Appendix 2-5: Rejected ecotox bibliography for Chlorpyrifos



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Keywords: Agriculture--Crop Production And Soil
Copyright - Springer Science+Business Media B.V. 2010
Language of summary - English
Pages - 191-205
ProQuest ID - 872174732
Document feature - References
Last updated - 2011-06-30
Place of publication - Dordrecht
Corporate institution author - Malchev, Ivan; Fletcher, Ron; Kott, Laima
DOI - 2377083891; 62414671; 108026; EPHY; SPVLEPHY106811752162 English

847. Malhat, Farag and Nasr, Islam. Organophosphorus Pesticides Residues in Fish Samples From the River Nile Tributaries in Egypt. 2011 Dec; 87, (6): 689-92.


Rec #: 39219
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: The concentration of organophosphorus pesticides in fish samples from different tributaries of the Nile River in Egypt was monitored. Fish samples were collected from El Menofiya, canal water supplies (El-Sarsawia, El-Bagoria and Bahr Shebin), in addition to El-Embaby, El-Menofi and Miet Rabiha drainage canals each 2 month during periods of 16 month, June 2007-Septemper 2008. Chloropyrifos, cadusafos, diazinon, prothiphos and malathion were detected in fish tissues samples at level below the maximum residue limit. The highest average amount of chlorpyrifos (9.38 ng g^sup -1^) and malathion (8.31 ng g^sup -1^) were detected in El-Embaby drain. Prothiphos were found in tissues collected from El-Sarsawia canal and Miet-Rabiha drain at mean concentration of 4.91 and 6.55 ng g^sup -1^, respectively. Diazinon was only found in one fish sample that collected from El-Menofi drain at the level of 9.23 ng g^sup -1^.[PUBLICATION ABSTRACT]
Keywords: Organophosphorus Compounds -- analysis
Keywords: Animals
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Water Supply
Keywords: Pesticide Residues
Keywords: Diazinon -- analysis
Keywords: Malathion
Keywords: Environmental Studies
Keywords: Chlorpyrifos
Keywords: Egypt
Keywords: Chlorpyrifos -- analysis
Keywords: Organophosphorus Compounds
Keywords: Malathion -- analysis
Keywords: Fishes
Keywords: Water Pollutants, Chemical
Keywords: Pesticide Residues -- analysis
Keywords: Rivers -- chemistry
Keywords: Diazinon
Keywords: Environmental Monitoring -- methods
Copyright - Springer Science+Business Media, LLC 2011
Language of summary - English
Location - Egypt
Pages - 689-92
ProQuest ID - 905875732
Document feature - References
SubjectsTermNotLitGenreText - Egypt
Last updated - 2012-03-23
Place of publication - New York
Corporate institution author - Malhat, Farag; Nasr, Islam
DOI - 2518732311; 65735241; 108019; BVCX; 21953307; SPVLBVCX128876419
Chambers HW, Boone JS, Carr RL, Chanbers JE (2001) Chemistry of organophosphours insecticides. In: Robert IK (ed) Hand book of pesticide toxicology, 2nd edn. Academic press, California, pp 913-917
Fillion, Julie, Hindle, Ralph 1995 "Multiresidue Determination of Pesticides in Fruit and Vegetables by Gas Chromatography-Mass-Selective Detection and Liquid Chromatography with Fluorescence Detection" Journal of AOAC International 78 5 1252-1266
Haven P, Rase H (1990) Detoxification of organophosphorus pesticides solutions. In: ACS symposium series 468, immerging technologies in hazardous waste management II, June, 1990, Atlantic City, NJ, USA
Lymann W, Reehl W, Rosenblatt D (1990) Hand book of chemistry property estimation methods. American Chemical Society, Washington
Meikle B, Youngson C (1970) Hydrolysis rate of Dowc 179 in water. Dow Chemical Company. Agricultural Research Rep. Gs-1154. Walnut Grove Greek, California, p 6
Schlauch MB (1989) Sensitized photodecomposition of Triazine herbicides. Master thesis, University of Illinois, Urbana
Tsuda, T, Kojima, M 1997 "Acute toxicity, accumulation and excretion of organophosphorous insecticides and their oxidation products in killifish" Chemosphere 35 5 939-949
Yamashita N, Urushigawa Y, Masunaga S, Walash MI, Miyazaki A (2000) Organochlorine pesticides in water, sediment and fish from the Nile River and Manzala Lake in Egypt. Int J Environ Anal Chem 77:289-303 English

848. Mancia, G.; Parati, G.; Bilo, G.; Choi, J.; Kilama, M. O.; Ruilope, L. M., and Talent Investigators. Blood Pressure Control by the Nifedipine Gits-Telmisartan Combination in Patients at High Cardiovascular Risk: the Talent Study.


Rec #: 50299
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: COMMENTS: Comment in: Expert Opin Pharmacother. 2012 Mar;13(4):607-11 (medline /22332938)
COMMENTS: Erratum in: J Hypertens. 2011 May;29(5):1022
ABSTRACT: BACKGROUND: Guidelines on hypertension regard combinations between two antihypertensive drugs to be the most important treatment strategy. Because of the complementary mechanism of action and the evidence of cardiovascular protective effects they include the combination of a calcium antagonist and an angiotensin receptor antagonist among the priorital ones to employ.
ABSTRACT: AIMS: To determine in hypertensive patients at high cardiovascular risk whether combining Nifedipine GITS at low dose and telmisartan reduced ambulatory and clinic blood pressure (BP) more than the combination components, controlled BP early after treatment initiation and allowed to also obtain a better long-term BP control compared to initiating treatment with the combination components and moving to the combination later.
ABSTRACT: METHODS: Four hundred and five patients with a clinic SBP ≥ 135 mmHg and with diabetes, a metabolic syndrome or organ damage were randomized to once-a-day telmisartan 80 mg, nifedipine GITS 20 mg or the combination of the two drugs in a 1: 1: 2 ratio for 8 weeks in the context of a multicenter double-blind study design. Patients on monotherapy were then moved to combination treatment and all three groups were followed for an additional 16-week period. Both 24-h and clinic BP were measured before treatment and at various times during treatment.
ABSTRACT: RESULTS: In the per-protocol patients (n = 327), baseline demographic and clinical characteristics were similar between the three groups. Baseline 24-h SBP values were 136.2 ± 11.6 mmHg (mean ± SD), 137.2 ± 12.5 mmHg and 136.8 ± 11.7 mmHg in the telmisartan monotherapy, nifedipine GITS monotherapy and combination therapy, respectively. The corresponding clinic values were 151.7 ± 11.8, 151.3 ± 11.9 and 151.1 ± 11.8 mmHg, respectively. All treatments lowered 24-h SBP significantly (P < 0.0001) but combination treatment (8 weeks) reduced it significantly more than monotherapies (10.8 ± 0.8 vs. 6.6 ± 1.1 mmHg and 8.0 ± 1.2 mmHg; P = 0.001 and 0.037). Similar data were obtained for clinic SBP for which the combination showed a significantly greater BP reduction (12.6 ± 0.6 vs. 8.6 ± 0.7 mmHg and 9.3 ± 0.8 mmHg; P = 0.003 and 0.024) also after 2 weeks of treatment. Moving from monotherapy to combination therapy increased the antihypertensive effect and made both ambulatory and clinic SBP superimposable in the three groups after 16 and 24 weeks of treatment. Similar findings were obtained for DBP.
ABSTRACT: CONCLUSION: Combination treatment with nifedipine GITS low dose and telmisartan provides a greater and earlier clinic and ambulatory BP reduction than the combination components in monotherapy. Initiating treatment with the combination did not result in any better longer term BP control compared to starting treatment with monotherapy and moving to the combination later.
MESH HEADINGS: Adult
MESH HEADINGS: Aged
MESH HEADINGS: Antihypertensive Agents/*administration &
MESH HEADINGS: dosage
MESH HEADINGS: Benzimidazoles/*administration &
MESH HEADINGS: dosage/adverse effects
MESH HEADINGS: Benzoates/*administration &
MESH HEADINGS: dosage/adverse effects
MESH HEADINGS: Blood Pressure/drug effects
MESH HEADINGS: Blood Pressure Monitoring, Ambulatory
MESH HEADINGS: Cardiovascular Diseases/*etiology
MESH HEADINGS: Delayed-Action Preparations
MESH HEADINGS: Double-Blind Method
MESH HEADINGS: Drug Therapy, Combination
MESH HEADINGS: Female
MESH HEADINGS: Humans
MESH HEADINGS: Hypertension/complications/*drug therapy/physiopathology
MESH HEADINGS: Male
MESH HEADINGS: Middle Aged
MESH HEADINGS: Nifedipine/*administration &
MESH HEADINGS: dosage/adverse effects
MESH HEADINGS: Prospective Studies
MESH HEADINGS: Risk eng

849. Manfo, F. P. T.; Moundipa, P. F.; Dechaud, H.; Tchana, A. N.; Nantia, E. A.; Zabot, M. T., and Pugeat, M. Effect of agropesticides use on male reproductive function: A study on farmers in Djutitsa (Cameroon). 2012; 27, (7): 423-432.


