Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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This new CNT-based electrochemical sensor thus provides a sensitive and quantitative tool for noninvasive biomonitoring of the exposure to organophosphate pesticides and nerve agents.
Keywords: CHEMICAL WARFARE NERVE, ACETYLCHOLINESTERASE ACTIVITY, FLUORESCENCE
ISI Document Delivery No.: 281JN

1456. Wang, Li; Wen, Yang; Guo, Xinqing; Wang, Guangli; Li, Shunpeng; Jiang, Jiandong, and Jiang, Jiandong. Degradation of Methamidophos by Hyphomicrobium Species Map-1 and the Biochemical Degradation Pathway. 2010 Jul; 21, (4): 513-523.


Rec #: 47819
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: Abstract: Methamidophos is one of the most widely used organophosphorus insecticides usually detectable in the environment. A facultative methylotroph, Hyphomicrobium sp. MAP-1, capable of high efficiently degrading methamidophos, was isolated from methamidophos-contaminated soil in China. It was found that the addition of methanol significantly promoted the growth of strain MAP-1 and enhanced its degradation of methamidophos. Further, this strain could utilize methamidophos as its sole carbon, nitrogen and phosphorus source for growth and could completely degrade 3,000mgl super(-1) methamidophos in 84h under optimal conditions (pH 7.0, 30 degree C). The enzyme responsible for methamidophos degradation was mainly located on the cell inner membrane (90.4%). During methamidophos degradation, three metabolites were detected and identified based on tandem mass spectrometry (MS/MS) and gas chromatography-mass spectrometry (GC-MS) analysis. Using this information, a biochemical degradation pathway of methamidophos by Hyphomicrobium sp. MAP-1 was proposed for the first time. Methamidophos is first cleaved at the P-N bond to form O,S-dimethyl hydrogen thiophosphate and NH sub(3). Subsequently, O,S-dimethyl hydrogen thiophosphate is hydrolyzed at the P-O bond to release -OCH sub(3) and form S-methyl dihydrogen thiophosphate. O,S-dimethyl hydrogen thiophosphate can also be hydrolyzed at the P-S bond to release -SCH sub(3) and form methyl dihydrogen phosphate. Finally, S-methyl dihydrogen thiophosphate and methyl dihydrogen phosphate are likely transformed into phosphoric acid.
Keywords: A 01380:Plant Protection, Fungicides & Seed Treatments
Keywords: Biodegradation
Keywords: methamidophos
Keywords: Methanol
Keywords: Phosphorus
Keywords: Enzymes
Keywords: Metabolites
Keywords: Hydrogen
Keywords: Hyphomicrobium
Keywords: Mass spectroscopy
Keywords: Environmental Studies
Keywords: Soil
Keywords: Carbon
Keywords: Insecticides
Keywords: Phosphate
Keywords: Gas chromatography
Keywords: Thiophosphate
Keywords: Inner membranes
Keywords: Pesticides
Keywords: Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts
Keywords: pH effects
Keywords: phosphoric acid
Keywords: Nitrogen
Date revised - 2010-02-01
Language of summary - English
Pages - 513-523
ProQuest ID - 810789871
SubjectsTermNotLitGenreText - Biodegradation; methamidophos; Methanol; Phosphorus; Enzymes; Metabolites; Hydrogen; Mass spectroscopy; Soil; Carbon; Insecticides; Phosphate; Gas chromatography; Thiophosphate; Inner membranes; Pesticides; pH effects; phosphoric acid; Nitrogen; Hyphomicrobium
Last updated - 2011-11-03
Corporate institution author - Wang, Li; Wen, Yang; Guo, Xinqing; Wang, Guangli; Li, Shunpeng; Jiang, Jiandong
DOI - OB-c9a8e414-d441-4acd-9c08mfgefd108; 13094097; 0923-9820; 1572-9729 English

1457. Wang, Ligang; Liang, Yongchao; Jiang, Xin, and Jiang, Xin. Analysis of Eight Organophosphorus Pesticide Residues in Fresh Vegetables Retailed in Agricultural Product Markets of Nanjing, China. 2008 Oct; 81, (4): 377-382.


