Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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extracts were assayed for genotoxic potential by Ames Salmonella/microsome test, DNA repair defective mutants, and bacteriophage lambda systems. The test samples exhibited significant mutagenicity with TA98, TA97a, and TA100 strains with the probable role of contaminating pesticides in the wastewater. However, XAD-concentrated samples were more mutagenic in both sites as compared to liquid-liquid-extracted samples. The damage in the DNA repair defective mutants in the presence of XAD-concentrated water samples were also found to be higher to that of liquid-liquid-extracted water samples at the dose level of 20 muL/mL culture. All the mutants invariably exhibited significant decline in their colony-forming units as compared to their isogenic wild-type counterparts. The survival was decreased by 81.7 and 75.5% in polA(-) strain in site I, and 76.0 and 73.5% in site II in polA(-) under the same experimental conditions after 6 h of treatment with XAD-concentrated and liquid-liquid-extracted samples, respectively. A significant decrease in the survival of bacteriophage lambda was also observed when treated with the test samples. Copyright 2008 Wiley Periodicals, Inc.
Keywords: Pesticides -- analysis
Keywords: Mutagens
Keywords: Soil Pollutants -- toxicity
Keywords: Escherichia coli K12 -- physiology
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Bacteriophage lambda -- genetics
Keywords: Water Pollutants, Chemical -- toxicity
Keywords: Salmonella typhimurium -- drug effects
Keywords: Pesticides -- toxicity
Keywords: India
Keywords: Soil Pollutants
Keywords: Escherichia coli K12 -- genetics
Keywords: Microbial Viability
Keywords: Water Pollutants, Chemical
Keywords: Bacteriophage lambda -- drug effects
Keywords: Salmonella typhimurium -- genetics
Keywords: Chromatography, Gas
Keywords: Escherichia coli K12 -- drug effects
Keywords: Chemical Fractionation
Keywords: Mutagens -- toxicity
Keywords: Salmonella typhimurium -- physiology
Keywords: Bacteriophage lambda -- physiology
Keywords: DNA Repair -- drug effects
Keywords: Soil Pollutants -- analysis
Keywords: DNA Damage -- drug effects
Keywords: Industrial Waste
Keywords: Mutagenicity Tests
Keywords: 0
Keywords: Mutagens -- analysis
Keywords: Waste Disposal, Fluid
Keywords: Pesticides
Keywords: Environmental Monitoring -- methods
Date completed - 2009-05-26
Date created - 2009-03-18
Date revised - 2012-12-20
Language of summary - English
Pages - 103-115
ProQuest ID - 67040265
Last updated - 2013-01-19
British nursing index edition - Environmental toxicology, April 2009, 24(2):103-115
Corporate institution author - Ansari, Mohd Ikram; Malik, Abdul
DOI - MEDL-18442071; 18442071; 1522-7278 eng

52. Anwar, Samina; Liaquat, Fauzia; Khan, Qaiser M; Khalid, Zafar M, and Iqbal, Samina. Biodegradation of Chlorpyrifos and Its Hydrolysis Product 3,5,6-Trichloro-2-Pyridinol by Bacillus Pumilus Strain C2a1. 2009 Aug 30; 168, (1): 400-405.


Rec #: 41059
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: Abstract: A bacterial strain C2A1 isolated from soil was found highly effective in degrading chlorpyrifos and its first hydrolysis metabolite 3,5,6-trichloro-2-pyridinol (TCP). On the basis of morphology, physiological characteristics, biochemical tests and 16S rRNA sequence analysis, strain C2A1 was identified as Bacillus pumilus. Role of strain C2A1 in the degradation of chlorpyrifos was examined under different culture conditions like pH, inoculum density, presence of added carbon/nutrient sources and pesticide concentration. Chlorpyrifos was utilized by strain C2A1 as the sole source of carbon and energy as well as it was co-metabolized in the presence of glucose, yeast extract and nutrient broth. Maximum pesticide degradation was observed at high pH (8.5) and high inoculum density when chlorpyrifos was used as the sole source and energy. In the presence of other nutrients, chlorpyrifos degradation was enhanced probably due to high growth on easily metabolizable compounds which in turn increased degradation. The strain C2A1 showed 90% degradation of TCP (300 mg L(-1)) within 8 days of incubation.
Keywords: 2921-88-2
Keywords: Insecticides -- metabolism
Keywords: Pyridones -- metabolism
Keywords: Bacillus -- metabolism
Keywords: 6515-38-4
Keywords: Hydrolysis
Keywords: Chlorpyrifos
Keywords: Pesticides -- metabolism
Keywords: 3,5,6-trichloro-2-pyridinol
Keywords: Insecticides
Keywords: 0
Keywords: Pyridones
Keywords: Pesticides
Keywords: Biodegradation, Environmental
Keywords: Chlorpyrifos -- metabolism
Date completed - 2009-08-05
Date created - 2009-06-05
Date revised - 2012-12-20
Language of summary - English
Pages - 400-405
ProQuest ID - 67322241
Last updated - 2013-01-19
British nursing index edition - Journal of hazardous materials, August 30, 2009, 168(1):400-405
Corporate institution author - Anwar, Samina; Liaquat, Fauzia; Khan, Qaiser M; Khalid, Zafar M; Iqbal, Samina
DOI - MEDL-19297093; 19297093; 1873-3336 eng

53. Anwar, T.; Ahmad, I., and Tahir, S. DETERMINATION OF PESTICIDE RESIDUES IN FRUITS OF NAWABSHAH DISTRICT, SINDH, PAKISTAN. 2011; 43, (2): 1133-1139.