Rec #: 64729
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: This study aimed at investigating the effect of agropesticides on male reproductive function in farmers in Djutitsa (West Cameroon). To this end, 47 farmers in Djutitsa were asked questions on their health status and pesticide use in agriculture. Thereafter, their blood samples were collected for assessment of sex hormones including serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), androstenedione, testosterone, as well as sex hormone binding globulin (SHBG). Their serum triiodothyronine (T3) and thyroxine (T4) levels were also measured. Thirty seven men not exposed to agropesticides were recruited as control group. Fifty six pesticides containing 25 active substances were currently used by farmers enrolled in our study, and most of their symptoms were related to spread/use of these chemicals. Compared to the control group, there was no significant difference in FSH, LH, SHBG, estradiol, and thyroid hormones (T3 and T4) levels. Farmers had significantly lower serum testosterone (20.93 +/- 1.03 nM vs. 24.32 +/- 1.32 nM; P < 0.05) and higher androstenedione level (3.83 +/- 0.20 nM vs. 2.80 +/- 0.15 nM; P < 0.001). Their serum free testosterone as well as bioavailable testosterone were unchanged, while estradiol/testosterone and androstenedione/testosterone ratios were significantly increased (0.45 +/- 0.03% vs. 0.33 +/- 0.02%; P < 0.01 and 12.26 +/- 3.64 vs 19.31 +/- 6.82; P < 0.001, respectively). Our results suggest that male farmers of Djutitsa (West Cameroon) are exposed to agropesticides due to improper protective tool, and this exposure may impair their reproductive function through inhibition of testosterone synthesis; probably by inhibition of testicular 17 beta- hydroxysteroid dehydrogenase (17HSD3) and induction of aromatase (CYP19).(c) 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.
Keywords: agropesticides, human, reproduction, testosterone, androstenedione
ISI Document Delivery No.: 960RK

850. Mangiafico, Salvatore S.; Newman, Julie; Merhaut, Donald J.; Gan, Jay; Faber, Ben, and Wu, Laosheng. Nutrients and Pesticides in Stormwater Runoff and Soil Water in Production Nurseries and Citrus and Avocado Groves in California. 2009; 19, (2): 360-367.


Rec #: 53579
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Potential water quality impacts of agricultural production include runoff and leaching losses of nutrients, pesticides, and sediment. Stormwater runoff and soil water samples were collected from citrus (Citrus spp.), avocado (Persea americana), and ornamental nursery sites in Ventura County, CA, across 19 months. Nitrate-nitrite-nitrogen concentrations in runoff ranged from 0.07 to 31.1 mg·L-1, with medians for groves and nurseries of 4.2 and 5.7 mg·L-1, respectively. Constituents in runoff exceeding benchmarks for surface waters included turbidity, chlorpyrifos, and some organochlorine pesticides. When detected, chlorpyrifos concentration was linearly related to sample turbidity (P = 0.0025, r2 = 0.49). This suggests that the retention of waterborne sediments on-site may be an effective method for mitigating runoff of this pesticide. Bifenthrin, permethrin, and diazinon were also detected in runoff, but concentrations did not exceed water quality benchmarks. Nutrient concentrations in soil water were generally similar to nutrient concentrations in stormwater runoff, suggesting that potential groundwater contamination from leaching at citrus, avocado, and nursery sites may be as much of a concern as stormwater from these operations, particularly on sites with sandy or structured soil texture or flat topography. Nitrate-nitrite-nitrogen and orthophosphate concentrations in soil water were linearly related to nitrogen and phosphorus fertilizer application rates across sites, respectively (P < 0.0001, r2 = 0.49 and 0.50, respectively), suggesting that proper nutrient management is important in reducing potential groundwater contamination at these operations.
Includes references 1022982218

851. Mani, V. G. T. and Konar, S. K. Acute Toxicity of Some Pesticides to Fish, Plankton and Worm. 1986; 16, (5): 145, (ABS) (8431-1Q16).


Rec #: 2420
Keywords: ABSTRACT
Call Number: NO ABSTRACT (CPY,MLN)
Notes: Chemical of Concern: CHD,CPY,MLN

852. Mann, H. D. Report of Dursban Insecticide Residue Analysis in Treated Cattle. 1966.


Rec #: 1090
Keywords: NO SOURCE
Call Number: NO SOURCE (CPY)
Notes: Chemical of Concern: CPY

853. Mansour, S. A. Environmental Impact of Pesticides in Egypt. 2008: 1-51.


Rec #: 2070
Keywords: SURVEY
Call Number: NO SURVEY (ADC,ATZ,AZ,CBL,CPY,CPYM,Captan,DMT,DZ,ES,MLN,MTM,PFF,PIRM,TBF)
Notes: Chemical of Concern: ADC,AMTR,ATZ,AZ,CBL,CPY,CPYM,Captan,DDE,DDT,DMT,DZ,EN,EPRN,ES,HCCH,MLN,MTM,PCB,PFF,PIRM,PPCP,PRN,TBF,TXP

854. Mansour, S. A. and Mossa, A. H. Adverse Effects of Lactational Exposure to Chlorpyrifos in Suckling Rats. samansour@hotmail.com//: 2010; 29, (2): 77-92.


Rec #: 210
Keywords: NO CONC
Call Number: NO CONC (CPY)
Notes: Chemical of Concern: CPY

855. Mansour, Sa ; Belal, M H; Abou-Arab, Aak; Gad, M F, and Mansour, SA. Monitoring of Pesticides and Heavy Metals in Cucumber Fruits Produced From Different Farming Systems. 2009 May; 75, (5): 601-609.


