Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 mu M, DZO did not cause cell death but it impaired the outgrowth of axon-like processes after 24 h. Densitometric scanning of Western blots of lysates of N2a cells revealed that exposure to 5 or 10 mu M DZO for 24 h increased the expression of phosphorylated neurofilament heavy chain (NFH) compared to controls, while there was no significant change in total NFH. By contrast, treatment of N2a cells with 1-10 mu M DZO resulted in marked reductions in the expression of the axon growth-associated protein GAP-43. DZO-treated cells also showed an increased expression of the heat shock protein HSP-70 compared to controls. The above biochemical changes were not temporally related to inhibition of acetylcholinesterase (AChE). These data suggest that biologically relevant, subcytotoxic levels of DZO may exert neurotoxic effects on differentiating cells and that the mechanisms involved are different from those attributed to its parent compound.
Keywords: Diazinon oxon, N2a neuroblastoma cells, Neurite outgrowth, NFII, GAP-43,
ISI Document Delivery No.: 428WW

1232. ---. Diazinon oxon interferes with differentiation of rat C6 glioma cells. 2009; 23, (8): 1548-1552.


Rec #: 68799
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: The purpose of this study was to evaluate the toxicity of diazinon oxon (DZO), a major in vivo metabolite of the organophosphate insecticide diazinon (DZ), on differentiating rat C6 glioma cells. At concentrations shown to be non-cytotoxic by both the MTT and the Kenacid blue dye binding assays (1, 5 and 10 mu M), DZO caused after 24 h a reduction in the number of extensions developed from C6 cells induced to differentiate by serum withdrawal and addition of sodium butyrate. Densitometric scanning of Western blots of extracts of C6 cells demonstrated that, at all concentrations used, DZO decreased after 24 h the expression of glial fibrillary acidic protein (GFAP) compared to controls. In addition, exposure to 10 mu M DZO for 24 h reduced the levels of tubulin and microtubule associated protein 1B (MAP1B). On the other hand, levels of MAP2c were not affected by DZO treatment. In contrast to our previous data on DZ, the above findings suggest that its oxon metabolite, DZO, may, at biologically relevant, subcytotoxic concentrations, interfere with glial cell differentiation. (C) 2009 Elsevier Ltd. All rights reserved.
Keywords: C6 cells, Diazinon oxon, Differentiation, GFAP, Microtubule proteins
ISI Document Delivery No.: 526GV

1233. ---. Fipronil interferes with the differentiation of mouse N2a neuroblastoma cells. 2011; 201, (1): 86-91.


Rec #: 68809
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: The purpose of this study was to evaluate the neurotoxic potential of the pesticide fipronil (FIP) towards the differentiation of mouse N2a neuroblastoma cells. At concentrations of 1, 5 and 10 mu M that were not cytotoxic, as shown by two different cell viability assays, FIP impaired potently after 24 h the development of axon-like processes, with a concentration of 1 mu M causing 50% inhibition. Densitometric analysis of immunoblots of extracts of N2a cells exposed to FIP demonstrated that the axon-inhibitory action of the pesticide was not accompanied by significant changes in the levels of total and phosphorylated neurofilament heavy chain (NFH). FIP also induced no alteration in the levels of total and tyrosinated alpha-tubulin. On the other hand, this pesticide caused severe disruption of the developmentally important ERK 1/2-MAP kinase signal transduction pathway, as evidenced by significant reductions in the activation state of MAPK kinase (MEK 1/2) and, particularly, ERK 1/2. The above data seem to justify very recent concerns that HP has the capacity to induce developmental neurotoxicity in mammals. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Keywords: Fipronil, Mouse N2a neuroblastoma cells, Neurite outgrowth, NFH,
ISI Document Delivery No.: 729NK

1234. Siervo, M.; Jackson, S. J., and Bluck, L. J. In-Vivo Nitric Oxide Synthesis Is Reduced in Obese Patients With Metabolic Syndrome: Application of a Novel Stable Isotopic Method.


