifos; fenamiphos; Pesticides (organophosphorus); Insecticides; Coumaphos; Dimethoate; Crops; Parathion; Livestock
Last updated - 2012-03-29
British nursing index edition - Reviews of Environmental Contamination and Toxicology [Rev. Environ. Contam. Toxicol.]. Vol. 205, pp. 117-162. 2010.
Corporate institution author - Caceres, Tanya; Megharaj, Mallavarapu; Venkateswarlu, Kadiyala; Sethunathan, Nambrattil; Naidu, Ravi
DOI - MD-0012838028; 12490718; 0179-5953 English

174. Canesi, L.; Borghi, C.; Gallo, G.; Capri, F.; Viarengo, A., and Dondero, F. Effects of the Organophosphate Pesticide Chlorpyriphos on the Responses of Mytilus Digestive Gland to the Natural Estrogen 17[beta]-Estradiol. 2008; 151, (Suppl. 1.1): S3(ABS).

Rec #: 500
Keywords: ABSTRACT
Call Number: NO ABSTRACT (CPY)
Notes: Chemical of Concern: CPY

175. Cao, L.; Liu, H. M.; Zhang, H.; Huang, K.; Gu, T.; Ni, H. Y.; Hong, Q., and Li, S. P. Characterization of a Newly Isolated Highly Effective 3,5,6-Trichloro-2-pyridinol Degrading Strain Cupriavidus pauculus P2. 2012; 65, (3): 231-236.

Rec #: 57339
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: Abstract: A bacterial strain P2 capable of degrading 3,5,6-trichloro-2-pyridinol (TCP) was isolated and characterized. Phylogenetic analysis based on 16S rRNA gene sequence indicated that it belonged to the genus of Cupriavidus, because it showed the highest sequence similarity to Cupriavidus pauculus LMG 3413(T) (99.7 %) and DNA-DNA relatedness value between strain P2 and C. pauculus LMG 3413(T) was 76.8 %. In combination with morphological, physiological and biochemical characters, strain P2 was identified as C. pauculus. It could use TCP as the sole carbon source and energy source for its growth. It showed a high average degradation rate of 10 mg/L h in mineral salt medium amended with TCP (50-800 mg/L). During TCP degradation, chloridion was released into the medium in two obvious discontinuous stages. Along with this, two colorful metabolites were produced. Finally, the molarity of the total released chloridion was three times that of the initial TCP in the medium. This is the first report of TCP-degrading strain from the genus of Cupriavidus and the detection of two colorful metabolites during TCP degradation. Strain P2 might be a promising candidate for its application in the bioremediation of TCP-polluted environments.
ISI Document Delivery No.: 977RJ

176. Cao, S. and Chen, S. J. Biphasic Folding Kinetics of Rna Pseudoknots and Telomerase Rna Activity.

Rec #: 51439
Notes: Chemical of Concern: CPY
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ABSTRACT: Using a combined master equation and kinetic cluster approach, we investigate RNA pseudoknot folding and unfolding kinetics. The energetic parameters are computed from a recently developed Vfold model for RNA secondary structure and pseudoknot folding thermodynamics. The folding kinetics theory is based on the complete conformational ensemble, including all the native-like and non-native states. The predicted folding and unfolding pathways, activation barriers, Arrhenius plots, and rate-limiting steps lead to several findings. First, for the PK5 pseudoknot, a misfolded 5' hairpin emerges as a stable kinetic trap in the folding process, and the detrapping from this misfolded state is the rate-limiting step for the overall folding process. The calculated rate constant and activation barrier agree well with the experimental data. Second, as an application of the model, we investigate the kinetic folding pathways for human telomerase RNA (hTR) pseudoknot. The predicted folding and unfolding pathways not only support the proposed role of conformational switch between hairpin and pseudoknot in hTR activity, but also reveal molecular mechanism for the conformational switch. Furthermore, for an experimentally studied hTR mutation, whose hairpin intermediate is destabilized, the model predicts a long-lived transient hairpin structure, and the switch between the transient hairpin intermediate and the native pseudoknot may be responsible for the observed hTR activity. Such finding would help resolve the apparent contradiction between the observed hTR activity and the absence of a stable hairpin.
MESH HEADINGS: Base Sequence
MESH HEADINGS: Models, Molecular
MESH HEADINGS: Mutagenesis, Site-Directed
MESH HEADINGS: Nucleic Acid Conformation
MESH HEADINGS: RNA/*chemistry/genetics/metabolism
MESH HEADINGS: Telomerase/chemistry/genetics/*metabolism
MESH HEADINGS: Thermodynamics eng