Rec #: 48579
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: Abstract: A total of 216kg of cucumber samples, representing three different types of farming production [e.g., conventional (C), greenhouse (G) and organic (O)], were collected from different locations in Giza governorate (Egypt), and subjected to pesticide residue and heavy metal analyses. Residues of some organochlorine pesticides (OCPs), such as hexachlorobenzene (HCB), heptachlor, aldrin, endrin, dieldrin and o,p'-DDT, as well as organophosphorus pesticides (OPPs), such as chlorpyrifos-methyl, thiometon and phorate were found in a number of samples at concentrations exceeding their MRLs. Lindane was detected in 33.3%, 50.0% and 25.0% of samples from C, G and O cucumber, respectively, without violation. The insecticide methamidophos showed high frequency in the analyzed samples of C, G and O cucumber accounting to 66.7%, 41.7% and 50.0%, respectively, without violation. The majority of the analyzed samples contained detectable concentrations of Zn, Cu, Mn, Fe, Cd, Pb, Cr, Ni and Co. Only, Pb and Cd were found in a number of samples at concentrations exceeding their MLs. Contamination among the three types of cucumber either by pesticides or heavy metals varied from a season to another. Generally, the greenhouse cucumber contained the highest value of total pesticide residues (1.016mgkg super(-) super(1)), followed by organic (0.442mgkg super(-) super(1)) and then conventional (0.415mgkg super(-) super(1)) cucumbers. Heavy metal contamination in the three cucumber types accounted to 4.968, 5.350 and 6.248mgkg super(-) super(1), respectively. The study shed light to the problem of multi toxicants in a food commodity such as cucumber; a common element in the daily human diet.
Keywords: Fruits
Keywords: Egypt, Arab Rep.
Keywords: Organochlorine compounds
Keywords: Toxicants
Keywords: Heavy metals
Keywords: phorate
Keywords: Pesticide residues
Keywords: P 5000:LAND POLLUTION
Keywords: Food
Keywords: Aldrin
Keywords: Copper
Keywords: Lead
Keywords: Environmental Studies
Keywords: Insecticides
Keywords: Zinc
Keywords: greenhouses
Keywords: Cadmium
Keywords: X 24330:Agrochemicals
Keywords: Manganese
Keywords: heavy metals
Keywords: Diets
Keywords: Pollution Abstracts; Toxicology Abstracts; Biotechnology and Bioengineering Abstracts
Keywords: Pesticides (organophosphorus)
Keywords: methamidophos
Keywords: Chromium
Keywords: heptachlor
Keywords: fruits
Keywords: Dieldrin
Keywords: Pesticides (organochlorine)
Keywords: Lindane
Keywords: W 30935:Food Biotechnology
Keywords: Food contamination
Keywords: Greenhouses
Keywords: Heptachlor
Keywords: Pesticides
Keywords: Endrin
Keywords: Hexachlorobenzene
Date revised - 2009-05-01
Language of summary - English
Location - Egypt, Arab Rep.
Pages - 601-609
ProQuest ID - 289683299
SubjectsTermNotLitGenreText - Egypt, Arab Rep.; heavy metals; Lead; Cadmium; Pesticide residues; Insecticides; greenhouses; Aldrin; Lindane; Food contamination; Diets; fruits; Toxicants; Dieldrin; Organochlorine compounds; Zinc; Hexachlorobenzene; Heptachlor; Heavy metals; Greenhouses; methamidophos; Endrin; Chromium; Pesticides (organochlorine); Food; Pesticides; Manganese; heptachlor; Copper; Pesticides (organophosphorus); Fruits; phorate
Last updated - 2011-11-07
Corporate institution author - Mansour, SA; Belal, M H; Abou-Arab, AAK; Gad, M F
DOI - OB-MD-0009535187; 9207133; 0045-6535 English

856. Manthripragada, A. D.; Costello, S.; Cockburn, M. G.; Bronstein, J. M., and Ritz, B. Paraoxonase 1, Agricultural Organophosphate Exposure, and Parkinson Disease. 2010; 21, (1): 87-94.


Rec #: 64819
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Background: Human, animal and cell models support a role for pesticides in the etiology of Parkinson disease. Susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates. Methods: We examined associations between Parkinson disease and the organophosphates diazinon, chlorpyrifos, and parathion, and the influence of a functional polymorphism at position 55 in the coding region of the PON1 gene (PON1-55). From I January 2001 through I January 2008, we recruited 351 incident cases and 363 controls from 3 rural California counties in a population-based case-control study. Participants provided a DNA sample, and residential exposure to organophosphates was determined from pesticide usage reports and a geographic information system (GIS) approach. We assessed the main effects of both genes and pesticides in unconditional logistic regression analyses, and evaluated the effect of carrying a PON1-55 MM variant on estimates of effects for diazinon, chlorpyrifos, and parathion exposures. Results: Carriers of the variant MM PON1-55 genotype exposed to organophosphates exhibited a greater than 2-fold increase in Parkinson disease risk compared with persons who had the wildtype or heterozygous genotype and no exposure (for diazinon, odds ratio = 2.2 [95% confidence interval = 1.1-4.5]; for chlorpyrifos, 2.6 [1.3-5.4]). The effect estimate for chlorpyrifos, was more pronounced in younger-onset cases and controls (<= 60 years) (5.3 [1.7-16]). No increase in risk was noted for parathion. Conclusion: The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering Susceptibility factors when studying environmental exposures in Parkinson disease.
Keywords: PESTICIDE EXPOSURE, CARDIOVASCULAR-DISEASE, PON1 GENE, POLYMORPHISMS,
ISI Document Delivery No.: 534CK

857. Maravgakis, G.; Tzatzarakis, M. N.; Alegakis, A. K.; Stivaktakis, P. D., and Tsatsakis, A. M. Diethyl Phosphates Accumulation in Rabbits' Hair as an Indicator of Long Term Exposure to Diazinon and Chlorpyrifos. Centre of Toxicological Sciences and Research Medical School, University of Crete, Voutes, Heraklion, 71409 Crete, Greece.//: 2012; 218, (1-3): 106-110.


Rec #: 2630
Keywords: NO EFFECT
Call Number: NO EFFECT (CPY,DZ)
Notes: Chemical of Concern: CPY,DZ

858. March, C.; ManclŁS, J. J.; Jim‚Nez, Y.; Arnau, A., and Montoya, A. A Piezoelectric Immunosensor for the Determination of Pesticide Residues and Metabolites in Fruit Juices.


Rec #: 78829
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: ABSTRACT: A quartz crystal microbalance (QCM) immunosensor was developed for the determination of the insecticide carbaryl and 3,5,6-trichloro-2-pyridinol (TCP), the main metabolite of the insecticide chlorpyrifos and of the herbicide triclopyr. The detection was based on a competitive conjugate-immobilized immunoassay format using monoclonal antibodies (MAbs). Hapten conjugates were covalently immobilized, via thioctic acid self-assembled monolayer (SAM), onto the gold electrode sensitive surface of the quartz crystal. This covalent immobilization allowed the reusability of the modified electrode surface for at least one hundred and fifty assays without significant loss of sensitivity. The piezoimmunosensor showed detection limits (analyte concentrations producing 10% inhibition of the maximum signal) of 11 and 7 microg l(-1) for carbaryl and TCP, respectively. The sensitivity attained (I(50) value) was around 30 microg l(-1) for both compounds. Linear working ranges were 15-53 microg l(-1) for carbaryl and 13-83 microg l(-1) for TCP. Each complete assay cycle took 20 min. The good sensitivity, specificity, and reusability achieved, together with the short response time, allowed the application of this immunosensor to the determination of carbaryl and TCP in fruits and vegetables at European regulatory levels, with high precision and accuracy.
MESH HEADINGS: Beverages/*analysis
MESH HEADINGS: Carbaryl/analysis
MESH HEADINGS: Chlorpyrifos/analysis
MESH HEADINGS: Electrochemistry/instrumentation/methods
MESH HEADINGS: Electrodes
MESH HEADINGS: Food Contamination/analysis
MESH HEADINGS: *Fruit
MESH HEADINGS: Glycolates/analysis
MESH HEADINGS: Immunoassay/*methods/standards
MESH HEADINGS: Pesticide Residues/*analysis/metabolism
MESH HEADINGS: Pyridones/analysis
MESH HEADINGS: Reproducibility of Results eng

859. Marchis, Daniela; Ferro, Gian Luca; Brizio, Paola; Squadrone, Stefania, and Abete, Maria Cesarina . Detection of pesticides in crops: A modified QuEChERS approach. 2012 May; 25, (1): 270-273.