Rec #: 50139
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: OBJECTIVES: Nitric oxide synthesis is declined in cardiovascular and metabolic diseases associated with endothelial dysfunction such as type 2 diabetes, hypertension or congestive heart failure. The objectives were to validate a novel stable isotopic method for the determination of in-vivo nitric oxide synthesis and to evaluate differences in nitric oxide synthesis in obese patients with and without metabolic syndrome (MetSyn).
ABSTRACT: METHODS: The new method, called oral nitrate test (ONT), measured the decay in saliva or urine samples of an oral dose of labelled sodium nitrate. The ONT method was compared to a validated method (frequent sampling arginine test, FSAT method) in 10 healthy adult volunteers (BMI range = 20.8-27.3 kg/m). The accuracy of the saliva ONT method was then tested by measuring nitric oxide synthesis in seven healthy, normal weight individuals, seven obese patients without MetSyn and seven obese patients with MetSyn.
ABSTRACT: RESULTS: The estimated rate of nitric oxide synthesis was 0.63 ± 0.20 μmol/h per kg from the data obtained from saliva, and 0.50 ± 0.14 μmol/h per kg from urine. The agreement of the saliva ONT method with the FSAT method (Δ = +0.02 ± 0.24; P = 0.79) was superior to the urine ONT method (Δ = -0.11 ± 0.20; P = 0.13). Obese patients with MetSyn had a significantly lower nitric oxide production rate (0.21 ± 0.13 μmol/h per kg; P = 0.009) than healthy normal weight individuals (0.63 ± 0.30 μmol/h per kg), whereas nitric oxide production rate was intermediate in obese patients without MetSyn (0.49 ± 0.22 μmol/h per kg; P = 0.33).
ABSTRACT: CONCLUSION: The advantages of the new saliva ONT method are its accuracy, sensitivity and lack of invasiveness, which could make it a reference method for the assessment of in-vivo rates of whole-body nitric oxide synthesis.
MESH HEADINGS: Adult
MESH HEADINGS: Case-Control Studies
MESH HEADINGS: Comorbidity
MESH HEADINGS: Diabetes Mellitus, Type 2/diagnosis/etiology/metabolism
MESH HEADINGS: Diagnostic Tests, Routine/*methods
MESH HEADINGS: Female
MESH HEADINGS: Heart Failure/diagnosis/etiology/metabolism
MESH HEADINGS: Humans
MESH HEADINGS: Hypertension/diagnosis/etiology/metabolism
MESH HEADINGS: Isotopes
MESH HEADINGS: Male
MESH HEADINGS: Metabolic Syndrome X/complications/epidemiology/*metabolism
MESH HEADINGS: Middle Aged
MESH HEADINGS: Models, Theoretical
MESH HEADINGS: Nitrates/*metabolism
MESH HEADINGS: Nitric Oxide/*metabolism
MESH HEADINGS: Obesity/complications/epidemiology/*metabolism
MESH HEADINGS: Reproducibility of Results
MESH HEADINGS: Saliva/*metabolism
MESH HEADINGS: Sensitivity and Specificity eng

1235. Sijm, D. T. H. M.; Flenner, C. K., and Opperhuizen, A. The Influence of Biochemical Species Differences on Acute Fish Toxicity of Organic Chemicals. D.T.H.M.Sijm, Res. Inst. Toxicol., Univ. Utrecht, NL-3508 TD Utrecht, Neth//: 1991; 100, (1-2): 33-35.


Rec #: 1330
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (CBL,CPY), NO REVIEW (CBL,CPY)
Notes: Chemical of Concern: CBL,CPY

1236. Sikka, P.; Walker, R.; Cockayne, R.; Wood, M. J.; Harrison, P. J., and Burnet, P. W. D-Serine Metabolism in C6 Glioma Cells: Involvement of Alanine-Serine-Cysteine Transporter (Asct2) and Serine Racemase (Srr) but Not D-Amino Acid Oxidase (Dao).