Rec #: 49119
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: A method to effectively remove pigments in fresh vegetables using activated carbon followed cleanup through solid phase extraction (SPE) cartridge to further reduce matrix interference and contamination, was established to determine eight organophosphorous pesticides (OPPs) by gas chromatography (GC) with nitrogen-phosphorus detection (NPD) in this study, and it has been successfully applied for the determination of eight OPPs in various fresh vegetables with the recoveries ranging from 61.8% to 107%. To evaluate eight OPPs residue level, some fresh vegetables retailed at three agricultural product markets (APM) of Nanjing in China were detected, the results showed that phorate in Shanghai green (0.0257 mu gg super(-1)) and Chinese cabbage (0.0398 mu gg super(-1)), dimethoate in Shanghai green (0.0466-0.0810 mu gg super(− ; 1)), Chinese cabbage (0.077 mu gg super(-1)), and spinach (0.118-0.124 mu gg super(-1 )), methyl-parathion in Shanghai green (0.0903 mu gg super(-1)), Chinese cabbage (0.157 mu gg super(-1)), and spinach (0.0924 mu gg super(-1)), malathion in Shanghai green (0.0342-0.0526 mu gg super(− ; 1)), chorpyrifos in spinach (0.106-0.204 mu gg super(-1 )), and Chinese cabbage (0.149 mu gg super(-1)), chlorfenvinfos in carrot (0.094-0.131 mu gg super(-1 )), were found. However, fonofos and fenthion were not detected in all the collected vegetable samples.
Keywords: Vegetables
Keywords: Contamination
Keywords: phorate
Keywords: Pesticide residues
Keywords: China, People's Rep., Jiangsu Prov., Nanjing
Keywords: Daucus
Keywords: Carbon (activated)
Keywords: EE 10:General Environmental Engineering
Keywords: Malathion
Keywords: Environmental Studies
Keywords: Gas chromatography
Keywords: Pigments
Keywords: Spinacia oleracea
Keywords: X 24330:Agrochemicals
Keywords: Environment Abstracts; Environmental Engineering Abstracts; Toxicology Abstracts
Keywords: Pesticides (organophosphorus)
Keywords: Activated carbon
Keywords: Agricultural products
Keywords: Fenthion
Keywords: Brassica
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: China, People's Rep., Shanghai
Keywords: China, People's Rep.
Keywords: Dimethoate
Keywords: dimethoate
Date revised - 2010-02-01
Language of summary - English
Location - China, People's Rep., Jiangsu Prov., Nanjing; China, People's Rep.; China, People's Rep., Shanghai
Pages - 377-382
ProQuest ID - 809589433
SubjectsTermNotLitGenreText - Pesticides (organophosphorus); Vegetables; Contamination; Gas chromatography; phorate; Pigments; Agricultural products; Carbon (activated); Dimethoate; Fenthion; Malathion; Pesticide residues; Activated carbon; dimethoate; Daucus; Spinacia oleracea; Brassica; China, People's Rep., Jiangsu Prov., Nanjing; China, People's Rep.; China, People's Rep., Shanghai
Last updated - 2011-10-24
Corporate institution author - Wang, Ligang; Liang, Yongchao; Jiang, Xin
DOI - OB-MD-0010968728; 11766985; 0007-4861; 1432-0800 English

1458. Wang, Na; Yi, Li; Shi, Lili; Kong, Deyang; Cai, Daoji; Wang, Donghua; Shan, Zhengjun, and Wang, Na. Pollution Level and Human Health Risk Assessment of Some Pesticides and Polychlorinated Biphenyls in Nantong of Southeast China. 2012 Oct 1; 24, (10): 1854-1860.