Rec #: 5880
Keywords: FOOD
Notes: Chemical of Concern: CPY
Abstract: The general term ÇŁpesticideÇĄ includes a large number of substances that belong to many different chemical classes. Pesticides are applied to crops at various stages of cultivation to provide protection against weeds and pests, and during post-harvest storage to preserve quality. The list of which pesticides are authorized for use in Europe is available on EU pesticides Database. The QuEChERS approach is a method designed for the analysis of pesticides in fruits and vegetables. This method is based on an extraction and clean-up step; it has been designed to be Quick Easy Cheap Effective Rugged and Safe. The aim of this study was to modify the QuEChERS method to be applied in the analysis of 9 organophosphate and 1 pyrethroid pesticides in raw materials for animal feeding introducing an additional liquidÇôliquid partition step. This additional step allowed us to concentrate the samples, avoiding any solvent evaporation, prior to the instrumental analysis. Once the method was optimized, it was carried out a pesticides quantization study using a GCÇôMS SIM multi-residue analysis. 45 samples of maize and soy coming from Northern Italy (Piedmont Region) were analysed during ten months. In 30 samples organophosphate pesticides were found up to 12.4-ámg-ákgęĆ1 of Chlorpyrifos, while no Deltamethrin was detected. QuEChERS/ Raw material/ Feed/ GCÇôMS

860. Markovic, Mirjana; Cupac, Svjetlana; Urovic, Rada; Milinovic, Jelena; Kljajic, Petar, and Markovic, Mirjana. Assessment of Heavy Metal and Pesticide Levels in Soil and Plant Products From Agricultural Area of Belgrade, Serbia. 2010 Feb; 58, (2): 341-351.


Rec #: 44229
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: This study was aimed to assess the levels of selected heavy metals and pesticides in soil and plant products from an agricultural area of Belgrade, Serbia and to indicate possible sources and risks of contamination. Soil, vegetable, and fruit samples from the most important agricultural city areas were collected from July to November of 2006. Metal contents were determined by atomic absorption spectrometry, whereas pesticide residues were analyzed by gas chromatography-mass spectrometry after extraction performed using solid-phase microextraction technique. Soil characterization based on the determination of selected physical and chemical properties revealed heterogeneous soils belonging to different soil groups. The concentrations of lead, cadmium, copper, and zinc in soil samples do not exceed the limits established by national and international regulations. Residues of the herbicide atrazine were detected in three soil samples, with levels lower than the relevant limit. The presence of other herbicides, namely prometryn, chloridazon, acetochlor, flurochloridone, and napropamide, was registered in some soil samples as well. Among the insecticides investigated in the soil, fenitrothion and chlorpyrifos were the only ones detected. In most of the investigated vegetable samples from the Obrenovac area, Pb and Cd contents are higher in comparison with the maximum levels, indicating the emission of coal combustion products from local thermal power plants as a possible source of contamination. Residue levels of some herbicides and insecticides (metribuzin, trifluralin, pendimethalin, bifenthrin, chlorpyrifos, and cypermethrin) determined in tomato, pepper, potato, and onion samples from Slanci, Ovca, and Obrenovac areas are even several times higher than the maximum residue levels. Inappropriate use of these plant protection products is considered to be the most probable reason of contamination. Because increased levels of heavy metals and pesticide residues found in plant products could pose a risk to consumers' health, their continual monitoring before product distribution to city markets is indispensable.
Keywords: Vegetables
Keywords: Contamination
Keywords: Plant protection
Keywords: Heavy metals
Keywords: P 5000:LAND POLLUTION
Keywords: Copper
Keywords: Mass spectroscopy
Keywords: Lead
Keywords: Pendimethalin
Keywords: Soil
Keywords: Agricultural Chemicals
Keywords: Insecticides
Keywords: Gas chromatography
Keywords: Solanum tuberosum
Keywords: Consumers
Keywords: Cadmium
Keywords: heavy metals
Keywords: plant protection
Keywords: Sustainability Science Abstracts; Environmental Engineering Abstracts; Environment Abstracts; Pollution Abstracts; Aqualine Abstracts; Toxicology Abstracts
Keywords: Chlorpyrifos
Keywords: cypermethrin
Keywords: metribuzin
Keywords: Allium cepa
Keywords: International regulations
Keywords: Serbia
Keywords: Fruits
Keywords: Combustion products
Keywords: Pesticide residues
Keywords: M3 1010:Issues in Sustainable Development
Keywords: Coal
Keywords: Environmental Studies
Keywords: Lycopersicon esculentum
Keywords: acetochlor
Keywords: Zinc
Keywords: Power plants
Keywords: X 24330:Agrochemicals
Keywords: Urban areas
Keywords: fruits
Keywords: AQ 00008:Effects of Pollution
Keywords: Herbicides
Keywords: Fenitrothion
Keywords: Heavy Metals
Keywords: Spectrometry
Keywords: Soil pollution
Keywords: Risk
Keywords: Atrazine
Keywords: Pesticides
Keywords: Trifluralin
Keywords: Solid phase methods
Date revised - 2010-02-01
Language of summary - English
Location - Serbia
Pages - 341-351
ProQuest ID - 809744244
SubjectsTermNotLitGenreText - Fruits; Vegetables; Contamination; Pesticide residues; Heavy metals; Plant protection; Combustion products; Coal; Copper; Lead; Mass spectroscopy; Pendimethalin; Soil; Insecticides; Gas chromatography; Zinc; Power plants; Consumers; Cadmium; Herbicides; Fenitrothion; Spectrometry; Chlorpyrifos; Soil pollution; metribuzin; Pesticides; Atrazine; Trifluralin; International regulations; Solid phase methods; plant protection; fruits; acetochlor; cypermethrin; heavy metals; Urban areas; Risk; Agricultural Chemicals; Heavy Metals; Lycopersicon esculentum; Solanum tuberosum; Allium cepa; Serbia
Last updated - 2011-11-03
Corporate institution author - Markovic, Mirjana; Cupac, Svjetlana; urovic, Rada; Milinovic, Jelena; Kljajic, Petar
DOI - OB-7358bb40-85f7-4194-a49emfgefd107; 12588272; 0090-4341; 1432-0703 English

861. Mart+ˇnez, C. Estevan; Vilanova, E., and Sogorb, M. A. Chlorpyrifos and its metabolite, chlorpyrifos-oxon, modify the genic expression of mouse embryonic stem cells after 12 h of exposure: Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX). 2011 Aug 28-; 205, Supplement, (0): S157.


Rec #: 2340
Keywords: ABSTRACT
Notes: Chemical of Concern: CPY

862. Martinez-Haro, M.; Vinuela, J., and Mateo, R. Exposure of Birds to Cholinesterase-Inhibiting Pesticides Following a Forest Application for Tick Control. 2007; 23, 347-349.


Rec #: 1100
Keywords: MIXTURE
Call Number: NO MIXTURE (CBL,CPY,MLN)
Notes: Chemical of Concern: CBL,CPY,MLN

863. Martins, J.; Esteves, C.; Limpo-Faria, A.; Barros, P.; Ribeiro, N.; Simoes, T.; Correia, M., and Delerue-Matos, C. Multiresidue Method for the Determination of Organophosphorus Pesticides in Still Wine and Fortified Wine Using Solid-Phase Microextraction and Gas Chromatography - Tandem Mass Spectrometry. 2011; 44, (6): 1021-1035.


Rec #: 64899
Keywords: CHEM METHODS
Notes: Chemical of Concern: CPY
Abstract: Abstract: A SPME-GC-MS/MS method for the determination of eight organophosphorus pesticides (azinphos-methyl, chlorpyriphos, chlorpyriphos-methyl, diazinon, fenitrothion, fenthion, malathion, and methidathion) in still and fortified wine was developed. The extraction procedure is simple, solvent free, and without any sample pretreatment. Limits of detection (LOD) and quantitation (LOQ) values in the range 0.1-14.3 mu g/L and 0.2-43.3 mu g/L, respectively, were obtained. The LOQ values are below the maximum residue levels (MRLs) established by European Regulation for grapes, with the exception of methidathion. Coefficients of correlation (R2) higher than 0.99 were obtained for the majority of the pesticides, in all different wines analyzed.
Keywords: Fortified wine, GC-MS, MS, Organophosphorus pesticides, SPME, Still wine
ISI Document Delivery No.: 746KS

864. Masson, P.; Froment, M. T.; Gillon, E.; Nachon, F.; Lockridge, O., and Schopfer, L. M. Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters. 2008; 275, (10): 2617-2631.


