Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos

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The applied ligand for the immunoassays was polyclonal goat anti-rabbit immunoglobulin (IgG) peroxidase conjugate. Concentration tests using direct binding assays showed the possibility of quantitative analysis. For ligand fishing to find a proper antibody to respond to each pesticide, acetylcholinesterase (AChE), and glutathione-s-transferase (GST) were tested. The reproducibility and precision of SPR measurements were evaluated. With this approach, the limit of detection for pesticide residues was 1 ng/mL and analysis took less than 11 min. Thus, it was demonstrated that detecting multi-class pesticide residues using SPR and IgG antibodies provides enough sensitivity and speed for use in portable SPR biosensors.
Keywords: Carbofuran
Keywords: Acetylcholinesterase
Keywords: Pesticide residues
Keywords: Food
Keywords: Peroxidase
Keywords: Carbaryl
Keywords: organophosphates
Keywords: Glutathione transferase
Keywords: Pesticides (carbamates)
Keywords: Chlorpyrifos
Keywords: Biosensors
Keywords: Antibodies
Keywords: surface plasmon resonance
Keywords: Pesticides
Keywords: Biotechnology and Bioengineering Abstracts
Keywords: Immunoglobulin G
Keywords: W 30955:Biosensors
Keywords: Immunoassays
Keywords: Diazinon
Date revised - 2008-10-01
Language of summary - English
Pages - 547-552
ProQuest ID - 20948282
SubjectsTermNotLitGenreText - Pesticide residues; surface plasmon resonance; Immunoglobulin G; Biosensors; Carbofuran; Acetylcholinesterase; Pesticides (carbamates); Glutathione transferase; Chlorpyrifos; Antibodies; organophosphates; Peroxidase; Pesticides; Immunoassays; Carbaryl; Food; Diazinon
Last updated - 2011-12-14
British nursing index edition - Food Science and Biotechnology [Food Sci. Biotech.]. Vol. 17, no. 3, pp. 547-552. Jun 2008.
Corporate institution author - Yang, G; Kang, S
DOI - MD-0008349435; 8370106; 1226-7708 English

1554. Yang, Q.; Nagano, T.; Shah, Y.; Cheung, C.; Ito, S., and Gonzalez, F. J. The Ppar Alpha-Humanized Mouse: a Model to Investigate Species Differences in Liver Toxicity Mediated by Ppar Alpha.

Rec #: 51379
Notes: Chemical of Concern: CPY
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ABSTRACT: To determine the impact of the species difference between rodents and humans in response to peroxisome proliferators (PPs) mediated by peroxisome proliferator-activated receptor (PPAR)alpha, PPAR alpha-humanized transgenic mice were generated using a P1 phage artificial chromosome (PAC) genomic clone bred onto a ppar alpha-null mouse background, designated hPPAR alpha PAC. In hPPAR alpha PAC mice, the human PPAR alpha gene is expressed in tissues with high fatty acid catabolism and induced upon fasting, similar to mouse PPAR alpha in wild-type (Wt) mice. Upon treatment with the PP fenofibrate, hPPAR alpha PAC mice exhibited responses similar to Wt mice, including peroxisome proliferation, lowering of serum triglycerides, and induction of PPAR alpha target genes encoding enzymes involved in fatty acid metabolism in liver, kidney, and heart, suggesting that human PPAR alpha (hPPAR alpha) functions in the same manner as mouse PPAR alpha in regulating fatty acid metabolism and lowering serum triglycerides. However, in contrast to Wt mice, treatment of hPPAR alpha PAC mice with fenofibrate did not cause significant hepatomegaly and hepatocyte proliferation, thus indicating that the mechanisms by which PPAR alpha affects lipid metabolism are distinct from the hepatocyte proliferation response, the latter of which is only induced by mouse PPAR alpha. In addition, a differential regulation of several genes, including the oncogenic let-7C miRNA by PPs, was observed between Wt and hPPAR alpha PAC mice that may contribute to the inherent difference between mouse and human PPAR alpha in activation of hepatocellular proliferation. The hPPAR alpha PAC mouse model provides an in vivo platform to investigate the species difference mediated by PPAR alpha and an ideal model for human risk assessment PPs exposure.
MESH HEADINGS: Antimetabolites/diagnostic use
MESH HEADINGS: Blotting, Northern
MESH HEADINGS: Bromodeoxyuridine/diagnostic use
MESH HEADINGS: Cell Proliferation/drug effects
MESH HEADINGS: Chromosomes, Artificial, Human/genetics
MESH HEADINGS: Cloning, Molecular
MESH HEADINGS: Drug-Induced Liver Injury/*pathology
MESH HEADINGS: Fenofibrate/pharmacology
MESH HEADINGS: Hypolipidemic Agents/pharmacology
MESH HEADINGS: Lipids/blood
MESH HEADINGS: Mice, Transgenic
MESH HEADINGS: Mitochondria, Liver/metabolism
MESH HEADINGS: Models, Biological
MESH HEADINGS: PPAR alpha/*physiology
MESH HEADINGS: RNA/biosynthesis
MESH HEADINGS: Reverse Transcriptase Polymerase Chain Reaction
MESH HEADINGS: Species Specificity eng