Rec #: 55789
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: Eight fruit samples of apple, guava, orange, grapes, pear, persimmon, banana and pear purchased from the local markets of Nawabshah district, Sindh and residues of pesticide of organophosphate (OP), pyrethroid and organochlorine (OC) (i.e., dichlorvos, fenvalerate, dimethoate, methyl parathion, fenitrothion, cypermethrin, endosulfan, deltamethrin, mevinphos, chlorpyriphos, profenofos and dicofol) were monitored in fruit samples by Gas Chromatography (GC). All the fruit samples were found contaminated except banana and among these only apple samples were found exceeding the maximum residue limits (MRL) of Codex Alimentarius Commission.
Keywords: VEGETABLES, ORGANOCHLORINE, EXPOSURE, FOOD
ISI Document Delivery No.: 750KY

54. Anwar, Tahir ; Ahmad, Imtiaz; Tahir, Seema, and Anwar, Tahir. Determination of Pesticide Residues in Soil of Nawabshah District, Sindh, Pakistan. 2012 Feb; 44, (1).


Rec #: 46899
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pesticide residues of organophosphate (OP) and organochlorine (OC) of most commonly used classes were monitored in soil samples collected from cotton growing areas in Nawabshah district, Sindh. All the 19 soil samples presently analyzed were found contaminated with used pesticides (i.e. dichlorvos, dimethoate, methyl parathion, fenitrothion, endosulfan, mevinphos, chlorpyriphos and profenofos) and the varying degree of concentration and frequency were found in the top soil. The most widely detected pesticide was chlorpyriphos found in 16 samples with mean concentration of 0.486 mg kg super(-1). Endosulfan was the second most often detected pesticide investigated in 15 samples containing the mean concentrations of 0.426 mg kg super(-1). Dimethoate was the third most detected pesticide in 14 samples with mean concentration of 0.555 mg kg super(-1).
Keywords: Pakistan
Keywords: Zoology
Keywords: Cotton
Keywords: Organochlorine compounds
Keywords: Pesticide residues
Keywords: Organophosphates
Keywords: P 5000:LAND POLLUTION
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Endosulfan
Keywords: Soil
Keywords: Pakistan, Sindh
Keywords: Pollution Abstracts; Environment Abstracts
Keywords: Dimethoate
Keywords: Dichlorvos
Date revised - 2012-10-01
Language of summary - English
Location - Pakistan, Sindh; Pakistan
ProQuest ID - 1125225668
SubjectsTermNotLitGenreText - Soil; Organochlorine compounds; Cotton; Zoology; Organophosphates; Pesticide residues; Dimethoate; Dichlorvos; Endosulfan; Pakistan, Sindh; Pakistan
Last updated - 2012-12-14
British nursing index edition - Pakistan Journal of Zoology [Pak. J. Zool.]. Vol. 44, no. 1, [np]. Feb 2012.
Corporate institution author - Anwar, Tahir; Ahmad, Imtiaz; Tahir, Seema
DOI - 41e489fd-05f1-45ad-82a3mfgefd108; 17259100; 0030-9923 English

55. Anyusheva, M.; Lamers, M.; Schwadorf, K., and Streck, T. Analysis of pesticides in surface water in remote areas in Vietnam: Coping with matrix effects and test of long-term storage stability. 2012; 92, (7): 797-809.


Rec #: 55799
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: During the last years, the increased use of pesticides and growing awareness of associated environmental and health problems have led to the implementation of various monitoring programmes in South-East Asia. The introduction of numerous new active ingredients and commercial pesticide formulations in connection with reports on pesticide-related health problems strongly indicate that the analytical procedures should be tested and evaluated for currently used pesticides. Coping with matrix effects and ensuring pesticide stability when samples are taken in remote areas are paramount. In the present study, we tested an analytical method that targets nine currently used pesticides in surface water in northern Vietnam. The method consists of solid phase extraction, storage at -18 degrees C in the adsorbed state, and capillary gas chromatography with nitrogen-phosphorus-detection of five insecticides (dichlorvos, fenobucarb, dimethoate, fenitrothion, and chlorpyrifos), three fungicides (chlorothalonil, metalaxyl, and edifenphos) and one herbicide (atrazine). We evaluated the potential analytical bias caused by matrix effect and investigated its possible causes. We also tested the long-term stability (up to 9 months) of pesticides adsorbed to Carbopack SPE cartridges when stored at temperatures below -18 degrees C. Adopting a matrix-matched calibration technique considerably improved the recovery values of seven of the nine tested pesticides. At spiking levels of 0.1 mu g L(-1) and 1 mu g L(-1) and after storage of 119 days at -18 degrees C, recovery values of these pesticides ranged from 67% to 107% and from 67% to 155%, respectively. For the remaining two pesticides recovered at 53-55% at both spiking levels - dichlorvos and chlorothalonil - the method could still be useful for semi-quantitative analysis or as a screening tool. Even though the general recommendation is to minimise storage time to reduce pesticides degradation, our results showed that storage times up to nine months can be adopted for atrazine, metalaxyl, fenitrothion, and chlorpyrifos.
Keywords: pesticide analysis, matrix effect, SPE, storage stability, water matrix
ISI Document Delivery No.: 942JD