177. Carafa, Roberta; Faggiano, Leslie; Real, Montserrat; Munne, Antoni; Ginebreda, Antoni; Guasch, Helena; Flo, Monica; Tirapu, Luis; Der Ohe, Peter Carsten Von, and Carafa, Roberta. Water Toxicity Assessment and Spatial Pollution Patterns Identification in a Mediterranean River Basin District. Tools for Water Management and Risk Analysis. 2011 Sep 15; 409, (20): 4269-4279.

Rec #: 47109
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: In compliance with the requirements of the EU Water Framework Directive, monitoring of the ecological and chemical status of Catalan river basins (NE Spain) is carried out by the Catalan Water Agency.The large amount of data collected and the complex relationships among the environmental variables monitored often mislead data interpretation in terms of toxic impact, especially considering that even pollutants at very low concentrations might contribute to the total toxicity.The total dataset of chemical monitoring carried out between 2007 and 2008 (232 sampling stations and 60 pollutants) has been analyzed using sequential advanced modeling techniques. Data on concentrations of contaminants in water were pre-treated in order to calculate the bioavailable fraction, depending on substance properties and local environmental conditions.The resulting values were used to predict the potential impact of toxic substances in complex mixtures on aquatic biota and to identify hot spots. Exposure assessment with Species Sensitivity Distribution (SSD) and mixture toxicity rules were used to compute the multi-substances Potentially Affected Fraction (msPAF).The combined toxicity of the pollutants analyzed in the Catalan surface waters might potentially impact more than 50% of the species in 10% of the sites.In order to understand and visualize the spatial distribution of the toxic risk, Self Organising Map (SOM), based on the Kohonen's Artificial Neural Network (ANN) algorithm, was applied on the output data of these models. Principal Component Analysis (PCA) was performed on top of Neural Network results in order to identify main influential variables which account for the pollution trends. Finally, predicted toxic impacts on biota have been linked and correlated to field data on biological quality indexes using macroinvertebrate and diatom communities (IBMWP and IPS). The methodology presented could represent a suitable tool for water managers in environmental risk assessment and management.
Keywords: Artificial intelligence
Keywords: Principal component analysis
Keywords: Risk analysis
Keywords: M2 556:General (556)
Keywords: Toxic substances
Keywords: Spatial distribution
Keywords: Neural networks
Keywords: Surface water
Keywords: Spain
Keywords: Bacillariophyceae
Keywords: Algorithms
Keywords: River basins
Keywords: Toxicity
Keywords: Risk Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Environmental Studies
Keywords: Bioavailability
Keywords: Biota
Keywords: Water management
Keywords: neural networks
Keywords: R2 23050:Environment
Date revised - 2012-01-01
Language of summary - English
Location - Spain
Pages - 4269-4279
ProQuest ID - 889690566
SubjectsTermNotLitGenreText - Principal component analysis; Spatial distribution; Water management; Neural networks; Algorithms; River basins; Bioavailability; Artificial intelligence; Risk analysis; Biota; Toxic substances; Surface water; neural networks; Toxicity; Bacillariophyceae; Spain
Last updated - 2012-08-02
Corporate institution author - Carafa, Roberta; Faggiano, Leslie; Real, Montserrat; Munne, Antoni; Ginebreda, Antoni; Guasch, Helena; Flo, Monica; Tirapu, Luis
DOI - OB-b3b16789-8ef3-46af-81f6csamfg201; 15619636; 0048-9697 English

178. Carlson, J. C.; Challis, J. K.; Hanson, M. L., and Wong, C. S. Stability of pharmaceuticals and other polar organic compounds stored on polar organic chemical integrative samplers and solid-phase extraction cartridges. 2013; 32, (2): 337-344.