1555. Yang, T. C.; Xu, X. M.; Hou, J.; Gong, Z. Y.; Cheng, Z. P.; Fan, W. Z.; Fu, T.; Wang, S. S.; Ye, X. J.; Wu, Y. P.; Chen, M.; Ling, F.; Feng, X. Y.; Zhu, G. R.; Ren, Z. Y.; Fu, G. M., and He, F. Dengue Fever Vector Composition and Pesticide Residues in Yiwu, Zhejiang Province, China. 2012; 47, (4): 309-315.

Rec #: 72589
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: In 2009, an outbreak of dengue fever occurred in Yiwu, the major international market in Zhejiang province, China. A mosquito vector eradication program was undertaken using several insecticides to limit further transmission of the dengue virus. At the conclusion of this effort, the affected area was surveyed for dengue fever vector species, and mosquito-breeding area water samples were collected and analyzed for residual pesticide content. The survey detected the Asian tiger mosquito, Aedes albopictus (Skuse), in 19 villages in Yiwu, accounting for 51.7% of the mosquitoes in the 89 samples collected. Other species collected included Armigeres subalbatus (Coquillett), Culex pipiens quinquefasciatus Say, Cx. tritaeniorhynchus Giles, Cx. mimulus Edwards, and Anopheles sinensis Wiedemann. Analysis of water from 45 mosquito-breeding sites using gas chromatography-mass spectrometry detected a total of 7 pesticides, including the herbicide prometryn, 2 organophosphate insecticides (chlorpyrifos and triazophos), and 3 pyrethroid insecticides (cyhalothrin, cypermethrin, and permethrin). The maximum level of permethrin detected was 323.9 mu g/L in breeding waters in which Ae. albopictus and Ar subalbatus coexisted.
Keywords: dengue, mosquito, vectors, pesticide residue, water analysis
ISI Document Delivery No.: 998WW

1556. Yang, X.; Wang, M.; Shu, S.; Zou, Z., and Xiang, K. [Damage and Control of Agrotis Ypsilon on Scrophularia Ningpoensis].

