8th European Meeting on Viral Zoonoses 22-25 October, 2017 Saint-Raphaël, France Sunday, October 22, 2017



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8th European Meeting on Viral Zoonoses

22-25 October, 2017

Saint-Raphaël, France

Sunday, October 22, 2017


16.00 – 18.15


Registration – PALAIS DES CONGRES




18.15 – 19.15


Welcome/Introduction – PALAIS DES CONGRES
RICHARD ELLIOTT MEMORIAL LECTURE
Amadou SALL, Dakar, Sénégal
Emerging zoonoses in Africa (O1)




19.30 – 21.30


Welcome Reception Buffet Dinner : Restaurant La Bulle d’Or


Monday, October 23, 2017

SESSION 1 : Ecology, Epidemiology and Evolution (1)
CHAIRS : Åke LUNDKVIST and Luiz Tadeu MORAES FIGUEIREDO

08.45 – 09.25
KEYNOTE TALK : Olli VAPALAHTI, Helsinki, Finland

Zika virus and its variation from mother to fetal brain (O2)


Time

Speaker

Title

9.25 – 9.45


Vaclav Honig

Brno, Czech Republic

(O3)


Changes in behaviour of ixodes ricinus ticks upon infection by tick-borne encephalitis virus

9.45 – 10.05

Teemu Smura

Helsinki, Finland

(O4)


Fatal tick-borne encephalitis virus infections caused by Siberian and European subtypes emerging in Kuutsalo Island, Kotka archipelago, Finland

10.05 – 10.25


Marta Trevisan

Padova, Italy

(O5)


Comparative analysis of Zika virus, West Nile virus and Dengue virus infection in human neural cells

10.25 – 10.45


Goran Bucht

Umeå, Sweden

(O6)


Vertical transmission – a possible explanation for the prevalence of mosquito-borne Inkoo- and Sindbis virus in northern Sweden

10.45 – 11.15

Coffee and Posters




11.15 – 11.35

Magnus Evander

Umeå, Sweden

(O7)


Association of Rift Valley fever virus infection with miscarriage in Sudanese women

11.35 – 11-55

Estela Escribano-Romero

Ciudad Real, Spain

(O8)


Magpies (pica pica) susceptibility to experimental West Nile virus infection

11.55 – 12.15

Wanda Markotter

Pretoria, South Africa

(O9)


Potential zoonotic viruses detected in insectivorous bat species and other non-volant mammals sharing the same ecosystem in South Africa

12.15 – 12.35

Marietjie Venter

Pretoria, South Africa

(10)


One health epidemiology and ecology of zoonotic arboviruses associated with neurological disease in South Africa (2008-2017).

12.35 – 14.15

Lunch break





Monday, October 23, 2017

SESSION 2 : Ecology, Epidemiology and Evolution (2)
CHAIRS : Xavier de LAMBALLERIE and Olli VAPALAHTI

14.15 – 14.55
KEYNOTE TALK : Xavier de LAMBALLERIE, Marseille, France

Zika virus seroepidemiological studies (O11)


Time

Speaker

Title

14.55 – 15.15

Meriadeg Le Gouil

Paris, France

(O12)


Macro & micro-evolution of coronaviruses in bats and emergence potentialities of a betacoronavirus in the western palearctic

15.15 – 15.35

Lorraine M McElhinney

Weybridge, UK

(O13)


Outbreak of haemorrhagic fever with renal syndrome in the United Kingdom

15.35 – 15.55

Jussi Hepojoki

Helsinki, Finland

(O14)


Characterization of HISV-1, the putative type species of a novel genus Hartmanivirus in the family Arenaviridae

15.55 – 16.30


Tea and Posters




16.30 – 16.50

Tatiana Kuznetsova

Tallinn, Estonia

(O15)


Hepatitis E virus infection in different groups of estonian patients and people who inject drugs

16.50 – 17.10

Per Eriksson

Uppsala, Sweden

(O16)


The Pig as a ”Mixing Vessel” for IAVs revisited; new data from virus attachment studies

17.10 – 17.30

Tove Hoffman

Uppsala, Sweden

(O17)


Evaluating the role of northward migratory birds in intercontinental transmission of tick-borne pathogens

17.30 – 17.50

Jonas Blomberg

Uppsala , Sweden

(O18)


Computerized multiplex antibody analysis diminishes problems with cross-reactivity for serological diagnosis of zoonotic virus infections

