Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos

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Two studies were conducted to determine how these two cultural practices may affect microbial activity and pesticide degradation within thatch and soil. Hollow tine cultivation briefly enhanced microbial activity within thatch while vertical mowing had no consistent effect on thatch or soil microbial activity. Neither cultivation practice consistently altered the aerobic degradation of 2,4-D, flutolanil or chlorpyrifos. Thatch and soil aerobic degradation constants obtained for flutolanil and chlorpyrifos supported the hypothesis that strongly adsorbed pesticides are shielded from microbial populations that degrade pesticides within thatch.
Start Page: 124
ISSN/ISBN: 9781109215137
Keywords: Thatch
Keywords: Turf cultivation
Keywords: 0285:Agronomy
Keywords: 0481:Soil sciences
Keywords: Microbial activity
Keywords: Pesticide degradation
Keywords: Biological sciences
0285: Agronomy
Turf cultivation
Microbial activity
Pesticide degradation
Copyright ProQuest, UMI Dissertations Publishing 2009
Mu, Yusong
0481: Soil sciences
Biological sciences English

933. Mugni, H.; Ronco, A., and Bonetto, C. Insecticide Toxicity to Hyalella curvispina in Runoff and Stream Water Within a Soybean Farm (Buenos Aires, Argentina). ILPLA (CCT La Plata-CONICET)--UNLP, Instituto de Limnologia "Dr. Raul. A. Ringuelet", Av. Calchaqui Km 23.5, 1888 Florencio Varela, Buenos Aires, Argentina. Elsevier BV//: 2011; 74, (3): 350-354.

Rec #: 2720
Keywords: MIXTURE
Notes: Chemical of Concern: ACO,ATZ,CPY,CYP,CuS,DMB,ES,GYP

934. Mukamal, K. J.; Ghimire, S.; Pandey, R.; O'meara, E. S., and Gautam, S. Antihypertensive Medications and Risk of Community-Acquired Pneumonia.

Rec #: 50659
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: OBJECTIVE: To determine whether angiotensin-converting enzyme (ACE) inhibitors and other antihypertensives are associated with risk of pneumonia.
ABSTRACT: METHODS: We conducted a nested case-control study of incident pneumonia in a subcohort of hypertensive adults insured by several large commercial plans throughout the United States. Individuals with pneumonia were matched on age, sex, region, and subscriber status with up to 10 controls free of pneumonia at the time of case diagnosis. We examined use of beta-blockers, calcium channel blockers, ACE inhibitors (lipophilic and hydrophilic), angiotensin receptor blockers, and thiazides in the prior 3 and 12 months.
ABSTRACT: RESULTS: A total of 7429 cases of pneumonia occurred among 305 958 hypertensive individuals. Risk of pneumonia was higher among users of beta-blockers [adjusted odds ratio (OR) 1.11; 95% confidence interval (CI) 1.03-1.19], calcium channel blockers (adjusted OR 1.09, 95% CI 1.00-1.17), and lipophilic ACE inhibitors (adjusted OR 1.15, 95% CI 1.03-1.28) in the preceding 3 months; risks were also higher for use in the preceding 12 months. We observed lower risk with thiazide use in the preceding 3 months (adjusted OR 0.90, 95% CI 0.81-0.99) and hydrophilic ACE inhibitor use in the preceding year (adjusted OR 0.86, 95% CI 0.75-0.99).
ABSTRACT: CONCLUSION: In this population of middle-aged Americans with hypertension, we observed a modestly higher risk of pneumonia with use of beta-blockers, calcium channel blockers, and lipophilic ACE inhibitors. These results are consistent with possible differences in noncardiovascular outcomes among users of antihypertensives and other commonly used cardiovascular drugs but require confirmation in other populations.
MESH HEADINGS: Adrenergic beta-Antagonists/adverse effects
MESH HEADINGS: Angiotensin-Converting Enzyme Inhibitors/adverse effects
MESH HEADINGS: Antihypertensive Agents/*adverse effects
MESH HEADINGS: Calcium Channel Blockers/adverse effects
MESH HEADINGS: Case-Control Studies
MESH HEADINGS: Cohort Studies
MESH HEADINGS: Community-Acquired Infections/*etiology
MESH HEADINGS: Hypertension/complications/drug therapy
MESH HEADINGS: Pneumonia/*etiology
MESH HEADINGS: Sodium Chloride Symporter Inhibitors/pharmacology eng