56. Aozowicka, B ; Jankowska, M; Kaczynski, P, and aozowicka, B . Pesticide Residues in Brassica Vegetables and Exposure Assessment of Consumers. 2012 Jun; 25, (2): 561-575.


Rec #: 42729
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: The presence of pesticide residues in Brassica vegetables (365 samples) produced in north-eastern Poland (2006-2009) was determined and their health risks assessed. The analytical procedure was developed to examine of 130 pesticides of different chemical classes (chloroorganic, phosphoroorganic, carbamates, strobilurines, neonicotinoids, amides, pyrimidines, benzimidazoles, imidazoles and triazoles) in broccoli, Brussels sprouts, cauliflower, head and Chinese cabbage. Pesticides were extracted using matrix solid phase dispersion (MSPD) and analyzed by gas chromatography (GC) with dual detection system: electron capture (ECD) and nitrogen-phosphorus (NPD). Linearity (R2 greater than or equal to 0.997) was good over the concentration range from 2.5 to 0.001 mg/kg for all the pesticides, and instrumental detection limits ranged from 0.001 to 0.01 mg/kg. Mean recoveries for vegetables spiked at three fortification levels (0.001-2.5 mg/kg) ranged from 70.07 to 118.90%. Relative standard deviations ranged from 0.15 to 8.58%, except: dicofol, pyridaben (acaricides), dichloran (fungicide), isofenphos, triasophos (insecticides) where mean recoveries were above 120% (122.2-127%) and also dichlofluanid, tecnazene (fungicides), dichlobenil (herbicide), endosulfan-sulfate, phorate, phosmet (insecticides) with mean recoveries below 70% (42.83-69.1%). The method used to monitor pesticide residues in vegetables. Fifteen different pesticides (insecticides mainly) were detected in 118 samples (32%), while multiple pesticides (more than one pesticide residue) in about 4% samples. Chlorpyrifos and cypermethrin were the most commonly detected pesticides. Chlorpyrifos was present in 27.4% items and ranged from 0.005 to 1.51 mg/kg, while cypermethrin were detected in 3.3% samples and ranged from 0.02 to 0.19 mg/kg. Thirty-three (9%) samples exceeded the maximum residue levels (MRLs). The dietary intake of residues of some pesticides can pose acute hazards. Data obtained were then used for estimating the potential health risks associated with the exposures to these pesticides. The estimated daily intakes (EDIs) ranged from 0.005% of the ADI (acceptable daily intake) for fenhexamid to 4.454% of the ADI for diazinon. Combine cumulative exposure for chlorpyrifos detected on Brassica were 0.777% of ADI. The results show that occurrence of pesticide residues in Brassica vegetables from this region could not be considered a serious public health problem. Nevertheless, an investigation into continuous monitoring and tighter regulation of pesticide residues in vegetables is recommended.
Keywords: Diets
Keywords: Cypermethrin
Keywords: Pesticide residues
Keywords: Risk Abstracts; Health & Safety Science Abstracts
Keywords: Brassica
Keywords: Public health
Keywords: Chlorpyrifos
Keywords: Health risks
Keywords: Insecticides
Keywords: Poland
Keywords: H 5000:Pesticides
Keywords: Pesticides
Keywords: Fungicides
Keywords: R2 23010:General: Models, forecasting
Date revised - 2012-10-01
Language of summary - English
Location - Poland
Pages - 561-575
ProQuest ID - 1093454209
SubjectsTermNotLitGenreText - Diets; Chlorpyrifos; Health risks; Insecticides; Cypermethrin; Pesticide residues; Fungicides; Pesticides; Public health; Brassica; Poland
Last updated - 2012-12-14
British nursing index edition - Food Control [Food Control]. Vol. 25, no. 2, pp. 561-575. Jun 2012.
Corporate institution author - aozowicka, B; Jankowska, M; Kaczynski, P
DOI - 2f6ee060-8198-4764-be4acsamfg201; 16187606; 0956-7135 English

57. Aranzazu Taborda, D. A.; De Rodriguez, B.; Vieco Duran, B., and Restrepo Betancur, L. F. Effect of Chlorpyrifos 0,0-Dietil 0-(3, 5, 6-Tricloro-2-Piridil Fosforotioato) in Juvenile of Tilapia (Oreochromis spp.) Males (Efecto del Clorpirifos 0,0-Dietil 0-(3,5,6-Tricloro-2-Piridil Fosforotioato) en Machos Juveniles de Tilapia (Oreochromis spp.)). daranta7@gmail.com//Grupo de Investigacion Centauro, Docente, Escuela de Medicina Veterinaria, Facultad de Ciencias Agrarias, Universidad de Antioquia, Medellin, Colombia. //: 2012; 25, (2): 276-291(SPA) (ENG ABS).