Rec #: 57359
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: The stability of 24 chemicals, including pharmaceuticals and personal care products, and some agrochemicals on extraction media was evaluated by preloading them onto Oasis hydrophilic lipophilic balanced solid-phase extraction (SPE) cartridges and polar organic chemical integrative samplers (POCIS) followed by storage at 20 degrees C over time. After 20 months, the average loss was 11% on POCIS, with only 2,4-dichlorophenoxyacetic acid, atrazine, chlorpyrifos, and gemfibrozil showing a statistically significant decline compared with initial concentrations. Losses on SPE cartridges were below 19%, with an average loss of 9%. In addition to laboratory spiked samples, multiple POCIS deployed in wastewater-impacted surface waters and SPE extracts of these waters were stored in their original coextracted matrix for nearly two years with minimal observed losses. Errors from typical sampling, handling, and concentration estimates from POCIS sampling rates were typically +/- 15 to 30% relative standard deviation, so observed storage losses are minimal for most POCIS applications. While losses during storage on SPE cartridges for 20 months were small but statistically significant for many compounds, addition of labeled internal standards prior to freezing should correct for such losses. Thus, storage of processed water samples for analysis of polar organic pollutants is viable for archival purposes or studies for which samples cannot be analyzed in the short term. Environ. Toxicol. Chem. 2013;32:337344. (C) 2012 SETAC
Keywords: Archival storage, Polar organic chemical integrative sampler,
ISI Document Delivery No.: 075ET

179. Carpenter, Kurt D; Sobieszczyk, Steven; Arnsberg, Andrew J; Rinella, Frank a, and Carpenter, Kurt D. Pesticide Occurrence and Distribution in the Lower Clackamas River Basin, Oregon, 2000-2005. 2008.