17.50 – 19.45

POSTER and WINE session


Tuesday, October 24, 2017

SESSION 3 : Virus / Host Interactions (1)
CHAIRS : Friedemann WEBER and Connie SCHMALJOHN

08.45 – 09.25
KEYNOTE TALK : Alain KOHL, Glasgow, UK

Zika virus - tropism and antiviral responses (O19)


Time

Speaker

Title

09.25 – 09.45

Branka Horvat

Lyon, France

(O20)


Immunopathogenesis of Nipah virus infection

09.45 – 10.05


Jan Hellert

Paris, France

(O21)


Structural basis for orthobunyavirus neutralization

10.05 – 10.25


Vincent Legros

Paris, France

(O22)


Chikungunya virus induces apoptosis in infected chondrocytes and promotes cartilage damages

10.25 – 10.45

Marina García

Buenos Aires, Argentina

(O23)


Human B cells: newly described targets for hantavirus infection

10.45 – 11.15

Coffee and Posters




11.15 – 11.35

Pierre-Yves Lozach

Heidelberg, Germany

(O24)


The non-structural protein NSs of rift valley fever virus: a novel model to study prion-like proteins?

11.35 – 11.55

Essia Belarbi

Paris, France

(O25)


Bioluminescent Ross River virus allows in vivo visualisation of acute and persistent alphaviral infection

11.55 – 12.15

Maria Günther

Insel Riems, Germany

(O26)


Interaction of matrix proteins with nuclear anp32b is conserved among Henipa-, Avula- and Respiroviruses

12.15 – 12.35

Mahmoud Naguib

Riems, Germany

(O27)


Reassortants between potentially zoonotic avian influenza viruses H5N1 and H9N2 from Egypt display different pathogenesis in chicken and ferret animal models

12.35 – 14.15

Lunch break





Tuesday, October 24, 2017

SESSION 4 : Virus-Host Interactions (2)
CHAIRS : Alain KOHL and Alexander PLYUSNIN

14.15 – 14.55
KEYNOTE TALK : Friedemann WEBER, (Germany)

Induction and suppression of the interferon response by RNA viruses (O28)


Time

Speaker

Title

14.55 – 15.15

Clément Jousselin

Paris, France

(O29)


Interaction of rabies virus polymerase with cellular factors and exploration of the functional consequences

15.15 – 15.35

Stéphanie Devignot

Giessen, Germany

(O30)


Complex interplay between CCHFV ovarian tumor (OTU) domain and the innate immune response

15.35 – 15.55

Stefan Pöhlmann

Göttingen, Germany

(O31)


A GXXXA motif in the transmembrane domain of the Ebola virus glycoprotein is required for Tetherin antagonism

15.55 – 16.30


Tea and Posters




16.30 – 16.50

Markus Hoffmann

Göttingen, Germany

(O32)


Fruit bat Tetherin (BST-2, CD317) is a potent innate immune factor that inhibits spread of highly pathogenic viruses in bat cells

16.50 – 17.10

Justine Basset

Paris, France

(O33)


Ciliobrevin D, a cytoplasmic dynein antagonist, to investigate the role of dynein in Flavivirus infectious cycle

17.10 – 17.30

Pablo Guardado-Calvo

Paris, France

(O34)


The structure of RVFV fusion protein reveals a lipid binding pocket conserved in class-ii fusion proteins

17.30 – 17.50

Ilona Rissanen

Helsinki, Finland

(O35)


The conserved and metastable architecture of the hantaviral glycoprotein envelope

17.50 – 18.10

Simone Lau

Giessen, Germany

(O36)


Rift Valley fever virus NSS virulence factor disrupts the nuclear pore complex

19.00

Bus departure for Gala Dinner


19.45 – 23.00

Gala Dinner


Wednesday, October 25, 2017

SESSION 5 : "Prevention and Control"
CHAIRS : Christina SPIROPOULOU and Noël TORDO

8.45 – 09.25
KEYNOTE TALK : Connie SCHMALJOHN, USA

DNA Vaccines for Hemorrhagic Fever with Renal Syndrome (O37)



Time

Speaker

Title

09.25 – 9.45

Luiz.T.M. Figueiredo

Ribeirao Preto, Brazil

(O38)


Yellow fever in Brazil 2016-2017: epizootics in primates and human cases

09.45 – 10.05

Ana-Belén Blázquez

Madrid, Spain

(O39)


Zika virus infection confers protection against West Nile virus challenge in mice

10.05 – 10.25


Mathieu Matéo

Lyon, France

(O40)


A potential vaccine platform against arenaviruses based on a recombinant hyper-attenuated Mopeia virus expressing heterologous glycoproteins