Rec #: 2430
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

58. Arb Trialists Collaboration. Effects of Telmisartan, Irbesartan, Valsartan, Candesartan, and Losartan on Cancers in 15 Trials Enrolling 138,769 Individuals.


Rec #: 50019
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: COMMENTS: Comment in: Nat Rev Cardiol. 2011 May;8(5):243 (medline /21451473)
COMMENTS: Comment in: J Hypertens. 2013 Jan;31(1):217 (medline /23221944)
COMMENTS: Comment in: J Hypertens. 2011 Apr;29(4):653-4 (medline /21389812)
ABSTRACT: BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) reduce cardiovascular disease (CVD) events, but a recent meta-analysis of selected studies suggested that ARBs may increase cancer risks.
ABSTRACT: OBJECTIVE: Candesartan, irbesartan, telmisartan, valsartan, and losartan were assessed for incident cancers in 15 large parallel long-term multicenter double-blind clinical trials of these agents involving 138,769 participants.
ABSTRACT: PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months. Incident cancer cases were compared in patients randomized to ARBs versus controls. In five trials (n=42,403), the ARBs were compared to ACEi and in 11 trials (n=63,313) to controls without ACEi. In addition, in seven trials (n=47,020), the effect of ARBs with ACEi was compared to ACEi alone and in two trials ARBs with ACEi versus ARB alone (n=25,712).
ABSTRACT: RESULTS: Overall, there was no excess of cancer incidence with ARB therapy compared to controls in the 15 trials [4549 (6.16%) cases of 73,808 allocated to ARB versus 3856 (6.31%) of 61 106 assigned to non-ARB controls; odds ratio (OR) 1.00, 95% confidence interval (CI) 0.95-1.04] overall or when individual ARBs were examined. ORs comparing combination therapy with ARB along with ACEi versus ACEi was 1.01 (95% CI 0.94-1.10), combination versus ARB alone 1.02 (95% CI 0.91-1.13), ARB alone versus ACEi alone 1.06 (95% CI 0.97-1.16) and ARB versus placebo/control without ACEi 0.97 (95% CI 0.91-1.04). There was no excess of lung, prostate or breast cancer, or overall cancer deaths associated with ARB treatment.
ABSTRACT: CONCLUSION: There was no significant increase in the overall or site-specific cancer risk from ARBs compared to controls.
MESH HEADINGS: Angiotensin-Converting Enzyme Inhibitors/*adverse effects
MESH HEADINGS: Benzimidazoles/therapeutic use
MESH HEADINGS: Benzoates/therapeutic use
MESH HEADINGS: Biphenyl Compounds/therapeutic use
MESH HEADINGS: Case-Control Studies
MESH HEADINGS: Double-Blind Method
MESH HEADINGS: Humans
MESH HEADINGS: Hypertension/complications/*drug therapy
MESH HEADINGS: Losartan/therapeutic use
MESH HEADINGS: Neoplasms/*chemically induced
MESH HEADINGS: *Randomized Controlled Trials as Topic
MESH HEADINGS: Tetrazoles/therapeutic use eng

59. Arcury, T. A.; Grzywacz, J. G.; Talton, J. W.; Chen, H.; Vallejos, Q. M.; Galv, N. L; Barr, D. B., and Quandt, S. A. Repeated Pesticide Exposure Among North Carolina Migrant and Seasonal Farmworkers.