Rec #: 49859
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pesticide occurrence and distribution in the lower Clackamas River basin was evaluated in 2000-2005, when 119 water samples were analyzed for a suite of 86-198 dissolved pesticides. Sampling included the lower-basin tributaries and the Clackamas River mainstem, along with paired samples of pre- and post-treatment drinking water (source and finished water) from one of four drinking water-treatment plants that draw water from the lower river. Most of the sampling in the tributaries occurred during storms, whereas most of the source and finished water samples from the study drinking-water treatment plant were obtained at regular intervals, and targeted one storm event in 2005. In all, 63 pesticide compounds were detected, including 33 herbicides, 15 insecticides, 6 fungicides, and 9 pesticide degradation products. Atrazine and simazine were detected in about half of samples, and atrazine and one of its degradates (deethylatrazine) were detected together in 30 percent of samples. Other high-use herbicides such as glyphosate, triclopyr, 2,4-D, and metolachlor also were frequently detected, particularly in the lower-basin tributaries. Pesticides were detected in all eight of the lower-basin tributaries sampled, and were also frequently detected in the lower Clackamas River. Although pesticides were detected in all of the lower basin tributaries, the highest pesticide loads (amounts) were found in Deep and Rock Creeks. These medium-sized streams drain a mix of agricultural land (row crops and nurseries), pastureland, and rural residential areas. The highest pesticide loads were found in Rock Creek at 172nd Avenue and in two Deep Creek tributaries, North Fork Deep and Noyer Creeks, where 15-18 pesticides were detected. Pesticide yields (loads per unit area) were highest in Cow and Carli Creeks, two small streams that drain the highly urban and industrial northwestern part of the lower basin. Other sites having relatively high pesticide yields included middle Rock Creek and upper Noyer Creek, which drain basins having nurseries, pasture, and rural residential land. Some concentrations of insecticides (diazinon, chlorpyrifos, azinphos-methyl, and p,p-DDE) exceeded U.S. Environmental Protection Agency (USEPA) aquatic-life benchmarks in Carli, Sieben, Rock, Noyer, Doane, and North Fork Deep Creeks. One azinphos-methyl concentration in Doane Creek (0.21 micrograms per liter [ mu g/L]) exceeded Federal and State of Oregon benchmarks for the protection of fish and benthic invertebrates. Concentrations of several other pesticide compounds exceeded non-USEPA benchmarks. Twenty-six pesticides or degradates were detected in the Clackamas River mainstem, typically at much lower concentrations than those detected in the lower-basin tributaries. At least 1 pesticide was detected in 65 percent of 34 samples collected from the Clackamas River, with an average of 2-3 pesticides per sample. Pesticides were detected in 9 (or 60 percent) of the 15 finished water samples collected from the study water-treatment plant during 2003-2005. These included 10 herbicides, 1 insecticide, 1 fungicide, 1 insect repellent, and 2 pesticide degradates. The herbicides diuron and simazine were the most frequently detected (four times each during the study), at concentrations far below human-health benchmarks-USEPA Maximum Contaminant Levels or U.S. Geological Survey human Health-Based Screening Levels (HBSLs). The highest pesticide concentration in finished drinking water was 0.18 mu g/L of diuron, which was 11 times lower than its low HBSL benchmark. Although 0?2 pesticides were detected in most finished water samples, 9 and 6 pesticides were detected in 2 storm-associated samples from May and September 2005, respectively. Three of the unregulated compounds detected in finished drinking water (diazinon-oxon, deethylatrazine [CIAT], and N, N-diethyl-m-toluamide [DEET]) do not have human-health benchmarks available for comparison. Although most of the 51 current.
Start Page: 99
End Page: 99
Keywords: Water Analysis
Keywords: Nursery grounds
Keywords: Water Sampling
Keywords: Canada, British Columbia, Rock Creek
Keywords: Freshwater
Keywords: Streams
Keywords: Insecticides
Keywords: Drinking Water
Keywords: Agricultural Chemicals
Keywords: Q1 01422:Environmental effects
Keywords: USA, Oregon, Clackamas R. basin
Keywords: SW 3060:Water treatment and distribution
Keywords: USA, Idaho, Deep Creek
Keywords: USA, Oregon
Keywords: Tributaries
Keywords: Rivers
Keywords: AQ 00001:Water Resources and Supplies
Keywords: Herbicides
Keywords: River basins
Keywords: Q5 01504:Effects on organisms
Keywords: Creek
Keywords: ASW, USA, Florida, New Estuary, North Fork
Keywords: Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources
Keywords: Pesticides
Keywords: Fungicides
Date revised - 2011-11-01
Language of summary - English
Location - ASW, USA, Florida, New Estuary, North Fork; Canada, British Columbia, Rock Creek; USA, Oregon, Clackamas R. basin; USA, Idaho, Deep Creek; USA, Oregon
Pages - 99
ProQuest ID - 904485064
SubjectsTermNotLitGenreText - Insecticides; Drinking Water; Fungicides; Nursery grounds; Pesticides; River basins; Herbicides; Creek; Tributaries; Rivers; Agricultural Chemicals; Water Analysis; Water Sampling; Streams; ASW, USA, Florida, New Estuary, North Fork; Canada, British Columbia, Rock Creek; USA, Oregon, Clackamas R. basin; USA, Idaho, Deep Creek; USA, Oregon; Freshwater
Last updated - 2012-12-14
British nursing index edition - Scientific Investigations Report. U.S. Geological Survey. no. 2008-5027, 99 p. 2008.
Corporate institution author - Carpenter, Kurt D; Sobieszczyk, Steven; Arnsberg, Andrew J; Rinella, Frank A
DOI - d970246a-a551-426f-9fc2csamfg201; 15961876; NO1102441 English

180. Carriger, J. F. and Rand, G. M. Aquatic Risk Assessment of Pesticides in Surface Waters in and Adjacent to the Everglades and Biscayne National Parks: II. Probabilistic Analyses. 2008; 17, (7): 680-696.

Rec #: 520
Notes: Chemical of Concern: ATZ,CPY,ES,ES1,ES2,MLN,MTL

181. ---. Aquatic Risk Assessment of Pesticides in Surface Waters in and Adjacent to the Everglades and Biscayne National Parks: I. Hazard Assessment and Problem Formulation. 2008; 17, (7): 660-679.