Rec #: 77889
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: OBJECTIVE: To study the damage of Agrotis ypsilon on Scrophularia ningpoensis and the control method, so as to provide scientific basis for its integrated pests management (IPM).
ABSTRACT: METHOD: The field investigation and the field controlling trial were carried out for the research.
ABSTRACT: RESULT: There is obvious relationship between the pre-season crops and the damage degree of S. ningpoensis. The damage rate of the fields which had planted maize and tobacco in the last planting season was much higher than that of the other fields. The average damage rate could reach 12.43% and 15.68%. The result of five pesticides against A. ypsilon in field trial showed that the controlling effect of 10% beta-cypermethrin EC 2000 times and 40% chlorpyrifos EC 1500 times were 92.53% and 91.69%, respectively.
ABSTRACT: CONCLUSION: A. ypsilon could be well controlled while 10% beta-cypermethrin EC or 40% chlorpyrifos EC are sprayed during the period of seedling.
MESH HEADINGS: Chlorpyrifos/pharmacology
MESH HEADINGS: Insect Control/*methods
MESH HEADINGS: Insecticides/pharmacology
MESH HEADINGS: Moths/drug effects/*physiology
MESH HEADINGS: Plant Diseases/*parasitology
MESH HEADINGS: Pyrethrins/pharmacology
MESH HEADINGS: Scrophularia/*parasitology chi

1557. Yang, X. B.; Ying, G. G., and Kookana, R. S. Rapid multiresidue determination for currently used pesticides in agricultural drainage waters and soils using gas chromatography-mass spectrometry. 2010; 45, (2): 152-161.

Rec #: 72599
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: An efficient and sensitive method for simultaneous determination of 38 pesticides in agricultural drainage waters and soils has been developed and validated. Water samples were extracted using solid-phase extraction with C18 cartridges while solid samples (suspended particle matter and soil) were extracted by using the quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction method. The target pesticides were analyzed by using gas chromatography-mass spectrometry with electron impact ionization. The proposed method allowed a simultaneous determination and confirmation of a large number of pesticides in agricultural drainage waters, suspended particle matters and soils/sediments with a good reproducibility and low detection limits. The developed method was applied to a survey of pesticides in a vegetable growing area of Guangzhou, China. The pesticides commonly found in the area were butachlor, carbofuran, dichlorvos, fipronil, isocarbophos and pyridaben.
Keywords: Drainage water, suspended particle matter, soil, solid phase extraction,
ISI Document Delivery No.: 595BO

1558. Yang, Zhong-Hua; Liu, Yu; Lu, Yue-Le; Wu, Tong; Zhou, Zhi-Qiang, and Liu, Dong-Hui. Dispersive suspended microextraction. 2011 Nov 14-; 706, (2): 268-274.

Rec #: 4990
Notes: Chemical of Concern: CPY
Abstract: A novel sample pre-treatment technique termed dispersive suspended microextraction (DSME) coupled with gas chromatography-flame photometric detection (GC-FPD) has been developed for the determination of eight organophosphorus pesticides (ethoprophos, malathion, chlorpyrifos, isocarbophos, methidathion, fenamiphos, profenofos, triazophos) in aqueous samples. In this method, both extraction and two phasesÇÖ separation process were performed by the assistance of magnetic stirring. After separating the two phases, 1 ++L of the suspended phase was injected into GC for further instrument analysis. Varieties of experiment factors which could affect the experiment results were optimized and the following were selected: 12.0 ++L p-xylene was selected as extraction solvent, extraction speed was 1200 rpm, extraction time was 30 s, the restoration speed was 800 rpm, the restoration time was 8 min, and no salt was added. Under the optimum conditions, limits of detections (LODs) varied between 0.01 and 0.05 ++g LêÆ1. The relative standard deviation (RSDs, n = 6) ranged from 4.6% to 12.1%. The linearity was obtained by five points in the concentration range of 0.1Çô100.0 ++g LêÆ1. Correlation coefficients (r) varied from 0.9964 to 0.9995. The enrichment factors (EFs) were between 206 and 243. In the final experiment, the developed method has been successfully applied to the determination of organophosphorus pesticides in wine and tap water samples and the obtained recoveries were between 83.8% and 101.3%. Compared with other pre-treatment methods, DSME has its own features and could achieve satisfied results for the analysis of trace components in complicated matrices. Organophosphorus pesticides/ Dispersive suspended microextraction/ Gas chromatography/ Wine/ Tap water

1559. Yao, Yuan; Harner, Tom; Blanchard, Pierrette; Tuduri, Ludovic; Waite, Don; Poissant, Laurier; Murphy, Clair; Belzer, Wayne; Aulagnier, Fabien, and Sverko, Ed. Pesticides in the Atmosphere Across Canadian Agricultural Regions. 2008 Aug 15; 42, (16): 5931-5937.