Rec #: 76809
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: COMMENTS: Cites: Am J Ind Med. 2009 Jul;52(7):539-50 (medline /19517490)
COMMENTS: Cites: Am J Ind Med. 2001 Nov;40(5):487-9 (medline /11675617)
COMMENTS: Cites: Am J Ind Med. 2008 Oct;51(10):782-94 (medline /18702096)
COMMENTS: Cites: Environ Health Perspect. 2008 May;116(5):687-94 (medline /18470300)
COMMENTS: Cites: J Expo Sci Environ Epidemiol. 2008 Mar;18(2):167-74 (medline /17495869)
COMMENTS: Cites: J Expo Sci Environ Epidemiol. 2007 Sep;17(6):559-66 (medline /17534384)
COMMENTS: Cites: Environ Health Perspect. 2007 Aug;115(8):1254-60 (medline /17687456)
COMMENTS: Cites: J Expo Sci Environ Epidemiol. 2007 Jul;17(4):321-30 (medline /17440487)
COMMENTS: Cites: Environ Health Perspect. 2007 May;115(5):792-8 (medline /17520070)
COMMENTS: Cites: Environ Health Perspect. 2006 Jul;114(7):999-1006 (medline /16835050)
COMMENTS: Cites: Environ Health Perspect. 2006 Jun;114(6):943-52 (medline /16759999)
COMMENTS: Cites: Environ Health Perspect. 2005 Dec;113(12):1802-7 (medline /16330368)
COMMENTS: Cites: Am J Ind Med. 1997 Sep;32(3):301-2 (medline /9219661)
COMMENTS: Cites: Anal Chem. 2004 May 1;76(9):2453-61 (medline /15117183)
COMMENTS: Cites: Annu Rev Public Health. 2004;25:155-97 (medline /15015917)
COMMENTS: Cites: Environ Health Perspect. 2004 Mar;112(3):382-7 (medline /14998757)
COMMENTS: Cites: Regul Toxicol Pharmacol. 2003 Aug;38(1):91-7 (medline /12878058)
COMMENTS: Cites: J Expo Anal Environ Epidemiol. 2003 May;13(3):203-10 (medline /12743614)
COMMENTS: Cites: Annu Rev Public Health. 2003;24:175-93 (medline /12359914)
COMMENTS: Cites: Am J Ind Med. 2001 Nov;40(5):490-501 (medline /11675618)
COMMENTS: Cites: J Agric Food Chem. 2008 Nov 26;56(22):10638-45 (medline /18947233)
ABSTRACT: BACKGROUND: Limited data document the multiple and repeated pesticide absorption experienced by farmworkers in an agricultural season or their risk factors.
ABSTRACT: METHODS: Data were collected from 196 farmworkers four times at monthly intervals in 2007. Urine samples were tested for 12 pesticide urinary metabolites. Questionnaire data provided measures of exposure risks.
ABSTRACT: RESULTS: Farmworkers had at least one detection for many pesticide urinary metabolites; for example, 84.2% had at least one detection for acephate, 88.8% for 3,5,6-trichloro-2-pyridinol. Most farmworkers had multiple detections for specific metabolites; for example, 64.8% had two or more detections for acephate, 64.8% for 3,5,6-trichloro-2-pyridinol, 79.1% for 3-phenoxybenzoic acid, and 86.7% for 2,4-dichlorophenoxyacetic acid. Housing type had a consistent significant association with metabolite detections.
ABSTRACT: CONCLUSIONS: Farmworkers are exposed to multiple pesticides across an agricultural season, and they experience repeated exposures to the same pesticides. Reducing farmworker pesticide exposure and delineating the health outcomes of this exposure require more detailed data. Am. J. Ind. Med. 53:802-813, 2010. (c) 2010 Wiley-Liss, Inc.
MESH HEADINGS: 2,4-Dichlorophenoxyacetic Acid/urine
MESH HEADINGS: Adolescent
MESH HEADINGS: Adult
MESH HEADINGS: Agriculture/*statistics &
MESH HEADINGS: numerical data
MESH HEADINGS: Benzoates/urine
MESH HEADINGS: Data Collection
MESH HEADINGS: Female
MESH HEADINGS: Health Status
MESH HEADINGS: Health Status Disparities
MESH HEADINGS: Humans
MESH HEADINGS: Male
MESH HEADINGS: Multivariate Analysis
MESH HEADINGS: /epidemiology
MESH HEADINGS: Occupational Diseases/*epidemiology/etiology/urine
MESH HEADINGS: Occupational Exposure/*adverse effects
MESH HEADINGS: Organothiophosphorus Compounds/urine
MESH HEADINGS: Pesticides/*toxicity/urine
MESH HEADINGS: Phosphoramides
MESH HEADINGS: Pyridones/urine
MESH HEADINGS: Questionnaires
MESH HEADINGS: Transients and Migrants/*statistics &
MESH HEADINGS: numerical data
MESH HEADINGS: Young Adult eng

60. Armes, M. N. ; Liew, Z.; Wang, A.; Wu, X. M.; Bennett, D. H.; Hertz-Picciotto, I., and Ritz, B. Residential Pesticide Usage in Older Adults Residing in Central California. 2011; 8, (8): 3114-3133.