10.25 – 10.45


Adeline Kerviel

London, UK

(O41)


Protective efficacy of Bluetongue Virus and African Horse Sickness Virus replication-deficient vaccine strains against virulent virus challenges in animal hosts

10.45 – 11.15

Coffee and Posters


11.15 – 11.35


Dawid Nidzworski

Gdańsk, Poland

(O42)


Mucosal vaccination against influenza virus infection with recombinant spores of Bacillus subtilis

11.35 – 11.55

Verena te Kamp

Insel Riems, Germany

(O43)


Tropism of attenuated GFP-expressing RABV vaccine after oral administration in different reservoir species

11.55 – 12.15

Christina F.Spiropoulou

Atlanta, USA

(O44)


From basic science to promising antivirals for hemorrhagic fever viruses

12.15 – 12.35

Nicole Pavio

Maisons Alfort, France



(O45)


Effect of a ribavirin analogue on the replication of hepatitis E virus in vitro



End of the Meeting
POSTERS BY SESSIONS
Ecology, Epidemiology and Evolution




AUTHORS

TITLE

P1

Mikaty, Guillain1; Gaayeb, Lobna; Pérez-Ramírez, Elisa; Picard, Marie; Fernández Pinero, Jovita; Dente, Maria Grazia; Declich, Silvia; Robert, Vincent; Jiménez-Clavero, Miguel Ángel; Victoir,

MediLabSecure: A virology and entomology laboratories network for a One Health approach of vector-borne and emerging viruses in the Mediterranean and Black Sea regions

P2

Ceylan Polat, Mustafa Sozen, Ferhat Matur, Ortac Cetintas, Muhsin Cogal, Faruk Colak, Mehmet Ali Oktem

Investigation of Hantavirus Existence in Mediterranean and Central Anatolia Regions of Turkey

P3

Miriam A. Sas, Ariel Vina-Rodriguez, Marc Mertens, Samuel Abah, Martin Eiden, Abdoulkadiri Souley, Martin H. Groschup

A one-step multiplex RT-qPCR for the universal detection of all CCHFV genotypes

P4

Hussein Alburkat, Teemu Smura, Barakat AM, Hasony HJ, Haider Al-Hello, Olli Vapalahti

The Presence and Seroprevalence of Lymphocytic choriomeningitis virus in Nasiriyah Governorate, Southern Iraq

P5

Essia Belarbi, Grit Schubert, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Nicolas Meda, Jean-Jacques MuyembeTamfum, Jean-Marie Kayembe, Karen Keddy, Marietjie Venter, Tim Eckmanns, Matthias Borchert & Fabian Leendertz

The ANDEMIA project: African Network for Improved Diagnostics, Epidemiology and Management of Common Infectious Agents

P6

Jenny C. Hessona,b, Jan O. Lundströma,c, Atalay Toka, Örjan Östmand, Åke Lundkvista,e

Temporal variation of antibodies against Sindbis virus in Swedish birds

P7

J Lindahl, B Bett, Å Lundkvist, U Magnusson and D Grace

Two examples of anthropogenic drivers of vector-borne diseases: Irrigation and urbanization

P8

Jenny C. Hessona,b, Marcus Blagrovea, Kenneth Sherlocka, Matthew Baylisa

Vector competence of northern European mosquitoes for West Nile and Usutu virus

P9

Ilkka Kivistö, Thomas Lilley, Eeva-Maria Kyheröinen, Anita Huovilainen, Olli Vapalahti & Tarja Sironen

Coronaviruses in Finnish bats

P10

Kerstin Fischer, Cécile Troupin, Juliet Jabaty, Alimou Camara, Sandra Diederich, Thomas Hoenen, Anne Balkema-Buschmann, Andreas Müller, Roland Suluku, Kristina M. Schmidt, Bashiru Koroma, Felixtina Jonsyn-Ellis, Noël Tordo, Thomas C. Mettenleiter, Martin H. Groschup

Ebola Foresight: The Role of Livestock and Wildlife Species in the Biology of Filoviruses

P11

Mehmet Ali Oktem, Ceylan Polat, Ferhat Matur, Sercan Irmak, Ortac Cetintas, Muhsin Cogal, Mustafa Sozen

New Hantavirus Positivity in Different Microtus and Crocidura Species From Turkey