935. Mukherjee, Irani. Determination of Pesticide Residues in Honey Samples. 2009 Dec; 83, (6): 818-21.

Rec #: 44439
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: Protocol for the determination of pesticides residues in honey samples have been standardized using a simple technique of liquid-liquid extraction. The method is sensitive to detect low levels of pesticides in honey. Honey sample was fortified with pesticides, namely, cypermethrin, fenvalerate, alphamethrin, lamba-cyhalothrin, endosulfan (α, β and sulfate) and chlorpyrifos. The method of extraction and clean up was optimized and validated in the laboratory. The method was applied to screen six samples of honey locally available for pesticides residues. Recoveries ranged from 60% to 90.6% with RSDs from 2% to 10%. Low recoveries were recorded for α and β -endosulfan in the range of 60%-71%. The LOQs, varied from 0.05 to 1.0 mg kg-1. [PUBLICATION ABSTRACT]
Keywords: Chromatography, Gas
Keywords: Food Contamination -- analysis
Keywords: Pesticide Residues
Keywords: Environmental Studies
Keywords: Endosulfan
Keywords: Nitriles
Keywords: Chlorpyrifos
Keywords: Chlorpyrifos -- analysis
Keywords: Honey -- analysis
Keywords: cypermethrin
Keywords: Pyrethrins -- analysis
Keywords: Pyrethrins
Keywords: Endosulfan -- analysis
Keywords: Nitriles -- analysis
Keywords: fenvalerate
Keywords: Chromatography, Liquid
Keywords: cyhalothrin
Keywords: Pesticide Residues -- analysis
Copyright - Springer Science+Business Media, LLC 2009
Language of summary - English
Pages - 818-21
ProQuest ID - 233185496
Last updated - 2012-03-03
Place of publication - New York
Corporate institution author - Mukherjee, Irani
DOI - 1903467681; 49537521; 108019; BVCX; 19547905; SPVLBVCX128839772 English

936. Mukherjee, Irani; Arora, Sumitra, and Mukherjee, Irani. Impact Analysis of Ipm Programs in Basmati Rice by Estimation of Pesticide Residues. 2011 Mar; 86, ( 3): 307-313.

Rec #: 39939
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: Samples of Basmati rice grain, soil and water were collected, from IPM and non-IPM field trials conducted at four regions of Haryana, Uttar Pradesh and Uttarakhand in India, for pesticide residue analysis. Out of 45 soil samples collected, only four non-IPM samples indicated the presence of chlorpyrifos and endosulfan in the range of ND (<0.001) to 0.05mg/kg. Carbendazim used at two locations of Dehradun and Kaithal was found below detectable limit (<0.05mg/kg) in both IPM and non-IPM trials. Out of total 22 samples of water analyzed, chlorpyriphos was detected in samples from Kaithal and Pant Nagar in the range 0.003-0.006 mu L/L, alpha -endosulfan isomer was detected in the range 0.005-0.03 mu L/L and the beta-isomer in the range 0.005-0.02 mu L/L in sample from Pant Nagar and Kaithal. The residues in all the grain sample of paddy were below detectable limit (<0.001-0.05mg/kg). The insecticides applied in IPM as well as non-IPM trials were found to be below maximum residue level (MRL).
Keywords: India, Haryana
Keywords: impact analysis
Keywords: Pesticide residues
Keywords: P 5000:LAND POLLUTION
Keywords: Environment Abstracts; Pollution Abstracts; Toxicology Abstracts
Keywords: Oryza sativa
Keywords: India, Uttar Pradesh
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Isomers
Keywords: Endosulfan
Keywords: Soil
Keywords: Chlorpyrifos
Keywords: Insecticides
Keywords: Rice fields
Keywords: Pesticides
Keywords: Grain
Keywords: Carbendazim
Keywords: X 24330:Agrochemicals
Date revised - 2011-05-01
Language of summary - English
Location - India, Haryana; India, Uttar Pradesh
Pages - 307-313
ProQuest ID - 864962203
SubjectsTermNotLitGenreText - Chlorpyrifos; Soil; Insecticides; Rice fields; Pesticide residues; Grain; Carbendazim; Endosulfan; Isomers; impact analysis; Pesticides; Oryza sativa; India, Haryana; India, Uttar Pradesh
Last updated - 2012-03-29
British nursing index edition - Bulletin of Environmental Contamination and Toxicology [Bull. Environ. Contam. Toxicol.]. Vol. 86, no. 3, pp. 307-313. Mar 2011.
Corporate institution author - Mukherjee, Irani; Arora, Sumitra
DOI - b4fc040a-6239-45aa-86demfgefd107; 14444708; 0007-4861; 1432-0800 English