Rec #: 42539
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Food consumption is one of the key exposure routes of humans to contaminants. This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls (PCBs) in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province, Southeast China. The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatographytandem mass spectrometry (GC-MS/MS). The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB) and mirex and other pesticides including chlorpyrifos, pyrethroid pesticides, metolachlor, pyridaben and trifluralin were frequently detected in the samples, which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong. Meanwhile, correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed. Combined with dietary survey results at the same sampling locations, human health risk assessment of ingestion through the dietary route was performed. The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area, however, the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels.
Keywords: Risk assessment
Keywords: Chemicals
Keywords: P 6000:TOXICOLOGY AND HEALTH
Keywords: Mass spectroscopy
Keywords: China, People's Rep., Jiangsu Prov.
Keywords: Environmental Studies
Keywords: Food consumption
Keywords: H 5000:Pesticides
Keywords: R2 23060:Medical and environmental health
Keywords: Sampling
Keywords: Pyrethroids
Keywords: X 24330:Agrochemicals
Keywords: PCB compounds
Keywords: PCB
Keywords: Metolachlor
Keywords: Diets
Keywords: Residues
Keywords: pyridaben
Keywords: Pesticides (organochlorine)
Keywords: Cancer
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Pollution Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Environment Abstracts
Keywords: Food selection
Keywords: Chlorpyrifos
Keywords: Health risks
Keywords: polychlorinated biphenyls
Keywords: Pesticides
Keywords: DDT
Keywords: Trifluralin
Keywords: Adipose tissue
Keywords: Hexachlorocyclohexane
Keywords: Contaminants
Keywords: Hexachlorobenzene
Date revised - 2013-01-01
Language of summary - English
Location - China, People's Rep., Jiangsu Prov.
Pages - 1854-1860
ProQuest ID - 1270229947
SubjectsTermNotLitGenreText - Metolachlor; Risk assessment; pyridaben; Pesticides (organochlorine); Mass spectroscopy; Cancer; Food selection; Chlorpyrifos; Food consumption; polychlorinated biphenyls; DDT; Adipose tissue; Trifluralin; Hexachlorocyclohexane; Sampling; Pyrethroids; Contaminants; PCB; Hexachlorobenzene; Chemicals; Diets; Health risks; Residues; Pesticides; PCB compounds; China, People's Rep., Jiangsu Prov.
Last updated - 2013-02-05
Corporate institution author - Wang, Na; Yi, Li; Shi, Lili; Kong, Deyang; Cai, Daoji; Wang, Donghua; Shan, Zhengjun
DOI - OB-c28f2ba0-6194-4862-b900-36551cc510ef; 17311173; 1001-0742 English

1459. Wang, P.; Tian, Y.; Wang, X. J.; Gao, Y.; Shi, R.; Wang, G. Q.; Hu, G. H., and Shen, X. M. Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China. 2012; 42, 100-104.


Rec #: 71709
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Although pesticide use is widespread in China, little is known about levels of exposure to organophosphate pesticides in the population and its potential adverse health effects. We investigated levels of organophosphate exposure in pregnant women and the association between organophosphate exposure and perinatal outcomes in Shanghai, China, by enrolling 187 healthy pregnant women between September 2006 and January 2007. Pesticide exposure was assessed by a questionnaire administered to the mothers in the hospital after delivery as well as by analyses of maternal urinary nonspecific metabolites of organophosphate pesticides (dimethyl and diethyl phosphates). Information on birth weight and length was collected from medical records. Geometric means of metabolites were 25.75 mu g/L for dimethylphosphate (DMP); 11.99 mu g/L for dimethylthiophosphate (DMTP); 9.03 mu g/L for diethylphosphate (DEP); and 9.45 mu g/L for diethyldithiophosphate (DETP). We found that a log unit increase in urinary DEP was associated with a decrease in gestational duration in girls by 1.79 weeks. [beta(adjusted) = 1.79 weeks per log(10) unit increase; 95% confidence interval (CI), -2.82 to -0.76: p = 0.001]. These data suggest that high pesticide level might adversely affect duration of gestation although this association was not present among boys. No associations for any of the organophosphate exposure measures were present for birth weight and length, suggesting that organophosphate pesticides may have no effects on fetal growth. Given that maternal urine pesticide levels in Shanghai were much higher than those reported in developed countries, more studies on the effects of in utero organophosphate exposure on fetal growth and child neurodevelopment are warranted. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords: Birth outcome, Birth weight, Gestational age, Organophosphate pesticide,
ISI Document Delivery No.: 931NL

