Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos

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diflubenzuron, but generally damage is not predicted and organophosphate insecticides (e.g. diazinon, chlorpyrifos, chlorfon) are required. Yersinia n. sp. (MH96) cf. entomophaga (EN65 strain) - a novel bacterium with insecticidal properties - is pathogenic to late instar Wiseana spp. larvae in laboratory assays and has potential as a biopesticide. This trial measured the effect of two formulations of EN65 and a commercial formulation of Bacillus thuringiensis var. kurstaki (Btk) against late instar porina. EN65 was formulated in a sprayable biopolymer and on to a kibbled wheat bait. Both EN65 formulations caused significant mortality of porina larvae and reduced feeding damage on white clover; efficacy was superior to Btk. Survival of the bacterium in the sprayable biopolymer formulation was enhanced compared to a non-formulated broth culture. Bacterial survival on the kibbled wheat bait was better when stored at 4 degree C compared to 20 degree C over 3 months.
Keywords: A 01380:Plant Protection, Fungicides & Seed Treatments
Keywords: K 03410:Animal Diseases
Keywords: Biological control
Keywords: Feeding
Keywords: Mortality
Keywords: Entomophaga
Keywords: Wiseana
Keywords: Diflubenzuron
Keywords: Plant protection
Keywords: Bacillus thuringiensis
Keywords: Biopolymers
Keywords: Survival
Keywords: organophosphates
Keywords: Pasture
Keywords: Yersinia
Keywords: J 02410:Animal Diseases
Keywords: Chlorpyrifos
Keywords: Triticum aestivum
Keywords: Insecticides
Keywords: Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology
Keywords: Pests
Keywords: Diazinon
Keywords: Bruton's tyrosine kinase
Date revised - 2008-12-01
Language of summary - English
Pages - 229-235
ProQuest ID - 290222496
SubjectsTermNotLitGenreText - Wiseana; Yersinia; Triticum aestivum; Entomophaga; Bacillus thuringiensis; Survival; Biopolymers; Bruton's tyrosine kinase; Biological control; Feeding; Chlorpyrifos; Mortality; Pasture; Pests; organophosphates; Diflubenzuron; Insecticides; Diazinon; Plant protection
Last updated - 2011-11-07
Corporate institution author - Brownbridge, M; Ferguson, C; Saville, D J; Swaminathan, J; Hurst, MRH; Jackson, T A
DOI - OB-MD-0008901874; 8690179; 1175-9003 English

157. Bryant, D. G. Balsam Woolly Aphid Adelges piceae (Ratz.). 1975: 250-254.

Rec #: 480
Notes: Chemical of Concern: CBF,CPY,DZ,FNT

158. Buchanan, I.; Liang, H. C.; Liu, Z. K.; Razaviarani, V., and Rahman, M. Z. Pesticides and Herbicides. 2010; 82, (10): 1594-1693.

Rec #: 57139
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: Abstract: This is a review of literature published in 2009 that covered issues related to the presence of pesticides and herbicides in the environment. The review is divided into nine sections, including analytical methods, toxicology, monitoring, ecology, fate and transport, modeling, risk assessment, management and minimization, and treatment strategies.
Keywords: pesticides, herbicides, insecticides, trace organic compounds,
ISI Document Delivery No.: 675OI

159. Buckley, T. J.; Geer, L. A.; Connor, T. H.; Robertson, S.; Sammons, D.; Smith, J.; Snawder, J., and Boeniger, M. A Pilot Study of Workplace Dermal Exposures to Cypermethrin at a Chemical Manufacturing Plant. 2011; 8, (10): 600-608.