937. Mukherjee, S. and Mukherjee, U. A Comprehensive Review of Immunosuppression Used for Liver Transplantation.

Rec #: 50699
Notes: Chemical of Concern: CPY
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ABSTRACT: Since liver transplantation was approved for the treatment of end stage liver disease, calcineurin inhibitors (CNI's) have played a critical role in the preservation of allograft function. Unfortunately, these medications cause a variety of Side effects such as diabetes, hypertension and nephrotoxicity which in turn result in significant morbidity and reduced quality of life. A variety of newer immunosuppressants have been evaluated over the last decade in an attempt to either substitute for CNI's or use with reduced dose CNI's while still preserving allograft function However, current data does not recommend complete cessation of CNI's due to unacceptably high rates of allograft rejection. As these medications have their own unique adverse effects, a careful assessment on their risks and benefits is essential, particularly when additive or synergistic effects with CNI's may occur. Furthermore, the impact of these newer medications on the risk of hepatitis C recurrence and progression remains to be elucidated. Controlled trials are urgently required to assist transplant physicians with choosing the optimum immunosuppressive regimen for their patients. This review will discuss commonly used immunosuppressants prescribed in liver transplantation, emerging therapties and where appropriate, the impact of these medications on the recurrence of hepatitis C after liver transplantation. eng

938. Munoz, A.; Vera, T.; Sidebottom, H.; Mellouki, A.; Borras, E.; Rodenas, M.; Clemente, E., and Vazquez, M. Studies on the Atmospheric Degradation of Chlorpyrifos-Methyl. 2011; 45, (5): 1880-1886.

Rec #: 65669
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: The gas-phase atmospheric degradation of chlorpyrifos-methyl (a widely used organophosphate insecticide in Southern European regions) has been investigated at the large outdoor European Photoreactor (EUPHORE) in Valencia, Spain. Photolysis under sunlight conditions and reaction with ozone were shown to be unimportant. The rate constant for reaction of chlorpyrifos-methyl with OH radicals was measured using a conventional relative rate method with cyclohexane and n-octane employed as reference compounds with k = (4.1 +/- 0.4) x 10(-11) cm(3) molecule(-1) s(-1) at 300 +/- 5 K and atmospheric pressure. The available evidence indicates that tropospheric degradation of chlorpyrifos-methyl is mainly controlled by reaction with OH radicals and that the tropospheric lifetime is estimated to be around 3.5 h. Significant aerosol formation was observed following the reaction of chlorpyrifos-methyl with OH radicals, and the main carbon-containing products detected in the gas phase were chlorpyrifos-methyl oxone and 3,5,6-trichloro..2-pyridinol.
ISI Document Delivery No.: 725HZ

939. Munoz, D; Bonner, Plr; Hargreaves, a J, and Munoz, D. Effects of Chlorpyrifos on Transglutaminase Activity in Differentiating Rat C6 Glioma Cells. 2010 Dec; 24, (8): 2104-2107.