Rec #: 49289
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: The Canadian Atmospheric Network for Currently Used Pesticides (CANCUP) was the first comprehensive, nationwide air surveillance study of pesticides in Canada. This paper presentsthe atmospheric occurrence and distribution of pesticides including organochlorine pesticides (OCPs), organophosphate pesticides (OPPs), acid herbicides (AHs), and neutral herbicides (NHs) during the spring to summer of 2004 and 2005 across agricultural regions in Canada. Atmospheric concentrations of pesticides varied within years and time periods, and regional characteristics were observed including the following: (i) highest air concentrations of several herbicides (e.g., mecoprop, triallate, and ethalfluralin) were found at Bratt's Lake, SK, a site in the Canadian Prairies; (ii) the west-coast site at Abbotsford, BC, had the maximum concentrations of diazinon; (iii) the fruit and vegetable growing region in Vineland, ON, showed highest levels for several insecticides including chlorpyrifos, endosulfan, and azinphos-methyl; (iv) high concentrations of atrazine and metolachlor were measured at St. Anicet, QC, a corn-growing region; (v) the Kensington site in PEI, Canada's largest potato-producing province, exhibited highest level of dimethoate. Analysis of particle- and gas-phase fractions of air samples revealed that most pesticides including OCPs, OPPs, and NHs exist mainly in the gas phase, while AHs exhibit more diversity in particle-gas partitioning behavior. This study also demonstrated that stirred up soil dust does not account for pesticides that are detected in the particle phase. The estimated dry and wet deposition fluxes indicate considerable atmospheric inputs for some current-use pesticides (CUPs). This data set represents the first measurements for many pesticides in the atmosphere, precipitation, and soil for given agricultural regions across Canada.
Keywords: Agriculture
Keywords: Air Pollutants
Keywords: Pesticide Residues
Keywords: Pesticide Residues -- chemistry
Keywords: Atmosphere
Keywords: Soil
Keywords: Pesticides -- chemistry
Keywords: 0
Keywords: Canada
Keywords: Pesticides
Keywords: Soil -- analysis
Keywords: Rain
Keywords: Time Factors
Keywords: Air Pollutants -- chemistry
Date completed - 2009-01-22
Date created - 2008-09-04
Date revised - 2012-12-20
Language of summary - English
Pages - 5931-5937
ProQuest ID - 69514981
Last updated - 2013-01-19
British nursing index edition - Environmental science & technology, August 15, 2008, 42(16):5931-5937
Corporate institution author - Yao, Yuan; Harner, Tom; Blanchard, Pierrette; Tuduri, Ludovic; Waite, Don; Poissant, Laurier; Murphy, Clair; Belzer, Wayne; Aulagnier, Fabien; Sverko, Ed
DOI - MEDL-18767647; 18767647; 0013-936X eng

1560. Ye, Xibiao ; Pierik, Frank H; Angerer, Jă Rgen; Meltzer, Helle Margrete; Jaddoe, Vincent W V; Tiemeier, Henning; Hoppin, Jane a, and Longnecker, Matthew P. Levels of Metabolites of Organophosphate Pesticides, Phthalates, and Bisphenol a in Pooled Urine Specimens From Pregnant Women Participating in the Norwegian Mother and Child Cohort Study (Moba). 2009 Sep; 212, (5): 481-491.