Rec #: 55839
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Information on residential pesticide usage and behaviors that may influence pesticide exposure was collected in three population-based studies of older adults residing in the three Central California counties of Fresno, Kern, and Tulare. We present data from participants in the Study of Use of Products and Exposure Related Behaviors (SUPERB) study (N = 153) and from community controls ascertained in two Parkinson's disease studies, the Parkinson's Environment and Gene (PEG) study (N = 359) and The Center for Gene-Environment Studies in Parkinson's Disease (CGEP; N = 297). All participants were interviewed by telephone to obtain information on recent and lifetime indoor and outdoor residential pesticide use. Interviews ascertained type of product used, frequency of use, and behaviors that may influence exposure to pesticides during and after application. Well over half of all participants reported ever using indoor and outdoor pesticides; yet frequency of pesticide use was relatively low, and appeared to increase slightly with age. Few participants engaged in behaviors to protect themselves or family members and limit exposure to pesticides during and after treatment, such as ventilating and cleaning treated areas, or using protective equipment during application. Our findings on frequency of use over lifetime and exposure related behaviors will inform future efforts to develop population pesticide exposure models and risk assessment.
Keywords: pesticides, residential exposure, exposure-related behavior, lifetime
ISI Document Delivery No.: 811WP

61. Armitage, J. M.; Franco, A.; Gomez, S., and Cousins, I. T. Modeling the potential influence of particle deposition on the accumulation of organic contaminants by submerged aquatic vegetation. 2008; 42, (11): 4052-4059.


Rec #: 55849
Keywords: MODELING
Notes: Chemical of Concern: CPY
Abstract: Abstract: Submerged aquatic vegetation can act as both a mitigating factor (e.g., reducing downstream impacts of pesticides following runoff/spray drift) and mobilizing factor (e.g., remobilization of contaminants from sediments) influencing the fate and distribution of organic contaminants in the environment. Consequently, there has been wide scientific and regulatory interest in assessing the role of these plants in different contamination scenarios. Mechanistic models describing the environmental fate of contaminants in submerged aquatic vegetation are useful tools for interpreting laboratory and field measurements in addition to providing valuable information to risk assessors. In this study, we developed a fugacity-based model to investigate the influence of particle deposition to plant surfaces on the fate and distribution of two substances in small ponds. The main motivation for conducting this study was to address the fact that the potential contribution of this process is not typically considered by many types of models describing contaminant dynamics in submerged aquatic vegetation. For the hydrophobic substance included in this evaluation (lambda-cyhalothrin), model performance was greatly improved by including this process. The model was also applied in a generic context to compare the importance of particle deposition versus direct water uptake as a function of chemical properties (log K(0W)) and concentration of suspended solids in the water column. The generic application demonstrated that contaminant mass transfer is dominated by particle deposition for chemicals with log K(0W) greater than approximately 5.5-6 across a wide range of suspended solid concentrations and can be important even for low log K(0W) substances in some circumstances. Further empirical and modeling studies are recommended to explore this process more comprehensively.
Keywords: POLYCHLORINATED-BIPHENYLS, WETLAND MESOCOSMS, METHYL-PARATHION, ACUTE
ISI Document Delivery No.: 306UW

62. Armstrong, Jenna L; Fenske, Richard a; Yost, Michael G; Galvin, Kit; Tchong-French, Maria; Yu, Jianbo, and Armstrong, Jenna L. Presence of Organophosphorus Pesticide Oxygen Analogs in Air Samples. 2013 Feb; 66, 145-150.


Rec #: 38419
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: A number of recent toxicity studies have highlighted the increased potency of oxygen analogs (oxons) of several organophosphorus (OP) pesticides. These findings were a major concern after environmental oxons were identified in environmental samples from air and surfaces following agricultural spray applications in California and Washington State. This paper reports on the validity of oxygen analog measurements in air samples for the OP pesticide, chlorpyrifos. Controlled environmental and laboratory experiments were used to examine artificial formation of chlorpyrifos-oxon using OSHA Versatile Sampling (OVS) tubes as recommended by NIOSH method 5600. Additionally, we compared expected chlorpyrifos-oxon attributable to artificial transformation to observed chlorpyrifos-oxon in field samples from a 2008 Washington State Department of Health air monitoring study using non-parametric statistical methods. The amount of artificially transformed oxon was then modeled to determine the amount of oxon present in the environment. Toxicity equivalency factors (TEFs) for chlorpyrifos-oxon were used to calculate chlorpyrifos-equivalent air concentrations. The results demonstrate that the NIOSH-recommended sampling matrix (OVS tubes with XAD-2 resin) was found to artificially transform up to 30% of chlorpyrifos to chlorpyrifos-oxon, with higher percentages at lower concentrations (<30 ng m super(-3)) typical of ambient or residential levels. Overall, the 2008 study data had significantly greater oxon than expected by artificial transformation, but the exact amount of environmental oxon in air remains difficult to quantify with the current sampling method. Failure to conduct laboratory analysis for chlorpyrifos-oxon may result in underestimation of total pesticide concentration when using XAD-2 resin matrices for occupational or residential sampling. Alternative methods that can accurately measure both OP pesticides and their oxygen analogs should be used for air sampling, and a toxicity equivalent factor approach should be used to determine potential health risks from exposures.
Keywords: Environmental monitoring
Keywords: Pollution monitoring
Keywords: Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Environment Abstracts; Risk Abstracts; Health & Safety Science Abstracts
Keywords: Resins
Keywords: Safety regulations
Keywords: P 0000:AIR POLLUTION
Keywords: Analogs
Keywords: Sprays
Keywords: Statistical analysis
Keywords: Toxicity
Keywords: Chlorpyrifos
Keywords: R2 23080:Industrial and labor
Keywords: Oxygen
Keywords: USA, Washington
Keywords: H 5000:Pesticides
Keywords: Pesticides
Keywords: Air sampling
Keywords: M2 551.5:General (551.5)
Keywords: USA, California
Keywords: Laboratory experiments
Keywords: ENA 01:Air Pollution
Date revised - 2013-01-01
Language of summary - English
Location - USA, Washington; USA, California
Pages - 145-150
ProQuest ID - 1268652762
SubjectsTermNotLitGenreText - Analogs; Statistical analysis; Laboratory experiments; Environmental monitoring; Chlorpyrifos; Pollution monitoring; Oxygen; Resins; Safety regulations; Sprays; Pesticides; Air sampling; Toxicity; USA, Washington; USA, California
Last updated - 2013-02-08
British nursing index edition - Atmospheric Environment [Atmos. Environ.]. Vol. 66, pp. 145-150. Feb 2013.
Corporate institution author - Armstrong, Jenna L; Fenske, Richard A; Yost, Michael G; Galvin, Kit; Tchong-French, Maria; Yu, Jianbo
DOI - 454788ae-946e-416e-97aacsamfg201; 17491934; 1352-2310 English

