Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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Our aim was to review the literature covering the current state of the art in mass spectrometry (MS) used to identify OP protein biomarkers. We identified general and specific research reports related to OP insecticides, OP toxicity, OP structure, and protein MS by searching PubMed and Chemical Abstracts for articles published before December 2008. A number of OP-based insecticides share common structural elements that result in predictable OP-protein adducts. The resultant OP-protein adducts show an increase in molecular mass that can be identified by MS and correlated with the OP agent. Customized OP-containing probes have also been used to tag and identify protein targets that can be identified by MS. MS is a useful and emerging tool for the identification of proteins that are modified by activated organophosphate insecticides. MS can characterize the structure of the OP adduct and also the specific amino acid residue that forms the key bond with the OP. Each protein that is modified in a unique way by an OP represents a unique molecular biomarker that with further research can lead to new correlations with exposure.
Keywords: Insecticides -- toxicity
Keywords: Organophosphorus Compounds -- analysis
Keywords: Animals
Keywords: Cholinesterases -- chemistry
Keywords: Cholinesterases
Keywords: Humans
Keywords: Amino Acid Sequence
Keywords: Environmental Pollutants -- analysis
Keywords: Insecticides -- analysis
Keywords: Environmental Studies
Keywords: Environmental Pollutants
Keywords: Environmental Monitoring
Keywords: Proteins -- drug effects
Keywords: Organophosphorus Compounds
Keywords: Cholinesterases -- drug effects
Keywords: Proteins -- chemistry
Keywords: Insecticides
Keywords: Molecular Sequence Data
Keywords: Environmental Exposure
Keywords: Mass Spectrometry -- methods
Keywords: Organophosphorus Compounds -- toxicity
Keywords: Proteins
Keywords: Biological Markers
Copyright - Copyright National Institute of Environmental Health Sciences Jan 2010
Language of summary - English
Pages - 11-9
ProQuest ID - 222623450
Last updated - 2012-03-04
Place of publication - Research Triangle Park
Corporate institution author - Thompson, Charles M; Prins, John M; George, Kathleen M
DOI - 1943895611; 50348511; 67001; ENHP; 20056576; INODENHP0006208103
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1370. Thompson, H. M. and Hunt, L. V. Extrapolating from Honeybees to Bumblebees in Pesticide Risk Assessment. 1999; 8, (3): 147-166.


Rec #: 1840
Keywords: REVIEW
Call Number: NO REVIEW (ACP,CPY,CYP,DM,DMT,DS,MOM,PMR,PRT)
Notes: EcoReference No.: 111784
Chemical of Concern: ACP,CPY,CYP,DM,DMT,DS,MOM,PHSL,PIM,PMR,PRT

1371. Thomsen, M.; Faber, J. H., and Sorensen, P. B. Soil ecosystem health and services - Evaluation of ecological indicators susceptible to chemical stressors. 2012; 16, 67-75.


Rec #: 70419
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: Abstract: The paper presents a methodological framework for quantifying soil ecosystem health with special focus on chemical stressors and ecological integrity as determinant for biological productivity of soil ecosystems. Ecological risk assessment is needed to facilitate the assessment of soil health and the capability of a soil to provide ecosystem services such as e.g. detoxification and decomposition of wastes, soil formation and renewal of soil fertility. We have developed such an approach that is based on systematic enumeration of vulnerable indicators that reflect essential soil ecosystem structures and processes that underlay such soil ecosystem services. The method is illustrated fora shortlist of common chemical stressors, represented by nickel, cadmium, chlorpyriphos, lindane and diazinon, and applied in a comparative assessment of suitability for use of grassland on contaminated soil. A comprehensive and relevant set of ecological integrity indicators has been analysed to derive a smaller core set of indicators highly relevant for all types of grassland use: i.e. reflecting ecological requirements to be fulfilled for any sustainable use of grassland. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords: Soil ecosystem health, Ecosystem services, Ecological requirements,
ISI Document Delivery No.: 888DT

1372. Thuy, P. T.; Anh, N. V., and van der Bruggen, B. Evaluation of Two Low-Cost-High-Performance Adsorbent Materials in the Waste-to-Product Approach for the Removal of Pesticides from Drinking Water. 2012; 40, (3): 246-253.