Rec #: 50579
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
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ABSTRACT: D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. Candidate mechanisms include SRR operating in alpha,beta-eliminase mode (converting D-serine to pyruvate) and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated. Here we report studies in C6 glioma cells, which "simulate" the forebrain, in that the cells express SRR and ASCT2 but lack DAO activity. We measured D-serine, ASCT2, SRR, and DAO expression and DAO activity in two situations: after incubation of cells for 48 hr with serine isomers and after increased or decreased SRR expression by transfection and RNA interference, respectively. Incubation with serine enantiomers decreased [(3)H]D-serine uptake and ASCT2 mRNA and increased SRR immunoreactivity but did not alter DAO immunoreactivity, and DAO activity remained undetectable. SRR overexpression increased D-serine and pyruvate and decreased [(3)H]D-serine uptake and ASCT2 mRNA but did not affect DAO. SRR knockdown did not alter any of the parameters. Our data suggest that D-serine transport mediated by ASCT2 contributes prominently to D-serine homeostasis when DAO activity is absent. The factors regulating D-serine are important for understanding normal NMDA receptor function and because D-serine, along with DAO and SRR, is implicated in the pathogenesis and treatment of schizophrenia.
MESH HEADINGS: Amino Acid Transport System ASC/genetics/*metabolism
MESH HEADINGS: Animals
MESH HEADINGS: Cell Line, Tumor
MESH HEADINGS: D-Amino-Acid Oxidase/genetics/*metabolism
MESH HEADINGS: Dose-Response Relationship, Drug
MESH HEADINGS: Gene Expression Regulation, Neoplastic/drug effects/physiology
MESH HEADINGS: Glioma/*metabolism
MESH HEADINGS: Proline/pharmacology
MESH HEADINGS: Pyruvic Acid/metabolism
MESH HEADINGS: RNA Interference/physiology
MESH HEADINGS: RNA, Messenger/metabolism
MESH HEADINGS: Racemases and Epimerases/genetics/*metabolism
MESH HEADINGS: Rats
MESH HEADINGS: Serine/*metabolism/pharmacology
MESH HEADINGS: Tritium/metabolism eng

1237. Silva, Emilia; Mendes, Maria Paula; Ribeiro, Luis; Cerejeira, Maria Jose, and Silva, Emilia. Exposure Assessment of Pesticides in a Shallow Groundwater of the Tagus Vulnerable Zone (Portugal): a Multivariate Statistical Approach (Jca). 2011 Aug; 19, (7): 2667-2680.