63. Arora, Sumitra and Arora, Sumitra. Analysis of Insecticides in Okra and Brinjal From Ipm and Non-Ipm Fields. 2009 Apr; 151, (1-4): 311-315.


Rec #: 41259
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: Samples of okra and brinjal fruits, collected from non-integrated pest management (Non-IPM) and IPM fields in village Raispur, Ghaziabad District (U.P.), were analyzed for pesticide residues. The residues of chlorpyrifos in soil were 4.219 and 1.135 mu g/g at harvest time in non-IPM and IPM fields of summer okra crop from initial value of 0.407 mu g/g before sowing, while in brinjal crop, it was not detected in soils of any trials. During first year of study, the residues of chlorpyrifos and cypermethrin in okra fruit were observed to be 5.75 and 0.625 mu g/g, respectively, for non-IPM fields; and 0.104 mu g/g of chlorpyrifos for IPM trials. The pesticide residues were found to be 0.77, 1.39, 0.4 and 0.32 mu g/g for cypermethrin, chlorpyrifos, monocrotophos and dimethoate, respectively, for non-IPM okra fruits in second year. For brinjal fruit, residues of cypermethrin and imidacloprid were not detected in IPM trials while it was found to be 0.28 and 0.78 mu g/g for cypermethrin and chlorpyrifos respectively, for non-IPM trials.
Keywords: Pesticide residues
Keywords: P 5000:LAND POLLUTION
Keywords: M3 1010:Issues in Sustainable Development
Keywords: fruits
Keywords: Pest control
Keywords: villages
Keywords: EE 10:General Environmental Engineering
Keywords: Sustainability Science Abstracts; Pollution Abstracts; Environment Abstracts; Environmental Engineering Abstracts
Keywords: Crops
Keywords: Environmental Studies
Keywords: ENA 06:Food & Drugs
Keywords: Soil
Keywords: Chlorpyrifos
Keywords: cypermethrin
Keywords: Insecticides
Keywords: Pesticides
Keywords: summer
Keywords: dimethoate
Date revised - 2010-02-01
Language of summary - English
Pages - 311-315
ProQuest ID - 810092802
SubjectsTermNotLitGenreText - Soil; Chlorpyrifos; cypermethrin; Insecticides; Pesticide residues; fruits; Pesticides; summer; Pest control; villages; dimethoate; Crops
Last updated - 2012-08-02
Corporate institution author - Arora, Sumitra
DOI - OB-MD-0010934212; 11715458; 0167-6369; 1573-2959 English

64. Arora, Sumitra; Mukherjee, Irani, and Trivedi, T P. Determination of Pesticide Residue in Soil, Water and Grain From Ipm and Non-Ipm Field Trials of Rice. 2008 Oct; 81, (4): 373-6.