Rec #: 57149
Notes: Chemical of Concern: CPY
Abstract: Abstract: Exposure during the manufacture of pesticides is of particular concern due to their toxicity and because little is known about worker exposure, since most studies have focused on end-use application within agriculture or buildings. Even though dermal exposure can be expected to dominate for pesticides, little is known about workplace dermal exposures or even appropriate methods for their assessment. The current study begins to address this gap by evaluating alternative methods for assessing dermal exposure at a chemical manufacturing plant. For this pilot study, eight workers were recruited from a U. S. plant that produced the pesticide cypermethrin. Exposure was evaluated using three approaches: (1) survey assessment (questionnaire), (2) biological monitoring, and (3) workplace environmental sampling including ancillary measurements of glove contamination (interior and exterior). In each case, cypermethrin was quantified by enzyme-linked immunosorbent assay (ELISA). Environmental measurements identified two potential pathways of cypermethrin exposure: glove and surface contamination. Workplace exposure was also indicated by urine levels (specific gravity adjusted) of the parent compound, which ranged from 35 to 253 mu g/L (median of 121 mu g/L) with no clear trend in levels from pre- to post-shift. An exploratory analysis intended to guide future studies revealed a positive predictive association (Spearman correlation, p <= 0.10) between post-shift urine concentrations and a subset of survey questions evaluating worker knowledge, attitudes, and perceptions (KAP) of workplace dermal hazards, i.e., personal protective equipment self-efficacy, and inverse associations with behavior belief and information belief scales. These findings are valuable in demonstrating a variety of dermal exposure methods (i.e., behavioral attributes, external contamination, and biomarker) showing feasibility and providing measurement ranges and preliminary associations to support future and more complete assessments. Although these pilot data are useful for supporting design and sample size considerations for larger exposure and health studies, there is a need for validation studies of the ELISA assay for quantification of cypermethrin and its metabolites in urine.
Keywords: attitudes, behavior, beliefs, biological monitoring, personal protective
ISI Document Delivery No.: 829QD

160. Budd, Robert; O'geen, Anthony; Goh, Kean S; Bondarenko, Svetlana; Gan, Jay, and Budd, Robert. Efficacy of Constructed Wetlands in Pesticide Removal From Tailwaters in the Central Valley, California. 2009 Mar 17; 43, (8): 2925-2930.

Rec #: 44929
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pollutants in agricultural irrigation return flow (tailwater) constitute a significant nonpoint source of pollution in intensive agricultural regions such as the Central Valley of California. Constructed wetlands (CWs) represent a feasible mitigation option to remove pollutants including pesticides in the tailwater. In this study, we evaluated two CWs in the Central Valley for their performance in removing pyrethroid and organophosphate insecticides under field-scale production conditions. Both CWs were found to be highly effective in reducing pyrethroid concentrations in the tailwater, with season-average concentration reductions ranging from 52 to 94%. The wetlands also reduced the flow volume by 68-87%, through percolation and evapotranspiration. When both concentration and volume reductions were considered, the season-average removal of pyrethroids ranged from 95 to 100%. The primary mechanism for pyrethroid removal was through sedimentation of pesticide-laden particles, which was influenced by hydraulic residence time and vegetation density. Temporal analysis indicates a potential efficiency threshold during high flow periods. The season-average removal of chlorpyrifos ranged 52-61%. The wetlands, however, were less effective at removing diazinon, likely due to its limited sorption to sediment particles. Analysis of pesticide partitioning showed that pyrethroids were enriched on suspended particles in the tailwater. Monitoring of pesticide association with suspended solids and bed sediments suggested an increased affinity of pyrethroids for lighter particles with the potential to move further downstream before subject to sedimentation. Results from this study show that flow-through CWs, when properly designed, are an effective practice for mitigating hydrophobic pesticides in the irrigation tailwater.
Keywords: Hydraulics
Keywords: Organophosphates
Keywords: Artificial wetlands
Keywords: intensive farming
Keywords: Particulates
Keywords: Aqualine Abstracts; Pollution Abstracts; Environment Abstracts; Water Resources Abstracts
Keywords: Artificial Wetlands
Keywords: mitigation
Keywords: Insecticides
Keywords: Agricultural Chemicals
Keywords: Wetlands
Keywords: USA, California
Keywords: Pyrethroids
Keywords: Sedimentation
Keywords: Sorption
Keywords: Sediment pollution
Keywords: Tailwater
Keywords: Irrigation
Keywords: Nonpoint Pollution Sources
Keywords: Vegetation
Keywords: Evapotranspiration
Keywords: AQ 00003:Monitoring and Analysis of Water and Wastes
Keywords: Suspended particulate matter
Keywords: Nonpoint pollution
Keywords: ENA 06:Food & Drugs
Keywords: Chlorpyrifos
Keywords: SW 1030:Use of water of impaired quality
Keywords: Pesticides
Keywords: Irrigation-return Flow
Keywords: Diazinon
Keywords: USA, California, Central Valley
Date revised - 2010-08-01
Language of summary - English
Location - USA, California; USA, California, Central Valley
Pages - 2925-2930
ProQuest ID - 754541534
SubjectsTermNotLitGenreText - Sediment pollution; Hydraulics; Sorption; Organophosphates; Artificial wetlands; Irrigation; Vegetation; Evapotranspiration; Suspended particulate matter; intensive farming; Particulates; Nonpoint pollution; Chlorpyrifos; mitigation; Insecticides; Pesticides; Pyrethroids; Sedimentation; Diazinon; Tailwater; Agricultural Chemicals; Nonpoint Pollution Sources; Wetlands; Irrigation-return Flow; Artificial Wetlands; USA, California; USA, California, Central Valley
Last updated - 2012-12-03
British nursing index edition - Environmental Science & Technology [Environ. Sci. Technol.]. Vol. 43, no. 8, pp. 2925-2930. 17 Mar 2009.
Corporate institution author - Budd, Robert; O'Geen, Anthony; Goh, Kean S; Bondarenko, Svetlana; Gan, Jay
DOI - e0d9e2f6-7c9d-47ac-a59ccsamfg201; 13267221; 0013-936X English