Rec #: 47179
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Purpose: To assess groundwater exposure to pesticides, in agricultural areas of 'Ribatejo' region (Portugal), and the influence of some key factors in that exposure, field, laboratory and modelling studies were carried out. Methods: The study was performed in maize, potato, sugar beet, tomato and vegetables agricultural areas, located in a shallow aquifer, with pesticides use and, in most cases, with irrigation practices. Pesticides used in the studied agricultural areas and having leaching potential were selected, being considered also other pesticides included in priority lists, defined in Europe. Evaluation of groundwater exposure to pesticides was carried out by successively: (1) groundwater sampling in seven campaigns over the period 2004-2006; (2) pesticide analysis [including isolation and concentration from the groundwater samples and further determination by gas chromatography-mass spectrometry (GC-MS) of 14 herbicides, four insecticides and two metabolites]; and (3) analysis and discussion of the results by applying joint correspondence analysis (JCA). Results: From the 20 pesticides and metabolites selected for the study, 11 were found in groundwater. Pesticides and metabolites most frequently detected were atrazine, alachlor, metolachlor, desethylatrazine, ethofumesate, alpha -endosulfan, metribuzine, lindane and beta -endosulfan. The results showed that groundwater exposure to pesticides is influenced by local factors-either environmental or agricultural, as precipitation, soil, geology, crops and irrigation practices. Spring and autumn were more associated with the detection of pesticides being more likely to observe mixtures of these compounds in a groundwater sample in these transition seasons. Conclusions: This work evidences the importance of models, which evaluate pesticides environmental behaviour, namely their water contamination potential (as Mackay multicompartimental fugacity model) and, specially, groundwater contamination potential (as GUS and Bacci and Gaggi leaching indices), in pesticide selection. Moreover, it reveals the importance to adapt proper statistical methods according to level of left-censored data. Using JCA was still possible to establish relations between pesticides and their temporal trend in a case study where there were more than 80% of data censored. This study will contribute to the Tagus river basin management plan with information on the patterns of pesticide occurrence in the alluvial aquifer system.
Keywords: Aquifers
Keywords: Portugal
Keywords: M2 556.38:Groundwater Basins (556.38)
Keywords: Statistical analysis
Keywords: Metabolites
Keywords: Europe
Keywords: Lycopersicon esculentum
Keywords: Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Environment Abstracts
Keywords: Australia, Queensland, Mackay
Keywords: Zea mays
Keywords: Environmental Studies--Pollution
Keywords: Solanum tuberosum
Keywords: Seasonal variability
Keywords: Leaching
Keywords: Sugar beet
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Irrigation
Keywords: Alachlor
Keywords: Herbicides
Keywords: Precipitation
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Spectrometry
Keywords: Pesticides
Keywords: Pesticides in river water
Keywords: Groundwater pollution
Keywords: Groundwater
Date revised - 2012-11-01
Language of summary - English
Location - Portugal; Australia, Queensland, Mackay; Europe
Pages - 2667-2680
ProQuest ID - 1222841701
SubjectsTermNotLitGenreText - Aquifers; Sugar beet; Leaching; Irrigation; Pesticides in river water; Statistical analysis; Seasonal variability; Precipitation; Spectrometry; Pesticides; Alachlor; Groundwater pollution; Herbicides; Metabolites; Groundwater; Lycopersicon esculentum; Zea mays; Solanum tuberosum; Portugal; Australia, Queensland, Mackay; Europe
Last updated - 2012-12-06
Corporate institution author - Silva, Emilia; Mendes, Maria Paula; Ribeiro, Luis; Cerejeira, Maria Jose
DOI - OB-991905e4-9d76-45a7-bddamfgefd107; 17024744; 0944-1344; 1614-7499 English

1238. Silva, Emă Lia; Batista, Sofia; Caetano, Lia; Cerejeira, Maria Josă; Chaves, Manuela, and Jacobsen, Sven-Erik. Integrated Approach for the Quality Assessment of Freshwater Resources in a Vineyard Area (South Portugal). 2011 May; 176, (1-4): 331-41.