Rec #: 70429
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: This study evaluates the performance of two low cost and high performance adsorption materials, i.e., activated carbon produced from two natural waste products: Bamboo and coconut shell, in the removal of three pesticides from drinking water sources. Due to the fact that bamboo and coconut shell are abundant and inexpensive materials in many parts of the world, they respond to the low-cost aspect. The adsorption capacities of two local adsorbents have been compared with commercial activated carbon to explore their potential to respond to the high quality aspect. Two pesticides were selected, namely dieldrin and chlorpyrifos, because they are commonly used in agriculture activities, and may remain in high concentrations in surface water used as drinking water sources. The results indicate that the adsorption of pesticides on activated carbons is influenced by physico-chemical properties of the activated carbon and the pesticides such as the presence of an aromatic ring, and their molar mass. The activated carbon produced from bamboo can be employed as low-cost and high performance adsorbent, alternative to commercial activated carbon for the removal of pesticides during drinking water production. The performance of activated carbon from bamboo was better due to its relatively large macroporosity and planar surface. The effect of adsorbent and pesticide characteristics on the performance was derived from batch experiments in which the adsorption behavior was studied on the basis of Freundlich isotherms.
Keywords: Activated carbon, Adsorption, Biomass, Surface water
ISI Document Delivery No.: 901NC

1373. Thuy, Pham Thi; Geluwe, Steven; Nguyen, Viet-Anh; Bruggen, Bart, and Thuy, Pham Thi. Current Pesticide Practices and Environmental Issues in Vietnam: Management Challenges for Sustainable Use of Pesticides for Tropical Crops in (South-East) Asia to Avoid Environmental Pollution. 2012 Oct; 14, (4): 379-387.


Rec #: 46479
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pesticides are widely used in modern agriculture to minimize financial losses and maintain food supplies. In southeast Asia, where agriculture is the principal economic activity, pesticides are considered essential, particularly in tropical regions seeking to enter the global economy by providing off-season fresh fruits and vegetables. The absence of a strong legal framework for pesticides facilitated a significant increase in the use of low-quality pesticides. Farmers ignore the risks, safety instructions, and protective directives when using pesticides. They are only concerned about the effectiveness of the pesticides for killing pests, without paying attention to the effects on their health and the environment. The improper usage of pesticides and the incorrect disposal of pesticide wastes contributed to the pollution of groundwater, surface water, and soil, and induced health problems in local communities. This paper describes the impact of the exposure of pesticides on human health and water resources in connection with the usage of pesticides and their management. Because of availability, the data are mainly taken for Northern Vietnam, and applied to the water quality in the delta; nevertheless, the problem relates to all countries in the delta, and similar situations may be found in other regions, particularly in Asia.
Keywords: Agriculture
Keywords: ISEW, Vietnam
Keywords: Health problems
Keywords: Surface water
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: M3 1010:Issues in Sustainable Development
Keywords: Environmental health
Keywords: Deltas
Keywords: Water quality
Keywords: Environmental Studies
Keywords: Public health
Keywords: Sustainability Science Abstracts; Pollution Abstracts
Keywords: Pesticides
Keywords: Economics
Keywords: INW, Asia
Keywords: ISEW, Southeast Asia
Date revised - 2012-11-01
Language of summary - English
Location - ISEW, Vietnam; INW, Asia; ISEW, Southeast Asia
Pages - 379-387
ProQuest ID - 1223189863
SubjectsTermNotLitGenreText - Agriculture; Health problems; Surface water; Economics; Pesticides; Environmental health; Deltas; Water quality; Public health; ISEW, Vietnam; INW, Asia; ISEW, Southeast Asia
Last updated - 2012-12-06
Corporate institution author - Thuy, Pham Thi; Geluwe, Steven; Nguyen, Viet-Anh; Bruggen, Bart
DOI - OB-8ff4d0ab-325d-4f97-a6famfgefd101; 17341016; 1438-4957; 1611-8227 English

1374. Tian, X.; Xu, F.; Lung, W. Y.; Meyerson, C.; Ghaffari, A. A.; Cheng, G., and Deng, J. C. Poly I:C Enhances Susceptibility to Secondary Pulmonary Infections by Gram-Positive Bacteria.