P12

Anne J Jääskeläinen, Hannimari Kallio-Kokko, Olli Vapalahti

Diagnosis of chikungunyavirus infections during years 2009-2017

P13

Jiaxin Ling, Tanja Strand, Åke Lundkvist, Alexander Plyusnin, Tarja Sironen

Complete genome and phylogeny of Seoul hantavirus from brown rats (Rattus norvegicus) in the Netherlands

P14

Kairi Värv, Jaanus Remm4, Julia Geller, Maria Vikentjeva, Åke Lundkvist, Irina Golovljova

Characterization of TBEV natural foci in Estonia

P15

Jiří Černý; Jana Elsterová; Jana Müllerová; Johanka Hrnková; Libor Grubhoffer ; and Daniel Růžek

Cool viruses from cold climate areas – surveillance for animal viruses in polar areas

P16

Lev Levanov, Anu Jääskeläinen, Olli Vapalahti

Test based on subtype-specific µ-capture igm immunoassay can distinguish between infections of european and siberian subtypes of tick-borne encephalitis virus

P17

Sarah Lumley, Maria Del Mar Fernández de Marco, Luis, M. Hernández-Triana, Daniel . L. Horton, Roger Hewson Jolyon M. Medlock, Anthony R. Fooks and Nicholas Johnson

Ability of British Aedes detritus mosquitoes to transmit Rift Valley fever virus

P18

Valentina Tagliapietra, Niccolò Alfano, Daniele Arnoldi, Roberto Rosà, Chiara Rossi, Fausta Rosso, Heidi C. Hauffe & Annapaola Rizzoli

Emerging rodent-borne viral diseases in Italy: distribution and observed trends in the Province of Trento, Italy.

P19

Aliona Špakovaa, Indrė Kučinskaitė-Kodzėa, Rasa Petraitytė-Burneikienėa, Aurelija Žvirblienėa, Sabrina Schmidtb, Mathias Schlegelb, Erik Lattweinc , Bernd Koellnerd, Rainer G. Ulrichb

Establishment of monoclonal antibody-based competitive ELISA for the diagnostics of human hantavirus infections

P20

Lauri Kareinen, Jussi Hepojoki, Satu Hepojoki, Jonas Schmidt-Chanasit Klaus Hedman and Olli Vapalahti


Rapid serodiagnostic tool for Zika virus infection with low cross-reactivity

P21

B. Albinsson, Å. Lundkvist, S. Vene, J. Blomberg , B. Rönnberg

Serological profile of TBE-infected patients in a vaccinated community – can you tell the difference?

P22

Giorgio Palù



Virus and antibody dynamics in travelers with acute Zika virus infection


P23

Ellen G. Murphy, Nicola J. Williams, Malcolm Bennett, Julian Chantrey, Daisy Jennings and Lorraine M. McElhinney

Diversity of Rodent borne viral zoonoses in the United kIngdom

P24

Essi M. Korhonen, Moses Masika, Christine Lorna Culverwell, Anne Jääskeläinen, Ruut Uusitalo, Dufton Mwaengo, Omu Anzala, Olli Vapalahti, Eili Huhtamo

Mosquito-borne viruses in Southern and Coastal Kenya



Virus-Host and Interactions


P25

Anne Gleize, Patrick Masson, Edouard De Castro, Ioannis Xenarios & Philippe Le Mercier

Clinical metagenomics; On the importance of databases.

P26

Claire Dumont*, François Enchéry, Quentin Bardin, Denis Gerlier and Branka Horvat

Nucleocytoplasmic trafficking of NiV W
and its ability to regulate the NF-κB pathway

P27

Yegor Korzyukov, Rommel Iheozor-Ejiofor, Anja Kipar, Udo Hetzel, Olli Vapalahti, Luis Martinez-Sobrido, Juan Carlos de la Torre, Jussi Hepojoki

Generation of replication-defective, GFP-expressing, recombinant vesicular stomatitis virus pseudotypes expressing reptarenavirus glycoproteins

P28

Jennifer Deborah Wuerth, Matthias Habjan, Andreas Pichlmair, Giulio Superti-Furga & Friedemann Weber

Sandfly fever Sicilian virus NSs Inhibits type I Interferon Induction.