Rec #: 40219
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: The organophosphorothioate compound chlorpyrifos (CPF) is a widely used pesticide, which is known to inhibit the differentiation of mouse N2a neuroblastoma and rat C6 glioma cells. This study in focused on the possible effects of CPF in the activity and expression of tissue transglutaminase (TGase 2) in differentiating C6 cells. Cells exposed for 24h to 10I14M CPF, which had no effect on cell viability, exhibited a significant increase in cytosolic TGase 2 activity. Western blotting analysis indicated that there was no change in the cytosolic TGase 2 protein levels, suggesting that the enzyme was activated under these conditions. When commercially available TGase 2 was incubated with CPF in vitro, an increase in activity was also observed, suggesting that CPF might interact directly with TGase 2.
Keywords: CSA Neurosciences Abstracts; Toxicology Abstracts
Keywords: Western blotting
Keywords: Pharmacy And Pharmacology
Keywords: N3 11028:Neuropharmacology & toxicology
Keywords: Enzymes
Keywords: Transglutaminase 2
Keywords: Neuroblastoma
Keywords: Chlorpyrifos
Keywords: Differentiation
Keywords: Glioma cells
Keywords: Pesticides
Keywords: Proteins
Keywords: X 24330:Agrochemicals
Date revised - 2011-10-01
Language of summary - English
Pages - 2104-2107
ProQuest ID - 849079201
SubjectsTermNotLitGenreText - Chlorpyrifos; Western blotting; Differentiation; Pesticides; Glioma cells; Enzymes; Proteins; Transglutaminase 2; Neuroblastoma
Last updated - 2011-12-12
Corporate institution author - Munoz, D; Bonner, PLR; Hargreaves, A J
DOI - OB-49f29b89-587d-472e-b897csaobj202; 14040942; 0887-2333 English

940. Munoz-Quezada, M. T.; Iglesias, V.; Lucero, B.; Steenland, K.; Barr, D. B.; Levy, K.; Ryan, P. B.; Alvarado, S., and Concha, C. Predictors of exposure to organophosphate pesticides in schoolchildren in the Province of Talca, Chile. 2012; 47, 28-36.

Rec #: 65709
Notes: Chemical of Concern: CPY
Abstract: Abstract: Background: Few data exist in Latin America concerning the association between organophosphate (OP) urinary metabolites and the consumption of fruits and vegetables and other exposure risk variables in schoolchildren. Methods: We collected samples of urine from 190 Chilean children aged 6-12 years, fruits and vegetables, water and soil from schools and homes, and sociodemographic data through a questionnaire. We measured urinary dialkylphosphate (DAP) OP metabolites and OP pesticide residues in food consumed by these 190 children during two seasons: December 2010 (summer) and May 2011 (fall). We analyzed the relationship between urinary DAP concentrations and pesticide residues in food, home pesticide use, and residential location. Results: Diethylalkylphosphates (DEAP) and dimethylalkylphosphates (DMAP) were detected in urine in 76% and 27% of the samples, respectively. Factors associated with urinary DEAP included chlorpyrifos in consumed fruits (p<0.0001), urinary creatinine (p<0.0001), rural residence (p = 0.02) and age less than 9 years (p = 0.004). Factors associated with urinary DMAP included the presence of phosmet residues in fruits (p<0.0001), close proximity to a farm (p = 0.002), home fenitrothion use (p = 0.009), and season (p<0.0001). Conclusions: Urinary DAP levels in Chilean school children were high compared to previously reported studies. The presence of chlorpyrifos and phosmet residues in fruits was the major factor predicting urinary DAP metabolite concentrations in children. (C) 2012 Elsevier Ltd. All rights reserved.
Keywords: Dialkylphosphate metabolites, Organophosphate pesticide residues,
ISI Document Delivery No.: 996AS

941. Muramatsu, D.; Iwai, A.; Aoki, S.; Uchiyama, H.; Kawata, K.; Nakayama, Y.; Nikawa, Y.; Kusano, K.; Okabe, M., and Miyazaki, T. Β-Glucan Derived From Aureobasidium Pullulans Is Effective for the Prevention of Influenza in Mice.

Rec #: 50049
Notes: Chemical of Concern: CPY
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ABSTRACT: β-(1→3)-D-glucans with β-(1→6)-glycosidic linked branches produced by mushrooms, yeast and fungi are known to be an immune activation agent, and are used in anti-cancer drugs or health-promoting foods.
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