Rec #: 64929
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: The effects of tyramine, serotonin and benzalkonium on the esterase and aryl acylamidase activities of wild-type human butyrylcholinesterase and its peripheral anionic site mutant, D70G, were investigated. The kinetic study was carried out under steady-state conditions with neutral and positively charged aryl acylamides [o-nitrophenylacetanilide, o-nitrotrifluorophenylacetanilide and m-(acetamido) N,N,N-trimethylanilinium] and homologous esters (o-nitrophenyl acetate and acetylthiocholine). Tyramine was an activator of hydrolysis for neutral substrates and an inhibitor of hydrolysis for positively charged substrates. The affinity of D70G for tyramine was lower than that of the wild-type enzyme. Tyramine activation of hydrolysis for neutral substrates by D70G was linear. Tyramine was found to be a pure competitive inhibitor of hydrolysis for positively charged substrates with both wild-type butyrylcholinesterase and D70G. Serotonin inhibited both esterase and aryl acylamidase activities for both positively charged and neutral substrates. Inhibition of wild-type butyrylcholinesterase was hyperbolic (i.e. partial) with neutral substrates and linear with positively charged substrates. Inhibition of D70G was linear with all substrates. A comparison of the effects of tyramine and serotonin on D70G versus the wild-type enzyme indicated that: (a) the peripheral anionic site is involved in the nonlinear activation and inhibition of the wild-type enzyme; and (b) in the presence of charged substrates, the ligand does not bind to the peripheral anionic site, so that ligand effects are linear, reflecting their sole interaction with the active site binding locus. Benzalkonium acted as an activator at low concentrations with neutral substrates. High concentrations of benzalkonium caused parabolic inhibition of the activity with neutral substrates for both wild-type butyrylcholinesterase and D70G, suggesting multiple binding sites. Benzalkonium caused linear, noncompetitive inhibition of the positively charged aryl acetanilide m-(acetamido) N,N,N-trimethylanilinium for D70G, and an unusual mixed-type inhibition/activation (alpha > beta > 1) for wild-type butyrylcholinesterase with this substrate. No fundamental difference was observed between the effects of ligands on the butyrylcholinesterase-catalysed hydrolysis of esters and amides. Thus, butyrylcholinesterase uses the same machinery, i.e. the catalytic triad S198/H448/E325, for the hydrolysis of both types of substrate. The differences in response to ligand binding depend on whether the substrates are neutral or positively charged, i.e. the differences depend on the function of the peripheral site in wild-type butyrylcholinesterase, or the absence of its function in the D70G mutant. The complex inhibition/activation effects of effectors, depending on the integrity of the peripheral anionic site, reflect the allosteric 'cross-talk' between the peripheral anionic site and the catalytic centre.
Keywords: aryl acylamidase, benzalkonium, butyrylcholinesterase, serotonin,
ISI Document Delivery No.: 292SF

865. Mast, M Alisa; Alvarez, David a, and Zaugg, Steven D. Deposition and Accumulation of Airborne Organic Contaminants in Yosemite National Park, California. 2012 Mar; 31, (3): 524-533.


Rec #: 42839
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Deposition and accumulation of airborne organic contaminants in Yosemite National Park were examined by sampling atmospheric deposition, lichen, zooplankton, and lake sediment at different elevations. Passive samplers were deployed in high-elevation lakes to estimate surface-water concentrations. Detected compounds included current-use pesticides chlorpyrifos, dacthal, and endosulfans and legacy compounds chlordane, dichlorodiphenyltrichloroethane-related compounds, dieldrin, hexachlorobenzene, and polychlorinated biphenyls. Concentrations in snow were similar among sites and showed little variation with elevation. Endosulfan concentrations in summer rain appeared to coincide with application rates in the San Joaquin Valley. More than 70% of annual pesticide inputs from atmospheric deposition occurred during the winter, largely because most precipitation falls as snow. Endosulfan and chlordane concentrations in lichen increased with elevation, indicating that mountain cold-trapping might be an important control on accumulation of these compounds. By contrast, chlorpyrifos concentrations were inversely correlated with elevation, indicating that distance from source areas was the dominant control. Sediment concentrations were inversely correlated with elevation, possibly because of the organic carbon content of sediments but also perhaps the greater mobility of organic contaminants at lower elevations. Surface-water concentrations inferred from passive samplers were at sub-parts-per-trillion concentrations, indicating minimal exposure to aquatic organisms from the water column. Concentrations in sediment generally were low, except for dichlorodiphenyldichloroethane in Tenaya Lake, which exceeded sediment guidelines for protection of benthic organisms. Copyright © 2011 SETAC.
Keywords: 2921-88-2
Keywords: Pesticides -- analysis
Keywords: Animals
Keywords: 115-29-7
Keywords: Organic Chemicals
Keywords: Zooplankton -- metabolism
Keywords: Water Pollutants, Chemical -- analysis
Keywords: Rain -- chemistry
Keywords: Polychlorinated Biphenyls
Keywords: Organic Chemicals -- analysis
Keywords: Air Pollutants -- analysis
Keywords: Polychlorinated Biphenyls -- analysis
Keywords: Phthalic Acids -- analysis
Keywords: Chlorpyrifos -- analysis
Keywords: California
Keywords: 118-74-1
Keywords: Hydrocarbons, Chlorinated
Keywords: Water Pollutants, Chemical
Keywords: Snow -- chemistry
Keywords: Phthalic Acids
Keywords: Lakes -- chemistry
Keywords: Hexachlorobenzene -- analysis
Keywords: Air Pollutants
Keywords: Lichens -- chemistry
Keywords: 1861-32-1
Keywords: Endosulfan
Keywords: Environmental Monitoring
Keywords: Chlorpyrifos
Keywords: 12789-03-6
Keywords: Chlordan
Keywords: Chlordan -- analysis
Keywords: 0
Keywords: Hydrocarbons, Chlorinated -- analysis
Keywords: Endosulfan -- analysis
Keywords: Pesticides
Keywords: Hexachlorobenzene
Keywords: dimethyl 2,3,5,6-tetrachloroterephthalate
Date completed - 2012-08-20
Date created - 2012-02-27
Date revised - 2012-12-20
Language of summary - English
Pages - 524-533
ProQuest ID - 923951323
Last updated - 2013-01-19
British nursing index edition - Environmental toxicology and chemistry / SETAC, March 2012, 31(3):524-533
Corporate institution author - Mast, M Alisa; Alvarez, David A; Zaugg, Steven D
DOI - MEDL-22189687; 22189687; 1552-8618 eng

866. Math, Renukaradhya K; Asraful Islam, Shah Md; Cho, Kye Man; Hong, Sun Joo; Kim, Jong Min; Yun, Myoung Geun; Cho, Ji Joong; Heo, Jae Young; Lee, Young Han; Kim, Hoon; Yun, Han Dae, and Kim, Hoon. Isolation of a Novel Gene Encoding a 3,5,6-Trichloro-2-Pyridinol Degrading Enzyme From a Cow Rumen Metagenomic Library. 2010 Jul; 21, (4): 565-573.