Rec #: 48359
Notes: Chemical of Concern: CPY
Abstract: Abstract: Concerns about reproductive and developmental health risks of exposure to organophosphate (OP) pesticides, phthalates, and bisphenol A (BPA) among the general population are increasing. Six dialkyl phosphate (DAP) metabolites, 3,5,6-trichloro-2-pyridinol (TCPy), BPA, and fourteen phthalate metabolites were measured in 10 pooled urine samples representing 110 pregnant women who participated in the Norwegian Mother and Child Birth Cohort (MoBa) study in 2004. Daily intakes were estimated from urinary data and compared with reference doses (RfDs) and daily tolerable intakes (TDIs). The MoBa women had a higher mean BPA concentration (4.50 microg/L) than the pregnant women in the Generation R Study (Generation R) in the Netherlands and the National Health and Nutrition Examination Survey (NHANES) in the United States. The mean concentration of total DAP metabolites (24.20 microg/L) in MoBa women was higher than that in NHANES women but lower than that in Generation R women. The diethyl phthalate metabolite mono-ethyl phthalate (MEP) was the dominant phthalate metabolite in all three studies, with the mean concentrations of greater than 300 microg/L. The MoBa and Generation R women had higher mean concentrations of mono-n-butyl phthalate (MnBP) and mono-isobutyl phthalate (MiBP) than the NHANES women. The estimated average daily intakes of BPA, chlorpyrifos/chlorpyrifos-methyl and phthalates in MoBa (and the other two studies) were below the RfDs and TDIs. The higher levels of metabolites in the MoBa participants may have been from intake via pesticide residues in food (organophosphates), consumption of canned food, especially fish/seafood (BPA), and use of personal care products (selected phthalates).
Keywords: Phthalic Acids
Keywords: bisphenol A
Keywords: Organophosphates
Keywords: Humans
Keywords: Environmental Exposure -- analysis
Keywords: Pesticides -- urine
Keywords: MLT3645I99
Keywords: Phthalic Acids -- urine
Keywords: Phenols
Keywords: Pregnancy
Keywords: 0
Keywords: Pesticides
Keywords: Cohort Studies
Keywords: Adult
Keywords: Organophosphates -- urine
Keywords: Middle Aged
Keywords: Norway
Keywords: Adolescent
Keywords: Phenols -- urine
Keywords: Female
Date completed - 2009-11-17
Date created - 2009-07-27
Date revised - 2012-12-20
Language of summary - English
Pages - 481-491
ProQuest ID - 67527223
Last updated - 2013-01-19
British nursing index edition - International journal of hygiene and environmental health, September 2009, 212(5):481-491
Corporate institution author - Ye, Xibiao; Pierik, Frank H; Angerer, JĂĽrgen; Meltzer, Helle Margrete; Jaddoe, Vincent W V; Tiemeier, Henning; Hoppin, Jane A; Longnecker, Matthew P
DOI - MEDL-19394271; 19394271; 1618-131X eng

1561. Yen, J.; Donerly, S.; Levin, E., and Linney, E. Differing Effects of 3 Organophosphates (Chlorpyrifos, Diazinon and Parathion) on Developing Zebrafish Nervous System. 2011; 33, (4): 509-510(ABS).

Rec #: 2830
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY,DZ,EPRN,PRN

1562. You, Jing; Pehkonen, Sari; Weston, Donald P; Lydy, Michael J, and You, Jing. Chemical Availability and Sediment Toxicity of Pyrethroid Insecticides to Hyalella Azteca: Application to Field Sediment With Unexpectedly Low Toxicity. 2008 Oct; 27, (10): 2124.

Rec #: 49149
Notes: Chemical of Concern: CPY
Abstract: Abstract: Chemical availability and sediment toxicity of pyrethroid insecticides to Hyalella Azteca were examined. The traditional TU method, which uses TOC-normalized total sediment concentration, predicted successfully the toxicity caused by pyrethroids and chloropyrifos with 84% accuracy in California sediments. The results showed that a single-point Tenax extraction could be used as a less expensive, simple alternative to determine not only the bioavailability of pyrethroids from sediment but also the sediment toxicity. The present results concluded that adsorption to sand might play a controlling role in pyrethroid bioavailability and that sediment toxicity to benthic invertebrates and predictive tools need to account for this potential adsorption phenomenon.
Keywords: SEDIMENT
Keywords: Environment Abstracts
Keywords: ENA 07:General
Date revised - 2009-08-01
Language of summary - English
Pages - 2124
ProQuest ID - 14838792
Document feature - |n 2 |t graphs
Last updated - 2011-12-15
British nursing index edition - Environmental Toxicology and Chemistry [Environ. Toxicol. Chem.]. Vol. 27, no. 10, 2124 p. Oct 2008.
Corporate institution author - You, Jing; Pehkonen, Sari; Weston, Donald P; Lydy, Michael J
DOI - b72ad638-dc5d-4cb5-8eebcsamfg301; 10734280; 0730-7268 English