161. ---. Removal Mechanisms and Fate of Insecticides in Constructed Wetlands. 2011 Jun; 83, (11): 1581-1587.

Rec #: 43289
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Constructed wetlands (CWs), along with other vegetative systems, are increasingly being promoted as a mitigation practice to treat non-point source runoff to reduce contaminants such as pesticides. However, studies so far have mostly focused on demonstrating contaminant removal efficiency. In this study, using two operational CWs located in the Central Valley of California, we explored the mechanisms underlying the removal of pyrethroids and chlorpyrifos from agricultural runoff water, and further evaluated the likelihood for the retained pesticides to accumulate within the CWs over time. In the runoff water passing through the CWs, pyrethroids were associated overwhelmingly with suspended solids >0.7 mu m, and the sorbed fraction accounted for 38-100% of the total concentrations. The derived K sub(d) values for the suspended solids were in the order of 10 super(4)-10 super(5), substantially greater than those reported for bulk soils and sediments. Distribution of pyrethroids in the wetland sediments was found to mimic organic carbon distribution, and was enriched in large particles that were partially decomposed plant materials, and clay-size particles (250 mu m) and the very fine particles, is thus essential in removing pyrethroids and chlorpyrifos in CWs. Under flooded and anaerobic conditions, most pyrethroids and chlorpyrifos showed moderate persistence, with DT50 values between 106-353d. However, the retained pyrethroids were very stable in dry and aerobic sediments between irrigation seasons, suggesting a possibility for accumulation over time. Therefore, the long-term ecological risks of CWs should be further understood before their wide adoption.
Keywords: Suspended solids
Keywords: Pollutant removal
Keywords: Irrigation
Keywords: Artificial wetlands
Keywords: Environment Abstracts; Pollution Abstracts; Toxicology Abstracts
Keywords: Adoption
Keywords: Particulates
Keywords: Anaerobic conditions
Keywords: Sediments
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Environmental Studies
Keywords: Chlorpyrifos
Keywords: Soil
Keywords: Insecticides
Keywords: Carbon
Keywords: Pesticides
Keywords: Wetlands
Keywords: USA, California
Keywords: Contaminants
Keywords: Pyrethroids
Keywords: X 24330:Agrochemicals
Keywords: USA, California, Central Valley
Keywords: Runoff
Date revised - 2011-10-01
Language of summary - English
Location - USA, California; USA, California, Central Valley
Pages - 1581-1587
ProQuest ID - 886117164
SubjectsTermNotLitGenreText - Irrigation; Adoption; Anaerobic conditions; Sediments; Chlorpyrifos; Soil; Carbon; Insecticides; Pesticides; Wetlands; Pyrethroids; Contaminants; Runoff; Pollutant removal; Suspended solids; Artificial wetlands; Particulates; USA, California; USA, California, Central Valley
Last updated - 2011-12-09
Corporate institution author - Budd, Robert; O'geen, Anthony; Goh, Kean S; Bondarenko, Svetlana; Gan, Jay
DOI - OB-e85b63bf-8148-4684-91f4csaobj201; 14893535; 0045-6535 English

162. Budd, Robert Livingston and Gan, Jianying. Constructed Wetlands as a Mitigation Strategy to Reduce Pesticide Loads in Agricultural Tailwater. 2009: (UMI# 3389647 ).