Rec #: 43999
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
Abstract: Abstract: 3,5,6-trichloro-2-pyridinol (TCP) is a major metabolite of the insecticide chlorpyrifos and is hazardous to human and animal health. A gene encoding a TCP degrading enzyme was cloned from a metagenomic library prepared from cow rumen. The gene (tcp3A) is 2.5kb in length, encoding a protein (Tcp3A) of 599 amino acid residues. Tcp3A has a potential signal sequence, as well as a putative ATP/GTP binding site, and a likely amidation site. The molecular weight of the enzyme is 62kDa by SDS-PAGE. Comparison of Tcp3A with the NCBI database using BLASTP revealed homology to amidohydrolase proteins. Recombinant Escherichia coli harboring the tcp3A gene could utilize TCP as the sole source of carbon. TLC and HPLC revealed that TCP was degraded by recombinant E. coli harboring tcp3A. This is the first report of a gene encoding a TCP degrading enzyme.
Keywords: High-performance liquid chromatography
Keywords: A 01360:Plant Diseases
Keywords: Amino acids
Keywords: Biodegradation
Keywords: Rumen
Keywords: GTP
Keywords: ATP
Keywords: Enzymes
Keywords: Metabolites
Keywords: Environmental Studies
Keywords: Chlorpyrifos
Keywords: Databases
Keywords: Carbon
Keywords: Insecticides
Keywords: Homology
Keywords: Molecular weight
Keywords: Escherichia coli
Keywords: Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts
Date revised - 2010-02-01
Language of summary - English
Pages - 565-573
ProQuest ID - 810916516
SubjectsTermNotLitGenreText - High-performance liquid chromatography; Biodegradation; Amino acids; Rumen; Enzymes; ATP; GTP; Metabolites; Chlorpyrifos; Databases; Carbon; Insecticides; Homology; Molecular weight; Escherichia coli
Last updated - 2011-11-03
Corporate institution author - Math, Renukaradhya K; Cho, Kye Man; Hong, Sun Joo; Kim, Jong Min; Yun, Myoung Geun; Cho, Ji Joong; Heo, Jae Young; Lee, Young Han; Kim, Hoon; Yun, Han Dae
DOI - OB-0fe430aa-ee7d-4010-b0b2mfgefd101; 13094101; 0923-9820; 1572-9729 English

867. Matthews, Andre R; Sutter, Mark E, and Rentz, Danielle E. Serum Paraoxonase-1 (Pon-1) Genotype and Exposure to Organophosphorous Insectides--Is There a High-Risk Population? 2011 Sep; 7, (3): 243-247.


Rec #: 43189
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: The Health Studies Branch (HSB) is responsible for responding to domestic and international requests for assistance with suspected and known environmental-associated public health threats as well as pursuing original environmental research. The HSB employs personnel with a wide variety of educational backgrounds and professional training including epidemiology, medicine, toxicology, statistics, and other environmental public health-related disciplines. This wide range of expertise is necessary to address the broad scope of potential environmental health threats. HSB scientists conduct studies on environmental exposures. Recent examples include the following: mercury exposure in children living in large urban areas, exposure to brevetoxins and microcystins arising from harmful algal blooms, and occupational exposures to pesticides. This article will present a brief description of an ongoing study of insecticide exposure and paraoxonase-1 (PON-1) genotype in banana plantation workers in Chinandega, Nicaragua. We will then discuss the enzyme PON-1 and its potential role in organophosphate insecticide metabolism and toxicity.
Keywords: United States
Keywords: 2921-88-2
Keywords: Animals
Keywords: Humans
Keywords: Aryldialkylphosphatase
Keywords: Organophosphorus Compounds -- adverse effects
Keywords: Insecticides -- adverse effects
Keywords: Organophosphorus Compounds
Keywords: Insecticides
Keywords: Chlorpyrifos -- adverse effects
Keywords: Insecticides -- toxicity
Keywords: Aryldialkylphosphatase -- genetics
Keywords: Centers for Disease Control and Prevention (U.S.)
Keywords: Organophosphate Poisoning
Keywords: Agricultural Workers' Diseases -- chemically induced
Keywords: EC 3.1.8.1
Keywords: Chlorpyrifos
Keywords: Risk
Keywords: Insecticides -- poisoning
Keywords: 0
Keywords: Agricultural Workers' Diseases -- epidemiology
Keywords: Environmental Exposure
Keywords: Aryldialkylphosphatase -- blood
Keywords: Occupational Exposure -- adverse effects
Keywords: Organophosphorus Compounds -- toxicity
Date completed - 2011-11-30
Date created - 2011-08-08
Date revised - 2012-12-20
Language of summary - English
Pages - 243-247
ProQuest ID - 893264799
Last updated - 2013-01-19
British nursing index edition - Journal of medical toxicology : official journal of the American College of Medical Toxicology, September 2011, 7(3):243-247
Corporate institution author - Matthews, Andre R; Sutter, Mark E; Rentz, Danielle E
DOI - MEDL-21786069; 21786069; 1937-6995 eng

868. Maver, L.; Stajnbaher, D.; Gros, L.; Kahne-Jurisevic, B.; Repse, B., and Sinigoj-Gacnik, K. Residues of organophosphorus pesticides in different food commodities in Slovenia, 1997-1998. 2007; 31, (1-2): 142-154.


Rec #: 64969
Keywords: SURVEY
Notes: Chemical of Concern: CPY
Abstract: Abstract: During the period 1997-1998 a total of 1237 samples of different food commodities were analysed for residues of organophosphorus pesticides in Slovenia. The domestic and imported commodities tested included fruits, vegetables, cereals, alcoholic drinks and food of animal origin such as liver, fish, eggs, milk and honey. Residues of organophosphates were detected in 8.2% of samples (101 samples). Violation rate was 0.5% (6 samples). The most frequently found were pirimiphos-methyl in samples of cereals and wheat flour, chlorpyrifos in imported grape and phosalone in apples. No residues of organophosphates were found in food of animal origin.
Keywords: pesticide residues, organophosphates, food commodities
ISI Document Delivery No.: 253KT

869. Maya, K.; Singh, R. S.; Upadhyay, S. N., and Dubey, Suresh K. Kinetic analysis reveals bacterial efficacy for biodegradation of chlorpyrifos and its hydrolyzing metabolite TCP. 2011 Nov; 46, (11): 2130-2136.


Rec #: 490
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Efficacy of soil bacterial communities comprising seven different isolates for biodegradation of chlorpyrifos and TCP (3,5,6-trichloro-2-pyridinol), a degradation product of chlorpyrifos, has been investigated. The concentration of chlorpyrifos has ranged from 25 to 200 mg chlorpyrifos/L, and that of TCP from 25 to 100 mg TCP/L. The average values of Ks and Vmax are found to be different for isolates 1Çô4, 5Çô6 and 7 for both chlorpyrifos and TCP. The Ks has ranged from 97 to 142.3 mg/L and Vmax from 7.4 to 12.1 mg/L/d for chlorpyrifos and 103.09 to 148.8 mg/L and 14.9 to 21.2 mg/L/d, respectively, for TCP. Results indicate the high affinity of bacterial community for degradation of both chlorpyrifos and TCP. The 16S rRNA gene sequence analysis has confirmed the genetic relatedness of isolates 1Çô4 with Pseudomonas, isolates 5 and 6 with Agrobacterium, and isolate 7 with Bacillus. Their degradation potential for chlorpyrifos and TCP has been found to be in the order: Pseudomonas > Agrobacterium > Bacillus. It has been also observed that all seven isolates are more efficient in degrading TCP compared to chlorpyrifos. Chlorpyrifos/ TCP/ Biodegradation/ Kinetics/ Molecular characterization

870. Mayer, M.; Semetey, V.; Gitlin, I.; Yang, J., and Whitesides, G. M. Using Ion Channel-Forming Peptides to Quantify Protein-Ligand Interactions.