Rec #: 2130
Keywords: REVIEW
Notes: Chemical of Concern: ATZ,CPY,ES,MLN,MTL

182. Carriger, J. F.; Rand, G. M.; Gardinali, P. R.; Perry, W. B.; Tompkins, M. S., and Fernandez, A. M. Pesticides of Potential Ecological Concern in Sediment from South Florida Canals: An Ecological Risk Prioritization for Aquatic Arthropods. 2006; 15, (1): 21-45.

Rec #: 510

183. Carter, H. L.; Evans, M. A., and Waldron, A. C. Pesticide Use on Major Crops in Ohio - 1978. SOIL; 1980: 47 p.

Rec #: 530
Keywords: NO EFFECT

184. Carvalho, F. P.; Fowler, S. W., and Readman, J. W. The Fate and Effects of Agrochemical Residues in Tropical Coastal Lagoons Investigated with 14C-Labelled Compounds and Radiotracer Techniques. F.P.Carvalho, Marine Environment Laboratory, International Atomic Energy Agency, Monaco, 98012, Monaco//: 1998; 26, (3): 1430-1432.

Rec #: 540
Keywords: FATE
Call Number: NO FATE (CPY)
Notes: Chemical of Concern: CPY

185. Carvalho, Fernando P; Villeneuve, Jean-Pierre; Cattini, C; RendăłN, Jaime, and Mota De Oliveira, J. Pesticide and Pcb Residues in the Aquatic Ecosystems of Laguna De Terminos, a Protected Area of the Coast of Campeche, Mexico. 2009 Feb; 74, (7): 988-995.

Rec #: 48819
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: The coastal lagoon system of Laguna de Terminos, Campeche, Mexico, a natural reserve since 1994, was investigated for contamination by agricultural and industrial chemical residues. Water, sediment and biota samples were analyzed for a wide variety of organochlorine and organophosphorus compounds. Chlorpyrifos was detected in water in concentrations up to 72 pgL(-1) and, amongst organochlorine compounds, summation operator PCB were measured averaging 1177 pgL(-1) and summation operator DDT 279 pgL(-1). Residues of chlorinated compounds were present in sediments and in biota with summation operator DDT averaging 190 pg g(-1) and 5876 pg g(-1) in sediment and oysters, respectively. Results show that the more widespread contaminants in the Laguna were residues of chlorinated hydrocarbons, such as DDTs, PCBs, endosulfan, and lindane. Concentrations of residues were not at an alarming level and were even lower than reported for other costal lagoons of the region. Still there is a need to implement control measures on persistent and bioaccumulative compounds that may reach the aquatic system of Laguna de Terminos.
Keywords: 50-29-3
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Polychlorinated Biphenyls
Keywords: Pesticide Residues
Keywords: Polychlorinated Biphenyls -- analysis
Keywords: Ecosystem
Keywords: 0
Keywords: Mexico
Keywords: Hydrocarbons, Chlorinated -- analysis
Keywords: Hydrocarbons, Chlorinated
Keywords: DDT
Keywords: Water Pollutants, Chemical
Keywords: Pesticide Residues -- analysis
Keywords: Geologic Sediments
Keywords: DDT -- analogs & derivatives
Keywords: DDT -- analysis
Date completed - 2009-03-18
Date created - 2009-02-03
Date revised - 2012-12-20
Language of summary - English
Pages - 988-995
ProQuest ID - 66879148
Last updated - 2013-01-19
British nursing index edition - Chemosphere, February 2009, 74(7):988-995
Corporate institution author - Carvalho, Fernando P; Villeneuve, Jean-Pierre; Cattini, C; RendĂłn, Jaime; Mota de Oliveira, J
DOI - MEDL-19022473; 19022473; 1879-1298 eng

186. Carvalho, Fernando P; Villeneuve, Jean-Pierre; Cattini, Chantal; Rendon, Jaime; Oliveira, Jmota, and Carvalho, Fernando P. Ecological Risk Assessment of Pcbs and Other Organic Contaminant Residues in Laguna De Terminos, Mexico. 2009 May; 18, (4): 403-416.