Rec #: 50009
Keywords: BACTERIA
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Secondary bacterial pneumonias are a frequent complication of influenza and other respiratory viral infections, but the mechanisms underlying viral-induced susceptibility to bacterial infections are poorly understood. In particular, it is unclear whether the host's response against the viral infection, independent of the injury caused by the virus, results in impairment of antibacterial host defense. Here, we sought to determine whether the induction of an "antiviral" immune state using various viral recognition receptor ligands was sufficient to result in decreased ability to combat common bacterial pathogens of the lung. Using a mouse model, animals were administered polyinosine-polycytidylic acid (poly I:C) or Toll-like 7 ligand (imiquimod or gardiquimod) intranasally, followed by intratracheal challenge with Streptococcus pneumoniae. We found that animals pre-exposed to poly I:C displayed impaired bacterial clearance and increased mortality. Poly I:C-exposed animals also had decreased ability to clear methicillin-resistant Staphylococcus aureus. Furthermore, we showed that activation of Toll-like receptor (TLR)3 and Retinoic acid inducible gene (RIG-I)/Cardif pathways, which recognize viral nucleic acids in the form of dsRNA, both contribute to poly I:C mediated impairment of bacterial clearance. Finally, we determined that poly I:C administration resulted in significant induction of type I interferons (IFNs), whereas the elimination of type I IFN signaling improved clearance and survival following secondary bacterial pneumonia. Collectively, these results indicate that in the lung, poly I:C administration is sufficient to impair pulmonary host defense against clinically important gram-positive bacterial pathogens, which appears to be mediated by type I IFNs.
MESH HEADINGS: Aminoquinolines/pharmacology
MESH HEADINGS: Animals
MESH HEADINGS: Antibodies/pharmacology
MESH HEADINGS: Antigens, Viral/administration &
MESH HEADINGS: dosage/*immunology
MESH HEADINGS: Disease Susceptibility
MESH HEADINGS: Gene Expression Regulation/drug effects
MESH HEADINGS: Imidazoles/pharmacology
MESH HEADINGS: Interferon Inducers/pharmacology
MESH HEADINGS: Interferon Type I/genetics/*immunology
MESH HEADINGS: Membrane Proteins/genetics/immunology
MESH HEADINGS: Methicillin-Resistant Staphylococcus aureus/immunology
MESH HEADINGS: Mice
MESH HEADINGS: Nerve Tissue Proteins/genetics/immunology
MESH HEADINGS: Pneumococcal Infections/genetics/*immunology/microbiology/mortality
MESH HEADINGS: Pneumonia, Bacterial/genetics/*immunology/microbiology/mortality
MESH HEADINGS: Poly I-C/administration &
MESH HEADINGS: dosage/*immunology
MESH HEADINGS: Receptor, Interferon alpha-beta/genetics/immunology
MESH HEADINGS: Signal Transduction/drug effects
MESH HEADINGS: Staphylococcal Infections/genetics/*immunology/microbiology/mortality
MESH HEADINGS: Streptococcus pneumoniae/immunology
MESH HEADINGS: Survival Rate
MESH HEADINGS: Toll-Like Receptor 3/genetics/immunology eng

1375. Tian, Y. and Yamauchi, T. Corrigendum to "Micronucleus Formation in 3-Day Mouse Embryos Associated with Maternal Exposure to Chlorpyrifos During the Early Preimplantation Period": [Reprod. Toxicol. 17 (2003) 401-405]. 2004; 18, (3): 451-754.


Rec #: 350
Keywords: ADDENDUM
Call Number: NO ADDENDUM (CPY)
Notes: Chemical of Concern: CPY

1376. Tierney, K. B. Neurotoxicity of Pesticides to Salmon: Physiology to Ethology. 2007: 367 p. (Publ As 89637,90046,89625,89700,101435).


Rec #: 1480
Keywords: PUBL AS
Call Number: NO PUBL AS (24D,24DXY,ATZ,CBL,CPY,DMT,DZ,ES,GYPI,LNR,MLN,MTM,SZ)
Notes: Chemical of Concern: 24D,24DXY,ATZ,CBL,CPY,DMT,DZ,EPRN,ES,GYPI,IPB,LNR,MLN,MTM,PRN,SZ

1377. Tierney, K. B.; Sampson, J. L.; Ross, P. S.; Sekela, M. A., and Kennedy, C. J. Salmon Olfaction is Impaired by an Environmentally Realistic Pesticide Mixture. 2008; 42, 4996-5001.


Rec #: 1490
Keywords: MIXTURE
Call Number: NO MIXTURE (ATZ,CPY,DMT,DZ,ES,LNR,MLN,MTM,SZ)
Notes: Chemical of Concern: ATZ,CPY,DMT,DZ,EPRN,ES,LNR,MLN,MTM,PRN,SZ

1378. Tierney, K. B.; Sekela, M. A.; Cobbler, C. E.; Xhabija, B.; Gledhill, M.; Ananvoranich, S., and Zielinski, B. S. EVIDENCE FOR BEHAVIORAL PREFERENCE TOWARD ENVIRONMENTAL CONCENTRATIONS OF URBAN-USE HERBICIDES IN A MODEL ADULT FISH. 2011; 30, (9): 2046-2054.


Rec #: 70479
Keywords: SURVEY,MIXTURE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Fish live in waters of contaminant flux. In three urban, fish-bearing waterways of British Columbia, Canada, we found the active ingredients of WeedEx (R), KillEx (R), and Roundup (R) herbicide formulations (2,4-D, dicamba, glyphosate, and mecoprop) at low to high ng/L concentrations (0.26 to 309 ng/L) in routine conditions, i.e., no rain for at least one week. Following rain, these concentrations increased by an average of eightfold, suggesting runoff as a major route of herbicide introduction in these waterways. To determine whether fish might be able to limit point-source exposures through sensory-driven behaviors, we introduced pulses of representative herbicide mixtures to individual adult zebrafish (a model species) in flow-through tanks. Fish did the opposite of limit exposure; they chose to spend more time in pulses of herbicide mixtures representative of those that may occur with rain events.
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