Rec #: 51369
Keywords: NO TOXICANT
Notes: Chemical of Concern: CPY
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ABSTRACT: This paper proposes a method for sensing affinity interactions by triggering disruption of self-assembly of ion channel-forming peptides in planar lipid bilayers. It shows that the binding of a derivative of alamethicin carrying a covalently attached sulfonamide ligand to carbonic anhydrase II (CA II) resulted in the inhibition of ion channel conductance through the bilayer. We propose that the binding of the bulky CA II protein (MW approximately 30 kD) to the ion channel-forming peptides (MW approximately 2.5 kD) either reduced the tendency of these peptides to self-assemble into a pore or extracted them from the bilayer altogether. In both outcomes, the interactions between the protein and the ligand lead to a disruption of self-assembled pores. Addition of a competitive inhibitor, 4-carboxybenzenesulfonamide, to the solution released CA II from the alamethicin-sulfonamide conjugate and restored the current flow across the bilayer by allowing reassembly of the ion channels in the bilayer. Time-averaged recordings of the current over discrete time intervals made it possible to quantify this monovalent ligand binding interaction. This method gave a dissociation constant of approximately 2 microM for the binding of CA II to alamethicin-sulfonamide in the bilayer recording chamber: this value is consistent with a value obtained independently with CA II and a related sulfonamide derivative by isothermal titration calorimetry.
MESH HEADINGS: Alamethicin/chemistry
MESH HEADINGS: Biochemistry/*methods
MESH HEADINGS: Calorimetry
MESH HEADINGS: Inhibitory Concentration 50
MESH HEADINGS: Ion Channels/chemistry
MESH HEADINGS: *Ions
MESH HEADINGS: Kinetics
MESH HEADINGS: Ligands
MESH HEADINGS: Lipid Bilayers/chemistry
MESH HEADINGS: Models, Statistical
MESH HEADINGS: Molecular Weight
MESH HEADINGS: Peptides/*chemistry
MESH HEADINGS: Proteins/*chemistry
MESH HEADINGS: Sulfonamides/chemistry
MESH HEADINGS: Time Factors eng

871. Mccarthy, Kathleen and McCarthy, Kathleen. Investigation of Hydrophobic Contaminants in an Urban Slough System Using Passive Sampling - Insights From Sampling Rate Calculations. 2008 Oct; 145, (1-3): 31-47.


Rec #: 45549
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: Semipermeable membrane devices (SPMDs) were deployed in the Columbia Slough, near Portland, Oregon, on three separate occasions to measure the spatial and seasonal distribution of dissolved polycyclic aromatic hydrocarbons (PAHs) and organochlorine compounds (OCs) in the slough. Concentrations of PAHs and OCs in SPMDs showed spatial and seasonal differences among sites and indicated that unusually high flows in the spring of 2006 diluted the concentrations of many of the target contaminants. However, the same PAHs - pyrene, fluoranthene, and the alkylated homologues of phenanthrene, anthracene, and fluorene - and OCs - polychlorinated biphenyls, pentachloroanisole, chlorpyrifos, dieldrin, and the metabolites of dichlorodiphenyltrichloroethane (DDT) - predominated throughout the system during all three deployment periods. The data suggest that storm washoff may be a predominant source of PAHs in the slough but that OCs are ubiquitous, entering the slough by a variety of pathways. Comparison of SPMDs deployed on the stream bed with SPMDs deployed in the overlying water column suggests that even for the very hydrophobic compounds investigated, bed sediments may not be a predominant source in this system. Perdeuterated phenanthrene (phenanthrene-d sub(10)). spiked at a rate of 2kg per SPMD, was shown to be a reliable performance reference compound (PRC) under the conditions of these deployments. Post-deployment concentrations of the PRC revealed differences in sampling conditions among sites and between seasons, but indicate that for SPMDs deployed throughout the main slough channel, differences in sampling rates were small enough to make site-to-site comparisons of SPMD concentrations straightforward.
Keywords: Q5 01503:Characteristics, behavior and fate
Keywords: Pollution monitoring
Keywords: Organochlorine compounds
Keywords: SW 3030:Effects of pollution
Keywords: Metabolites
Keywords: Outer continental shelf
Keywords: Freshwater
Keywords: Storms
Keywords: Streams
Keywords: phenanthrene
Keywords: pyrene
Keywords: Insecticides
Keywords: Sulfur dioxide
Keywords: Assessments
Keywords: Pollutants
Keywords: Aromatic hydrocarbons
Keywords: Sampling
Keywords: Aqualine Abstracts; Pollution Abstracts; Environment Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality
Keywords: PCB compounds
Keywords: Seasonal variations
Keywords: PCB
Keywords: O 4060:Pollution - Environment
Keywords: Polycyclic aromatic hydrocarbons
Keywords: Seasonal Distribution
Keywords: USA, Oregon, Portland
Keywords: Chlorine compounds
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Dieldrin
Keywords: Brackish
Keywords: Seasonal distribution
Keywords: AQ 00003:Monitoring and Analysis of Water and Wastes
Keywords: Sediments
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Chlorpyrifos
Keywords: Channels
Keywords: Pesticides
Keywords: High Flow
Keywords: DDT
Keywords: polycyclic aromatic hydrocarbons
Keywords: water column
Keywords: Contaminants
Date revised - 2010-02-01
Language of summary - English
Location - USA, Oregon, Portland
Pages - 31-47
ProQuest ID - 21277349
SubjectsTermNotLitGenreText - Chlorine compounds; Pesticides; Dieldrin; DDT; Aromatic hydrocarbons; Seasonal distribution; Sampling; Outer continental shelf; PCB; Pollution monitoring; Organochlorine compounds; Metabolites; Storms; Streams; Sediments; Channels; Chlorpyrifos; phenanthrene; pyrene; Insecticides; Sulfur dioxide; polycyclic aromatic hydrocarbons; water column; Contaminants; Seasonal variations; PCB compounds; Polycyclic aromatic hydrocarbons; Seasonal Distribution; Assessments; Pollutants; High Flow; USA, Oregon, Portland; Freshwater; Brackish
Last updated - 2012-03-29
British nursing index edition - Environmental Monitoring and Assessment [Environ. Monit. Assess.]. Vol. 145, no. 1-3, pp. 31-47. Oct 2008.
Corporate institution author - McCarthy, Kathleen
DOI - MD-0011180736; 11886878; CS1014404; 0167-6369; 1573-2959 English

872. Mccarty, K. M.; Ryan, L.; Houseman, E. A.; Williams, P. L.; Miller, D. P.; Quamruzzaman, Q.; Rahman, M.; Mahiuddin, G.; Smith, T.; Gonzalez, E.; Su, L., and Christiani, D. C. A Case-Control Study of Gst Polymorphisms and Arsenic Related Skin Lesions.


Rec #: 51469
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
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ABSTRACT: BACKGROUND: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates.
ABSTRACT: METHODS: We investigated whether polymorphisms in GSTT1, GSTP1 and GSTM1 were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001-2002.
ABSTRACT: RESULTS AND DISCUSSION: GSTT1 homozygous wildtype status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10-2.19). The GSTP1 GG polymorphism was associated with greater odds of skin lesions compared to GSTP1 AA, (OR 1.86 (95%CI 1.15-3.00). No evidence of effect modification by GSTT1, GSTM1 or GSTP1 polymorphisms on the association between arsenic exposure and skin lesions was detected.
ABSTRACT: CONCLUSION: GSTT1 wildtype and GSTP1 GG are associated with increased risk of skin lesions.
MESH HEADINGS: Adolescent
MESH HEADINGS: Adult
MESH HEADINGS: Arsenic/analysis
MESH HEADINGS: Arsenic Poisoning/diagnosis/*epidemiology
MESH HEADINGS: Case-Control Studies
MESH HEADINGS: Causality
MESH HEADINGS: Female
MESH HEADINGS: Genotype
MESH HEADINGS: Glutathione S-Transferase pi/*genetics
MESH HEADINGS: Glutathione Transferase/*genetics
MESH HEADINGS: Humans
MESH HEADINGS: /epidemiology
MESH HEADINGS: Male
MESH HEADINGS: Odds Ratio
MESH HEADINGS: *Polymorphism, Genetic
MESH HEADINGS: Regression Analysis
MESH HEADINGS: Risk Factors
MESH HEADINGS: Skin Neoplasms/*epidemiology/*genetics
MESH HEADINGS: Water Supply/analysis eng

873. McCollister, S. B.; Kociba, R. J.; Gehring, P. J., and Humiston, C. G. Results of Two-Year Dietary Feeding Studies on Dowco 179 in Beagle Dogs. 1971.


Rec #: 1110
Keywords: NO SOURCE
Call Number: NO SOURCE (CPY)
Notes: Chemical of Concern: CPY

874. Mcknight, Ursula S; Rasmussen, Jes J; Kronvang, Brian; Bjerg, Poul L; Binning, Philip J, and McKnight, Ursula S. Integrated Assessment of the Impact of Chemical Stressors on Surface Water Ecosystems. 2012 Jun 15; 427-428, 319-331.