Rec #: 48599
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: Laguna de Terminos, a wide coastal lagoon system in Campeche, Mexico, was investigated for the contamination by polychlorobiphenyls (PCBs). Distribution of these industrial chemical contaminants along with pesticide residues in the lagoon, as well as their sediment-water partitioning and bioaccumulation by oysters and fish were assessed. Contaminant concentrations in the lagoon were compared with toxicity data for aquatic organisms and the ecotoxicological risks discussed. Current contaminant concentrations generally were several orders of magnitude below acute toxic levels for the most sensitive aquatic species and this seems compatible with the status of nature reserve and functions aimed at Laguna de Terminos. In particular, Penaeidae shrimp species that are the most valuable fisheries resources of Campeche with important populations in the Laguna are not impaired with the current low levels of these contaminants. Nevertheless, due to known environmental persistence, the surveillance of chlorinated contaminant levels in the lagoon ecosystems is recommended.
Keywords: Risk assessment
Keywords: Aquatic organisms
Keywords: D 04070:Pollution
Keywords: Ecosystems
Keywords: Contamination
Keywords: Pesticide residues
Keywords: Pollution effects
Keywords: Ecology Abstracts; Toxicology Abstracts; Pollution Abstracts; Environmental Engineering Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality
Keywords: Toxicity tests
Keywords: Lagoons
Keywords: Environmental Studies
Keywords: Industrial wastes
Keywords: oysters
Keywords: Penaeidae
Keywords: Penaeid shrimps
Keywords: Fisheries
Keywords: Pollutant persistence
Keywords: Nature reserves
Keywords: Chemical pollution
Keywords: X 24330:Agrochemicals
Keywords: PCB compounds
Keywords: Marine crustaceans
Keywords: PCB
Keywords: EE 40:Water Pollution: Monitoring, Control & Remediation
Keywords: Sediment pollution
Keywords: Marine
Keywords: Data processing
Keywords: nature reserves
Keywords: Q5 01504:Effects on organisms
Keywords: Toxicity
Keywords: Bioaccumulation
Keywords: polychlorinated biphenyls
Keywords: Shrimp fisheries
Keywords: ISE, Mexico
Keywords: Fish
Keywords: Coastal lagoons
Keywords: Contaminants
Keywords: fishery resources
Date revised - 2010-02-01
Language of summary - English
Location - ISE, Mexico
Pages - 403-416
ProQuest ID - 289764902
SubjectsTermNotLitGenreText - Penaeidae; ISE, Mexico; Toxicity; Lagoons; PCB compounds; Fish; nature reserves; Chemical pollution; Contaminants; Aquatic organisms; oysters; Risk assessment; Sediment pollution; Ecosystems; Bioaccumulation; Pesticide residues; fishery resources; Coastal lagoons; Toxicity tests; PCB; Pollutant persistence; Shrimp fisheries; Marine crustaceans; Industrial wastes; Pollution effects; polychlorinated biphenyls; Data processing; Contamination; Nature reserves; Fisheries; Marine
Last updated - 2011-10-26
Corporate institution author - Carvalho, Fernando P; Villeneuve, Jean-Pierre; Cattini, Chantal; Rendon, Jaime; Oliveira, JMota
DOI - OB-MD-0009516332; 9297686; CS0934997; 0963-9292; 1573-3017 English

187. Casida, John E; Nomura, Daniel K; Vose, Sarah C, and Fujioka, Kazutoshi. Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and Endocannabinoids. 2008 Sep 25; 175, (1-3): 355-364.

Rec #: 49179
Notes: Chemical of Concern: CPY
Abstract: Abstract: Lipases play key roles in nearly all cells and organisms. Potent and selective inhibitors help to elucidate their physiological functions and associated metabolic pathways. Organophosphorus (OP) compounds are best known for their anticholinesterase properties but selectivity for lipases and other targets can also be achieved through structural optimization.
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