Rec #: 51829
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pyrethroid and organophosphate pesticides have been found in numerous waterways throughout the United States. Monitoring studies within the San Diego Creek watershed in Orange County, California, confirmed that runoff from agricultural fields are a primary contributor to pesticide loads within these waterways. As a mitigation option for non-point pesticide pollution, constructed wetlands were investigated in this study to reduce pesticide loading in agricultural tailwaters. Multiple wetlands located along the San Joaquin River in the Stanilaus County were observed over two consecutive irrigation seasons. The wetlands were found to be very effective at reducing pyrethroid concentrations (52-100%) and moderately effective at reducing chlorpyrifos concentrations (52-61%) under two flow regimes, with loads reduced by 95-100% in the outgoing water. Vertical transport of pyrethroids was found to be negligible, and less than 10% of chlorpyrifos was found to leach below 16 cm in the wetland floors. A significant increase in removal efficiencies between seasons within one portion of the wetland was observed, and was attributed to a dramatic increase in vegetation and decreased flow rates. Pyrethroids overwhelmingly sorbed to suspended solids greater than 0.7 μm (62-93%), with resulting apparent partitioning coefficients (K d a ) ranging from 1.9 × 104 to 3.1 × 105 . The freely dissolved concentrations of permethrin represented approximately 26-39% of its total mass in water samples with a decreasing trend in concentrations toward the outlet, signaling a decrease in the bioavailable fraction in the outgoing flow. Pesticide concentrations mimicked organic carbon content of the deposited sediment particle fractions. The highest concentrations were associated with larger particles comprised of aggregates of organic and decomposed plant material, which are less susceptible to sedimentation. This observation helps explain why the sediment basin was not effective at removing pesticides from the tailwater. Effective wetland lengths (L 1/2 ) necessary to reduce pesticide concentrations by 50% were estimated to be less than 100 m for cyhalothrin, cypermethrin and permethrin under low flow (0.03 m3 s -1 ), but reaching 267 m under high flow conditions (0.07 m -3 s-1 ). The degradation studies indicate that the pesticides have the potential for persisting within the wetland system between irrigation seasons. While the half-lives of λ-cyhalothrin, cypermethrin, esfenvalerate, and permethrin were less than 1 yr (r2 > 0.48) under anaerobic conditions, no detectable dissipation occurred for most pesticides in situ during the dry season. Bifenthrin was found to be relatively stable in all sediments, indicating its potential for prolonged persistence within the wetland systems. The results from this study indicate that constructed wetlands may act as a sink for most pyrethroids, and the removal is achieved through sedimentation and sediment trapping by vegetation and gravity. However, accumulation of pesticides over time, and the associated environmental risks of the accumulated pesticide residues, should be further understood if constructed wetlands are to be widely used as a management practice.
Start Page: 167
ISSN/ISBN: 9781109564372
Keywords: 0768:Environmental science
Keywords: Mitigation
Keywords: Degradation
Keywords: Pesticides
Keywords: Constructed wetlands
Keywords: Health and environmental sciences
Keywords: Agricultural tailwater
Constructed wetlands
Copyright ProQuest, UMI Dissertations Publishing 2009
Budd, Robert Livingston
0768: Environmental science
Health and environmental sciences
Agricultural tailwater English

163. Buratti, S.; Fabbri, E.; Bacchi, S., and Pasteris, A. Combined Effects of Salinity and Chlorpyrifos on the Earthworm Eisenia andrei. Univ Bologna, CIRSA, I-40126 Bologna, Italy//: 2012; 163, (1): S6(ABS).

Rec #: 2440
Keywords: ABSTRACT
Call Number: NO ABSTRACT (CPY)
Notes: Chemical of Concern: CPY

164. Buratti, S. ; Fabbri, E.; Bacchi, S., and Pasteris, A. Combined effects of salinity and chlorpyrifos on the earthworm Eisenia andrei: 28th Congress - European Society for Comparative Physiology and Biochemistry - Cellular and molecular mechanisms for physiological adaptation to multiple stress Bilbao, 2-5 September 2012. 2012 Sep; 163, Supplement, (0): S6.