Rec #: 43379
Keywords: MIXTURE
Notes: Chemical of Concern: CPY
Abstract: Abstract: An integrated chemical and biological approach for the quality assessment of freshwater resources in a vineyard area of the 'Alentejo' region (South Portugal) is presented. This includes analysis to 11 pesticide compounds and whole toxicity testing on algae and crustaceans. Simazine, terbuthylazine, terbutryn, desethylatrazine and chlorpyrifos were the most frequently detected pesticides in water collected from wells and drainage channels. Mixtures of up to three compounds in different qualitative combinations were also found. The quality standards for individual pesticides (0.1 ÎĽg L^sup -1^) and pesticides-total (0.5 ÎĽg L^sup -1^) were exceeded in some samples. However, their maximum concentrations were lower than the WHO guidelines, the USEPA health advisory values and the environmental quality standards for priority substances applicable to surface water. In five samples, the herbicides terbuthylazine and terbutryn and the insecticide chlorpyrifos did not pass the toxicity exposure ratio (TER) trigger values specified for aquatic organisms (algae, Daphnia and fish). Maximum toxic effects on Daphnia magna (100%) and Pseudokirchneriella subcapitata (82.56%) were determined in groundwater samples, while in surface water, no toxicity was observed. Concerning effects on Heterocypris incongruens in sediment samples collected at the drainage channels, mortality and growth inhibition values were below 38%. Pro-active management of the use of pesticides is recommended for implementing at the farm and catchment level to reduce inputs into ground- and surface water.[PUBLICATION ABSTRACT]
Keywords: Agriculture
Keywords: Portugal
Keywords: Pesticides -- analysis
Keywords: Geologic Sediments -- chemistry
Keywords: Animals
Keywords: Fresh Water -- chemistry
Keywords: Daphnia -- drug effects
Keywords: 9175:Western Europe
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Water Pollutants, Chemical -- toxicity
Keywords: Vitis
Keywords: 9130:Experimental/theoretical
Keywords: Pesticides -- toxicity
Keywords: Environmental Studies
Keywords: 1540:Pollution control
Keywords: Fresh Water -- analysis
Keywords: Geologic Sediments -- analysis
Keywords: Fishes
Keywords: Pesticides
Keywords: Water Pollutants, Chemical
Keywords: Environmental Monitoring -- methods
Copyright - Springer Science+Business Media B.V. 2011
Language of summary - English
Location - Portugal
Pages - 331-41
ProQuest ID - 860404228
Document feature - References
SubjectsTermNotLitGenreText - Portugal
Last updated - 2012-03-08
Place of publication - Dordrecht
Corporate institution author - Silva, Emília; Batista, Sofia; Caetano, Lia; Cerejeira, Maria José; Chaves, Manuela; Jacobsen, Sven-erik
DOI - 2312896881; 60037201; 108264; EVMT; 20625821; SPVLEVMT106611761-41586
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1239. Silva, Emă Lia; Pereira, Ana Carina; Estalagem, Soraia Patră Cia; Moreira-Santos, Matilde; Ribeiro, Rui, and Cerejeira, Maria Josă. Assessing the Quality of Freshwaters in a Protected Area Within the Tagus River Basin District (Central Portugal). 2012 Sep; 41, ( 5): 1413-26.


Rec #: 46539
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: Water-sediment quality was assessed in an agricultural zone of a protected area within the Tagus River basin district (central Portugal) combining chemical analysis to 12 pesticide compounds and whole toxicity testing using the bacterium Vibrio fischeri, the algae Pseudokirchneriella subcapitata, the crustacean Daphnia magna, and the midge Chironomus riparius. The herbicides alachlor, atrazine ethofumesate, metolachlor, terbuthylazine, the insecticides chlorfenvinphos and chlorpyrifos, and the metabolite 3,4-dichloroaniline were detected in surface water samples at four sites and in groundwater samples from six wells, during four sampling occasions. Measured concentrations were compared with parametric values for human consumption, groundwater quality standards, and environmental quality standards applicable to surface water established in European Union legislation. Most severe adverse effects were noted on the growth of P. subcapitata and lethality of D. magna in nondiluted water samples. Taking into account the values calculated by the method of toxic unit summation for pesticide mixtures, it was not possible to link the pesticides found to the toxicity detected in the water samples. Conducting this study with chemical analyses and biotests provided a more comprehensive quality assessment and realistic picture of the environmental samples analyzed, although additional studies are needed to evaluate the performance of mixture models for predicting mixture toxicity. This study underlines the importance of chemical analysis and whole toxicity testing as tools for assessing the impact of human activity on the status of water, mainly in protected zones. [PUBLICATION ABSTRACT]
Keywords: Pesticides -- analysis
Keywords: Rivers
Keywords: Portugal
Keywords: Animals
Keywords: Chironomidae
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Groundwater -- analysis
Keywords: Water Quality
Keywords: Daphnia
Keywords: Aquatic Organisms
Keywords: Environmental Studies
Keywords: Risk Assessment
Keywords: Pesticides -- toxicity
Keywords: Geologic Sediments -- analysis
Keywords: Pesticides
Keywords: Toxicity Tests
Keywords: Water Pollutants, Chemical
Keywords: Aliivibrio fischeri
Copyright - Copyright American Society of Agronomy Sep 2012
Language of summary - English
Location - Portugal
Pages - 1413-26
ProQuest ID - 1095114916
Document feature - Maps; Tables; Graphs; References
SubjectsTermNotLitGenreText - Portugal
Last updated - 2013-01-02
CODEN - JEVQAA
Place of publication - Madison
Corporate institution author - Silva, Emília; Pereira, Ana Carina; Estalagem, Soraia Patrícia; Moreira-Santos, Matilde; Ribeiro, Rui; Cerejeira, Maria José
DOI - 2781795541; 72865612; 13216; JEVQAA; STEQ; 23099932; INNNSTEQ0001069795
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1240. Silva, Kaline Catiely Campos; Assis, Caio Rodrigo Dias; Oliveira, Vagne Melo; Carvalho, Luiz Bezerra; Bezerra, Ranilson Souza, and Silva, Kaline Catiely Campos. Kinetic and Physicochemical Properties of Brain Acetylcholinesterase From the Peacock Bass (Cichla Ocellaris) and in Vitro Effect of Pesticides and Metal Ions. 2013 Jan 15; 126, 191-197.