1460. Wang, P. P.; Dai, W. J.; Ge, L.; Yan, M.; Ge, S. G., and Yu, J. H. Visible light photoelectrochemical sensor based on Au nanoparticles and molecularly imprinted poly(o-phenylenediamine)-modified TiO(2) nanotubes for specific and sensitive detection chlorpyrifos. 2013; 138, (3): 939-945.


Rec #: 71719
Keywords: CHEM METHODS
Notes: Chemical of Concern: CPY
Abstract: Abstract: A molecular imprinted polymer thin film for photoelectrochemical (PEC) sensing of chlorpyrifos molecules was first constructed by electropolymerizing the o-phenylenediamine (o-PD) monomer and chlorpyrifos template molecule on gold nanoparticles-modified titanium dioxide nanotubes. The resulting PEC sensors were characterized by scanning electron microscopy, ultraviolet (UV)-vis spectra and electrochemical impedance spectra. Clearly, the imprinted film showed high selectivity to chlorpyrifos in our case. Under visible light irradiation, poly(o-phenylenediamine) (PoPD) can generate the photoelectric transition from the highest occupied molecular orbital (HOMO) to the lowest unoccupied molecular orbital (LUMO), delivering the excited electrons to the AuNPs, and then to the conduction band (CB) of the titanium dioxide nanotubes (TiO(2) NTs). Simultaneously, it is believed that a positively charged hole (h(+)) of PoPD that took part in the oxidation process was consumed to promote the amplification of photocurrent response. Under the optimal experimental conditions, the photocurrents were proportional to the concentrations of chlorpyrifos ranging from 0.05 to 10 mu mol L(-1) with the detection limit of 0.96 nmol L(-1). The PEC sensor had an excellent specificity and could be successfully applied to the detection of reduced chlorpyrifos in green vegetables, indicating a promising application in PEC sensing.
Keywords: PHOTOCATALYSIS, PESTICIDES, FILMS, NANOSTRUCTURES, DECOMPOSITION,
ISI Document Delivery No.: 062TD

1461. Wang, Q. H.; Yang, J.; Wu, J. Y.; Zhang, G. A., and Li, R. H. Phytoremediation of Chlorpyrifos in Aquatic Environment by Three Emergent Macrophytes. Beijing Research & Development Center for Grass and Environment, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China, Journal of Agro-Environment Science//: SOIL; 2010; 29, (4): 769-772(CHI) (ENG ABS).


Rec #: 2660
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

1462. Wang, Shenghui; Zhang, Chen; Yan, Yanchun, and Wang, Shenghui. Biodegradation of Methyl Parathion and P-Nitrophenol by a Newly Isolated Agrobacterium Sp. Strain Yw12. 2012 Feb; 23, (1): 107-116.