Rec #: 2490
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY

165. Burbacher, Thomas M.; Cole, Toby B.; Fisher, Jenna; Park, Sarah; Hong, Sungwoo; Griffith, William C., and Faustman, Elaine M. Outcome in mice exposed in utero to chlorpyrifos. 2010; 32, (4): 504.

Rec #: 2560
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY

166. Burns, K. A. and Vanden Heuvel, J. P. Modulation of Ppar Activity Via Phosphorylation.

Rec #: 51419
Notes: Chemical of Concern: CPY
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ABSTRACT: Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of transcription factors that respond to specific ligands by altering gene expression in a cell-, developmental- and sex-specific manner. Three subtypes of this receptor have been discovered (PPARalpha, beta and gamma), each apparently evolving to fulfill different biological niches. PPARs control a variety of target genes involved in lipid homeostasis, diabetes and cancer. Similar to other nuclear receptors, the PPARs are phosphoproteins and their transcriptional activity is affected by cross-talk with kinases and phosphatases. Phosphorylation by the mitogen-activated protein kinases (ERK- and p38-MAPK), Protein Kinase A and C (PKA, PKC), AMP Kinase (AMPK) and glycogen synthase kinase-3 (GSK3) affect their activity in a ligand-dependent or -independent manner. The effects of phosphorylation depend on the cellular context, receptor subtype and residue metabolized which can be manifested at several steps in the PPAR activation sequence including ligand affinity, DNA binding, coactivator recruitment and proteasomal degradation. The review will summarize the known PPAR kinases that directly act on these receptors, the sites affected and the result of this modification on receptor activity.
MESH HEADINGS: Cyclic AMP-Dependent Protein Kinases/metabolism
MESH HEADINGS: Extracellular Signal-Regulated MAP Kinases/metabolism
MESH HEADINGS: Growth Substances/physiology
MESH HEADINGS: Mitogen-Activated Protein Kinase Kinases/metabolism
MESH HEADINGS: PPAR alpha/metabolism
MESH HEADINGS: PPAR delta/metabolism
MESH HEADINGS: PPAR gamma/metabolism
MESH HEADINGS: PPAR-beta/metabolism
MESH HEADINGS: Peroxisome Proliferator-Activated Receptors/*metabolism
MESH HEADINGS: Phosphorylation
MESH HEADINGS: Signal Transduction
MESH HEADINGS: Transcription Factors/metabolism eng

167. Butchi, N. B.; Woods, T.; Du, M.; Morgan, T. W., and Peterson, K. E. Tlr7 and Tlr9 Trigger Distinct Neuroinflammatory Responses in the Cns .

Rec #: 50089
Notes: Chemical of Concern: CPY
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ABSTRACT: Toll-like receptors (TLRs) 7 and 9 recognize nucleic acid determinants from viruses and bacteria and elicit the production of type I interferons and proinflammatory cytokines. TLR7 and TLR9 are similar regarding localization and signal transduction mechanisms. However, stimulation of these receptors has differing effects in modulating viral pathogenesis and in direct toxicity in the central nervous system (CNS). In the present study, we examined the potential of the TLR7 agonist imiquimod and the TLR9 agonist cytosine-phosphate-guanosine oligodeoxynucleotide (CpG-ODN) to induce neuroinflammation after intracerebroventricular inoculation. CpG-ODN induced a more robust inflammatory response than did imiquimod after inoculation into the CNS, with higher levels of several proinflammatory cytokines and chemokines. The increase in cytokines and chemokines correlated with breakdown of the blood-cerebrospinal fluid barrier and recruitment of peripheral cells to the CNS in CpG-ODN-inoculated mice. In contrast, TLR7 agonists induced a strong interferon β response in the CNS but only low levels of other cytokines. The difference in response to these agonists was not due to differences in distribution or longevity of the agonists but rather was correlated with cytokine production by choroid plexus cells. These results indicate that despite the high similarity of TLR7 and TLR9 in binding nucleic acids and inducing similar downstream signaling, the neuroinflammation response induced by these receptors differs dramatically due, at least in part, to activation of cells in the choroid plexus.
MESH HEADINGS: Animals, Newborn
MESH HEADINGS: Brain/metabolism/pathology
MESH HEADINGS: Central Nervous System/*metabolism
MESH HEADINGS: Chemokines/metabolism
MESH HEADINGS: Choroid Plexus/metabolism
MESH HEADINGS: Cytokines/metabolism
MESH HEADINGS: Immunohistochemistry/methods
MESH HEADINGS: In Situ Hybridization
MESH HEADINGS: Inflammation/*metabolism
MESH HEADINGS: Mice, Transgenic
MESH HEADINGS: Real-Time Polymerase Chain Reaction/methods
MESH HEADINGS: Toll-Like Receptor 7/*metabolism
MESH HEADINGS: Toll-Like Receptor 9/*metabolism eng