1563. Young, B. M.; Tulve, N. S.; Egeghy, P. P.; Driver, J. H.; Zartarian, V. G.; Johnston, J. E.; Delmaar, C. J. E.; Evans, J. J.; Smith, L. A.; Glen, G.; Lunchick, C.; Ross, J. H.; Xue, J. P., and Barnekow, D. E. Comparison of four probabilistic models (CARES (R), Calendex (TM), ConsExpo, and SHEDS) to estimate aggregate residential exposures to pesticides. 2012; 22, (5): 522-532.

Rec #: 72739
Notes: Chemical of Concern: CPY
Abstract: Abstract: Two deterministic models (US EPA's Office of Pesticide Programs Residential Standard Operating Procedures (OPP Residential SOPs) and Draft Protocol for Measuring Children's Non-Occupational Exposure to Pesticides by all Relevant Pathways (Draft Protocol)) and four probabilistic models (CARES (R), Calendex (TM), ConsExpo, and SHEDS) were used to estimate aggregate residential exposures to pesticides. The route-specific exposure estimates for young children (2-5 years) generated by each model were compared to evaluate data inputs, algorithms, and underlying assumptions. Three indoor exposure scenarios were considered: crack and crevice, fogger, and flying insect killer. Dermal exposure estimates from the OPP Residential SOPs and the Draft Protocol were 4.75 and 2.37 mg/kg/day (crack and crevice scenario) and 0.73 and 0.36 mg/kg/day (fogger), respectively. The dermal exposure estimates (99th percentile) for the crack and crevice scenario were 16.52, 12.82, 3.57, and 3.30 mg/kg/day for CARES, Calendex, SHEDS, and ConsExpo, respectively. Dermal exposure estimates for the fogger scenario from CARES and Calendex (1.50 and 1.47 mg/kg/day, respectively) were slightly higher than those from SHEDS and ConsExpo (0.74 and 0.55 mg/kg/day, respectively). The ConsExpo derived non-dietary ingestion estimates (99th percentile) under these two scenarios were higher than those from SHEDS, CARES, and Calendex. All models produced extremely low exposure estimates for the flying insect killer scenario. Using similar data inputs, the model estimates by route for these scenarios were consistent and comparable. Most of the models predicted exposures within a factor of 5 at the 50th and 99th percentiles. The differences identified are explained by activity assumptions, input distributions, and exposure algorithms.
Keywords: model, probabilistic, SHEDS, CARES, ConsExpo, Calendex
ISI Document Delivery No.: 994MD

1564. Yousif, I. O. Micronucleus analysis and mitotic index in a Jordanian population exposed to pesticides of organophosphate: malathion and chlorpyrifos. 2011; 64, (2): 173-178.