Rec #: 46879
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: Abstract: Strain Yw12, isolated from activated sludge, could completely degrade and utilize methyl parathion as the sole carbon, phosphorus and energy sources for growth in the basic salt media. It could also completely degrade and utilize p-nitrophenol as the sole carbon and energy sources for growth in the minimal salt media. Phenotypic features, physiological and biochemical characteristics, and phylogenetic analysis of 16S rRNA sequence showed that this strain belongs to the genus of Agrobacterium sp. Response surface methodology was used to optimize degradation conditions. Under its optimal degradation conditions, 50 mg l super(-1) MP was completely degraded within 2 h by strain Yw12 and the degradation product PNP was also completely degraded within 6 h. Furthermore, strain Yw12 could also degrade phoxim, methamidophos, chlorpyrifos, carbofuran, deltamethrin and atrazine when provided as the sole carbon and energy sources. Enzymatic analysis revealed that the MP degrading enzyme of strain Yw12 is an intracellular enzyme and is expressed constitutively. These results indicated that strain Yw12 might be used as a potential and effective organophosphate pesticides degrader for bioremediation of contaminated sites.
Keywords: Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE)
Date revised - 2012-06-01
Language of summary - English
Pages - 107-116
ProQuest ID - 954649339
Last updated - 2012-12-05
British nursing index edition - Biodegradation [Biodegradation]. Vol. 23, no. 1, pp. 107-116. Feb 2012.
Corporate institution author - Wang, Shenghui; Zhang, Chen; Yan, Yanchun
DOI - 57e5dd8f-0505-44b5-9b0amfgefd101; 16398953; 0923-9820; 1572-9729 English

1463. Wang, Shumei; Wang, Zhilun; Zhang, Yibei; Wang, Jiang , and Guo, Rong. Pesticide residues in market foods in Shaanxi Province of China in 2010. 2013 Jun 1-; 138, (2Çô3): 2016-2025.


Rec #: 5820
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: The aim of this study was to investigate the pesticide residues in market vegetables in Shaanxi Province of China. The concentrations of 33 pesticides were determined by gas chromatography (GC) in 285 samples. Ten organophosphorus pesticides (OPs) were found in concentrations ranging from 0.004 to 0.257 mg/kg. The mean levels of omethoate, phorate, chlorpyrifos, methidathion, ethoprophos in vegetables exceeded the maximum residue limits (MRLs) allowed by the Ministry of Health, of China. Other detectable OP pesticide residues levels were below their MRLs. Dicofol were detectable in green pepper and chives samples. Five pyrethroid pesticides (PYRs) were detectable in vegetable samples respectively. The results provide useful information on the current contamination status of a key agricultural area in China, and point to the need for urgent action to control the excessive use of some chemicals. Vegetables/ Pesticide/ Residues/ Analytical performance criteria/ Food safety

1464. Wang, X. G.; Revskaya, E.; Bryan, R. A.; Strickler, H. D.; Burk, R. D.; Casadevall, A., and Dadachova, E. Treating Cancer as an Infectious Disease--Viral Antigens as Novel Targets for Treatment and Potential Prevention of Tumors of Viral Etiology.


Rec #: 51399
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: BACKGROUND: Nearly 20% of human cancers worldwide have an infectious etiology with the most prominent examples being hepatitis B and C virus-associated hepatocellular carcinoma and human papilloma virus-associated cervical cancer. There is an urgent need to find new approaches to treatment and prevention of virus-associated cancers.
ABSTRACT: METHODOLOGY/PRINCIPAL FINDINGS: Viral antigens have not been previously considered as targets for treatment or prevention of virus-associated cancers. We hypothesized that it was possible to treat experimental HPV16-associated cervical cancer (CC) and Hepatitis B-associated hepatocellular carcinoma (HCC) by targeting viral antigens expressed on cancer cells with radiolabeled antibodies to viral antigens. Treatment of experimental CC and HCC tumors with (188)Re-labeled mAbs to E6 and HBx viral proteins, respectively, resulted in significant and dose-dependent retardation of tumor growth in comparison with untreated mice or mice treated with unlabeled antibodies.
ABSTRACT: CONCLUSIONS/SIGNIFICANCE: This strategy is fundamentally different from the prior uses of radioimmunotherapy in oncology, which targeted tumor-associated human antigens and promises increased specificity and minimal toxicity of treatment. It also raises an exciting possibility to prevent virus-associated cancers in chronically infected patients by eliminating cells infected with oncogenic viruses before they transform into cancer.
MESH HEADINGS: Animals
MESH HEADINGS: Antigens, Viral/chemistry
MESH HEADINGS: Carcinoma, Hepatocellular/virology
MESH HEADINGS: Cell Line, Tumor
MESH HEADINGS: Female
MESH HEADINGS: Hepatitis/complications
MESH HEADINGS: Humans
MESH HEADINGS: Medical Oncology/methods
MESH HEADINGS: Mice
MESH HEADINGS: Mice, Nude
MESH HEADINGS: Models, Biological
MESH HEADINGS: Neoplasms/*pathology/*virology
MESH HEADINGS: Papillomaviridae/metabolism
MESH HEADINGS: Radioimmunotherapy/methods
MESH HEADINGS: Uterine Cervical Neoplasms/virology eng