Rec #: 49109
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: Soil, water and rice grain samples from field trials conducted under the IPM and non-IPM modules in Kaithal (Haryana) region were analyzed for pendimethalin, atrazine, lindane and chlorpyriphos, and in Dehradun (Uttarakhand) region, samples were analyzed for carbendazim only. The pesticide residues were found below the detectable limit in the soil and water samples of the Kaithal region. From Dehradun region the residues of carbendazim in rice grains were detected at 0.001 mg/kg level, and in soil they were in the range of 0.03-0.001 mg/kg. The insecticides applied in IPM as well as non-IPM trials in both regions were observed to be below the prescribed maximum residue level. [PUBLICATION ABSTRACT]
Keywords: Cereals -- chemistry
Keywords: Agriculture
Keywords: Water -- analysis
Keywords: Oryza sativa -- chemistry
Keywords: Chromatography, Gas
Keywords: Hydrogen-Ion Concentration
Keywords: Spectrophotometry, Ultraviolet
Keywords: Pesticide Residues
Keywords: Water
Keywords: Chromatography, High Pressure Liquid
Keywords: Environmental Studies
Keywords: Soil
Keywords: Soil -- analysis
Keywords: Pesticide Residues -- analysis
Keywords: Electrochemistry
Keywords: Insect Control
Copyright - Springer Science+Business Media, LLC 2008
Language of summary - English
Pages - 373-6
ProQuest ID - 233186011
Document feature - References
Last updated - 2012-02-29
Place of publication - New York
Corporate institution author - Arora, Sumitra; Mukherjee, Irani; Trivedi, T P
DOI - 1896279561; 49370061; 108019; BVCX; 18679559; SPVLBVCX128819493 English

65. Artus, C.; Boujrad, H.; Bouharrour, A.; Brunelle, M. N.; Hoos, S.; Yuste, V. J.; Lenormand, P.; Rousselle, J. C.; Namane, A.; England, P.; Lorenzo, H. K., and Susin, S. A. Aif Promotes Chromatinolysis and Caspase-Independent Programmed Necrosis by Interacting With Histone H2ax.


Rec #: 50559
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
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ABSTRACT: Programmed necrosis induced by DNA alkylating agents, such as MNNG, is a caspase-independent mode of cell death mediated by apoptosis-inducing factor (AIF). After poly(ADP-ribose) polymerase 1, calpain, and Bax activation, AIF moves from the mitochondria to the nucleus where it induces chromatinolysis and cell death. The mechanisms underlying the nuclear action of AIF are, however, largely unknown. We show here that, through its C-terminal proline-rich binding domain (PBD, residues 543-559), AIF associates in the nucleus with histone H2AX. This interaction regulates chromatinolysis and programmed necrosis by generating an active DNA-degrading complex with cyclophilin A (CypA). Deletion or directed mutagenesis in the AIF C-terminal PBD abolishes AIF/H2AX interaction and AIF-mediated chromatinolysis. H2AX genetic ablation or CypA downregulation confers resistance to programmed necrosis. AIF fails to induce chromatinolysis in H2AX or CypA-deficient nuclei. We also establish that H2AX is phosphorylated at Ser139 after MNNG treatment and that this phosphorylation is critical for caspase-independent programmed necrosis. Overall, our data shed new light in the mechanisms regulating programmed necrosis, elucidate a key nuclear partner of AIF, and uncover an AIF apoptogenic motif.
MESH HEADINGS: Animals
MESH HEADINGS: Apoptosis Inducing Factor/chemistry/*metabolism
MESH HEADINGS: Calpain/metabolism
MESH HEADINGS: Caspases/*metabolism
MESH HEADINGS: Cell Line
MESH HEADINGS: Chromatin/*metabolism
MESH HEADINGS: Cyclophilin A/genetics/metabolism
MESH HEADINGS: DNA Damage
MESH HEADINGS: Down-Regulation
MESH HEADINGS: Fibroblasts/cytology/metabolism
MESH HEADINGS: Gene Deletion
MESH HEADINGS: Histones/chemistry/genetics/*metabolism
MESH HEADINGS: Methylnitronitrosoguanidine/pharmacology
MESH HEADINGS: Mice
MESH HEADINGS: Models, Molecular
MESH HEADINGS: Necrosis/*metabolism
MESH HEADINGS: Poly(ADP-ribose) Polymerases/metabolism
MESH HEADINGS: bcl-2-Associated X Protein/metabolism eng

66. Aschner, M.; Levin, E. D.; Sunol, C.; Olopade, J. O.; Helmcke, K. J.; Avila, D. S.; Sledge, D.; Ali, R. H.; Upchurch, L.; Donerly, S.; Linney, E.; Forsby, A.; Ponnuru, P., and Connor, J. R. Gene-environment interactions: Neurodegeneration in non-mammals and mammals. 2010; 31, (5): 582-588.


Rec #: 55909
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: Abstract: The understanding of how environmental exposures interact with genetics in central nervous system dysfunction has gained great momentum in the last decade. Seminal findings have been uncovered in both mammalian and non-mammalian model in large result of the extraordinary conservation of both genetic elements and differentiation processes between mammals and non-mammalians. Emerging model organisms, such as the nematode and zebrafish have made it possible to assess the effects of small molecules rapidly, inexpensively, and on a miniaturized scale. By combining the scale and throughput of in vitro screens with the physiological complexity and traditional animal studies, these models are providing relevant information on molecular events in the etiology of neurodegenerative disorders. The utility of these models is largely driven by the functional conservation seen between them and higher organisms, including humans so that knowledge obtained using non-mammalian model systems can often provide a better understanding of equivalent processes, pathways, and mechanisms in man. Understanding the molecular events that trigger neurodegeneration has also greatly relied upon the use of tissue culture models.
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