Rec #: 42379
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: Brain acetylcholinesterase (AChE; EC 3.1.1.7) from peacock bass (Cichla ocellaris) was characterized and the effect of organophosphorus and carbamate pesticides as well as ions and heavy metals was evaluated. The kinetic parameters Kmand Vmaxwere determined as 0.769mM and 0.189U/mg of protein respectively. Optimal pH and temperature were found to be 8.0 and 45 degree C. The enzyme retained approximately half of the activity after incubation at 50 degree C for 30min. Total cholinesterase activity on brain of this species can be ascribed to AChE according to selective inhibitors analysis (neostigmine, eserine and BW284c5 reduced its activity whereas no effect was noticed for Iso-OMPA). Seven pesticides (five organophosphates: dichlorvos, diazinon, chlorpyrifos, temephos, tetraethyl pyrophosphate - TEPP and two carbamates: carbaryl and carbofuran) showed inhibitory effects on C. ocellaris AChE. However, the strongest effect was observed with carbofuran (IC50=0.21 mu M and Ki=2.5710-3 mu M). The following ions (1mM) showed to inhibit its activity (decrescent order): Hg2+>As3+>Cu2+>Zn2+. EDTA2- did not affect enzyme activity. The present study provides assay conditions and data to suggest this enzyme as in vitro biomarker of organophosphorus and carbamate pesticides in routine environmental screening programs.
Keywords: neostigmine
Keywords: Cichla ocellaris
Keywords: Heavy metals
Keywords: Acetylcholinesterase
Keywords: Carbaryl
Keywords: Biomarkers
Keywords: Q5 01502:Methods and instruments
Keywords: Environmental factors
Keywords: X 24330:Agrochemicals
Keywords: pH effects
Keywords: Toxicology
Keywords: pyrophosphates
Keywords: Temperature effects
Keywords: Screening
Keywords: Ions
Keywords: Data processing
Keywords: Metal ions
Keywords: Carbofuran
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Physicochemical properties
Keywords: Brain
Keywords: Environment Abstracts; Toxicology Abstracts; Pollution Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality
Keywords: Temperature
Keywords: Enzymes
Keywords: carbofuran
Keywords: Q1 01485:Species interactions: pests and control
Keywords: Pesticides (carbamates)
Keywords: biomarkers
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Kinetics
Keywords: Pesticides
Keywords: Diazinon
Date revised - 2013-01-01
Language of summary - English
Pages - 191-197
ProQuest ID - 1268651576
SubjectsTermNotLitGenreText - Screening; Metal ions; Heavy metals; Physicochemical properties; Pesticides; Brain; Biomarkers; Environmental factors; Toxicology; Temperature effects; Ions; neostigmine; Data processing; Carbofuran; Acetylcholinesterase; Enzymes; Carbaryl; Pesticides (carbamates); biomarkers; Chlorpyrifos; Kinetics; pH effects; Diazinon; pyrophosphates; Temperature; carbofuran; Cichla ocellaris
Last updated - 2013-02-08
British nursing index edition - Aquatic Toxicology [Aquat. Toxicol.]. Vol. 126, pp. 191-197. 15 Jan 2013.
Corporate institution author - Oliveira, Vagne Melo; Carvalho, Luiz Bezerra; Bezerra, Ranilson Souza
DOI - 442984a8-56ec-4414-85d4csamfg201; 17497625; 0166-445X English