1465. WANG, Xu; LI, Jilong; XING, Houjuan, and XU, Shiwen. Review of Toxicology of Atrazine and Chlorpyrifos on Fish. 2011 Dec; 18, (4): 88-92.


Rec #: 1150
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: Atrazine (ATR) and chlorpyrifos (CPF) are widely used in agriculture, but have resulted in a series of toxicological and environmental problems. They were heavily used which have potential threat to fish and rodents. Several recent laboratory studies have shown ATR and CPF could lead to oxidative damage, immunocyte reduced and inhibit acetylcholinesterase (AChE). In order to clarify the toxicity of ATR and CPF, this paper summarized the adverse effects of ATR and CPF on reproduction, nerve and immune systems in fish. atrazine/ chlorpyrifos/ toxicity

1466. Wang, Y.; Dawson, V. L., and Dawson, T. M. Poly(Adp-Ribose) Signals to Mitochondrial Aif: a Key Event in Parthanatos.


Rec #: 50799
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: Poly(ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic diseases by mediating caspase-independent cell death, which has recently been designated parthanatos to distinguish it from other forms of cell death such as apoptosis, necrosis and autophagy. Mitochondrial apoptosis-inducing factor (AIF) release and translocation to the nucleus is the commitment point for parthanatos. This process involves a pathogenic role of poly(ADP-ribose) (PAR) polymer. It generates in the nucleus and translocates to the mitochondria to mediate AIF release following lethal PARP-1 activation. PAR polymer itself is toxic to cells. Thus, PAR polymer signaling to mitochondrial AIF is the key event initiating the deadly crosstalk between the nucleus and the mitochondria in parthanatos. Targeting PAR-mediated AIF release could be a potential approach for the therapy of neurologic disorders.
MESH HEADINGS: Animals
MESH HEADINGS: Apoptosis Inducing Factor/*metabolism
MESH HEADINGS: *Cell Death
MESH HEADINGS: Cell Nucleus/*metabolism
MESH HEADINGS: Humans
MESH HEADINGS: Mitochondria/*metabolism
MESH HEADINGS: Poly Adenosine Diphosphate Ribose/*metabolism
MESH HEADINGS: Poly(ADP-ribose) Polymerases/metabolism
MESH HEADINGS: *Signal Transduction eng

1467. Wang, Z. W.; Li, F. L.; He, A. F.; Tang, Y. L., and Qiu, Y. P. The Distribution and Degradation of Chlorthalonil and Chlorpyrifos in Tomatoes in Greenhouse. College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China,//: SOIL; 2011; 30, (6): 1076-1081(CHI) (ENG ABS).


Rec #: 2640
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (CPY,CTN)
Notes: Chemical of Concern: CPY,CTN

1468. Wang, Zhuang and Huang, Li Ping. Mixture Toxicity Effects of Organic Pollutants. 2008.


Rec #: 51889
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: Abstract: Mixtures of organic pollutants frequently expose in the realistic environment. Ecological toxicologists historically have assessed the risks associated with exposure to single chemicals in laboratory, including acute and chronic toxicity test. However, based on the experiment for single chemicals, it is difficult to reflect the ecological behavior and environmental harmfulness. Increasing awareness of the extent of mixture contamination, therefore, has brought into sharp focus on developing computational models for quantificationally predicting the toxicity of chemical mixtures. This thesis studied whether the observed toxicity of mixture composed of components with different dose-level or toxicity degree deviate the conception of concentration addition (CA) and independent action (IA). The
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