Rec #: 46679
Keywords: FATE
Notes: Chemical of Concern: CPY
Abstract: Abstract: The release of chemicals such as chlorinated solvents, pesticides and other xenobiotic organic compounds to streams, either from contaminated sites, accidental or direct application/release, is a significant threat to water resources. In this paper, different methods for evaluating the impacts of chemical stressors on stream ecosystems are evaluated for a stream in Denmark where the effects of major physical habitat degradation can be disregarded. The methods are: (i) the Danish Stream Fauna Index, (ii) Toxic Units (TU), (iii) SPEAR indices, (iv) Hazard Quotient (HQ) index and (v) AQUATOX, an ecological model. The results showed that the hydromorphology, nutrients, biological oxygen demand and contaminants (pesticides and trichloroethylene from a contaminated site) originating from groundwater do not affect the good ecological status in the stream. In contrast, the evaluation by the novel SPEARpesticides index and TU indicated that the site is far from obtaining good ecological status - a direct contradiction to the ecological index currently in use in Denmark today - most likely due to stream sediment-bound pesticides arising from the spring spraying season. In order to generalise the findings of this case study, the HQ index and AQUATOX were extended for additional compounds, not only partly to identify potential compounds of concern, but also to determine thresholds where ecological impacts could be expected to occur. The results demonstrate that some commonly used methods for the assessment of ecological impact are not sufficient for capturing - and ideally separating - the effects of all anthropogenic stressors affecting ecosystems. Predictive modelling techniques can be especially useful in supporting early decisions on prioritising hot spots, serving to identify knowledge gaps and thereby direct future data collection. This case study presents a strong argument for combining bioassessment and modelling techniques to multi-stressor field sites, especially before cost-intensive studies are conducted.
Keywords: Ecosystems
Keywords: Degradation
Keywords: Surface water
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: M3 1010:Issues in Sustainable Development
Keywords: Environment Abstracts; Pollution Abstracts; Sustainability Science Abstracts
Keywords: Solvents
Keywords: Xenobiotics
Keywords: Streams
Keywords: ENA 02:Toxicology & Environmental Safety
Keywords: Environmental Studies
Keywords: Case studies
Keywords: Pesticides
Keywords: Denmark
Keywords: Trichloroethylene
Date revised - 2012-06-01
Language of summary - English
Location - Denmark
Pages - 319-331
ProQuest ID - 1020197882
SubjectsTermNotLitGenreText - Case studies; Degradation; Ecosystems; Surface water; Pesticides; Solvents; Xenobiotics; Trichloroethylene; Streams; Denmark
Last updated - 2012-08-02
Corporate institution author - McKnight, Ursula S; Rasmussen, Jes J; Kronvang, Brian; Bjerg, Poul L; Binning, Philip J
DOI - OB-d1baa92d-90c0-476b-9b63csamfg201; 16794313; 0048-9697 English

875. Mech, A.; Orynbayeva, Z.; Irgebayev, K.; Kolusheva, S., and Jelinek, R. Screening Membrane Interactions of Pesticides by Cells Decorated with Chromatic Polymer Nanopatches. 2009; 22, (1): 90-96.


Rec #: 65029
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: Elucidating the factors contributing to the cell toxicity of pesticides and other environmentally sensitive small molecules is critical for evaluation of their health impacts and for understanding the biological processes that they affect. Disruption and permeation of the plasma membrane, which constitutes the critical interface between the cell and its environment, are recognized initiators of cytotoxicity. We present a new approach for predicting pesticide cytotoxicity through rapid screening of membrane interactions of pesticides using a recently developed live-cell chromatic sensor. The sensing platform comprises living mammalian cells labeled with polydiacetylene (PDA), a chromatic polymer that undergoes intense fluorescence transformations induced by structural perturbations of the membrane bilayer. Within a short time after the addition of membrane-interacting tested compounds to the labeled cells, the PDA patches emit high fluorescence, which can be monitored by conventional spectroscopy and microscopy apparatuses. The chromatic technology facilitates rapid evaluation of membrane activity of pesticide compounds and is capable of distinguishing between toxic effects associated with membrane interactions vs intracellular mechanisms.
Keywords: PYRETHROID INSECTICIDE ALLETHRIN, DEVELOPMENTAL NEUROTOXICITY,
ISI Document Delivery No.: 396PF

876. Medina-Diaz, I M; Rubio-Ortiz, M; Martinez-Guzman, M C; Davalos-Ibarra, R L; Rojas- Garcia, Ae; Robledo-Marenco, M L; Barron-Vivanco, B S; Giron-Perez, Mi; Elizondo, G, and Medina-Diaz, I M. Organophosphate Pesticides Increase the Expression of Alpha Glutathione S-Transferase in Hepg2 Cells. 2011 Dec; 25, (8): 2074-2079.


Rec #: 42999
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: CPY
Abstract: Abstract: Chlorpyrifos and methyl parathion are among the most widely used insecticides in the world. Human populations are constantly exposed to low doses of both due to their extensive use and presence in food and drinking water. Glutathione S-transferase (GST) catalyzes the conjugation of glutathione on electrophilic substrates and is an important line of defense in the protection of cellular components from reactive species. GST alpha1 (GSTA1) is the predominant isoform of GST expressed in the human liver; thus, determining the effect of insecticides on GSTA1 transcription is very important. In the present study, we analyzed the effects of methyl parathion and chlorpyrifos on GSTA1 gene expression in HepG2 cells using real time PCR, and activity and immunoreactive protein assays. The results demonstrated that exposure to methyl parathion and chlorpyrifos increased the level of GSTA1 mRNA, GSTA1 immunoreactive protein and GST activity relative to a control. These results demonstrated that these insecticides can increase the expression of GSTA1. In conclusion, HepG2 cell cultures treated with methyl parathion and chlorpyrifos could be a useful model for studying the function of GSTA1 and its role in the metabolism of xenobiotics in the liver.
Keywords: Pesticides (organophosphorus)
Keywords: Pharmacy And Pharmacology
Keywords: Food
Keywords: Transcription
Keywords: Cell culture
Keywords: Xenobiotics
Keywords: Glutathione transferase
Keywords: Gene expression
Keywords: Chlorpyrifos
Keywords: Insecticides
Keywords: Liver
Keywords: Polymerase chain reaction
Keywords: Methyl parathion
Keywords: Drinking water
Keywords: X 24330:Agrochemicals
Keywords: Toxicology Abstracts
Keywords: Metabolism
Date revised - 2012-01-01
Language of summary - English
Pages - 2074-2079
ProQuest ID - 910051963
SubjectsTermNotLitGenreText - Pesticides (organophosphorus); Food; Transcription; Cell culture; Xenobiotics; Glutathione transferase; Chlorpyrifos; Gene expression; Insecticides; Liver; Polymerase chain reaction; Methyl parathion; Drinking water; Metabolism
Last updated - 2012-01-26
Corporate institution author - Medina-Diaz, I M; Rubio-Ortiz, M; Martinez-Guzman, M C; Davalos-Ibarra, R L; Rojas- Garcia, AE; Robledo-Marenco, M L; Barron-Vivanco, B S; Giron-Perez, MI; Elizondo, G
DOI - OB-5fef4bd8-825b-4d76-a7cbcsamfg201; 16058571; 0887-2333 English

877. Medjdoub, A.; Merzouk, S. A.; Merzouk, H.; Chiali, F. Z., and Narce, M. Effects of Mancozeb and Metribuzin on in vitro proliferative responses and oxidative stress of human and rat spleen lymphocytes stimulated by mitogens. 2011; 101, (1): 27-33.


Rec #: 65059
Keywords: IN VITRO
Notes: Chemical of Concern: CPY
Abstract: Abstract: Pesticides have been shown to possess marked immunotropic activity. The aim of this work was to study the
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