Rec #: 72749
Notes: Chemical of Concern: CPY
Abstract: Abstract: A longitudinal study of possible genetic damage in Jordanian workers occupationally exposed to a mixture of pesticides containing malathion and chlorpyrifos was studied. Micronucleus assay and mitotic index were selected to achieve this purpose. A second series of blood samples was taken 8 months after the workers were removed from agricultural field to detect DNA repair in lymphocytes of the same subjects. Regardless of the sampling time the exposed workers showed an increased number of micronucleus (MN) frequency. After 8 months of non-exposure the workers showed a significantly decreased number of MN frequency compared to the results of the first sampling, but it was still significantly higher than the controls indicating a possible risk of cytogenetic damage for the exposed group. Besides that, malathion and chlorpyrifos lowered the mitotic index in peripheral lymphocyte cells of the exposed subjects.
Keywords: cytotoxicity, genotoxicity, lymphocytes, micronucleus, mitotic index,
ISI Document Delivery No.: 844KW

1565. Yu, X. Y.; Zhao, Y. D.; Wang, D. I.; Hou, F. H., and Liu, X. J. Impact on the Activity of Acetylcholinesterase(AChE) in Head and Bioconcentration in Zebrafish (Brachydanio rerio) After Chronic Exposure to Chlorpyrifos and Triazophos. 2008; 27, (6): 2452-2455.

Rec #: 1580
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

1566. Yuan, L. L.; Pollard, A. I., and Carlisle, D. M. Using Propensity Scores to Estimate the Effects of Insecticides on Stream Invertebrates from Observational Data. 2009; 28, (7): 1518-1527.

Rec #: 1590
Keywords: SURVEY
Notes: Chemical of Concern: CBL,CPY,DZ

1567. Yue, Y. D. ; Zhang, R.; Fan, W., and Tang, F. High-Performance Thin-Layer Chromatographic Analysis of Selected Organophosphorous Pesticide Residues in Tea. 2008; 91, (5): 1210-1217.

Rec #: 72789
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: The separation of 9 organophosphates (monocrotophos, quinalphos, triazophos, parathion-methyl, isofenphos-methyl, temephos, parathion, phoxim-ethyl, and chlorpyrifos) by high-performance thin-layer chromatography (HPTLC) with automated multiple development was studied. The HPTLC method was developed and validated for analysis of residues of phoxim-ethyl and chlorpyrifos in tea. The sample was extracted with acetonitrile and cleaned up by ENVI-CARB solid-phase extraction. The extract was directly applied as bands to glass-backed silica gel 60F(254) HPTLC plates. The plates were developed with dichloromethane-hexane (1 + 1, v/v) in a glass twin-trough chamber. Evaluation of the developed HPTLC plates was performed densitometrically. The results indicated that the detection limits of phoxim and chlorpyrifos were 5.0 x 10(-9) and 1.0 x 10(-8) g, respectively. Recoveries of the pesticides from tea by this analytical method were 90.7-105.5%, and relative standard deviations were 7.3-13.5%. The precision and accuracy of the method were generally satisfactory for analysis of pesticide residues in tea.
ISI Document Delivery No.: 362XB

1568. Zaheer Khan, M.; Yasmeen, G.; Naqvi, S. N. H., and Perveen, A. Activity of Cholinesterase and Alkaline Phosphatase in Liver, Kidney and Brain of Euphlyctis cyanophlyctis Under the Effect of Chlorpyrifos and Dathrin. 2008; 2, (2): 349-356.

Rec #: 1600
Call Number: NO DURATION (CPY)
Notes: Chemical of Concern: CPY

1569. Zaja, Roko ; Loncar, Jovica; Popovic, Marta; Smital, Tvrtko, and Zaja, Roko. First Characterization of Fish P-Glycoprotein (Abcb1) Substrate Specificity Using Determinations of Its Atpase Activity and Calcein-Am Assay With Plhc-1/Dox Cell Line. 2011 May; 103, (1-2): 53-62.

Rec #: 47339
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: P-glycoprotein (P-gp; abcb1) is one of the major ABC transport proteins that mediates multixenobiotic resistance (MXR) defense in fish. In order to offer a sound evaluation of its ecotoxicological relevance it is critical to characterize substrate specificity of fish P-gp. Measurement of the ATPase activity is a reliable approach often used to discern type of interaction of various drugs with mammalian P-gp. A similar assay has never been used for characterization of P-gp in aquatic organisms and the main goal of this study was to develop a specific ATPase assay for characterization of fish P-gp.
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