1241. Silva, L. D.; Omoto, C.; Bleicher, E., and Dourado, P. M. [Monitoring the Susceptibility to Insecticides in Bemisia Tabaci (Gennadius) (Hemiptera: Aleyrodidae) Populations From Brazil].


Rec #: 507
Keywords: NON-ENGLISH
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Monitoring the susceptibility of a pest population to pesticides is essential for resistance management programs. The objective of this research was to evaluate the genetic variability in pesticide susceptibility in populations of Bemisia tabaci (Gennadius) collected from different Brazilian agricultural regions through the use of two different tests. Four whitefly populations, two from Goiás state (GO-1 and GO-2) e two from Bahia state (BA-1 and BA-2), were tested against a susceptible reference one (SusIAC). A residual contact bioassay was used to evaluate the pesticide susceptibility of each population by using diagnostic concentration bioassays and by estimating the baseline susceptibility data to each one of the tested insecticides, acetamiprid, imidacloprid, thiamethoxam, chlorpyrifos and endosulfan. Adult insects of unknown age and sex were tested. Evaluations were performed after 24h for endosulfan and 48 h for the other chemicals. Both procedures showed significant differences in the susceptibility to the pesticides among B. tabaci populations. However, the discrimination among B. tabaci populations was more evident with the use of diagnosis tests. The population GO-2 was significantly less susceptible to the tested pesticides than SusIAC, mainly to neonicotinoids. The most critical resistance situation of B. tabaci was detected to thiamethoxam, followed by imidacloprid.
MESH HEADINGS: Animals
MESH HEADINGS: Brazil
MESH HEADINGS: Hemiptera/*drug effects/*genetics
MESH HEADINGS: Insecticides/*pharmacology
TITLE ABBREVIATION: Neotrop Entomol por. Monitoramento da suscetibilidade a inseticidas em populações de Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) no Brasil.

1242. Simon, S.; Defrance, H., and Sauphanor, B. Effect of Codling Moth Management on Orchard Arthropods. 2007; 122, (3): 340-348.


Rec #: 2160
Keywords: MIXTURE
Call Number: NO MIXTURE (24D,24DXY,ACP,ALSV,AZ,CPY,CYF,Captan,Cu,DMT,DOD,DU,FRM,GFSNH,GYP,IMC,MOIL,MP,MZB,OXD,PRB,QZFE,RTN,SFR,SZ,TDF,THM)
Notes: Chemical of Concern: 24D,24DXY,ACP,ALSV,AMTL,AZ,CPY,CYF,Captan,Cu,DMT,DOD,DU,FRM,GFSNH,GYP,HCZ,IMC,MOIL,MP,MZB,OXD,PHSL,PRB,QZFE,RTN,SFR,SZ,TDF,THM,TPM,TYF

1243. Sinegre, G.; Babinot, M.; Vigo, G., and Tourenq, J. N. Sensitiveness of Three Chironomus (Diptera) Species to Eight Larvicides Used for Mosquito Control (Sensibilite de Trois Especes de Chironomus (Diptera) a huit Insecticides Utilises en Demoustication). 1990; 26, (1): 65-71(FRE) (ENG ABS).