P29

Julien Fouret, Noémie Aurine, François Enchéry, Marie Guinier, Magali Roche, Marc Bailly-Bechet, Branka Horvat, Catherine Legras-Lachuer

Towards understanding of anti-viral response in bats: comparative positive selection analysis combined with functional network

P30

François Enchéry, Claire Dumont, Noémie Aurine, Quentin Bardin, Louis-Marie Bloyet, Cyrille Mathieu, Denis Gerlier, Chloé Journo and Branka Horvat

Modulation of the NF-κB signaling pathway by Nipah virus W nonstructural protein

P31

Marie Moroso, Pauline Verlhac, Olivier Ferraris, Christophe N. Peyrefitte, Hubert P. Endtz, Mathias Faure, Juliet E. Bryant, Glaucia Paranhos-Baccalà

Induction of an autophagy response in human hepatocytes infected by Crimean-Congo hemorrhagic fever virus

P32

M. Alejandra Tortorici, Alexandra C. Walls, Xiaoli Xiong, Brandon Frenz, Joost Snijder, Wentao Li, Craig Yoshioka, Andrew T. McGuire, Peter Rottier, Frank DiMaio, Berend-Jan Bosch, David Veesler & Félix A. Rey

Structural studies of coronavirus spike proteins.

P33

Janne Tynell & Jonas Klingström

Functional characterization of the hantavirus S segment untranslated region

P34

Debbie Ferguson, Jo Hall, Claire Ham, Adrian Jenkins, Elaine Giles, Sarah Kempster, Neil Berry, Neil Almond

Long Term Tissue Presence of Zika Virus in Old World and New World Non Human Primates.

P35

Kirill Nemirov, Alexander Plyusnin, Åke Lundkvist and Noël Tordo.

Development of minireplicon systems for dobrava and tula hantaviruses

P36

Ilona Rissanen, Antra Zeltina, Asim Ahmed, Kristopher Azarm, Patrick Hong, Shannon Beaty, Sham Nambulli, W. Paul Duprex, Benhur Lee, and Thomas A. Bowden

Structural determinants for the glycoprotein-mediated spillover of emerging henipaviruses

P37

Patrick Masson, Chantal Hulo, Edouard De Castro, Lydie Bougueleret, Ioannis Xenarios & Philippe Le Mercier

ViralZone: recent updates to the virus knowledge resource

P38

A. Schoen, F. Weber

Toward a characterization of the type I interferon system of bat cells

P39

Rommel Iheozor-Ejiofor, Lev Levanov, Jussi Hepojoki, Tomas Strandin, Åke Lundkvist, Alexander Plyusnin, and Olli Vapalahti

Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoprotein for use in neutralization tests

P40

A. von Brunn, M. A. Müller, B. von Brunn, J. Lei, C. Drosten, R. Hilgenfeld, Y. Ma-Lauer

SARS-CoV replication is down-regulated by p53 via interaction of the SARS-Unique Domain and PLpro with E3 ubiquitin ligase RCHY1


Prevention and Control


P41

Sabrina Kali , Corinne Jallet, Yu Wu, Valérie Pons, Jean-Christophe Cintrat, Julien Barbier, Daniel Gillet, Noël Tordo.

Innovative antiviral strategies targetting different steps of rabies virus infection

P42

Suvi Kuivanen, Maxim M. Bespalov, Jatin Nandania, Aleksandr Ianevski,Vidya Velagapudi, Jef K. De Brabander, Denis E. Kainov, Olli Vapalahti

Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism

P43

Paul Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Marga van Setten, Erick Bermúdez Méndez, Dubravka Drabek, Jeroen Kortekaas

Development of Rift Valley fever virus neutralizing nanobody complexes using bacterial superglues.

P44

Hadas Cohen-Dvashi, Ron Amon, Vered Padler-Karavani, and Ron Diskin

Targeting zoonotic TfR1-tropic arenaviruses at their Achilles heel:
structure-based rational design of universal immunotherapy

P45

Guy Mong Ky Tran & Adrien Caprani

Highly pathogenic Influenza virus A H5N1 Indonesia & Vietnam Hemagglutinin (HA1) contains an urokinase-plasminogen activator explaining the fibrinolysis.

P46

Guy Mong Ky Tran & Adrien Caprani

Avian Influenza virus A H5N1 polymerases PA, PB1 and hemagglutinin contain a platelet integrin ITGB3 inducing auto-immune anti-platelet antibodies and thrombocytopenia.

P47

Guy Mong Ky Tran & Adrien Caprani

Highly pathogenic Influenza virus A H5N1 (Vietnam, Hong Kong) polymerase PB2 contains a snake disintegrin homologous to platelet integrin ITGA2b (gpIIb), which blocks the formation of platelet clot.

P48

Dario Akaberi, Åke Lundkvist, Navaneethan Palanisamy and Johan Lennerstrand

In-silico identification of potential Zika Virus NS2B-NS3 protease inhibitors



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