168. Buzanska, Leonora; Sypecka, Joanna; Nerini-Molteni, Silvia; Compagnoni, Anna; Hogberg, Helena T; Del Torchio, Riccardo; Domanska-Janik, Krystyna; Zimmer, Jens, and Coecke, Sandra. A Human Stem Cell-Based Model for Identifying Adverse Effects of Organic and Inorganic Chemicals on the Developing Nervous System. 2009 Oct; 27, (10): 2591-2601.

Rec #: 44599
Notes: Chemical of Concern: CPY
Abstract: Abstract: The aim of our study was to investigate whether a human neural stem cell line derived from umbilical cord blood (HUCB-NSC) can serve as a reliable test model for developmental neurotoxicity (DNT). We assessed the sensitivity of HUCB-NSCs at different developmental stages to a panel of neurotoxic (sodium tellurite, methylmercury chloride, cadmium chloride, chlorpyrifos, and L-glutamate) and non-neurotoxic (acetaminophen, theophylline, and D-glutamate) compounds. In addition, we investigated the effect of some compounds on key neurodevelopmental processes like cell proliferation, apoptotic cell death, and neuronal and glial differentiation. Less differentiated HUCB-NSCs were generally more sensitive to neurotoxicants, with the notable exception of L-glutamate, which showed a higher toxicity to later stages. The relative potencies of the compounds were: cadmium chloride > methylmercury chloride >> chlorpyrifos >> L-glutamate. Fifty nanomolar methylmercury chloride (MeHgCl) inhibited proliferation and induced apoptosis in early-stage cells. At the differentiated stage, 1 muM MeHgCl induced selective loss of S100 beta-expressing astrocytic cells. One millimolar L-glutamate did not influence the early stages of HUCB-NSC development, but it affected late stages of neuronal differentiation. A valuable system for in vitro DNT assessment should be able to discriminate between neurotoxic and non-neurotoxic compounds and show different susceptibilities to chemicals according to developmental stage and cell lineage. Although not exhaustive, this work shows that the HUCB-NSC model fulfils these criteria and may serve as a human in vitro model for DNT priority setting.
Keywords: 2921-88-2
Keywords: Sensitivity and Specificity
Keywords: Nerve Growth Factors -- metabolism
Keywords: Glutamic Acid
Keywords: Neurons -- drug effects
Keywords: Humans
Keywords: Nervous System -- drug effects
Keywords: S100 Proteins -- analysis
Keywords: Nerve Growth Factors
Keywords: Biological Markers -- analysis
Keywords: S100 Proteins
Keywords: S-100 calcium-binding protein beta subunit
Keywords: Methylmercury Compounds
Keywords: Apoptosis -- drug effects
Keywords: Toxicity Tests -- methods
Keywords: Nervous System -- growth & development
Keywords: S100 Proteins -- metabolism
Keywords: 10108-64-2
Keywords: Cell Differentiation -- drug effects
Keywords: Fetal Blood -- cytology
Keywords: Cell Proliferation -- drug effects
Keywords: Embryonic Stem Cells -- cytology
Keywords: Neurons -- metabolism
Keywords: RWZ4L3O1X0
Keywords: Dose-Response Relationship, Drug
Keywords: Nerve Growth Factors -- analysis
Keywords: Predictive Value of Tests
Keywords: Neuroglia -- drug effects
Keywords: 56-86-0
Keywords: Neurotoxins -- toxicity
Keywords: Methylmercury Compounds -- toxicity
Keywords: Cadmium Chloride
Keywords: Neuroglia -- metabolism
Keywords: Chlorpyrifos
Keywords: Embryonic Stem Cells -- drug effects
Keywords: Embryonic Stem Cells -- metabolism
Keywords: Glutamic Acid -- toxicity
Keywords: 0
Keywords: Chlorpyrifos -- toxicity
Keywords: Cell Differentiation -- physiology
Keywords: methylmercuric chloride
Keywords: Cadmium Chloride -- toxicity
Keywords: Neurotoxins
Keywords: Cell Line
Keywords: Biological Markers
Keywords: Biological Markers -- metabolism
Date completed - 2010-02-17
Date created - 2009-11-03
Date revised - 2012-12-20
Language of summary - English
Pages - 2591-2601
ProQuest ID - 734123032
Last updated - 2013-01-19
British nursing index edition - Stem cells (Dayton, Ohio), October 2009, 27(10):2591-2601
Corporate institution author - Buzanska, Leonora; Sypecka, Joanna; Nerini-Molteni, Silvia; Compagnoni, Anna; Hogberg, Helena T; del Torchio, Riccardo; Domanska-Janik, Krystyna; Zimmer, Jens; Coecke, Sandra
DOI - MEDL-19609937; 19609937; 1549-4918 eng