Rec #: 1340
Keywords: NON-ENGLISH
Call Number: NON-ENGLISH (CPY)
Notes: Chemical of Concern: CPY

1244. Singh, B; Dogra, T D, and Singh, B. Rapid Method for the Determination of Some Organophosphorus Insecticides in a Small Amount of Serum in Emergency and Occupational Toxicology Cases. 2009 Aug; 13, (2): 84-87.


Rec #: 44689
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: A simple and rapid method is described for the estimation of some organophosphorus insecticides in the serum of occupationally exposed persons. The compounds are extracted with a mixture of acetone and diethyl ether (1:1 v/v) in acidic medium and the extraction residue is analyzed by gas chromatography with nitrogen phosphorus detection method. Linearity was acceptable over concentrations from 0.25 to 4.0 kg/mL. The method percentile recovery for the six different organophosphorus insecticides was 86.3% for phorate, 78.3% for dimethoate, 82.3% for malathion, 79.4% for chlorpyrifos, 80.2% for diazinon, and 68.5% for ethion at the kg/mL level. Serum samples of nine workers who had been occupationally exposed to malathion in an insecticide manufacturing factory, were analyzed and malathion was found at low levels in all the samples.
Keywords: acetone
Keywords: Organophosphorus compounds
Keywords: Residues
Keywords: phorate
Keywords: Phosphorus
Keywords: H 1000:Occupational Safety and Health
Keywords: Malathion
Keywords: Chlorpyrifos
Keywords: Toxicology Abstracts; Health & Safety Science Abstracts
Keywords: Factories
Keywords: Insecticides
Keywords: Gas chromatography
Keywords: Pesticides
Keywords: Dimethoate
Keywords: Acetone
Keywords: Phosphorus compounds
Keywords: Ethers
Keywords: X 24330:Agrochemicals
Keywords: Diazinon
Keywords: dimethoate
Keywords: Toxicology
Keywords: Occupational exposure
Keywords: Nitrogen
Date revised - 2009-11-01
Language of summary - English
Pages - 84-87
ProQuest ID - 21218536
SubjectsTermNotLitGenreText - Chlorpyrifos; Insecticides; Gas chromatography; phorate; Phosphorus; Dimethoate; Acetone; Ethers; Diazinon; Malathion; Nitrogen; acetone; Organophosphorus compounds; Residues; Factories; Pesticides; Phosphorus compounds; dimethoate; Occupational exposure; Toxicology
Last updated - 2012-03-29
British nursing index edition - Indian Journal of Occupational & Environmental Medicine [Indian J. Occup. Environ. Med.]. Vol. 13, no. 2, pp. 84-87. May-Aug 2009.
Corporate institution author - Singh, B; Dogra, T D
DOI - MD-0010891971; 11148548; 0973-2284 English

1245. Singh, L. P.; Gill, S. S., and Tuteja, N. Unraveling the Role of Fungal Symbionts in Plant Abiotic Stress Tolerance.


Rec #: 50219
Keywords: REVIEW
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: Fungal symbionts have been found associated with every plant studied in natural ecosystem, where they colonize and reside entirely in the internal tissues of their host plant or partially. Fungal endophytes can express/form a range of different lifestyle/relationships with different host including symbiotic, mutualistic, commensalistic and parasitic in response to host genotype and environmental factors. In mutualistic association fungal endophyte can enhance growth, increase reproductive success and confer biotic and abiotic stress tolerance to its host plant. Since abiotic stress such as, drought, high soil salinity, heat, cold, oxidative stress, heavy metal toxicity is the common adverse environmental conditions that affect and limit crop productivity worldwide. It may be a promising alternative strategy to exploit fungal endophytes to overcome the limitations to crop production brought by abiotic stress. There is increasing interest in developing the potential biotechnological applications of fungal endophytes for improving plant stress tolerance and sustainable production of food crops.
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