169. Buznikov, G. A.; Nikitina, L. A.; Bezuglov, V. V.; Milosevic, I.; Lazarevic, L.; Rogac, L.; Ruzdijic, S.; Slotkin, T. A., and Rakic, L. M. Sea urchin embryonic development provides a model for evaluating therapies against beta-amyloid toxicity. 2008; 75, (1): 94-100.

Rec #: 57259
Notes: Chemical of Concern: CPY
Abstract: Abstract: Accumulation of P-amyloid protein is an Alzheimer's disease hallmark but also may be mechanistically involved in neurodegeneration. One of its cleavage peptides, A beta 42, has been used to evaluate the mechanisms underlying amyloid-induced cytotoxicity and targeting of acetylcholine systems. We studied Sphaerechinus granularis sea urchin embryos which utilize acetylcholine and other neurotransmitters as morphogens. At a threshold concentration of 0.1 mu M A beta 42, there was damage to the larval skeleton, accumulation of ectodermal cells in the blastocoele and underdevelopment of larval arms. Raising the A beta 42 concentration to 0.2-0.4 mu M produced anomalies depending on the stage at which A beta 42 was introduced: at the first cleavage divisions, abnormalities appeared within 1-2 cell cycles; at the mid-blastula stage, the peak period of sensitivity to A beta 42, gastrulation was blocked; at later stages, there was progressive damage to the larval skeleton, digestive tract and larval spicules, as well as regression of larval arms. Each of these anomalies could be offset by the addition of lipid-permeable analogs of acetylcholine (arachidonoyl dimethylaminoethanol), serotonin (arachidonoyl serotonin) and cannabinoids (arachidonoyl vanillylamine), with the greatest activity exhibited by the acetylcholine analog. These results indicate that sea urchin embryos provide a model suitable to characterize the mechanisms underlying the cytotoxicity of A beta 42, as well as providing a system that enables the rapid screening of potential therapeutic interventions. The protection provided by neurotransmitter analogs, especially that for acetylcholine, points to unsuspected advantages of existing therapies that enhance cholinergic function, as well as indicating novel approaches that may prove protective in Alzheimer's disease. (C) 2007 Elsevier Inc. All rights reserved.
Keywords: acetylcholine, Alzheimer's disease, beta-amyloid, cannabinoids,
ISI Document Delivery No.: 253AO

170. Buznikov, Gennady a; Nikitina, Lyudmila a; Seidler, Frederic J; Slotkin, Theodore a; Bezuglov, Vladimir V; Miloseviä‡, Ivan; Lazareviä‡, Lidija; Rogac, Ljubica; Ruzdijiä‡, Sabera, and Rakiä‡, Ljubisa M. Amyloid Precursor Protein 96-110 and Beta-Amyloid 1-42 Elicit Developmental Anomalies in Sea Urchin Embryos and Larvae That Are Alleviated by Neurotransmitter Analogs for Acetylcholine, Serotonin and Cannabinoids. 2008; 30, (6): 503-509.

Rec #: 45489
Notes: Chemical of Concern: CPY
Abstract: Abstract: Amyloid precursor protein (APP) is overexpressed in the developing brain and portions of its extracellular domain, especially
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